DE68929447T2 - Gerät zur Probenentnahme - Google Patents

Gerät zur Probenentnahme Download PDF

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Publication number
DE68929447T2
DE68929447T2 DE68929447T DE68929447T DE68929447T2 DE 68929447 T2 DE68929447 T2 DE 68929447T2 DE 68929447 T DE68929447 T DE 68929447T DE 68929447 T DE68929447 T DE 68929447T DE 68929447 T2 DE68929447 T2 DE 68929447T2
Authority
DE
Germany
Prior art keywords
skin
mucosal membrane
bioactive material
substantially continuously
sampling device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68929447T
Other languages
English (en)
Other versions
DE68929447D1 (de
Inventor
Peretz Glikfeld
Christopher Cullander
Robert S Hinz
Richard H Guy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Berkeley filed Critical University of California
Application granted granted Critical
Publication of DE68929447D1 publication Critical patent/DE68929447D1/de
Publication of DE68929447T2 publication Critical patent/DE68929447T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
DE68929447T 1988-01-29 1989-01-27 Gerät zur Probenentnahme Expired - Lifetime DE68929447T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15015988A 1988-01-29 1988-01-29
US29939789A 1989-01-24 1989-01-24

Publications (2)

Publication Number Publication Date
DE68929447D1 DE68929447D1 (de) 2003-02-06
DE68929447T2 true DE68929447T2 (de) 2004-01-15

Family

ID=26847373

Family Applications (3)

Application Number Title Priority Date Filing Date
DE68924716T Expired - Lifetime DE68924716T2 (de) 1988-01-29 1989-01-27 Gerät zur iontophoretischen nichtinvasiven Messung oder Abgabe von Substanzen.
DE68929447T Expired - Lifetime DE68929447T2 (de) 1988-01-29 1989-01-27 Gerät zur Probenentnahme
DE68929508T Expired - Lifetime DE68929508T2 (de) 1988-01-29 1989-01-27 Device zum kontinuierlichen Nachweis des Gehaltes eines bioaktiven Materials

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68924716T Expired - Lifetime DE68924716T2 (de) 1988-01-29 1989-01-27 Gerät zur iontophoretischen nichtinvasiven Messung oder Abgabe von Substanzen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE68929508T Expired - Lifetime DE68929508T2 (de) 1988-01-29 1989-01-27 Device zum kontinuierlichen Nachweis des Gehaltes eines bioaktiven Materials

Country Status (11)

Country Link
US (1) US5279543A (de)
EP (3) EP0326398B1 (de)
JP (1) JP2907342B2 (de)
KR (1) KR970011449B1 (de)
AT (3) ATE256420T1 (de)
DE (3) DE68924716T2 (de)
DK (1) DK175443B1 (de)
ES (3) ES2188624T3 (de)
IE (1) IE63406B1 (de)
PT (1) PT89560B (de)
WO (1) WO1989006989A1 (de)

Families Citing this family (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956032B1 (en) * 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5131403A (en) * 1991-06-05 1992-07-21 Becton Dickinson And Company Method for obtaining blood using iontophoresis
JPH0670987A (ja) * 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置
AU5121593A (en) * 1992-12-14 1994-07-04 Tovarischestvo S Orgranichennoi Otvetstvennostju "Bikap" Device for electrotreating a liquid
US5771890A (en) * 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
DE69519023T2 (de) * 1994-06-24 2001-06-13 Cygnus Therapeutic Systems Einrichtung zur iontophoretischen probennahme
DE59505328D1 (de) * 1994-12-09 1999-04-15 Novartis Ag Transdermales system
WO2000023144A1 (en) * 1995-04-23 2000-04-27 Electromagnetic Bracing Systems, Inc. Transdermal active drug delivery system and method
IL113459A (en) * 1995-04-23 2000-07-16 Electromagnetic Bracing System Electrophoretic cuff apparatus
US5624415A (en) * 1995-04-24 1997-04-29 Alza Corporation Reduction of skin irritation and resistance during electrotransport
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
US20040062759A1 (en) * 1995-07-12 2004-04-01 Cygnus, Inc. Hydrogel formulations for use in electroosmotic extraction and detection of glucose
CA2226176C (en) * 1995-07-12 2003-09-16 Cygnus, Inc. Hydrogel patch
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5989409A (en) * 1995-09-11 1999-11-23 Cygnus, Inc. Method for glucose sensing
US5735273A (en) * 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
WO1997019188A1 (en) * 1995-11-22 1997-05-29 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
US6002954A (en) * 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
JP3316820B2 (ja) 1995-12-28 2002-08-19 シィグナス インコーポレィティド 被験者の生理的分析物の継続モニタリング装置及び方法
US5713353A (en) 1996-04-19 1998-02-03 Castano; Jaime A. Optical method and device for determining blood glucose levels
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US5908401A (en) * 1996-05-08 1999-06-01 The Aps Organization, Llp Method for iontophoretic delivery of antiviral agents
US6385487B1 (en) 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
US5954685A (en) * 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
EP0914178B1 (de) 1996-06-18 2003-03-12 Alza Corporation Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
WO1998022820A1 (en) 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
US6246904B1 (en) 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
US6650934B2 (en) 1996-12-17 2003-11-18 Alza Corp Polymeric foam reservoirs for an electrotransport delivery device
US6018679A (en) * 1997-01-29 2000-01-25 Novartis Finance Corp. Iontophoretic transdermal delivery and control of adverse side-effects
US6139718A (en) 1997-03-25 2000-10-31 Cygnus, Inc. Electrode with improved signal to noise ratio
US6085115A (en) * 1997-05-22 2000-07-04 Massachusetts Institite Of Technology Biopotential measurement including electroporation of tissue surface
JP4441000B2 (ja) * 1997-06-23 2010-03-24 克郎 立花 生体組織処理装置
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029365A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
EP1911488A3 (de) 1997-12-11 2008-12-03 Alza Corporation Vorrichtung zur Verstärkung des Flusses transdermaler Mittel
USRE37796E1 (en) 1997-12-16 2002-07-23 Biophoretic Therapeutic Systems, Llc Methods for iontophoretic delivery of antiviral agents
US5968005A (en) * 1998-01-07 1999-10-19 Tu; Hosheng Devices and means for treating canker sores
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US7066884B2 (en) * 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US6059736A (en) * 1998-02-24 2000-05-09 Tapper; Robert Sensor controlled analysis and therapeutic delivery system
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
US6587705B1 (en) 1998-03-13 2003-07-01 Lynn Kim Biosensor, iontophoretic sampling system, and methods of use thereof
US5916154A (en) * 1998-04-22 1999-06-29 Nellcor Puritan Bennett Method of enhancing performance in pulse oximetry via electrical stimulation
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) * 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) * 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) * 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
WO1999058190A1 (en) * 1998-05-13 1999-11-18 Cygnus, Inc. Collection assemblies for transdermal sampling system
WO1999058050A1 (en) * 1998-05-13 1999-11-18 Cygnus, Inc. Signal processing for measurement of physiological analytes
ATE246356T1 (de) 1998-05-13 2003-08-15 Cygnus Therapeutic Systems Vorrichtung zum vorhersagen von physiologischen messwerten
EP1077634B1 (de) 1998-05-13 2003-07-30 Cygnus, Inc. Überwachung physiologischer analyte
DE69937738D1 (de) * 1998-07-21 2008-01-24 Altea Therapeutics Corp Verfahren und vorrichtung zur kontinuierlichen überwachung eines analyten
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
CA2342801A1 (en) 1998-09-04 2000-03-16 Powderject Research Limited Monitoring methods using particle delivery methods
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
ATE254877T1 (de) 1998-09-17 2003-12-15 Cygnus Therapeutic Systems Gerät zum zusammendrücken einer gel/sensor- einheit
DE69908602T2 (de) 1998-09-30 2004-06-03 Cygnus, Inc., Redwood City Verfahren und vorrichtung zum vorhersagen von physiologischen messwerten
US6180416B1 (en) 1998-09-30 2001-01-30 Cygnus, Inc. Method and device for predicting physiological values
US6391643B1 (en) 1998-10-28 2002-05-21 Cygnus, Inc. Kit and method for quality control testing of an iontophoretic sampling system
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
EP1135052A1 (de) 1999-02-12 2001-09-26 Cygnus, Inc. Gerät und verfahren zur häufigen messung von analyten anwesend im biologischen system
EP1175241A1 (de) 1999-03-08 2002-01-30 PALTI, Yoram Vorrichtung und verfahren zur transdermalen medikamentenverabreichung
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US6553253B1 (en) 1999-03-12 2003-04-22 Biophoretic Therapeutic Systems, Llc Method and system for electrokinetic delivery of a substance
ATE290902T1 (de) 1999-04-16 2005-04-15 Johnson & Johnson Consumer Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
CA2369336A1 (en) 1999-04-22 2000-11-02 Cygnus, Inc. Hydrogel in an iontophoretic device to measure glucose
US6669663B1 (en) * 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6682938B1 (en) 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
US6673625B2 (en) 1999-09-15 2004-01-06 The Regents Of The University Of California Saccharide sensing molecules having enhanced fluorescent properties
WO2001060448A1 (en) 2000-02-18 2001-08-23 University Of Utah Research Foundation Methods for extracting substances using alternating current
CA2400325A1 (en) 2000-02-18 2001-08-23 University Of Utah Research Foundation Methods for delivering agents using alternating current
CA2374751C (en) 2000-03-17 2009-10-13 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
DZ3338A1 (fr) * 2000-03-29 2001-10-04 Univ Virginia Méthode, systeme et programme d'ordinateur pour l'évaluation de régulation de glycemique du diabète à partir de données contrôllées automatiquement
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6885883B2 (en) * 2000-05-16 2005-04-26 Cygnus, Inc. Methods for improving performance and reliability of biosensors
WO2002017210A2 (en) 2000-08-18 2002-02-28 Cygnus, Inc. Formulation and manipulation of databases of analyte and associated values
WO2002015777A1 (en) * 2000-08-18 2002-02-28 Cygnus, Inc. Methods and devices for prediction of hypoglycemic events
US20020026111A1 (en) * 2000-08-28 2002-02-28 Neil Ackerman Methods of monitoring glucose levels in a subject and uses thereof
IT1320262B1 (it) * 2000-09-27 2003-11-26 Servizi Medico Estetici Italia Dispositivo erogatore per la somministrazione transdermica di unasostanza contenente un principio attivo e relativa testina erogatrice.
US6537243B1 (en) 2000-10-12 2003-03-25 Abbott Laboratories Device and method for obtaining interstitial fluid from a patient for diagnostic tests
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7137975B2 (en) * 2001-02-13 2006-11-21 Aciont, Inc. Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
US6927246B2 (en) 2001-02-15 2005-08-09 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs and methods for making them
KR20010067623A (ko) * 2001-02-23 2001-07-13 홍영표 전기삼투압을 이용한 무채혈 글루코스 추출법
MXPA03009121A (es) * 2001-04-04 2004-11-22 Johnson & Johnson Dispositivo de suministro de electrotransporte transdermico que incluye una composicion de reserva compatible antimicrobiana.
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
WO2003000127A2 (en) 2001-06-22 2003-01-03 Cygnus, Inc. Method for improving the performance of an analyte monitoring system
EP1270041A1 (de) * 2001-06-22 2003-01-02 Universite De Geneve Vorrichtung zum nicht-invasiven Bestimmen von relativen Konzentrationen von Substanzen in einem biologischen System
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
EP1476210B1 (de) 2002-02-11 2008-09-24 Antares Pharma, Inc. Intradermales injektionsgerät
DE60334365D1 (de) 2002-03-22 2010-11-11 Animas Technologies Llc Leistungsverbesserung einer analytenüberwachungsvorrichtung
TR200200942A2 (tr) * 2002-04-08 2004-02-23 Tuncer De��M �. Üre ölçer/üre saati:insan kanındaki ürenin ters iyontoforez ile, kan veya biyolojik örnek alınmadan tespiti.
US7865372B2 (en) * 2002-04-09 2011-01-04 Panasonic Corporation Health management system and health management method
US7099713B2 (en) 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems
WO2004015539A2 (en) 2002-08-13 2004-02-19 University Of Virginia Patent Foundation Managing and processing self-monitoring blood glucose
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
US7018345B2 (en) * 2002-12-06 2006-03-28 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis system
US20060129035A1 (en) * 2002-12-27 2006-06-15 Kaoru Asano Devices, methods, and systems for measuring analytes extracted through skin
US20060254912A1 (en) * 2003-03-04 2006-11-16 Amos Nussinovitch System and method for treating biological tissue usiing curret electrical field
JP4381705B2 (ja) * 2003-03-26 2009-12-09 シスメックス株式会社 経皮的分析物抽出システムと分析システムおよび経皮的分析物抽出方法と分析方法
US7258673B2 (en) * 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US20050069925A1 (en) 2003-08-15 2005-03-31 Russell Ford Microprocessors, devices, and methods for use in monitoring of physiological analytes
US7189341B2 (en) * 2003-08-15 2007-03-13 Animas Technologies, Llc Electrochemical sensor ink compositions, electrodes, and uses thereof
JP2005137416A (ja) * 2003-11-04 2005-06-02 Sysmex Corp 経皮的分析物抽出システム及び経皮的分析物分析システム
CN1636505B (zh) * 2004-01-09 2011-11-09 希森美康株式会社 提取器具、提取装置和血糖值测量装置
EP1561418B1 (de) * 2004-02-03 2011-08-17 Sysmex Corporation Analysegerät, Patrone, Patronenkit
US20050220439A1 (en) * 2004-03-19 2005-10-06 Carton Owen A Interactive multimedia system and method
US20050226921A1 (en) * 2004-04-13 2005-10-13 Kortzebom Robert N Non-invasive analysis and controlled dosage transdermal active patch
NZ582466A (en) 2004-07-30 2011-09-30 Adeza Biomedical Corp Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
US20060094945A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis
CA2584699C (en) 2004-10-28 2015-12-08 Sontra Medical Corporation System and method for analyte sampling and analysis with hydrogel
JP2006167428A (ja) 2004-11-16 2006-06-29 Sysmex Corp 分析物抽出装置、分析装置、分析物抽出方法および分析方法
JP5216328B2 (ja) 2005-01-24 2013-06-19 アンタレス ファーマ インコーポレイテッド あらかじめ充填された針補助シリンジジェット式注射器
US8809773B2 (en) * 2005-03-22 2014-08-19 Carnegie Mellon University Membrane interface apparatus and method for mass spectrometry
US20060223786A1 (en) * 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
KR100788186B1 (ko) * 2005-12-09 2007-12-26 주식회사 테크라인 송풍형 이온발생장치의 일체형 챔버와 챔버의 탈부착방식구조
WO2007081853A2 (en) 2006-01-05 2007-07-19 University Of Virginia Patent Foundation Method, system and computer program product for evaluation of blood glucose variability in diabetes from self-monitoring data
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20070264130A1 (en) * 2006-01-27 2007-11-15 Phluid, Inc. Infusion Pumps and Methods for Use
WO2007123142A1 (ja) * 2006-04-20 2007-11-01 Tti Ellebeau, Inc. イオントフォレーシス装置
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
JP5025159B2 (ja) * 2006-04-28 2012-09-12 シスメックス株式会社 生体成分測定装置
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
US8010188B2 (en) * 2006-11-14 2011-08-30 Kagoshima University Drug injecting device
US20080154513A1 (en) 2006-12-21 2008-06-26 University Of Virginia Patent Foundation Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US8812071B2 (en) * 2007-03-07 2014-08-19 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
US7947227B2 (en) * 2007-03-23 2011-05-24 Geno Llc Kit for the conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US8386027B2 (en) 2007-04-27 2013-02-26 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US8986253B2 (en) * 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
EP2268342B1 (de) 2008-03-10 2015-09-16 Antares Pharma, Inc. Injektionsgerät-sicherheitsvorrichtung
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US20090287180A1 (en) * 2008-05-19 2009-11-19 Diperna Paul M Disposable pump reservoir and related methods
CN105380662B (zh) * 2008-07-31 2018-06-12 希森美康株式会社 用于测定活体内成分的方法、装置及收集部件
ES2738539T3 (es) 2008-08-05 2020-01-23 Antares Pharma Inc Inyector de dosis múltiples
US8408421B2 (en) * 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) * 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
JP5470010B2 (ja) * 2008-12-22 2014-04-16 シスメックス株式会社 生体内成分測定方法および生体内成分測定装置
EP3703066A1 (de) 2009-02-25 2020-09-02 The University of Virginia Patent Foundation Verfahren, system und computerprogrammprodukt zur cgm-basierten prävention von hypoglykämie durch hypoglykämierisikobewertung und sanfte reduktion der insulinabgabe
WO2010108116A1 (en) 2009-03-20 2010-09-23 Antares Pharma, Inc. Hazardous agent injection system
WO2011014704A2 (en) * 2009-07-30 2011-02-03 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
JP5572016B2 (ja) * 2009-08-04 2014-08-13 シスメックス株式会社 組織液抽出用デバイス、その製造方法、及び該デバイスを用いた組織液の分析方法
US9327105B2 (en) 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
US8882819B2 (en) 2011-02-16 2014-11-11 Richard Crowder Handheld device for treating oral ulcers and sores
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
WO2012174480A2 (en) 2011-06-17 2012-12-20 Halozyme, Inc. Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9700245B2 (en) 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
JP6165786B2 (ja) 2012-03-06 2017-07-19 アンタレス・ファーマ・インコーポレーテッド 離脱力特徴を備える充填シリンジ
KR20150011346A (ko) 2012-04-06 2015-01-30 안타레스 팔마, 인코퍼레이티드 테스토스테론 조성물의 바늘-보조식 젯 주입 투여 장치 및 방법
WO2013169800A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
US10179239B2 (en) 2013-01-15 2019-01-15 Itrace Biomedical Inc. Personalized pain management treatments
CA2900672C (en) 2013-02-11 2018-03-27 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
JP6030803B2 (ja) 2013-03-11 2016-11-24 アンタレス・ファーマ・インコーポレーテッド ピニオンシステムを有する用量注射器
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CA2919663A1 (en) 2013-07-29 2015-02-05 Kural Corp. Therapeutic electron and ion transfer via half-cell
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
EP3307388B1 (de) 2015-06-10 2022-06-22 Ekos Corporation Ultraschallkatheter
CN109414227A (zh) 2016-04-26 2019-03-01 巴斯大学 用于非侵入性监测物质的多路复用经皮提取和检测装置及其使用方法
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
DE102018119137B4 (de) * 2018-08-07 2021-08-19 Pac Tech-Packaging Technologies Gmbh Verfahren und Vorrichtung zur Reparatur einer Prüfkontaktanordnung
CN110470851B (zh) * 2019-08-28 2022-06-03 重庆工业职业技术学院 一种通过汗液测定驾驶员是否饮酒的装置
WO2021167918A1 (en) 2020-02-18 2021-08-26 Roche Diabetes Care, Inc. Device for collection of volatile compounds from skin for non-invasive measurement of blood-glucose values
DK4048152T3 (da) 2020-07-29 2024-03-11 Biolinq Incorporated System til kontinuerlig analytovervågning med mikronålsindretning
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
EP4153276A4 (de) 2021-05-08 2023-11-08 Biolinq, Inc. Fehlererkennung für eine auf mikronadelarray basierende kontinuierliche analytüberwachungsvorrichtung
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH530006A (de) * 1970-10-01 1972-10-31 Hoffmann La Roche Elektrodenanordnung
US3794910A (en) * 1971-07-26 1974-02-26 Sherwood Medical Ind Inc Iontophoresis and conductivity analysis circuit
US4767401A (en) * 1975-04-22 1988-08-30 Maurice Seiderman Iontophoretic administration of ionizable or polar medicaments to a mammalian body
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4166457A (en) * 1976-08-16 1979-09-04 University Of Utah Research Institute Fluid self-sealing bioelectrode
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
US4195641A (en) * 1977-12-15 1980-04-01 Burton Larry W Spectroscopic analysis of chemical substances
GB2033575B (en) * 1978-05-24 1983-03-02 Rolfe P Investigating substances in a patient's bloodstream
US4239046A (en) * 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4365637A (en) * 1979-07-05 1982-12-28 Dia-Med, Inc. Perspiration indicating alarm for diabetics
US4401122A (en) * 1979-08-02 1983-08-30 Children's Hospital Medical Center Cutaneous methods of measuring body substances
US4633879A (en) * 1979-11-16 1987-01-06 Lec Tec Corporation Electrode with disposable interface member
US4329999A (en) * 1980-03-03 1982-05-18 Michael Phillips Patient attached patch and method of making
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
GB2087567B (en) * 1980-11-11 1984-09-19 Searle & Co Apparatus for monitoring partial pressure of gas in a flowing liquid
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
DE3273269D1 (en) * 1981-03-06 1986-10-23 Medtronic Inc Iontophoretic electrode
US4820263A (en) * 1981-03-06 1989-04-11 Medtronic, Inc. Apparatus and method for iontophoretic drug delivery
US4411648A (en) * 1981-06-11 1983-10-25 Board Of Regents, The University Of Texas System Iontophoretic catheter device
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4477971A (en) * 1981-11-06 1984-10-23 Motion Control, Inc. Iontophoretic electrode structure
US4419092A (en) * 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
US4693711A (en) * 1981-12-22 1987-09-15 Bremer Roger E Long-life biomedical transcutaneous drug application device and method of transcutaneous application of drugs
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
US4699146A (en) * 1982-02-25 1987-10-13 Valleylab, Inc. Hydrophilic, elastomeric, pressure-sensitive adhesive
GB2116850B (en) * 1982-03-15 1985-08-29 Wescor Inc Sweat collection device
CA1247960A (en) * 1983-03-24 1989-01-03 Hideki Aoki Transcutaneously implantable element
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
WO1986007269A1 (en) * 1985-06-10 1986-12-18 Drug Delivery Systems Inc. Programmable control and mounting system for transdermal drug applicator
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4808152A (en) * 1983-08-18 1989-02-28 Drug Delivery Systems Inc. System and method for controlling rate of electrokinetic delivery of a drug
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US4727881A (en) * 1983-11-14 1988-03-01 Minnesota Mining And Manufacturing Company Biomedical electrode
IL75048A0 (en) * 1984-05-04 1985-08-30 Dervieux Dominique Bipolar electrodes and apparatus comprising them for the relief of pains
GB2159717B (en) * 1984-06-08 1988-05-18 Sciotronic Ltd Medical electrode
DK8601218A (de) * 1984-07-18 1986-03-17
US4744787A (en) * 1984-10-29 1988-05-17 Medtronic, Inc. Iontophoresis apparatus and methods of producing same
US4747819A (en) * 1984-10-29 1988-05-31 Medtronic, Inc. Iontophoretic drug delivery
US4585652A (en) * 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
US4700710A (en) * 1985-03-12 1987-10-20 Murray Electronics Associates Limited Partnership Apertured adhesively applied body electrode apparatus and method
US4679560A (en) * 1985-04-02 1987-07-14 Board Of Trustees Of The Leland Stanford Junior University Wide band inductive transdermal power and data link
US4832036A (en) * 1985-05-13 1989-05-23 Baxter International Inc. Medical electrode
US4722354A (en) * 1985-06-14 1988-02-02 Jens Axelgaard Electrical stimulation electrode
JPS6222662A (ja) * 1985-07-19 1987-01-30 林原 健 イオン導入電子治療器
US4756314A (en) * 1985-10-28 1988-07-12 Alza Corporation Sweat collection patch
JPS62139672A (ja) * 1985-12-14 1987-06-23 林原 健 正負イオントホレ−ゼ用治療器
JPS62159661A (ja) * 1985-12-31 1987-07-15 林原 健 正、負両イオン導入用低周波治療器
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
US4717378A (en) * 1986-03-31 1988-01-05 Medtronic, Inc. Methods for detecting dehydration of a biomedical hydrogel
JPH0794380B2 (ja) * 1986-04-24 1995-10-11 久光製薬株式会社 経皮投薬用皮膚処理剤
US4706680A (en) * 1986-06-30 1987-11-17 Nepera Inc. Conductive adhesive medical electrode assemblies
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
AU7769187A (en) * 1986-09-01 1988-03-03 Paul Max Grinwald Iontophoretic apparatus
US4848353A (en) * 1986-09-05 1989-07-18 Minnesota Mining And Manufacturing Company Electrically-conductive, pressure-sensitive adhesive and biomedical electrodes
JPS63102768A (ja) * 1986-10-20 1988-05-07 山之内製薬株式会社 イオントフオレ−シス用の新規プラスタ−構造体
US4786277A (en) * 1986-11-21 1988-11-22 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4810699A (en) * 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
CA1317522C (en) * 1987-03-20 1993-05-11 Dan Sibalis Transdermal drug delivery system
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
CA1333114C (en) * 1987-11-25 1994-11-15 Daniel C. Duan Pressure-sensitive adhesives and bioelectrodes constructed with the adhesive

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EP0326398A3 (de) 1991-03-20
EP0673622A2 (de) 1995-09-27
ATE230283T1 (de) 2003-01-15
KR970011449B1 (ko) 1997-07-11
PT89560B (pt) 1995-05-31
EP0326398A2 (de) 1989-08-02
EP0673622B1 (de) 2003-01-02
US5279543A (en) 1994-01-18
DK179390A (da) 1990-07-28
ES2188624T3 (es) 2003-07-01
EP0326398B1 (de) 1995-11-08
ATE129909T1 (de) 1995-11-15
EP1121896A1 (de) 2001-08-08
EP1121896B1 (de) 2003-12-17
DK175443B1 (da) 2004-10-25
DE68924716T2 (de) 1996-07-04
KR900700155A (ko) 1990-08-11
DE68929447D1 (de) 2003-02-06
DE68929508D1 (de) 2004-01-29
IE63406B1 (en) 1995-04-19
ATE256420T1 (de) 2004-01-15
WO1989006989A1 (en) 1989-08-10
PT89560A (pt) 1989-11-10
AU3183889A (en) 1989-08-25
AU639888B2 (en) 1993-08-12
EP0673622A3 (de) 1995-11-08
DE68929508T2 (de) 2004-09-30
ES2085863T3 (es) 1996-06-16
ES2213077T3 (es) 2004-08-16
JP2907342B2 (ja) 1999-06-21
JPH04502561A (ja) 1992-05-14
IE890285L (en) 1989-07-29
DE68924716D1 (de) 1995-12-14
DK179390D0 (da) 1990-07-27

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