DE68926118D1 - Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren - Google Patents

Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren

Info

Publication number
DE68926118D1
DE68926118D1 DE68926118T DE68926118T DE68926118D1 DE 68926118 D1 DE68926118 D1 DE 68926118D1 DE 68926118 T DE68926118 T DE 68926118T DE 68926118 T DE68926118 T DE 68926118T DE 68926118 D1 DE68926118 D1 DE 68926118D1
Authority
DE
Germany
Prior art keywords
ion channel
pct
membranes
conductance
selectivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68926118T
Other languages
English (en)
Other versions
DE68926118T2 (de
Inventor
Peter Osman
Bruce Cornell
Burkhard Raguse
Lionel King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ambri Ltd
Original Assignee
Australian Membrane and Biotechnology Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Australian Membrane and Biotechnology Research Institute Ltd filed Critical Australian Membrane and Biotechnology Research Institute Ltd
Publication of DE68926118D1 publication Critical patent/DE68926118D1/de
Application granted granted Critical
Publication of DE68926118T2 publication Critical patent/DE68926118T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
DE68926118T 1988-08-18 1989-08-17 Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren Expired - Fee Related DE68926118T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI999488 1988-08-18
PCT/AU1989/000352 WO1990002327A1 (en) 1988-08-18 1989-08-17 Improvements in sensitivity and selectivity of ion channel membrane biosensors

Publications (2)

Publication Number Publication Date
DE68926118D1 true DE68926118D1 (de) 1996-05-02
DE68926118T2 DE68926118T2 (de) 1996-08-22

Family

ID=3773305

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926118T Expired - Fee Related DE68926118T2 (de) 1988-08-18 1989-08-17 Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren

Country Status (6)

Country Link
US (1) US5234566A (de)
EP (1) EP0432188B1 (de)
AT (1) ATE136119T1 (de)
CA (1) CA1315338C (de)
DE (1) DE68926118T2 (de)
WO (1) WO1990002327A1 (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328847A (en) * 1990-02-20 1994-07-12 Case George D Thin membrane sensor with biochemical switch
AU666113B2 (en) * 1991-03-27 1996-02-01 Ambri Limited Ionic reservoir at electrode surface
US6652808B1 (en) 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6569382B1 (en) * 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
EP0637384B1 (de) * 1992-04-22 1996-10-02 Ecole Polytechnique Federale De Lausanne Lipidmembranen fur biosensoranwendungen
EP1130387A1 (de) * 1992-10-01 2001-09-05 Australian Membrane And Biotechnology Research Institute Linkerlipid zur Sensormembranen
AU663243B2 (en) * 1992-12-03 1995-09-28 Ambri Limited Analyte detection by competitive inhibition of ion channel gating
US5401377A (en) * 1993-08-06 1995-03-28 Biomedix, Inc. Ion-selective sensor with polymeric membrane having phospholipid dispersed therein
US5494831A (en) * 1993-08-30 1996-02-27 Hughes Aircraft Company Electrochemical immunosensor system and methods
WO1995008637A1 (en) * 1993-09-21 1995-03-30 Washington State University Research Foundation Immunoassay comprising ligand-conjugated, ion channel receptor immobilized in lipid film
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
US7314708B1 (en) 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US6726880B1 (en) 1993-11-01 2004-04-27 Nanogen, Inc. Electronic device for performing active biological operations and method of using same
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US6375899B1 (en) 1993-11-01 2002-04-23 Nanogen, Inc. Electrophoretic buss for transport of charged materials in a multi-chamber system
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
AU777515B2 (en) * 1993-11-01 2004-10-21 Nanogen, Inc. Devices and systems for molecular biological reactions, analysis and diagnostics
US7172864B1 (en) * 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US6315953B1 (en) * 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6254827B1 (en) 1993-11-01 2001-07-03 Nanogen, Inc. Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US5556528A (en) * 1994-05-10 1996-09-17 Biotechnology Research & Development Corporation Structures with field responsive permeation control
US7857957B2 (en) 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
AT402935B (de) * 1994-10-19 1997-09-25 Pittner Fritz Biorekognitions-gesteuerter, ionenfluss-modulirender biosensor
AUPM950094A0 (en) 1994-11-16 1994-12-08 Australian Membrane And Biotechnology Research Institute Detection device and method
US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) * 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
AUPN366995A0 (en) * 1995-06-20 1995-07-13 Australian Membrane And Biotechnology Research Institute Self-assembly of bilayer membrane sensors
US5879878A (en) * 1995-06-20 1999-03-09 Australian Membrane And Biotechnology Research Institute Method of producing a first layer electrode membrane for a biosensor
US5719033A (en) * 1995-06-28 1998-02-17 Motorola, Inc. Thin film transistor bio/chemical sensor
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
WO1997020203A1 (de) * 1995-11-28 1997-06-05 Thomas Schalkhammer Neuartige membranen und membran-dna/rna-sensoren
AU708021B2 (en) * 1996-02-08 1999-07-29 Ambri Limited Enzyme detection biosensors
AUPN980796A0 (en) 1996-05-13 1996-06-06 Australian Membrane And Biotechnology Research Institute Improved reservoir components
US5756879A (en) * 1996-07-25 1998-05-26 Hughes Electronics Volatile organic compound sensors
US6699719B2 (en) * 1996-11-29 2004-03-02 Proteomic Systems, Inc. Biosensor arrays and methods
US6503452B1 (en) * 1996-11-29 2003-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biosensor arrays and methods
WO1998023948A1 (en) * 1996-11-29 1998-06-04 The Board Of Trustees Of The Leland Stanford Junior University Arrays of independently-addressable supported fluid bilayer membranes and methods of use thereof
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US5945774A (en) * 1997-03-28 1999-08-31 Industrial Technology Research Institute Open package for crystal oscillator chips
US6537441B1 (en) * 1997-06-04 2003-03-25 Australian Membrane And Biotechnology Research Biosensor involving the use of optically sensitive moieties
WO1999009140A1 (en) 1997-08-20 1999-02-25 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
JP3486171B2 (ja) 1997-12-17 2004-01-13 エコル・ポリテクニック・フェデラル・ドゥ・ロザンヌ（エ・ペー・エフ・エル） ミクロ構造キャリア上における細胞単体および再構成膜系のポジショニングおよび電気生理学的特性決定
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
AU745416B2 (en) * 1998-02-02 2002-03-21 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US5961934A (en) * 1998-02-18 1999-10-05 Biospace International Inc. Dynamically controlled crystallization method and apparatus and crystals obtained thereby
DK173381B1 (da) * 1998-03-03 2000-09-11 Unisense Aps Fremgangsmåde til at regulere følsomheden af en mikrosensor samt mikrosensor, der gør brug af fremgangsmåden
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
CA2348002A1 (en) * 1998-10-27 2000-05-04 Malcolm W. Mcgeoch Biological ion channels in nanofabricated detectors
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
EP1141704B1 (de) 1998-12-05 2011-06-15 Xention Limited Grenzflächen-patch-clamp-verfahren und -gerät
US7270969B2 (en) 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
WO2001034764A2 (en) * 1999-11-08 2001-05-17 Cytion S.A. Apparatus and methods for positioning and analyzing biological membranous objects
AU2001241474A1 (en) * 2000-02-11 2001-08-20 The Texas A And M University System Biosensor compositions and methods of use
US20030139336A1 (en) * 2000-03-21 2003-07-24 Norwood James Henry Interface patch clamping
EP1287351A2 (de) * 2000-05-18 2003-03-05 The Board Of Trustees Of The Leland Stanford Junior University Lipiddoppelschicht-matrizen-verfahren und -vorrichtungen
US20030129581A1 (en) * 2000-06-06 2003-07-10 Owen David Geraint Patch-clamping method and apparatus
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US6730212B1 (en) 2000-10-03 2004-05-04 Hrl Laboratories, Llc Sensor for chemical and biological materials
US7008524B2 (en) * 2000-10-03 2006-03-07 Hrl Laboratories, Llc Sensors with variable response behavior
SE0004334D0 (sv) * 2000-11-24 2000-11-24 Sahltech Ab Electron spectroscopy
US6835552B2 (en) * 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
ATE336723T1 (de) * 2001-01-18 2006-09-15 Univ Newcastle Ventures Ltd Biosensor mit kovalent gebundenen membranüberspannenden proteinen
US20030104428A1 (en) * 2001-06-21 2003-06-05 President And Fellows Of Harvard College Method for characterization of nucleic acid molecules
EP1278064B1 (de) * 2001-07-18 2008-07-02 CSEM Centre Suisse d'Electronique et de Microtechnique SA Mikroelektrodenanordnung mit hoher Dichte
US6783645B2 (en) * 2001-12-18 2004-08-31 Dionex Corporation Disposable working electrode for an electrochemical cell
JP2005526972A (ja) * 2002-05-02 2005-09-08 シファーゲン バイオシステムズ， インコーポレイテッド 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ
EP1504114B1 (de) * 2002-05-10 2017-07-12 The Texas A & M University System Stochastische bestimmung von analyten mittels kovalenten wechselwirkungen
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US7267751B2 (en) * 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
US20040110205A1 (en) * 2002-09-23 2004-06-10 Hui Wang Methods and systems for nanopore data analysis
US20040121377A1 (en) * 2002-10-05 2004-06-24 Chiaki Ishii Spatially encoded and mobile arrays of tethered lipids
US20040092004A1 (en) * 2002-11-07 2004-05-13 Hrl Laboratories, Llc Sensor for detection of enzyme and enzyme detection method for aerosolized bacteria in the enviromnment
US20040197821A1 (en) * 2003-04-04 2004-10-07 Bauer Alan Joseph Rapid-detection biosensor
US8187865B2 (en) * 2003-06-12 2012-05-29 California Institute Of Technology Nanowire sensor, sensor array, and method for making the same
US7846738B2 (en) * 2003-08-15 2010-12-07 President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
WO2005022136A1 (en) * 2003-08-26 2005-03-10 University Of Cincinnati Selectively permeable film supported membrane
KR100613398B1 (ko) * 2003-11-25 2006-08-17 한국과학기술연구원 캔틸레버 센서형 분석 시스템, 제조 방법 및 이를 이용한극미세 물질 감지 방법
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US7314542B2 (en) * 2004-09-23 2008-01-01 Nanogen, Inc. Methods and materials for optimization of electronic transportation and hybridization reactions
GB2432424B (en) * 2004-10-14 2008-09-10 Electronic Bio Sciences Llc Integrated sensing array for producing a biofinger print of an analyte
US7741106B2 (en) * 2005-09-21 2010-06-22 Moyle William R Sensors for biomolecular detection and cell classification
CN101443656B (zh) * 2006-03-16 2013-08-14 环球纳米传感器技术公司 介电传感方法和系统
US20070224637A1 (en) * 2006-03-24 2007-09-27 Mcauliffe Joseph C Oxidative protection of lipid layer biosensors
US20110121840A1 (en) 2007-02-20 2011-05-26 Gurdial Singh Sanghera Lipid Bilayer Sensor System
DE102007043132B4 (de) * 2007-09-11 2012-07-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Biosensor und Verfahren zum Messen einer Konzentration eines Analyten in einem Medium
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
WO2010004115A1 (fr) * 2008-06-27 2010-01-14 Stmicroelectronics (Research & Development) Limited Dispositif d'analyse biologique de type pixel, biocapteur cmos et procedes de fabrication correspondants
EP2580588B1 (de) 2010-06-08 2014-09-24 President and Fellows of Harvard College Nanoporen-vorrichtung mit graphengetragener künstlicher lipidmembran
WO2012009322A1 (en) * 2010-07-12 2012-01-19 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Methods and device for tuning multiplexed markers for disease assay
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US9341592B2 (en) 2012-04-09 2016-05-17 Bharath Takulapalli Field effect transistor, device including the transistor, and methods of forming and using same
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
WO2014146020A2 (en) * 2013-03-15 2014-09-18 Takulapalli Bharath Biomarker sensor array and circuit and methods of using and forming same
DE102013013295A1 (de) 2013-08-12 2015-02-12 Airbus Defence and Space GmbH Ionendosiervorrichtung für eine Energiespeichervorrichtung, Verfahren zum Herstellen einer Ionendosiervorrichtung und Energiespeichervorrichtung
AU2015302235A1 (en) 2014-08-13 2017-02-16 Arizona Board Of Regents On Behalf Of Arizona State University Noninvasive body fluid stress sensing
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
US11073508B2 (en) 2017-03-28 2021-07-27 Arizona Board Of Regents On Behalf Of The University Of Arizona Rapid conductance based ion channel analysis
WO2019007842A1 (en) * 2017-07-03 2019-01-10 Roche Diabetes Care Gmbh METHOD AND ELECTRONIC UNIT FOR DETECTING IN VIVO PROPERTIES OF A BIOSENSOR
EP3938779A1 (de) 2019-03-12 2022-01-19 Oxford Nanopore Technologies Limited Nanoporenerfassungsvorrichtung und verfahren zu deren betrieb und deren herstellung
KR102322684B1 (ko) * 2019-07-18 2021-11-04 성균관대학교산학협력단 바이오 센서, 이의 제조 방법 및 이를 이용한 이온 검출 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59212757A (ja) * 1983-05-19 1984-12-01 Toshiba Corp 流通型イオンセンサ体
EP0138150A3 (de) * 1983-10-05 1988-06-01 E.I. Du Pont De Nemours And Company Membrane für Diagnoseelektroden mit spezifischen Enzym/Ionophor-Paaren
CA1223039A (en) * 1984-03-26 1987-06-16 Michael Thompson Chemical selective sensors utilizing admittance modulated membranes
US4661235A (en) * 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
US4776944A (en) * 1986-03-20 1988-10-11 Jiri Janata Chemical selective sensors utilizing admittance modulated membranes
GB8622788D0 (en) * 1986-09-22 1986-10-29 Atomic Energy Authority Uk Sensor

Also Published As

Publication number Publication date
US5234566A (en) 1993-08-10
EP0432188A4 (en) 1991-10-16
EP0432188A1 (de) 1991-06-19
WO1990002327A1 (en) 1990-03-08
DE68926118T2 (de) 1996-08-22
CA1315338C (en) 1993-03-30
EP0432188B1 (de) 1996-03-27
ATE136119T1 (de) 1996-04-15

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