DE68922894T2 - Pharmazeutische Ionenaustauscherharzzusammensetzung. - Google Patents
Pharmazeutische Ionenaustauscherharzzusammensetzung.Info
- Publication number
- DE68922894T2 DE68922894T2 DE68922894T DE68922894T DE68922894T2 DE 68922894 T2 DE68922894 T2 DE 68922894T2 DE 68922894 T DE68922894 T DE 68922894T DE 68922894 T DE68922894 T DE 68922894T DE 68922894 T2 DE68922894 T2 DE 68922894T2
- Authority
- DE
- Germany
- Prior art keywords
- ion exchange
- exchange resin
- resin composition
- alcohol
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888826407A GB8826407D0 (en) | 1988-11-11 | 1988-11-11 | Pharmaceutical ion exchange resin composition |
| GB888828592A GB8828592D0 (en) | 1988-12-07 | 1988-12-07 | Pharmaceutical ion exchange resin composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68922894D1 DE68922894D1 (de) | 1995-07-06 |
| DE68922894T2 true DE68922894T2 (de) | 1996-01-11 |
Family
ID=26294609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68922894T Expired - Lifetime DE68922894T2 (de) | 1988-11-11 | 1989-11-10 | Pharmazeutische Ionenaustauscherharzzusammensetzung. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5071646A (de) |
| EP (1) | EP0368682B1 (de) |
| JP (1) | JP2825202B2 (de) |
| AT (1) | ATE123218T1 (de) |
| AU (1) | AU621949B2 (de) |
| CA (1) | CA2002492A1 (de) |
| DE (1) | DE68922894T2 (de) |
| DK (1) | DK175154B1 (de) |
| ES (1) | ES2075061T3 (de) |
| GB (1) | GB2225941B (de) |
| IE (1) | IE893625L (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9003904D0 (sv) * | 1990-12-07 | 1990-12-07 | Astra Ab | Method for the manufacture of a pharmaceutical dosage form |
| SE9003903D0 (sv) * | 1990-12-07 | 1990-12-07 | Astra Ab | New pharmaceutical formulations |
| US5275820A (en) * | 1990-12-27 | 1994-01-04 | Allergan, Inc. | Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles |
| US5840339A (en) * | 1991-07-30 | 1998-11-24 | Kunin; Robert | Blood cholesterol reducing pharmaceutical composition |
| SE9103110D0 (sv) * | 1991-10-24 | 1991-10-24 | Kabi Pharmacia Ab | New drug formulation |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| US5296228A (en) * | 1992-03-13 | 1994-03-22 | Allergan, Inc. | Compositions for controlled delivery of pharmaceutical compounds |
| US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
| USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| IL119660A (en) * | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
| US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
| GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
| US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| GB9517883D0 (en) * | 1995-09-01 | 1995-11-01 | Euro Celtique Sa | Improved pharmaceutical ion exchange resin composition |
| GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
| WO1998036737A1 (en) * | 1997-02-25 | 1998-08-27 | The Procter & Gamble Company | Wet granulating method |
| US5980882A (en) * | 1997-04-16 | 1999-11-09 | Medeva Pharmaceuticals Manufacturing | Drug-resin complexes stabilized by chelating agents |
| RU2241458C2 (ru) | 1997-12-22 | 2004-12-10 | Эро-Селтик, С.А. | Комбинации агонист/антагонист опиоида |
| US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
| US8545880B2 (en) * | 1999-02-26 | 2013-10-01 | Andrx Pharmaceuticals, Llc | Controlled release oral dosage form |
| US6210716B1 (en) | 1999-02-26 | 2001-04-03 | Andrx Pharmaceuticals, Inc. | Controlled release bupropion formulation |
| EP2295043A1 (de) | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Hydrocodon-Formulierungen mit gesteuerter Freisetzung |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| JP2003522144A (ja) | 2000-02-08 | 2003-07-22 | ユーロ−セルティーク，エス．エイ． | オピオイドアゴニストおよびアンタゴニストを含む制御放出組成物 |
| MXPA02008183A (es) * | 2000-02-24 | 2002-11-29 | Upjohn Co | Combinaciones de farmacos novedosos. |
| US6855721B1 (en) | 2000-07-28 | 2005-02-15 | Indevus Pharmaceuticals, Inc. | Methods and compositions for alleviating stuttering |
| CN101317825A (zh) | 2000-10-30 | 2008-12-10 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
| UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
| CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
| SI1416842T1 (sl) | 2001-07-18 | 2009-06-30 | Euro Celtique Sa | Farmacevtske kombinacije oksikodona in naloksona |
| ES2326794T3 (es) | 2001-08-06 | 2009-10-20 | Euro-Celtique S.A. | Formulaciones de agonistas opioides con antagonista liberable y secuestrado. |
| US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
| US20030099711A1 (en) * | 2001-08-29 | 2003-05-29 | David Meadows | Sustained release preparations |
| US20030180249A1 (en) * | 2002-03-18 | 2003-09-25 | Khanna Satish Chandra | Dosage forms for hygroscopic active ingredients |
| ES2546010T3 (es) | 2002-04-05 | 2015-09-17 | Euro-Celtique S.A. | Preparación farmacéutica que contiene oxicodona y naloxona |
| PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
| US6893660B2 (en) * | 2002-11-21 | 2005-05-17 | Andrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions without a stabilizer |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
| US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
| CN1845722A (zh) * | 2003-09-03 | 2006-10-11 | 马林克罗特公司 | 粒状缓释制剂及其生产 |
| US20050181050A1 (en) * | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
| US7429617B2 (en) * | 2004-04-27 | 2008-09-30 | Medicinova, Inc. | Phenoxyalkycarboxylic acid derivatives in the treatment of interstitial cystitis |
| CN1968697B (zh) * | 2004-05-14 | 2012-05-16 | 株式会社绿十字 | 右旋吗啡喃的神经保护特性 |
| EP1604666A1 (de) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit |
| US20080095842A1 (en) * | 2004-12-06 | 2008-04-24 | Antarkar Amit K | Rapidly Disintegrating Taste Masked Compositions and a Process for Its Preparations |
| EP1846040A2 (de) * | 2005-01-28 | 2007-10-24 | Collegium Pharmaceutical, Inc. | Nicht ionische und nicht wässrige transportelemente zur topischen und oralen verabreichung träger-komplexierter wirkstoffe |
| EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
| US8343546B2 (en) * | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
| US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
| BRPI0709606B8 (pt) | 2006-03-16 | 2021-05-25 | Tris Pharma Inc | suspensão líquida administrável oralmente com características de liberação modificada |
| PL2526932T3 (pl) | 2006-06-19 | 2017-12-29 | Alpharma Pharmaceuticals Llc | Kompozycja farmaceutyczna |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| WO2009088385A1 (en) * | 2008-01-04 | 2009-07-16 | Capricorn Pharma Inc. | Resin-complex granulation for water-soluble drugs and associated methods |
| SG174286A1 (en) | 2009-03-10 | 2011-10-28 | Euro Celtique Sa | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
| US20120107381A1 (en) * | 2009-05-13 | 2012-05-03 | Relypsa, Inc. | Powder formulations of potassium-binding active agents |
| JP2013119550A (ja) | 2011-12-08 | 2013-06-17 | Medicinova Inc | 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の処置方法 |
| US8962687B2 (en) | 2012-12-05 | 2015-02-24 | Medicinova, Inc. | Method of treating liver disorders |
| WO2014167440A1 (en) * | 2013-03-26 | 2014-10-16 | Wockhardt Limited | Modified release pharmaceutical compositions of cyclobenzaprine or salts thereof |
| NZ716267A (en) | 2013-07-23 | 2017-05-26 | Euro Celtique Sa | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
| ES2843511T3 (es) | 2013-07-25 | 2021-07-19 | Medicinova Inc | Métodos para reducir las concentraciones en sangre de triglicéridos, colesterol total y lipoproteínas de baja densidad |
| US20150321989A1 (en) | 2014-05-08 | 2015-11-12 | Medicinova, Inc. | Method of treating idiopathic pulmonary fibrosis |
| US9346754B2 (en) | 2014-05-08 | 2016-05-24 | Medicinova, Inc. | Method of treating advanced non-alcoholic steatohepatitis |
| CN106470678A (zh) | 2014-06-02 | 2017-03-01 | 美迪诺亚公司 | 抑制或治疗纤维化的方法 |
| JP6827924B2 (ja) | 2014-11-26 | 2021-02-10 | メディシノバ・インコーポレイテッドＭｅｄｉｃｉＮｏｖａ， Ｉｎｃ． | イブジラスト及びリルゾールの組み合わせを含む医薬および組成物 |
| US11590228B1 (en) | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
| CN109890371A (zh) | 2016-08-26 | 2019-06-14 | 斯瑞尼瓦萨饶·韦帕切杜 | 组合物及其方法 |
| US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
| WO2022251464A1 (en) | 2021-05-28 | 2022-12-01 | Medicinova, Inc. | Phenoxyalkylcarboxylic acid derivatives and their use in lowering triglyceride levels |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB791281A (en) * | 1955-01-13 | 1958-02-26 | Genatosan Ltd | Pharmaceutical products |
| GB822728A (en) * | 1955-07-14 | 1959-10-28 | Pfizer & Co C | Vitamin products and process of preparing same |
| GB835932A (en) * | 1956-03-27 | 1960-05-25 | Ciba Ltd | Process for the manufacture of therapeutic tablet granulations |
| FR792M (de) * | 1959-11-13 | 1961-09-11 | ||
| US3138525A (en) * | 1961-06-16 | 1964-06-23 | Hoffmann La Roche | Castor wax-amprotropine-resin compositions |
| GB982150A (en) * | 1961-09-29 | 1965-02-03 | Glaxo Group Ltd | Therapeutic resin complexes |
| BE635819A (de) * | 1962-08-06 | |||
| DE2706660A1 (de) * | 1977-02-17 | 1978-08-24 | Merck Patent Gmbh | Ascorbinsaeure enthaltende granulate und verfahren zu ihrer herstellung |
| GB1566609A (en) * | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
| US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
| DE2929456A1 (de) * | 1979-07-20 | 1981-02-05 | Lentia Gmbh | Zusammensetzung mit verlaengerter broncholytischer und tokolytischer wirksamkeit, ein verfahren zu deren herstellung und broncholytisch und tokolytisch wirkendes mittel |
| US4404346A (en) * | 1980-08-05 | 1983-09-13 | Rohm And Haas Company | Production of powdered resin and the powdered resin so produced |
| US4369175A (en) * | 1981-07-27 | 1983-01-18 | Ciba-Geigy Corporation | Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them |
| CH655507B (de) * | 1983-01-12 | 1986-04-30 | ||
| US4847362A (en) * | 1985-02-01 | 1989-07-11 | New York University | Method for purifying antihemophilic factor |
| EP0200252B1 (de) * | 1985-05-02 | 1999-03-10 | Yamanouchi Europe B.V. | Trimethoprim und ein Sulfonamid enthaltende Tabletten |
| EP0199855A1 (de) * | 1985-05-02 | 1986-11-05 | Gist-Brocades N.V. | Trimethoprim und ein Sulfonamid enthaltende Tabletten |
| US4748361A (en) * | 1985-12-05 | 1988-05-31 | Mitsubishi Kinzoku Kabushiki Kaisha | Permanent magnet electric motor |
| US4788055A (en) * | 1985-12-09 | 1988-11-29 | Ciba-Geigy Corporation | Resinate sustained release dextromethorphan composition |
| DD249634B1 (de) * | 1986-06-04 | 1988-09-21 | Bitterfeld Chemie | Cholesterolsenkendes mittel und verfahren zu seiner herstellung |
| IL90245A (en) * | 1988-05-11 | 1994-04-12 | Glaxo Group Ltd | Resin adsorption containing ranitidine together with synthetic resin replaces cations, its preparation and pharmaceutical preparations containing it |
-
1989
- 1989-11-08 CA CA002002492A patent/CA2002492A1/en not_active Abandoned
- 1989-11-09 US US07/434,416 patent/US5071646A/en not_active Expired - Lifetime
- 1989-11-09 JP JP1290147A patent/JP2825202B2/ja not_active Expired - Lifetime
- 1989-11-09 AU AU44530/89A patent/AU621949B2/en not_active Expired
- 1989-11-10 GB GB8925492A patent/GB2225941B/en not_active Revoked
- 1989-11-10 AT AT89311701T patent/ATE123218T1/de not_active IP Right Cessation
- 1989-11-10 ES ES89311701T patent/ES2075061T3/es not_active Expired - Lifetime
- 1989-11-10 DE DE68922894T patent/DE68922894T2/de not_active Expired - Lifetime
- 1989-11-10 IE IE893625A patent/IE893625L/xx not_active IP Right Cessation
- 1989-11-10 DK DK198905645A patent/DK175154B1/da not_active IP Right Cessation
- 1989-11-10 EP EP89311701A patent/EP0368682B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0368682A1 (de) | 1990-05-16 |
| CA2002492A1 (en) | 1990-05-11 |
| GB2225941A (en) | 1990-06-20 |
| US5071646A (en) | 1991-12-10 |
| AU4453089A (en) | 1990-05-17 |
| ATE123218T1 (de) | 1995-06-15 |
| DE68922894D1 (de) | 1995-07-06 |
| ES2075061T3 (es) | 1995-10-01 |
| EP0368682B1 (de) | 1995-05-31 |
| IE893625L (en) | 1990-05-11 |
| DK564589A (da) | 1990-05-12 |
| GB2225941B (en) | 1992-12-09 |
| GB8925492D0 (en) | 1989-12-28 |
| DK564589D0 (da) | 1989-11-10 |
| AU621949B2 (en) | 1992-03-26 |
| JP2825202B2 (ja) | 1998-11-18 |
| DK175154B1 (da) | 2004-06-21 |
| JPH02243618A (ja) | 1990-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |