DE69027031T2 - Nicht glycosierte proteine, analoge des menschlichen interleukin-3 - Google Patents
Nicht glycosierte proteine, analoge des menschlichen interleukin-3Info
- Publication number
- DE69027031T2 DE69027031T2 DE69027031T DE69027031T DE69027031T2 DE 69027031 T2 DE69027031 T2 DE 69027031T2 DE 69027031 T DE69027031 T DE 69027031T DE 69027031 T DE69027031 T DE 69027031T DE 69027031 T2 DE69027031 T2 DE 69027031T2
- Authority
- DE
- Germany
- Prior art keywords
- glycosized
- analogs
- proteins
- human interleukin
- urticaria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/823—Lower fungi, e.g. mold
- Y10S530/824—Yeasts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/374,667 US5128450A (en) | 1989-06-30 | 1989-06-30 | Nonglycosylated human interleukin-3 analog proteins |
PCT/US1990/003345 WO1991000350A1 (en) | 1989-06-30 | 1990-06-13 | Nonglycosylated human interleukin-3 analog proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69027031D1 DE69027031D1 (de) | 1996-06-20 |
DE69027031T2 true DE69027031T2 (de) | 1996-12-19 |
Family
ID=23477728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69027031T Expired - Fee Related DE69027031T2 (de) | 1989-06-30 | 1990-06-13 | Nicht glycosierte proteine, analoge des menschlichen interleukin-3 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5128450A (de) |
EP (1) | EP0482013B1 (de) |
JP (1) | JPH04506342A (de) |
AT (1) | ATE138099T1 (de) |
AU (1) | AU630207B2 (de) |
CA (1) | CA2033182A1 (de) |
DE (1) | DE69027031T2 (de) |
DK (1) | DK0482013T3 (de) |
ES (1) | ES2090135T3 (de) |
FI (1) | FI916077A0 (de) |
NO (1) | NO301482B1 (de) |
WO (1) | WO1991000350A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
US5705362A (en) * | 1992-05-25 | 1998-01-06 | Gist-Brocades, N.V. | Modified signal sequences |
US5463029A (en) * | 1992-11-23 | 1995-10-31 | Immunex Corporation | Purification of fusion proteins comprising GM-CSF and IL-3 |
US6361976B1 (en) | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production |
US6403076B1 (en) | 1992-11-24 | 2002-06-11 | S. Christopher Bauer | Compositions for increasing hematopoiesis with interleukin-3 mutants |
US5772992A (en) * | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
US6153183A (en) * | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
EP0672145B1 (de) * | 1992-11-24 | 2003-04-23 | G.D. Searle & Co. | Interleukin-3 (il-3)-polypeptide mith mehreren mutationen |
US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5501962A (en) * | 1993-06-21 | 1996-03-26 | G. D. Searle & Co. | Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same |
CA2176115A1 (en) * | 1993-11-10 | 1995-05-18 | Clifford M. Snapper | Compositions and method for stimulating antibody release by b lymphocytes |
US6017523A (en) * | 1995-06-06 | 2000-01-25 | G.D. Searle & Co. | Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides |
DE60036915T2 (de) | 1999-01-13 | 2008-08-07 | Alchemia Oncology Pty Ltd., Hawthorn | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
WO2002069977A1 (en) | 2001-03-01 | 2002-09-12 | Hollis-Eden Pharmaceuticals, Inc. | Use of certain steroids for treatment of blood cell deficiencies |
EP1427447A4 (de) * | 2001-08-27 | 2007-05-23 | Alchemia Oncology Ltd | Verbesserte therapieprotokolle |
JP4212827B2 (ja) * | 2002-05-16 | 2009-01-21 | シスメックス株式会社 | 骨髄液有核細胞自動分析方法 |
CA2496867A1 (en) | 2002-08-28 | 2004-03-11 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment methods |
EP1848738A1 (de) * | 2005-01-25 | 2007-10-31 | Apollo Life Sciences Limited | Parameterausgewählte gm-csf, il-3, il-4, il-5 und chimären davon für therapeutische und diagnostische zwecke |
WO2007012133A1 (en) * | 2005-07-27 | 2007-02-01 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
EA013877B1 (ru) * | 2005-09-07 | 2010-08-30 | Алкемиа Онколоджи Пти Лимитед | Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения |
JP5628544B2 (ja) * | 2010-04-07 | 2014-11-19 | 株式会社豊田中央研究所 | クロストリジウム・サーモセラム由来のタンパク質複合体を構築するためのタンパク質及びその利用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4695542A (en) * | 1983-10-04 | 1987-09-22 | Dnax Research Institute Of Molecular And Cellular Biology, Inc. | cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity |
US4877729A (en) * | 1986-07-14 | 1989-10-31 | Genetics Institute, Inc. | Recombinant DNA encoding novel family of primate hematopoietic growth factors |
IL84852A (en) * | 1986-12-16 | 1994-06-24 | Gist Brocades Nv | Molecular coding and expression of LI-3 |
EP0790307A1 (de) * | 1986-12-16 | 1997-08-20 | Gist-Brocades B.V. | Molekulare Klonierung und Expression von menschlichem IL-3 |
AU1496688A (en) * | 1987-01-20 | 1988-08-10 | Immunex Corporation | Human interleukin-3 proteins |
OA09736A (en) * | 1987-02-18 | 1993-11-30 | Schering Biotech Corp | "Human interleukin-3 and muteins thereof". |
WO1990001039A1 (en) * | 1988-07-20 | 1990-02-08 | Immunex Corporation | Nonglycosylated human interleukin-3 compositions |
-
1989
- 1989-06-30 US US07/374,667 patent/US5128450A/en not_active Expired - Lifetime
-
1990
- 1990-06-13 ES ES90909318T patent/ES2090135T3/es not_active Expired - Lifetime
- 1990-06-13 WO PCT/US1990/003345 patent/WO1991000350A1/en active IP Right Grant
- 1990-06-13 CA CA002033182A patent/CA2033182A1/en not_active Abandoned
- 1990-06-13 AT AT90909318T patent/ATE138099T1/de not_active IP Right Cessation
- 1990-06-13 DK DK90909318.9T patent/DK0482013T3/da active
- 1990-06-13 JP JP2508883A patent/JPH04506342A/ja active Pending
- 1990-06-13 EP EP90909318A patent/EP0482013B1/de not_active Expired - Lifetime
- 1990-06-13 AU AU58216/90A patent/AU630207B2/en not_active Ceased
- 1990-06-13 DE DE69027031T patent/DE69027031T2/de not_active Expired - Fee Related
-
1991
- 1991-12-20 FI FI916077A patent/FI916077A0/fi not_active Application Discontinuation
- 1991-12-27 NO NO915116A patent/NO301482B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO915116D0 (no) | 1991-12-27 |
NO301482B1 (no) | 1997-11-03 |
ATE138099T1 (de) | 1996-06-15 |
ES2090135T3 (es) | 1996-10-16 |
EP0482013B1 (de) | 1996-05-15 |
EP0482013A1 (de) | 1992-04-29 |
CA2033182A1 (en) | 1990-12-31 |
US5128450A (en) | 1992-07-07 |
DK0482013T3 (da) | 1996-06-03 |
DE69027031D1 (de) | 1996-06-20 |
FI916077A0 (fi) | 1991-12-20 |
JPH04506342A (ja) | 1992-11-05 |
AU5821690A (en) | 1991-01-17 |
WO1991000350A1 (en) | 1991-01-10 |
AU630207B2 (en) | 1992-10-22 |
NO915116L (no) | 1992-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |