DE69019609T2 - Proteine und deren Herstellung. - Google Patents
Proteine und deren Herstellung.Info
- Publication number
- DE69019609T2 DE69019609T2 DE69019609T DE69019609T DE69019609T2 DE 69019609 T2 DE69019609 T2 DE 69019609T2 DE 69019609 T DE69019609 T DE 69019609T DE 69019609 T DE69019609 T DE 69019609T DE 69019609 T2 DE69019609 T2 DE 69019609T2
- Authority
- DE
- Germany
- Prior art keywords
- fused protein
- fused
- lymphokine
- vaccine
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 102000004169 proteins and genes Human genes 0.000 title abstract 8
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17603689 | 1989-07-07 | ||
JP5281690 | 1990-03-06 | ||
JP9393890 | 1990-04-11 | ||
JP13818090 | 1990-05-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69019609D1 DE69019609D1 (de) | 1995-06-29 |
DE69019609T2 true DE69019609T2 (de) | 1995-11-30 |
Family
ID=27462829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69019609T Expired - Fee Related DE69019609T2 (de) | 1989-07-07 | 1990-07-05 | Proteine und deren Herstellung. |
Country Status (5)
Country | Link |
---|---|
US (2) | US5556946A (de) |
EP (1) | EP0406857B1 (de) |
AT (1) | ATE123065T1 (de) |
CA (1) | CA2020668C (de) |
DE (1) | DE69019609T2 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6100064A (en) * | 1984-04-06 | 2000-08-08 | Chiron Corporation | Secreted viral proteins useful for vaccines and diagnostics |
ATE123065T1 (de) * | 1989-07-07 | 1995-06-15 | Takeda Chemical Industries Ltd | Proteine und deren herstellung. |
US6737521B1 (en) * | 1990-05-11 | 2004-05-18 | The Rockefeller University | Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria |
US5824319A (en) * | 1990-10-04 | 1998-10-20 | Research Corporation Technologies, Inc. | Varicella-zoster virus antigen |
KR920703614A (ko) * | 1990-10-04 | 1992-12-18 | 티모시 제이. 렉카르트 | 바리셀라-조스터 바이러스 항원 |
WO1993021324A1 (en) * | 1992-04-21 | 1993-10-28 | Institut Pasteur | Recombinant mutants for inducing specific immune responses |
US5935580A (en) * | 1992-04-21 | 1999-08-10 | Institut Pasteur | Recombinant mutants for inducing specific immune responses |
CA2176115A1 (en) * | 1993-11-10 | 1995-05-18 | Clifford M. Snapper | Compositions and method for stimulating antibody release by b lymphocytes |
US7094767B2 (en) | 1994-07-22 | 2006-08-22 | Merck & Co., Inc. | Polynucleotide herpes virus vaccine |
IL114576A0 (en) * | 1994-07-22 | 1995-11-27 | Merck & Co Inc | Polynucleotide herpes virus vaccine |
US6080409A (en) | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
EP0803573A1 (de) * | 1996-04-25 | 1997-10-29 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Polycistronische Expressionskonstrukt mit Cytokinen für multivalente Impstoffe |
EP0805207A1 (de) * | 1996-05-02 | 1997-11-05 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Polycistronische Expressionsplasmid für Tumorabstossungen |
WO1999029732A2 (en) | 1997-12-08 | 1999-06-17 | Lexigen Pharmaceuticals Corporation | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
JP2002511432A (ja) * | 1998-04-15 | 2002-04-16 | レキシジェン ファーマシューティカルズ コーポレイション | 新脈管形成インヒビターの同時投与による抗体−サイトカイン融合タンパク質媒介性免疫応答の増強 |
PL352332A1 (en) * | 1999-05-19 | 2003-08-11 | Lexigen Pharm Corp | Expression and export of interferon-alpha proteins as fc fusion proteins |
SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
CN1235911C (zh) * | 1999-08-09 | 2006-01-11 | 利思进药品公司 | 多细胞因子-抗体复合物 |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
EP1228214A2 (de) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietinformen mit verbesserten eigenschaften |
DK1252192T3 (da) | 2000-02-11 | 2006-11-20 | Merck Patent Gmbh | Forbedring af antistofbaserede fusionsproteiners serumhalveringstid |
ES2288967T3 (es) * | 2000-06-29 | 2008-02-01 | Merck Patent Gmbh | Reforzamiento de las respuestas inmunes mediadas por la proteina de fusion anticuerpo-citoquina por medio del tratamiento combinado por agentes que mejoran la incorporacion de inmunocitoquina. |
DE60042687D1 (de) | 2000-09-15 | 2009-09-17 | Pasteur Institut | Proteinhaltigen Vektoren zur Einführung von Moleküle in CD11b exprimirende Zellen |
MXPA03008031A (es) * | 2001-03-07 | 2003-12-04 | Merck Patent Gmbh | Tecnologia de expresion para proteinas que contienen porcion de anticuerpo isotipo hibrida. |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
US6969517B2 (en) | 2001-05-03 | 2005-11-29 | Emd Lexigen Research Center Corp. | Recombinant tumor specific antibody and use thereof |
GB0112818D0 (en) * | 2001-05-25 | 2001-07-18 | Lorantis Ltd | Conjugate |
ES2381025T3 (es) * | 2001-12-04 | 2012-05-22 | Merck Patent Gmbh | Inmunocitocinas con selectividad modulada |
EP1517700B1 (de) * | 2002-04-22 | 2012-03-28 | Recopharma AB | Mucin-fusionspolypeptid-vakzine, zusammensetzungen und ihre verwendung |
PT1572748E (pt) * | 2002-12-17 | 2010-09-28 | Merck Patent Gmbh | Anticorpo humanizado (h14.18) do anticorpo 14.18 de rato que se liga ao gd2 e a sua fusão com a il-2 |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
ES2305886T3 (es) * | 2003-12-30 | 2008-11-01 | Merck Patent Gmbh | Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo. |
EP1699821B1 (de) * | 2003-12-31 | 2012-06-20 | Merck Patent GmbH | Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MIT VERBESSERTER PHARMAKOKINETIK |
WO2005066348A2 (en) * | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
BRPI0519000A2 (pt) * | 2004-12-09 | 2008-12-23 | Merck Patent Gmbh | variantes de il-7 com imunogenicidade reduzida |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
KR20120030383A (ko) * | 2009-04-22 | 2012-03-28 | 메르크 파텐트 게엠베하 | 변형된 FcRn 결합 자리를 갖는 항체 융합 단백질 |
CN111018994A (zh) * | 2018-10-10 | 2020-04-17 | 江苏健安生物科技有限公司 | 一种vzv病毒亚单元融合抗原 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703004A (en) * | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
EP0158198A1 (de) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA und ihre Verwendung |
US4761375A (en) * | 1984-05-08 | 1988-08-02 | Genetics Institute, Inc. | Human interleukin-2 cDNA sequence |
US5109113A (en) * | 1986-05-02 | 1992-04-28 | Genentech, Inc. | Membrane anchor fusion polypeptides |
DE3751664T2 (de) * | 1986-08-01 | 1996-06-05 | Commw Scient Ind Res Org | Rekombinanter impfstoff |
IL84154A0 (en) * | 1986-10-16 | 1988-03-31 | Microgenesys Inc | Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells and vaccines against acquired immune deficiency syndrome containing the same |
WO1988002634A1 (en) * | 1986-10-20 | 1988-04-21 | Chiron Corporation | Vaccine for use in the therapeutic treatment of hsv |
US5273876A (en) * | 1987-06-26 | 1993-12-28 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene |
PT89121A (pt) * | 1987-12-04 | 1989-12-29 | Du Pont | Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural |
DE68926380T2 (de) * | 1988-11-14 | 1996-09-12 | Kanegafuchi Chemical Ind | Sphärische Vinylchloridharzgranulate und Verfahren zu ihrer Herstellung |
ZA898139B (en) * | 1988-11-17 | 1990-08-29 | Hoffmann La Roche | Recombinant interleukin-2 hybrid proteins |
IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
EP0433442A4 (en) * | 1989-07-06 | 1992-08-05 | Seragen, Inc. | Hybrid molecules |
ATE123065T1 (de) * | 1989-07-07 | 1995-06-15 | Takeda Chemical Industries Ltd | Proteine und deren herstellung. |
DE10021124A1 (de) * | 2000-04-29 | 2001-10-31 | Efen Elektrotech Fab | Abgesicherter kapazitiver Teiler |
JP3664091B2 (ja) * | 2001-01-12 | 2005-06-22 | 日本ビクター株式会社 | 変調方法、変調装置、復調方法、復調装置、情報記録媒体に記録する方法、情報伝送方法および情報伝送装置 |
-
1990
- 1990-07-05 AT AT90112851T patent/ATE123065T1/de not_active IP Right Cessation
- 1990-07-05 EP EP90112851A patent/EP0406857B1/de not_active Expired - Lifetime
- 1990-07-05 DE DE69019609T patent/DE69019609T2/de not_active Expired - Fee Related
- 1990-07-06 CA CA002020668A patent/CA2020668C/en not_active Expired - Fee Related
-
1995
- 1995-02-08 US US08/386,354 patent/US5556946A/en not_active Expired - Fee Related
-
1996
- 1996-02-13 US US08/600,545 patent/US5728552A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE123065T1 (de) | 1995-06-15 |
CA2020668C (en) | 2001-10-02 |
EP0406857A1 (de) | 1991-01-09 |
US5556946A (en) | 1996-09-17 |
DE69019609D1 (de) | 1995-06-29 |
US5728552A (en) | 1998-03-17 |
EP0406857B1 (de) | 1995-05-24 |
CA2020668A1 (en) | 1991-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |