DE68920578T2 - Verschiedenartige Zelluloseether enthaltende, oral verabreichbare Arzneimittelformen mit gesteuerter Wirkstofffreigabe. - Google Patents

Verschiedenartige Zelluloseether enthaltende, oral verabreichbare Arzneimittelformen mit gesteuerter Wirkstofffreigabe.

Info

Publication number
DE68920578T2
DE68920578T2 DE68920578T DE68920578T DE68920578T2 DE 68920578 T2 DE68920578 T2 DE 68920578T2 DE 68920578 T DE68920578 T DE 68920578T DE 68920578 T DE68920578 T DE 68920578T DE 68920578 T2 DE68920578 T2 DE 68920578T2
Authority
DE
Germany
Prior art keywords
containing controlled
active ingredients
cellulose ether
oral forms
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68920578T
Other languages
English (en)
Other versions
DE68920578D1 (de
Inventor
David Emil Edgren
Judy A Magruder
Gurdish Kaur Bhatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE68920578D1 publication Critical patent/DE68920578D1/de
Application granted granted Critical
Publication of DE68920578T2 publication Critical patent/DE68920578T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
DE68920578T 1987-04-06 1989-08-14 Verschiedenartige Zelluloseether enthaltende, oral verabreichbare Arzneimittelformen mit gesteuerter Wirkstofffreigabe. Expired - Lifetime DE68920578T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/034,971 US4786503A (en) 1987-04-06 1987-04-06 Dosage form comprising parallel lamine
US07/039,405 US4871548A (en) 1987-04-06 1987-04-17 Controlled release dosage form comprising different cellulose ethers

Publications (2)

Publication Number Publication Date
DE68920578D1 DE68920578D1 (de) 1995-02-23
DE68920578T2 true DE68920578T2 (de) 1995-05-04

Family

ID=39967167

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3811114A Expired - Lifetime DE3811114C2 (de) 1987-04-06 1988-03-31 Zweischichtige Dosierungsform zur Abgabe eines Wirkstoffs
DE68920578T Expired - Lifetime DE68920578T2 (de) 1987-04-06 1989-08-14 Verschiedenartige Zelluloseether enthaltende, oral verabreichbare Arzneimittelformen mit gesteuerter Wirkstofffreigabe.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3811114A Expired - Lifetime DE3811114C2 (de) 1987-04-06 1988-03-31 Zweischichtige Dosierungsform zur Abgabe eines Wirkstoffs

Country Status (21)

Country Link
US (3) US4786503A (de)
EP (1) EP0413061B1 (de)
JP (2) JP2916147B2 (de)
KR (1) KR950003918B1 (de)
AT (1) ATE116844T1 (de)
AU (1) AU601033B2 (de)
BE (1) BE1001699A3 (de)
CA (1) CA1331739C (de)
CH (1) CH677447A5 (de)
DE (2) DE3811114C2 (de)
ES (2) ES2006394A6 (de)
FR (1) FR2613224B1 (de)
GB (1) GB2203338B (de)
GR (1) GR1000053B (de)
IE (1) IE67156B1 (de)
IT (1) IT1219750B (de)
LU (1) LU87189A1 (de)
NL (1) NL8800867A (de)
PT (1) PT91442B (de)
SE (1) SE503611C2 (de)
ZA (1) ZA882034B (de)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364620A (en) * 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
JP2921861B2 (ja) * 1989-07-05 1999-07-19 旭光学工業株式会社 オートフォーカスカメラ
US5776493A (en) * 1989-07-14 1998-07-07 Alza Corporation Oral osmotic device for delivery of nystatin with hydrogel driving member
US5130140A (en) * 1989-09-14 1992-07-14 Hoeschst-Roussel Pharmaceuticals Inc. Method of making direct dry compressible acetaminophen composition
US5198228A (en) * 1989-09-14 1993-03-30 Hoechst-Roussel Pharmaceuticals Inc. Direct dry compressible acetaminophen tablet
US5037658A (en) * 1989-09-14 1991-08-06 Hoechst-Roussel Pharmaceuticals, Inc. Direct dry compressible acetaminophen composition
IE66933B1 (en) * 1990-01-15 1996-02-07 Elan Corp Plc Controlled absorption naproxen formulation for once-daily administration
US5009895A (en) * 1990-02-02 1991-04-23 Merck & Co., Inc. Sustained release with high and low viscosity HPMC
IE64128B1 (en) * 1990-02-26 1995-07-12 Byrne Rynne Holdings Ltd A pharmaceutical composition
SE9003904D0 (sv) * 1990-12-07 1990-12-07 Astra Ab Method for the manufacture of a pharmaceutical dosage form
US5232704A (en) * 1990-12-19 1993-08-03 G. D. Searle & Co. Sustained release, bilayer buoyant dosage form
US5204116A (en) * 1991-05-01 1993-04-20 Alza Corporation Dosage form providing immediate therapy followed by prolonged therapy
US5160744A (en) * 1991-06-27 1992-11-03 Alza Corporation Verapmil therapy
US6764697B1 (en) 1991-06-27 2004-07-20 Alza Corporation System for delaying drug delivery up to seven hours
GB2260081B (en) * 1991-10-04 1995-11-29 Euro Celtique Sa Use of ibuprofen/codeine mixtures in treatment of chronic pain
GB9121204D0 (en) * 1991-10-04 1991-11-20 Euro Celtique Sa Medicament
US5407686A (en) * 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5409709A (en) * 1991-11-29 1995-04-25 Lion Corporation Antipyretic analgesic preparation containing ibuprofen
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
US5248310A (en) * 1992-03-27 1993-09-28 Alza Corporation Oral osmotic device with hydrogel driving member
US5512299A (en) * 1992-03-30 1996-04-30 Alza Corporation Method of treating oral inflammatory disease
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
IT1255522B (it) * 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
IT1256393B (it) * 1992-11-17 1995-12-04 Inverni Della Beffa Spa Forme matriciali multistrato per il rilascio controllato di principi attivi
ES2194863T3 (es) * 1992-11-30 2003-12-01 Kv Pharm Co Materiales farmaceuticos con enmascarado de sabor.
US5573776A (en) * 1992-12-02 1996-11-12 Alza Corporation Oral osmotic device with hydrogel driving member
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
IT1264696B1 (it) * 1993-07-09 1996-10-04 Applied Pharma Res Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US5397574A (en) * 1993-10-04 1995-03-14 Andrx Pharmaceuticals, Inc. Controlled release potassium dosage form
CA2211325C (en) * 1993-10-13 2006-08-15 H. Joseph Horacek Extended release clonidine formulation
US5484607A (en) * 1993-10-13 1996-01-16 Horacek; H. Joseph Extended release clonidine formulation
US5393765A (en) * 1993-12-13 1995-02-28 Hoffmann-La Roche Inc. Pharmaceutical compositions with constant erosion volume for zero order controlled release
GB9401894D0 (en) * 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
US5407687A (en) * 1994-02-22 1995-04-18 Glaxo Inc. Ranitidine solid dosage form
DE4408326A1 (de) * 1994-03-11 1995-09-14 Hexal Pharma Gmbh Retardtablette mit einem Gehalt an Diclofenac-Na
FR2723586A1 (fr) * 1994-08-11 1996-02-16 Seth Pawan Nouvelles compositions contenant de la cimetidine et associations en derivant
US5543099A (en) * 1994-09-29 1996-08-06 Hallmark Pharmaceutical, Inc. Process to manufacture micronized nifedipine granules for sustained release medicaments
US6103263A (en) * 1994-11-17 2000-08-15 Andrx Pharmaceuticals, Inc. Delayed pulse release hydrogel matrix tablet
AU737464B2 (en) * 1995-01-09 2001-08-23 J. Rettenmaier & Soehne Gmbh + Co. Kg Pharmaceutical excipient having improved compressibility
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6395303B1 (en) * 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6936277B2 (en) * 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
SI9500173B (sl) * 1995-05-19 2002-02-28 Lek, Trofazna farmacevtska oblika s konstantnim in kontroliranim sproščanjem amorfne učinkovine za enkrat dnevno aplikacijo
MXPA98003802A (es) * 1995-11-14 2005-04-29 Abbott Gmbh & Co Kg Preparaciones de hormona tiroidea estabilizadas ymetodos para fabricar las mismas.
US5733578A (en) * 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US5789014A (en) * 1995-12-25 1998-08-04 Shin-Etsu Chemical Co., Ltd. Method of manufacturing a solid preparation coated with non-solvent coating
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
CA2269880C (en) * 1996-05-09 2004-11-23 William A. Mallow Biocidal coating composition
US6280509B1 (en) 1996-05-09 2001-08-28 Alistagen Corporation Biocidal coating compositions and method
US5948437A (en) * 1996-05-23 1999-09-07 Zeneca Limited Pharmaceutical compositions using thiazepine
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7179486B1 (en) 1997-04-01 2007-02-20 Nostrum Pharmaceuticals, Inc. Process for preparing sustained release tablets
US6210710B1 (en) 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
US20050276836A1 (en) * 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
ES2234139T3 (es) * 1997-08-11 2005-06-16 Alza Corporation Forma de dosificacion de un agente activo de liberacion prolongada adaptada para la retencion gastrica.
IN186245B (de) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
US5948440A (en) * 1997-12-17 1999-09-07 Ranbaxy Laboratories Limited Modified release matrix formulation of cefaclor and cephalexin
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US8524277B2 (en) * 1998-03-06 2013-09-03 Alza Corporation Extended release dosage form
USD426020S (en) * 1998-03-20 2000-05-30 Colgate-Palmolive Company Detergent tablet
USD422749S (en) * 1998-03-20 2000-04-11 Colgate-Palmolive Company Detergent tablet
USD423141S (en) * 1998-03-20 2000-04-18 Colgate-Palmolive Company Detergent tablet
ES2347968T3 (es) * 1998-07-28 2010-11-26 Takeda Pharmaceutical Company Limited Preparacion solida que se disgrega rapidamente.
US6214381B1 (en) 1998-09-08 2001-04-10 Effcon, Inc. Methazolamide composition and method of use
KR20010075370A (ko) * 1998-09-25 2001-08-09 낸시 엠. 그레이 경구 투여용 액상 약제
US20020169145A1 (en) * 1998-10-14 2002-11-14 Rajen Shah Sustained release pharmaceutical composition and method of releasing pharmaceutically active agent
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
US6419960B1 (en) 1998-12-17 2002-07-16 Euro-Celtique S.A. Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
US6635281B2 (en) 1998-12-23 2003-10-21 Alza Corporation Gastric retaining oral liquid dosage form
US6797283B1 (en) 1998-12-23 2004-09-28 Alza Corporation Gastric retention dosage form having multiple layers
US6109487A (en) * 1999-02-12 2000-08-29 Dart Industries Inc. Container with dispensing assembly
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6231650B1 (en) 1999-09-17 2001-05-15 Alistagen Corporation Biocidal coating composition
US20030219488A1 (en) * 1999-12-22 2003-11-27 Hedden David B. Sustained-release formulation of a cyclooxygenase-2 inhibitor
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
US6242003B1 (en) 2000-04-13 2001-06-05 Novartis Ag Organic compounds
AR030557A1 (es) * 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
GB0009522D0 (en) * 2000-04-19 2000-06-07 Smithkline Beecham Plc Composition
US7838032B2 (en) * 2000-04-28 2010-11-23 Reckitt Benckiser Inc. Sustained release of guaifenesin
US8012504B2 (en) * 2000-04-28 2011-09-06 Reckitt Benckiser Inc. Sustained release of guaifenesin combination drugs
US7985420B2 (en) * 2000-04-28 2011-07-26 Reckitt Benckiser Inc. Sustained release of guaifenesin combination drugs
US6955821B2 (en) * 2000-04-28 2005-10-18 Adams Laboratories, Inc. Sustained release formulations of guaifenesin and additional drug ingredients
US6372252B1 (en) 2000-04-28 2002-04-16 Adams Laboratories, Inc. Guaifenesin sustained release formulation and tablets
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US6767899B1 (en) * 2000-08-29 2004-07-27 Leiner Health Services Corp. Composition and method for treatment of conditions having an inflammatory component
BR0114272A (pt) * 2000-09-29 2003-08-26 Solvay Pharm Bv Formulação farmacêutica de liberação prolongada independente da força iÈnica
KR100685945B1 (ko) 2000-12-29 2007-02-23 엘지.필립스 엘시디 주식회사 액정표시장치 및 그 제조방법
US6607512B2 (en) * 2001-01-09 2003-08-19 Genzyme Corporation Device for delivery of liquid and gel-like surgical materials and methods for use thereof
FR2822378A1 (fr) * 2001-03-23 2002-09-27 Igen Ipsor Generiques Nouveau procede de realisation de comprimes bicouches a liberation controlee
US20060127474A1 (en) * 2001-04-11 2006-06-15 Oskar Kalb Pharmaceutical compositions comprising fluvastatin
CA2449415A1 (en) * 2001-04-20 2002-10-31 Lavipharm Laboratories Inc. Intraoral delivery of nicotine for smoking cessation
US20030091630A1 (en) * 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US20060159743A1 (en) * 2001-10-25 2006-07-20 Depomed, Inc. Methods of treating non-nociceptive pain states with gastric retentive gabapentin
US20070184104A1 (en) * 2001-10-25 2007-08-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US20030104052A1 (en) * 2001-10-25 2003-06-05 Bret Berner Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US20030152622A1 (en) * 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
US7612112B2 (en) 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
EA200401334A1 (ru) * 2002-04-11 2005-04-28 Ранбакси Лабораторис Лимитед Фармацевтические композиции карбидопы и леводопы с контролируемым высвобождением
US20040086566A1 (en) * 2002-11-04 2004-05-06 Alpharma, Inc. Waxy matrix dosage forms
AU2003303631B2 (en) * 2002-12-26 2008-05-29 Nuvo Pharmaceuticals (Ireland) Designated Activity Company Multilayer Dosage Forms Containing NSAIDs and Triptans
CA2554012A1 (en) * 2003-01-21 2004-08-05 Smartrix Technologies Inc. Oral dosage formulation
US20050013863A1 (en) * 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
AU2004275835B2 (en) * 2003-09-26 2011-06-23 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
MXPA06003450A (es) * 2003-09-26 2006-08-31 Johnson & Johnson Recubrimiento de farmaco que proporciona alta carga del farmaco y metodos para proporcionar el mismo.
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
WO2005030166A1 (en) * 2003-09-26 2005-04-07 Alza Corporation Oros push-stick for controlled delivery of active agents
DE602004030931D1 (de) * 2003-11-04 2011-02-17 Supernus Pharmaceuticals Inc
EP1680098A4 (de) * 2003-11-04 2012-06-13 Supernus Pharmaceuticals Inc Verzögerte freisetzung von positiv geladenen pharmakologisch wirksamen molekülen aus einer polymer-haltigen matrix mit polarisierten sauerstoffatomen
US8709476B2 (en) 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
SI2070530T1 (sl) 2004-05-14 2016-05-31 Merck Sharp & Dohme Corp. Zdravljenje bolezni, povezanih z uporabo antibiotikov
US7897172B2 (en) * 2004-05-18 2011-03-01 L. Perrigo Company Tablets exhibiting reduced drug release variability
US9592197B2 (en) * 2004-12-16 2017-03-14 Sovereign Pharmaceuticals, Llc Dosage form containing diphenhydramine and another drug
US20070003622A1 (en) * 2004-12-16 2007-01-04 Sovereign Pharmaceuticals, Ltd. Diphenhydramine containing dosage form
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
CN101068532B (zh) * 2004-09-30 2012-03-14 斯科尔医药公司 布洛芬改进释放剂型
US20060068009A1 (en) * 2004-09-30 2006-03-30 Scolr Pharma, Inc. Modified release ibuprofen dosage form
US20070077297A1 (en) 2004-09-30 2007-04-05 Scolr Pharma, Inc. Modified release ibuprofen dosage form
US7529255B2 (en) * 2005-04-21 2009-05-05 Microsoft Corporation Peer-to-peer multicasting using multiple transport protocols
CN1883456B (zh) * 2005-06-20 2010-12-15 常州市第四制药厂有限公司 掩味药物颗粒及其制备方法和用途
MX2007015783A (es) * 2005-06-22 2008-02-21 Takeda Pharmaceutical Tableta que contiene un ingrediente dificilmente soluble.
US20080166407A1 (en) * 2005-07-29 2008-07-10 Shalaby Shalaby W Solid oral formulations for combination therapy
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
US20070092565A1 (en) * 2005-10-25 2007-04-26 Pharmascience Inc. Gastric retention drug delivery system
US20090176882A1 (en) 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US20070218135A1 (en) * 2006-03-14 2007-09-20 Glenmark Pharmaceuticals Limited Sustained release matrix pharmaceutical composition
US9011930B2 (en) * 2006-05-01 2015-04-21 Zycal Bioceuticals Healthcare Company, Inc. Nutritional supplement and use thereof
US8128460B2 (en) * 2006-09-14 2012-03-06 The Material Works, Ltd. Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
US7749537B2 (en) * 2006-12-04 2010-07-06 Scolr Pharma, Inc. Method of forming a tablet
US20100172991A1 (en) * 2007-06-08 2010-07-08 Henry Joseph Horacek Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
MX2009013384A (es) * 2007-06-08 2010-01-25 Addrenex Pharmaceuticals Inc Formulacion de liberacion extendida, y metodo para tratar disregulacion adrenergica.
WO2009137827A2 (en) 2008-05-09 2009-11-12 Tiara Pharmaceuticals, Inc. Controlled release of n-acetylcysteine (nac) for reduction of systemic and/or vascular inflammation
WO2010019915A1 (en) * 2008-08-15 2010-02-18 Depomed Inc. Gastric retentive pharmaceutical compositions for treatment and prevention of cns disorders
US20100233259A1 (en) * 2008-12-12 2010-09-16 Pascal Grenier Dosage form of ropinirole
TWI478733B (zh) * 2009-05-13 2015-04-01 Wyeth Llc 突釋藥物釋放組合物
RU2017124629A (ru) 2011-01-20 2019-01-30 Бионевиа Фармасьютикалс Инк. Композиции с модифицированным высвобождением эпалрестата или его производных и способы их использования
US9351924B2 (en) 2011-03-11 2016-05-31 Snu R&Db Foundation Drug delivery system including laminated structure
WO2012124869A1 (ko) * 2011-03-11 2012-09-20 서울대학교산학협력단 적층 구조를 포함하는 약물 전달 시스템
CN104023725B (zh) * 2011-08-16 2019-04-26 卡迪欧拉有限公司 控释制剂
ES2639132T3 (es) * 2011-11-21 2017-10-25 Denka Company Limited Clínker de endurecimiento ultrarrápido, composición de cemento que utiliza el mismo, y método para producir el mismo
US20130143867A1 (en) 2011-12-02 2013-06-06 Sychroneuron Inc. Acamprosate formulations, methods of using the same, and combinations comprising the same
US10166207B2 (en) 2013-06-05 2019-01-01 Synchroneuron, Inc. Acamprosate formulations, methods of using the same, and combinations comprising the same
CA2936740C (en) 2014-10-31 2017-10-10 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US9617230B2 (en) 2014-12-22 2017-04-11 Farmington Pharma Development Creatine prodrugs, compositions and methods of use thereof
EA201791455A1 (ru) 2014-12-22 2017-12-29 Кардиора Пти Лтд. Способ лечения
US11278506B2 (en) 2015-10-09 2022-03-22 Rb Health (Us) Llc Pharmaceutical formulation
US9980946B1 (en) 2017-01-25 2018-05-29 Effcon Laboratories, Inc. Extended release methazolamide formulation
TWI815832B (zh) 2017-12-01 2023-09-21 美商奧特吉尼克斯製藥公司 肌酸前藥、其組合物及使用方法
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870790A (en) * 1970-01-22 1975-03-11 Forest Laboratories Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose
CH630257A5 (en) * 1975-03-17 1982-06-15 Hoffmann La Roche Sustained release formulation
US4167558A (en) * 1976-02-13 1979-09-11 Hoffmann-La Roche Inc. Novel sustained release tablet formulations
US4140755A (en) * 1976-02-13 1979-02-20 Hoffmann-La Roche Inc. Sustained release tablet formulations
US4357469A (en) * 1979-06-14 1982-11-02 Forest Laboratories, Inc. Carrier base material for prolonged release therapeutic compositions
US4226849A (en) * 1979-06-14 1980-10-07 Forest Laboratories Inc. Sustained release therapeutic compositions
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS57110254A (en) * 1980-12-29 1982-07-09 Teijin Ltd Coating agent of injured membrane part of oral cavity
JPS5839618A (ja) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd 持続性積層錠剤
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4556678A (en) * 1982-06-24 1985-12-03 Key Pharmaceuticals, Inc. Sustained release propranolol tablet
US4553973A (en) * 1982-07-12 1985-11-19 Alza Corporation Process for preparing osmotic device
US4540566A (en) * 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
US4610870A (en) * 1984-10-05 1986-09-09 E. R. Squibb & Sons, Inc. Controlled release formulation
US4693895A (en) * 1984-10-26 1987-09-15 Alza Corporation Colon delivery system
EP0227814A1 (de) * 1985-07-02 1987-07-08 The Upjohn Company Therapeutische zusammensetzungen mit bimodalabgabe-charakteristiken
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine

Also Published As

Publication number Publication date
US4871548A (en) 1989-10-03
JPS63258808A (ja) 1988-10-26
LU87189A1 (fr) 1988-11-17
IE67156B1 (en) 1996-03-06
FR2613224A1 (fr) 1988-10-07
GR1000053B (el) 1990-05-11
AU1406588A (en) 1988-10-06
US4786503A (en) 1988-11-22
KR950003918B1 (ko) 1995-04-20
SE8801240D0 (sv) 1988-04-05
IT8867302A0 (it) 1988-04-05
NL8800867A (nl) 1988-11-01
JPH0776181B2 (ja) 1995-08-16
DE68920578D1 (de) 1995-02-23
BE1001699A3 (fr) 1990-02-13
EP0413061A1 (de) 1991-02-20
GB2203338A (en) 1988-10-19
CH677447A5 (de) 1991-05-31
IE892845A1 (en) 1991-03-13
DE3811114C2 (de) 1996-05-30
PT91442B (pt) 1995-07-06
CA1331739C (en) 1994-08-30
ATE116844T1 (de) 1995-01-15
GB8807493D0 (en) 1988-05-05
SE8801240L (sv) 1988-10-07
IT1219750B (it) 1990-05-24
AU601033B2 (en) 1990-08-30
JP2916147B2 (ja) 1999-07-05
ES2069588T3 (es) 1995-05-16
SE503611C2 (sv) 1996-07-15
FR2613224B1 (fr) 1990-12-07
PT91442A (pt) 1990-03-08
US4946685A (en) 1990-08-07
ES2006394A6 (es) 1989-04-16
KR880012212A (ko) 1988-11-26
GR880100214A (en) 1989-01-31
GB2203338B (en) 1991-07-17
DE3811114A1 (de) 1988-11-10
ZA882034B (en) 1988-09-15
JPH0393731A (ja) 1991-04-18
EP0413061B1 (de) 1995-01-11

Similar Documents

Publication Publication Date Title
DE68920578T2 (de) Verschiedenartige Zelluloseether enthaltende, oral verabreichbare Arzneimittelformen mit gesteuerter Wirkstofffreigabe.
EE03292B1 (et) Prootonpumba inhibiitorit sisaldav paljuosaline ravimpreparaat ja selle valmistamise protsess
PT97369A (pt) Processo para a preparacao de formulacoes farmaceutica na qual o sabor do medicamento e disfarcado por meio de revestimento do medicamento com uma membrana polimerica
KR950007841A (ko) 트라마돌 염을 함유하는 서방성 약물 제제
MY100721A (en) Therapeutic agent.
SE8406081D0 (sv) Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
SE9703206D0 (sv) Oral komposition innehållande olanzapin och förfarande för framställning därav
EE03137B1 (et) Veterinaarravim ja protsess selle valmistamiseks
DE69106501T2 (de) Osmotisches dosiersystem zur verabreichung von flüssigen arzneimitteln.
ES8201596A1 (es) Procedimiento de obtencion de mucopolisacaridos
ES2009216A6 (es) Metodo de preparar un derivado de interleucina-lalfa.
ATE143257T1 (de) Arzneiabgabesystem, verfahren zu dessen herstellung sowie dessen verwendung
ATE202926T1 (de) Pharmazeutische brausepräparate enthaltend bioabbaubare mikrokapseln zur kontrolierten wirkstofffreisetzung
NO176082C (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat inneholdende bunazosin, for perkutan tilförsel
IT8220758A1 (it) Prodotti farmaceutici in forma-ritardo e procedimento per ottenerli
ES8303915A1 (es) "procedimiento para la preparacion de comprimidos a base del antibiotico fosfomicina".
JO1881B1 (en) Formula II for multi unit disc calibration

Legal Events

Date Code Title Description
8364 No opposition during term of opposition