DE69006947T2 - Stabilisiertes FGF-Mittel und dessen Herstellung. - Google Patents
Stabilisiertes FGF-Mittel und dessen Herstellung.Info
- Publication number
- DE69006947T2 DE69006947T2 DE69006947T DE69006947T DE69006947T2 DE 69006947 T2 DE69006947 T2 DE 69006947T2 DE 69006947 T DE69006947 T DE 69006947T DE 69006947 T DE69006947 T DE 69006947T DE 69006947 T2 DE69006947 T2 DE 69006947T2
- Authority
- DE
- Germany
- Prior art keywords
- fgf protein
- stabilized
- production
- water
- stabilized fgf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17622889 | 1989-07-07 | ||
JP13633390 | 1990-05-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69006947D1 DE69006947D1 (de) | 1994-04-07 |
DE69006947T2 true DE69006947T2 (de) | 1994-08-25 |
Family
ID=26469955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69006947T Expired - Fee Related DE69006947T2 (de) | 1989-07-07 | 1990-07-05 | Stabilisiertes FGF-Mittel und dessen Herstellung. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5189148A (de) |
EP (1) | EP0406856B1 (de) |
JP (1) | JP2536247B2 (de) |
CN (1) | CN1049106A (de) |
AT (1) | ATE102044T1 (de) |
AU (1) | AU632344B2 (de) |
CA (1) | CA2020654A1 (de) |
DE (1) | DE69006947T2 (de) |
DK (1) | DK0406856T3 (de) |
ES (1) | ES2062206T3 (de) |
FI (1) | FI903440A0 (de) |
HU (1) | HU205862B (de) |
IE (1) | IE902470A1 (de) |
NO (1) | NO902995L (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5202311A (en) * | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
US5714458A (en) * | 1990-07-18 | 1998-02-03 | Farmitalia Carlo Erba S.R.L. | Stable pharmaceutical compositions containing a fibroblast growth factor |
GB9015824D0 (en) * | 1990-07-18 | 1990-09-05 | Erba Carlo Spa | Stable pharmaceutical compositions containing a fibroblast growth factor |
US5500409A (en) * | 1990-10-01 | 1996-03-19 | Thomas Jefferson University | Method for inhibiting collagen synthesis by keloid fibroblasts |
TW209174B (de) * | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
WO1993000077A1 (en) | 1991-06-21 | 1993-01-07 | University Of Cincinnati | Orally administrable therapeutic proteins and method of making |
DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
CA2080538A1 (en) * | 1991-10-21 | 1993-04-22 | Joseph V. Bondi | Lyophilized acidic fibroblast growth factor |
CA2080537A1 (en) * | 1991-10-21 | 1993-04-22 | David B. Volkin | Stabilized topical acidic fibroblast growth factor formulation |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5482929A (en) * | 1991-12-26 | 1996-01-09 | Kaken Pharmaceutical Co., Ltd. | Composition of stabilized fibroblast growth factor |
US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
DE4242889A1 (de) * | 1992-12-18 | 1994-06-23 | Merck Patent Gmbh | Hohlendoprothesen mit Knochenwachstumsfördernder Füllung |
JP3349535B2 (ja) * | 1993-01-12 | 2002-11-25 | フロイント産業株式会社 | 球形顆粒の製造方法 |
US5331095A (en) * | 1993-04-12 | 1994-07-19 | Scios Nova Inc. | Process for purification of basic fibroblast growth factor |
JP3639593B2 (ja) * | 1993-05-31 | 2005-04-20 | 科研製薬株式会社 | 塩基性線維芽細胞増殖因子含有架橋ゼラチンゲル製剤 |
JPH07112940A (ja) * | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
WO1998009645A1 (fr) * | 1996-09-04 | 1998-03-12 | Dott Research Laboratory | Compositions medicamenteuses contenant des peptides, destinees a l'administration orale |
US6692961B1 (en) * | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
US5851579A (en) * | 1996-10-28 | 1998-12-22 | Eastman Chemical Company | Aqueous enteric coating compositions |
CA2395534A1 (en) * | 1999-06-07 | 2000-12-14 | Fibersugar Aps | Particulate fibre composition |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
JP2003518485A (ja) | 1999-12-23 | 2003-06-10 | ファイザー・プロダクツ・インク | 向上された薬物濃度を与える医薬組成物 |
JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
US9387094B2 (en) | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
JP2005505351A (ja) | 2001-10-12 | 2005-02-24 | オステオテック インコーポレーテッド | 改善された骨移植片 |
FR2836011B1 (fr) * | 2002-02-20 | 2004-05-14 | Goemar Lab Sa | Agent pour la stimulation des defenses naturelles des plantes et procede pour sa mise en oeuvre |
ES2401575T3 (es) * | 2002-04-01 | 2013-04-22 | Kaken Pharmaceutical Co., Ltd. | Preparación viscosa para uso dental que contiene factor de crecimiento de fibroblastos básico |
EP1638486A4 (de) | 2003-06-11 | 2010-09-29 | Osteotech Inc | Osteoimplantate und verfahren zu ihrer herstellung |
ES2396689T3 (es) | 2003-12-11 | 2013-02-25 | Isto Technologies Inc. | Sistema de cartílago particulado |
US20070004036A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for keratinocyte culture |
US20070128685A1 (en) * | 2005-07-01 | 2007-06-07 | Rodolfo Faudoa | Methods and compositions for cell culture |
US20070003541A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for therapeutics |
US8480757B2 (en) | 2005-08-26 | 2013-07-09 | Zimmer, Inc. | Implants and methods for repair, replacement and treatment of disease |
WO2007056671A1 (en) | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US20080154233A1 (en) * | 2006-12-20 | 2008-06-26 | Zimmer Orthobiologics, Inc. | Apparatus for delivering a biocompatible material to a surgical site and method of using same |
WO2008128075A1 (en) | 2007-04-12 | 2008-10-23 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
JP2012506733A (ja) | 2008-10-24 | 2012-03-22 | ウォーソー・オーソペディック・インコーポレーテッド | 骨形成を促進するための組成物および方法 |
SG10201706813WA (en) * | 2012-03-30 | 2017-10-30 | Ajinomoto Kk | Culture medium for proliferating stem cell, which contains sulfated compound |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
WO2017089016A1 (en) | 2015-11-27 | 2017-06-01 | Masarykova Univerzita | Thermostable fgf2 polypeptide, use thereof |
JP2021138648A (ja) * | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
EP4183796A1 (de) | 2021-11-19 | 2023-05-24 | Enantis s.r.o. | Thermostabiles fgf10-polypeptid oder fragment davon, verwendung davon |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4717717A (en) * | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
NZ222413A (en) * | 1986-11-05 | 1991-06-25 | Ethicon Inc | Compositions containing a polypeptide growth factor and a water-soluble cellulose polymer stabiliser |
JP2526965B2 (ja) * | 1987-02-24 | 1996-08-21 | 武田薬品工業株式会社 | ムテイン,dnaおよびその用途 |
NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
NZ226170A (en) * | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
-
1990
- 1990-06-06 CA CA002020654A patent/CA2020654A1/en not_active Abandoned
- 1990-07-03 US US07/547,454 patent/US5189148A/en not_active Expired - Fee Related
- 1990-07-04 NO NO90902995A patent/NO902995L/no unknown
- 1990-07-05 JP JP2178917A patent/JP2536247B2/ja not_active Expired - Lifetime
- 1990-07-05 EP EP90112850A patent/EP0406856B1/de not_active Expired - Lifetime
- 1990-07-05 DE DE69006947T patent/DE69006947T2/de not_active Expired - Fee Related
- 1990-07-05 DK DK90112850.4T patent/DK0406856T3/da active
- 1990-07-05 AT AT90112850T patent/ATE102044T1/de not_active IP Right Cessation
- 1990-07-05 ES ES90112850T patent/ES2062206T3/es not_active Expired - Lifetime
- 1990-07-06 CN CN90103391A patent/CN1049106A/zh active Pending
- 1990-07-06 HU HU904116A patent/HU205862B/hu not_active IP Right Cessation
- 1990-07-06 AU AU58799/90A patent/AU632344B2/en not_active Ceased
- 1990-07-06 FI FI903440A patent/FI903440A0/fi not_active IP Right Cessation
- 1990-07-06 IE IE247090A patent/IE902470A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
US5189148A (en) | 1993-02-23 |
DK0406856T3 (da) | 1994-07-04 |
CA2020654A1 (en) | 1991-01-08 |
JP2536247B2 (ja) | 1996-09-18 |
NO902995L (no) | 1991-01-08 |
JPH04128239A (ja) | 1992-04-28 |
HU904116D0 (en) | 1990-12-28 |
AU5879990A (en) | 1991-01-10 |
ATE102044T1 (de) | 1994-03-15 |
HUT54895A (en) | 1991-04-29 |
ES2062206T3 (es) | 1994-12-16 |
FI903440A0 (fi) | 1990-07-06 |
EP0406856A2 (de) | 1991-01-09 |
EP0406856B1 (de) | 1994-03-02 |
CN1049106A (zh) | 1991-02-13 |
NO902995D0 (no) | 1990-07-04 |
IE902470A1 (en) | 1991-02-13 |
EP0406856A3 (en) | 1991-04-10 |
HU205862B (en) | 1992-07-28 |
DE69006947D1 (de) | 1994-04-07 |
AU632344B2 (en) | 1992-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |