DE69000240D1 - Nifedipine enthaltende zusammensetzungen und verfahren zu ihrer herstellung. - Google Patents

Nifedipine enthaltende zusammensetzungen und verfahren zu ihrer herstellung.

Info

Publication number
DE69000240D1
DE69000240D1 DE9090301005T DE69000240T DE69000240D1 DE 69000240 D1 DE69000240 D1 DE 69000240D1 DE 9090301005 T DE9090301005 T DE 9090301005T DE 69000240 T DE69000240 T DE 69000240T DE 69000240 D1 DE69000240 D1 DE 69000240D1
Authority
DE
Germany
Prior art keywords
nifedipine
polyvinylpyrrolidone
amount
production
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE9090301005T
Other languages
English (en)
Other versions
DE69000240T2 (de
Inventor
Alan Rhodes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethical Pharmaceuticals Ltd
Original Assignee
Ethical Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethical Pharmaceuticals Ltd filed Critical Ethical Pharmaceuticals Ltd
Application granted granted Critical
Publication of DE69000240D1 publication Critical patent/DE69000240D1/de
Publication of DE69000240T2 publication Critical patent/DE69000240T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DE9090301005T 1989-02-14 1990-01-31 Nifedipine enthaltende zusammensetzungen und verfahren zu ihrer herstellung. Expired - Fee Related DE69000240T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898903328A GB8903328D0 (en) 1989-02-14 1989-02-14 Nifedipine-containing pharmaceutical compositions and process for the preparation thereof

Publications (2)

Publication Number Publication Date
DE69000240D1 true DE69000240D1 (de) 1992-09-10
DE69000240T2 DE69000240T2 (de) 1993-02-11

Family

ID=10651674

Family Applications (1)

Application Number Title Priority Date Filing Date
DE9090301005T Expired - Fee Related DE69000240T2 (de) 1989-02-14 1990-01-31 Nifedipine enthaltende zusammensetzungen und verfahren zu ihrer herstellung.

Country Status (17)

Country Link
US (1) US5145683A (de)
EP (1) EP0385582B1 (de)
JP (1) JPH07112974B2 (de)
AT (1) ATE79032T1 (de)
AU (1) AU626130B2 (de)
CA (1) CA2008972C (de)
DE (1) DE69000240T2 (de)
DK (1) DK0385582T3 (de)
ES (1) ES2052168T3 (de)
FI (1) FI95347C (de)
GB (1) GB8903328D0 (de)
GR (1) GR3005477T3 (de)
IE (1) IE64682B1 (de)
NO (1) NO175925C (de)
NZ (1) NZ232287A (de)
PH (1) PH26850A (de)
ZA (1) ZA90904B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624683A (en) * 1986-08-06 1997-04-29 Eisai Co., Ltd. Sustained-release multi-granule tablet
GB9200607D0 (en) * 1992-01-13 1992-03-11 Ethical Pharma Ltd Pharmaceutical compositions containing nifedipine and process for the preparation thereof
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5662933A (en) * 1993-09-09 1997-09-02 Edward Mendell Co., Inc. Controlled release formulation (albuterol)
US6726930B1 (en) * 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
ATE212838T1 (de) * 1994-12-29 2002-02-15 Shire Deutschland Gmbh & Co Kg Pharmazeutische zubereitungen, enthaltend nifedipin und verfahren zu ihrer herstellung
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
CN1049114C (zh) * 1995-12-07 2000-02-09 上海华联制药公司 一种制备缓释药物制剂的方法
WO1998001117A1 (en) * 1996-07-08 1998-01-15 Edward Mendell Co., Inc. Sustained release matrix for high-dose insoluble drugs
EP0852141A1 (de) 1996-08-16 1998-07-08 J.B. Chemicals & Pharmaceuticals Ltd. Nifedipin enthaltende pharmazeutische Zusammensetzung mit verzögerter Wirkstofffreigabe, sowie dessen Herstellungsprozess
IT1284604B1 (it) * 1996-09-27 1998-05-21 Roberto Valducci Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US6056977A (en) 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US6168806B1 (en) 1999-03-05 2001-01-02 Fang-Yu Lee Orally administrable nifedipine pellet and process for the preparation thereof
US20040115134A1 (en) * 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
JP4627825B2 (ja) * 1999-09-27 2011-02-09 三生医薬株式会社 被包粒状物質及びその製造方法
KR100463496B1 (ko) * 1999-09-30 2005-01-06 펜웨스트 파머슈티칼즈 컴파니 고가용성 약물용 서방성 메트리스 시스템
ATE329579T1 (de) * 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
CA2452874A1 (en) * 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Oral administration of 6-hydroxy-oxymorphone for use as an analgesic
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
EP2112925A4 (de) * 2006-11-15 2013-01-09 Abbott Lab Formulierungen mit fester pharmazeutischer dosierung
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
RU2629843C1 (ru) * 2016-05-24 2017-09-04 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) Способ получения мази нифедипина (варианты)
CN109172534B (zh) * 2018-10-23 2020-08-07 迪沙药业集团有限公司 一种硝苯地平缓释片剂组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
US4285665A (en) * 1978-05-08 1981-08-25 Johnson, Matthey & Co., Limited Engines
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung
JPS5846019A (ja) * 1981-09-14 1983-03-17 Kanebo Ltd 持続性ニフエジピン製剤
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung
FR2556964A1 (fr) * 1983-12-23 1985-06-28 Ile De France Nouvelles formes galeniques du sulpiride utilisables par voie orale
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
IT1178511B (it) * 1984-09-14 1987-09-09 Pharmatec Spa Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio
IT1187751B (it) * 1985-10-15 1987-12-23 Eurand Spa Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute
SE457326B (sv) * 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa

Also Published As

Publication number Publication date
DK0385582T3 (da) 1992-09-14
EP0385582B1 (de) 1992-08-05
GB8903328D0 (en) 1989-04-05
FI95347C (fi) 1996-01-25
IE900286L (en) 1990-08-14
AU4893790A (en) 1990-08-23
CA2008972C (en) 1996-09-03
IE64682B1 (en) 1995-08-23
JPH07112974B2 (ja) 1995-12-06
DE69000240T2 (de) 1993-02-11
NO900370D0 (no) 1990-01-26
NZ232287A (en) 1992-01-29
NO175925C (no) 1995-01-04
NO175925B (no) 1994-09-26
EP0385582A1 (de) 1990-09-05
AU626130B2 (en) 1992-07-23
FI900633A0 (fi) 1990-02-08
PH26850A (en) 1992-11-05
ATE79032T1 (de) 1992-08-15
GR3005477T3 (de) 1993-05-24
ZA90904B (en) 1991-06-26
JPH02235815A (ja) 1990-09-18
ES2052168T3 (es) 1994-07-01
FI95347B (fi) 1995-10-13
NO900370L (no) 1990-08-15
CA2008972A1 (en) 1990-08-14
US5145683A (en) 1992-09-08

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Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: NIFEDIPIN ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND VERFAHREN ZU IHRER HERSTELLUNG

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee