DE69006000D1 - Verstärker des transdermalen Flusses in Kombination mit Iontophorese für die topische Verabreichung von Arzneimitteln. - Google Patents
Verstärker des transdermalen Flusses in Kombination mit Iontophorese für die topische Verabreichung von Arzneimitteln.Info
- Publication number
- DE69006000D1 DE69006000D1 DE90312217T DE69006000T DE69006000D1 DE 69006000 D1 DE69006000 D1 DE 69006000D1 DE 90312217 T DE90312217 T DE 90312217T DE 69006000 T DE69006000 T DE 69006000T DE 69006000 D1 DE69006000 D1 DE 69006000D1
- Authority
- DE
- Germany
- Prior art keywords
- iontophoresis
- drug delivery
- topical drug
- flow enhancer
- transdermal flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/443,699 US5023085A (en) | 1989-11-29 | 1989-11-29 | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69006000D1 true DE69006000D1 (de) | 1994-02-24 |
DE69006000T2 DE69006000T2 (de) | 1994-05-05 |
Family
ID=23761854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE90312217T Expired - Fee Related DE69006000T2 (de) | 1989-11-29 | 1990-11-08 | Verstärker des transdermalen Flusses in Kombination mit Iontophorese für die topische Verabreichung von Arzneimitteln. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5023085A (de) |
EP (1) | EP0435436B1 (de) |
JP (1) | JPH0688912B2 (de) |
KR (1) | KR930007248B1 (de) |
AT (1) | ATE99961T1 (de) |
AU (1) | AU613281B1 (de) |
CA (1) | CA2030943A1 (de) |
DE (1) | DE69006000T2 (de) |
DK (1) | DK0435436T3 (de) |
HU (1) | HUT55629A (de) |
IE (1) | IE63597B1 (de) |
IL (1) | IL96449A (de) |
MY (1) | MY109727A (de) |
NZ (1) | NZ236253A (de) |
PH (1) | PH27105A (de) |
PT (1) | PT96021B (de) |
ZA (1) | ZA909512B (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5196410A (en) * | 1986-10-31 | 1993-03-23 | Pfizer Inc. | Transdermal flux enhancing compositions |
DE3880923T3 (de) * | 1987-02-23 | 1997-12-18 | Shiseido Co Ltd | Perkutaner absorptionspromotor und dermatologische zusammensetzung für externe anwendung. |
US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5262165A (en) * | 1992-02-04 | 1993-11-16 | Schering Corporation | Transdermal nitroglycerin patch with penetration enhancers |
US5302172A (en) * | 1990-03-15 | 1994-04-12 | North Carolina State University | Method and composition for iontophoresis |
US5383848A (en) * | 1990-04-12 | 1995-01-24 | Gensia, Inc. | Iontophoretic administration of drugs |
US6600950B1 (en) * | 1990-11-01 | 2003-07-29 | Robert Tapper | Iontophoretic treatment system |
US6575957B1 (en) * | 1990-11-01 | 2003-06-10 | Robert Tapper | Iontophoretic treatment system |
US6582416B2 (en) | 1990-11-01 | 2003-06-24 | Robert Tapper | Iontophoretic treatment system |
US6223076B1 (en) | 1990-11-01 | 2001-04-24 | Robert Tapper | Sweat control system |
US6139537A (en) * | 1990-11-01 | 2000-10-31 | Tapper; Robert | Iontophoretic treatment system |
US5224927A (en) * | 1990-11-01 | 1993-07-06 | Robert Tapper | Iontophoretic treatment system |
US6238381B1 (en) | 1990-11-01 | 2001-05-29 | Robert Tapper | Iontophoretic treatment system |
US6235013B1 (en) | 1990-11-01 | 2001-05-22 | Robert Tapper | Iontophoretic treatment system |
US5131403A (en) * | 1991-06-05 | 1992-07-21 | Becton Dickinson And Company | Method for obtaining blood using iontophoresis |
US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
EP0552879B1 (de) * | 1992-01-21 | 1998-08-19 | Macrochem Corporation | Iontophoretische verbesserte Verabreichung von Medikamenten |
CA2183875C (en) * | 1992-06-02 | 2003-10-14 | Robert M. Myers | Electrotransport drug delivery device |
US5580574A (en) * | 1994-04-28 | 1996-12-03 | Hoffmann-La Roche Inc. | Pharmaceutical composition for transdermal delivery |
US5594015A (en) * | 1994-06-22 | 1997-01-14 | Regents Of The University Of California | Thiazolidine derivatives for the treatment of psoriasis |
ATE197396T1 (de) * | 1994-07-13 | 2000-11-11 | Alza Corp | Zusammensetzung und verfahren zur förderung von transdermaler elektrotransport-darreichung |
US5540654A (en) * | 1994-09-02 | 1996-07-30 | North Carolina State University | Iontophoretic electrode |
US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
US5736580A (en) * | 1994-11-14 | 1998-04-07 | Alza Croporation | Composition, device, and method for electrotransport agent delivery |
US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
US5985316A (en) * | 1995-04-28 | 1999-11-16 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
US6355025B1 (en) | 1995-06-07 | 2002-03-12 | Alza Corporation | Adjustable electrotransport drug delivery using a fixed output controller |
AU7286996A (en) * | 1995-10-18 | 1997-05-07 | Ciba-Geigy Ag | Thermopile powered transdermal drug delivery device |
US7094422B2 (en) | 1996-02-19 | 2006-08-22 | Acrux Dds Pty Ltd. | Topical delivery of antifungal agents |
AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
AUPO907697A0 (en) * | 1997-09-09 | 1997-10-02 | Day, Robert Edward | Chemical supplementation of bone |
GB9723669D0 (en) | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
EP1135188B1 (de) | 1998-11-02 | 2007-11-28 | ALZA Corporation | Iontophoretische vorrichtung mit einem materialverträglichen antimikrobiellen wirkstoff |
JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
CA2400074A1 (en) | 2000-02-18 | 2001-08-23 | William I. Higuchi | Methods for extracting substances using alternating current |
EP1259285A1 (de) | 2000-02-18 | 2002-11-27 | University of Utah | Verfahren zur abreichung von medikamenten durch wechselstrom |
US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
US7137975B2 (en) * | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
JP4320177B2 (ja) * | 2001-04-04 | 2009-08-26 | アルザ・コーポレーシヨン | 抗微生物適合性レザバー組成物を含む経皮性電気輸送デリバリー装置 |
US7099713B2 (en) | 2002-06-28 | 2006-08-29 | Battelle Memorial Institute | Skin conduction and transport systems |
US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
US20050220439A1 (en) * | 2004-03-19 | 2005-10-06 | Carton Owen A | Interactive multimedia system and method |
US20060222692A1 (en) * | 2005-03-31 | 2006-10-05 | Fairfield Clinical Trials Llc | Method and compositions for transdermal administration of antimicrobial medications |
CA2613875C (en) * | 2005-07-04 | 2018-09-25 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
US20070292492A1 (en) * | 2006-06-16 | 2007-12-20 | Friden Phllip M | Pharmaceutical formulations for iontophoretic tetracycline antibiotic delivery |
WO2009158477A1 (en) | 2008-06-25 | 2009-12-30 | Us Worldmeds Llc | Skin patches and sustained-release formulations comprising lofexidine for transdermal and oral delivery |
US20110281834A1 (en) * | 2008-11-10 | 2011-11-17 | Friden Phillip M | Pharmaceutical Formulations for Iontophoretic Delivery of a Corticosteroid |
US20100331812A1 (en) * | 2009-06-29 | 2010-12-30 | Nitric Biotherapeutics, Inc. | Pharmaceutical Formulations for Iontophoretic Delivery of an Immunomodulator |
EP2557924B1 (de) | 2010-04-13 | 2019-06-12 | Relmada Therapeutics, Inc. | Dermale pharmazeutische zusammensetzungen aus 1-methyl-2',6'-pipecoloxylidid und verwendungsverfahren dafür |
AU2014369916A1 (en) | 2013-12-24 | 2016-06-16 | Durect Corporation | Uses of oxygenated cholesterol sulfates (OCS) |
US11564970B2 (en) | 2017-10-09 | 2023-01-31 | The Broad Institute, Inc. | Compositions and methods for combinatorial drug discovery in nanoliter droplets |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
US4405616A (en) * | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4316893A (en) * | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
US4954487A (en) * | 1979-01-08 | 1990-09-04 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
JPS6036299B2 (ja) * | 1981-07-02 | 1985-08-20 | タカラベルモント株式会社 | イオン導入器 |
HU185691B (en) * | 1982-02-09 | 1985-03-28 | Richter Gedeon Vegyeszet | Process for preparing a new analgetic pharmaceutical composition |
US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
US4919648A (en) * | 1983-08-18 | 1990-04-24 | Drug Delivery Systems Inc. | High tack drug patch |
JPS6222662A (ja) * | 1985-07-19 | 1987-01-30 | 林原 健 | イオン導入電子治療器 |
MY102980A (en) * | 1986-10-31 | 1993-03-31 | Pfizer | Transdermal flux enhancing compositions |
US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
ATE80313T1 (de) * | 1988-02-29 | 1992-09-15 | Pfizer | Mittel zur erhoehung des transdermalen penetrationsflusses. |
-
1989
- 1989-11-29 US US07/443,699 patent/US5023085A/en not_active Expired - Fee Related
-
1990
- 1990-11-02 PH PH41182A patent/PH27105A/en unknown
- 1990-11-08 EP EP90312217A patent/EP0435436B1/de not_active Expired - Lifetime
- 1990-11-08 AT AT90312217T patent/ATE99961T1/de not_active IP Right Cessation
- 1990-11-08 DE DE90312217T patent/DE69006000T2/de not_active Expired - Fee Related
- 1990-11-08 DK DK90312217.4T patent/DK0435436T3/da active
- 1990-11-22 IL IL9644990A patent/IL96449A/en not_active IP Right Cessation
- 1990-11-27 ZA ZA909512A patent/ZA909512B/xx unknown
- 1990-11-27 MY MYPI90002098A patent/MY109727A/en unknown
- 1990-11-27 CA CA002030943A patent/CA2030943A1/en not_active Abandoned
- 1990-11-28 NZ NZ236253A patent/NZ236253A/xx unknown
- 1990-11-28 IE IE428190A patent/IE63597B1/en not_active IP Right Cessation
- 1990-11-28 HU HU907681A patent/HUT55629A/hu unknown
- 1990-11-28 KR KR1019900019334A patent/KR930007248B1/ko not_active IP Right Cessation
- 1990-11-28 AU AU67069/90A patent/AU613281B1/en not_active Ceased
- 1990-11-28 PT PT96021A patent/PT96021B/pt not_active IP Right Cessation
- 1990-11-29 JP JP2333509A patent/JPH0688912B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0435436A3 (en) | 1992-01-08 |
IE904281A1 (en) | 1991-06-05 |
JPH03176426A (ja) | 1991-07-31 |
JPH0688912B2 (ja) | 1994-11-09 |
PH27105A (en) | 1993-03-16 |
IE63597B1 (en) | 1995-05-17 |
NZ236253A (en) | 1993-05-26 |
EP0435436A2 (de) | 1991-07-03 |
PT96021B (pt) | 1998-02-27 |
MY109727A (en) | 1997-05-31 |
US5023085A (en) | 1991-06-11 |
AU613281B1 (en) | 1991-07-25 |
KR930007248B1 (ko) | 1993-08-04 |
DK0435436T3 (da) | 1994-02-28 |
ZA909512B (en) | 1992-06-24 |
KR910009250A (ko) | 1991-06-28 |
IL96449A (en) | 1996-07-23 |
ATE99961T1 (de) | 1994-01-15 |
PT96021A (pt) | 1991-09-13 |
EP0435436B1 (de) | 1994-01-12 |
DE69006000T2 (de) | 1994-05-05 |
HUT55629A (en) | 1991-06-28 |
CA2030943A1 (en) | 1991-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |