DE68918657D1 - Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen. - Google Patents

Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen.

Info

Publication number
DE68918657D1
DE68918657D1 DE68918657T DE68918657T DE68918657D1 DE 68918657 D1 DE68918657 D1 DE 68918657D1 DE 68918657 T DE68918657 T DE 68918657T DE 68918657 T DE68918657 T DE 68918657T DE 68918657 D1 DE68918657 D1 DE 68918657D1
Authority
DE
Germany
Prior art keywords
detection
nucleic acid
acid sequences
specific nucleic
specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68918657T
Other languages
English (en)
Other versions
DE68918657T2 (de
Inventor
Edwin F Ullman
Thomas C Goodman
Paul D Stull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE68918657D1 publication Critical patent/DE68918657D1/de
Publication of DE68918657T2 publication Critical patent/DE68918657T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
DE68918657T 1988-08-25 1989-08-24 Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen. Expired - Lifetime DE68918657T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/236,967 US5185243A (en) 1988-08-25 1988-08-25 Method for detection of specific nucleic acid sequences

Publications (2)

Publication Number Publication Date
DE68918657D1 true DE68918657D1 (de) 1994-11-10
DE68918657T2 DE68918657T2 (de) 1995-05-18

Family

ID=22891769

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918657T Expired - Lifetime DE68918657T2 (de) 1988-08-25 1989-08-24 Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen.

Country Status (5)

Country Link
US (2) US5185243A (de)
EP (1) EP0357336B1 (de)
JP (1) JPH02135100A (de)
CA (1) CA1340775C (de)
DE (1) DE68918657T2 (de)

Families Citing this family (247)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
EP0379369B1 (de) * 1989-01-19 1996-09-04 BEHRINGWERKE Aktiengesellschaft Nukleinsäure-Amplifikation unter Verwendung eines Einzelprimers
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
CA2035010C (en) * 1990-01-26 1996-12-10 Keith C. Backman Method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
JPH04222599A (ja) * 1990-04-20 1992-08-12 Syntex Usa Inc 二重受容体ポリヌクレオチド検定方法
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
WO1993021311A1 (en) * 1992-04-15 1993-10-28 Commonwealth Scientific And Industrial Research Organisation Immortalisation of human cells by gene silencing
EP0642592A4 (de) * 1992-05-29 1997-01-02 Abbott Lab Ligase kettenreaktion beginnend mit rna sequenzen.
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US6436635B1 (en) * 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5658757A (en) * 1993-03-31 1997-08-19 The Regents Of The University Of California Cloned leptospira outer membrane protein
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
WO1995021270A2 (en) * 1994-02-04 1995-08-10 Beckman Instruments, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
AU694187B2 (en) * 1994-02-07 1998-07-16 Beckman Coulter, Inc. Ligase/polymerase-mediated genetic bit analysis TM of single nucleotide polymorphisms and its use in genetic analysis
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
WO1995035390A1 (en) * 1994-06-22 1995-12-28 Mount Sinai School Of Medicine Of The City University Of New York Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
USRE38442E1 (en) * 1994-06-22 2004-02-24 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US5843666A (en) * 1994-09-02 1998-12-01 Lumigen, Inc. Chemiluminescent detection methods using dual enzyer-labeled binding partners
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US20060063193A1 (en) * 1995-04-11 2006-03-23 Dong-Jing Fu Solid phase sequencing of double-stranded nucleic acids
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5686310A (en) * 1995-06-06 1997-11-11 University Of Virginia Patent Foundation Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP0912761A4 (de) 1996-05-29 2004-06-09 Cornell Res Foundation Inc Bestimmung von unterschieden in der nukleisäuresequenz mittels einer kombination von ligasebestimmung und polymerase-kettenreaktion
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
ES2203815T3 (es) * 1996-07-18 2004-04-16 Dade Behring Marburg Gmbh Reactivos para analisis de acido micofenolico.
DE69722917T2 (de) 1996-07-18 2004-05-06 Dade Behring Marburg Gmbh Reagenzien für tests für mycophenolsäure
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
DE69738206T2 (de) 1996-11-06 2008-07-17 Sequenom, Inc., San Diego DNA-Diagnostik mittels Massenspektrometrie
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
AU9673198A (en) * 1997-10-02 1999-04-27 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US6233565B1 (en) 1998-02-13 2001-05-15 Saranac Software, Inc. Methods and apparatus for internet based financial transactions with evidence of payment
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6153442A (en) * 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
US6303325B1 (en) 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
EP1090293B2 (de) * 1998-06-24 2019-01-23 Illumina, Inc. Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6140083A (en) * 1998-07-23 2000-10-31 The Regents Of The University Of California Leptospiral outer membrane protein, LipL46
MXPA01005267A (es) * 1998-11-27 2002-04-24 Synaptics Uk Ltd Sensor de posicion.
AU4058500A (en) * 1999-03-30 2000-10-16 Nanogen, Inc. Single nucleotide polymorphic discrimination by electronic dot blot assay on semiconductor microchips
ATE295430T1 (de) * 1999-03-31 2005-05-15 Us Gov Health & Human Serv Typisierung von humanen enteroviren
US20060275782A1 (en) * 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
DK1923471T3 (da) 1999-04-20 2013-04-02 Illumina Inc Detektion af nukleinsyrereaktioner på bead-arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
ES2319380T3 (es) * 1999-07-26 2009-05-07 Clinical Micro Sensors, Inc. Determinacion de secuencias de acido nucleico usando la deteccion electronica.
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
CA2399733C (en) * 2000-02-07 2011-09-20 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) * 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
ATE412774T1 (de) 2000-02-16 2008-11-15 Illumina Inc Parallele genotypisierung mehrerer patientenproben
WO2001073122A1 (en) * 2000-03-28 2001-10-04 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
AU2001265121A1 (en) * 2000-05-30 2001-12-11 Applera Corporation Methods for detecting target nucleic acids using coupled ligation and amplification
CA2412721A1 (en) * 2000-06-26 2002-01-03 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ATE380883T1 (de) 2000-10-24 2007-12-15 Univ Leland Stanford Junior Direkte multiplex charakterisierung von genomischer dna
EP1409721A2 (de) * 2000-11-13 2004-04-21 Gnothis Holding SA Nachweis von nukleinsäure-polymorphismen
AU2002228974A1 (en) * 2000-12-13 2002-06-24 Nugen Technologies, Inc Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
CA2439074A1 (en) 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
EP1366197B1 (de) * 2001-03-09 2007-05-09 Nugen Technologies, Inc. Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
CA2443999A1 (en) * 2001-04-16 2002-10-24 Applera Corporation Methods and compositions for nucleotide analysis
US7838270B2 (en) * 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
CA2448484A1 (en) * 2001-05-25 2002-12-05 Xenon Genetics, Inc. Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
EP2246438B1 (de) 2001-07-12 2019-11-27 Illumina, Inc. Multiplex-nukleinsäurereaktionen
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
AU2002367750A1 (en) * 2001-08-14 2003-11-03 Discovery, Inc. Isothermal amplification in nucleic acid analysis
US7179658B2 (en) * 2001-09-06 2007-02-20 Beckman Coulter, Inc. Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
ATE540127T1 (de) * 2001-11-19 2012-01-15 Affymetrix Inc Multiplex pcr
EP2196544A1 (de) 2001-11-21 2010-06-16 Applied Biosystems, LLC Kit für Ligationsdetektionsreaktionen unter Verwendung von kodierten Markern
EP1860200A1 (de) * 2001-12-03 2007-11-28 Illumina, Inc. Multiplexverfahren zur Methylierungsdetektion
US9575070B2 (en) * 2001-12-04 2017-02-21 Wayne State University Neoepitope detection of disease using protein arrays
US20040171047A1 (en) * 2002-05-22 2004-09-02 Dahl Gary A. Target-dependent transcription
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
WO2004026109A2 (en) * 2002-09-20 2004-04-01 Wayne State University Molecular targets of cancer and aging
EP1403379A1 (de) * 2002-09-24 2004-03-31 QIAGEN GmbH Verbesserte Koamplifikation von Nukleinsäuren
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US20050003371A1 (en) * 2002-10-23 2005-01-06 Stratagene Modified nucleotides and methods of labeling nucleic acids
EP1558756A4 (de) * 2002-10-23 2006-09-27 Applera Corp Verfahren und zusammensetzung zumnachweis von targets
WO2004046344A2 (en) * 2002-11-19 2004-06-03 Applera Corporation Polynucleotide sequence detection assays
EP1572974A2 (de) * 2002-11-19 2005-09-14 Applera Corporation Polynukleotidsequenznachweistests und-analyse
WO2004074818A2 (en) * 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
CA2513985C (en) * 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
EP1460425A1 (de) * 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Entglykosilierte Enzymen für Konjugaten
WO2004092418A2 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
WO2005001129A2 (en) * 2003-06-06 2005-01-06 Applera Corporation Mobility cassettes
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CA2528577C (en) 2003-06-20 2012-08-07 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
AU2004269196B2 (en) * 2003-09-03 2010-03-04 Shmuel Bukshpan Methods and apparatus for rapid crystallization of biomolecules
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
WO2005042785A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
US20050130213A1 (en) * 2003-12-10 2005-06-16 Tom Morrison Selective ligation and amplification assay
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
SE0400441D0 (sv) * 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
EP1574583A1 (de) * 2004-03-10 2005-09-14 Roche Diagnostics GmbH Verfahren zur Isolierung von Bakterien aus biologischen Proben
US8679788B2 (en) 2004-03-22 2014-03-25 The Johns Hopkins University Methods for the detection of nucleic acid differences
WO2005112108A1 (ja) * 2004-05-17 2005-11-24 Hitachi Kokusai Electric Inc. 基板処理装置及び半導体デバイス製造方法
US7622281B2 (en) * 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
EP1804059A2 (de) 2004-05-21 2007-07-04 Atonomics A/S Oberflächenschallwellensensor mit einem Hydrogel
US7785843B2 (en) * 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
WO2006000647A1 (en) * 2004-06-29 2006-01-05 Wallac Oy Integrated non-homogeneous nucleic acid amplification and detection
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
EP1666150B1 (de) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Präparieren von Nucleinsäuren
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
CN101184839A (zh) * 2005-04-08 2008-05-21 纳斯泰克制药公司 用于呼吸道病毒感染的RNAi治疗
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
CA2651815A1 (en) 2006-05-10 2007-11-22 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
WO2008085024A1 (en) * 2007-01-12 2008-07-17 Erasmus University Medical Center Rotterdam Identification and detection of peptides relating to specific disorders
US7862999B2 (en) * 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US8008010B1 (en) 2007-06-27 2011-08-30 Applied Biosystems, Llc Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor
US7790401B2 (en) 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
WO2009052179A2 (en) 2007-10-15 2009-04-23 Idexx Laboratories, Inc. Feline pancreatic lipase
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
US20100121198A1 (en) * 2008-11-07 2010-05-13 Den-Mat Holdings Llc Multi-Purpose Illumination System And Method For Tissue Examination
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
EP2245064B1 (de) 2007-12-21 2014-07-23 Medimmune Limited BINDUNGSELEMENTE FÜR INTERLEUKIN-4-REZEPTOR ALPHA (IL-4Ralpha)
EP2240606B1 (de) * 2008-01-14 2016-10-12 Applied Biosystems, LLC Zusammensetzungen, verfahren und kits zum nachweis von ribonukleinsäure
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
JP2012531887A (ja) 2009-04-01 2012-12-13 ディクステリティー ダイアグノーティクス インコーポレイテッド 化学的ライゲーション依存型プローブ増幅(clpa)
EP2488876B1 (de) 2009-10-13 2017-03-01 Nanostring Technologies, Inc Proteinnachweis über nanoreporter
WO2011059686A2 (en) 2009-10-29 2011-05-19 Wisconsin Alumni Research Foundation Detection of b-cell activating factor as a biomaker for antibody mediated rejection in transplant recipients
EP2516463B1 (de) 2009-12-23 2016-06-15 4-Antibody AG Bindeelemente für menschliches cytomegalovirus
US8420801B2 (en) 2010-01-08 2013-04-16 Roche Molecular Systems, Inc. Recovery of nucleic acids from magnetic glass particles
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
US8329424B2 (en) 2010-06-25 2012-12-11 Siemens Healthcare Diagnostics Reduction in false results in assay measurements
EP2601531A1 (de) 2010-08-04 2013-06-12 IDEXX Laboratories, Inc. Nachweis von zersetzungsprodukten von hundespezifischem nt-probnp
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
US9255144B2 (en) 2010-12-20 2016-02-09 Medimmune Limited Anti-IL-18 antibodies and their uses
WO2012106385A2 (en) 2011-01-31 2012-08-09 Apprise Bio, Inc. Methods of identifying multiple epitopes in cells
JP6017458B2 (ja) 2011-02-02 2016-11-02 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション 大量並列連続性マッピング
EP2710145B1 (de) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Verfahren und zusammensetzungen zum nachweis von zielnukleinsäuren
WO2012166918A1 (en) 2011-05-31 2012-12-06 Idexx Laboratories, Inc. DETECTION OF DEGRADATION PRODUCTS OF FELINE NT-proBNP
ES2556580T3 (es) 2011-07-08 2016-01-19 Keygene N.V. Genotipado a base de secuencias en base a ensayos de ligación a oligonucleótidos
US8586322B2 (en) 2012-03-07 2013-11-19 Siemens Healthcare Diagnostics, Inc Sandwich assay for immunosuppressant drugs
US9658218B2 (en) 2012-05-07 2017-05-23 Siemens Healthcare Diagnostics Inc. Determination of total analyte concentration
JP6525872B2 (ja) 2012-08-08 2019-06-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 細胞中の複数のエピトープを同定するためのダイナミックレンジを高めること
ME03751B (de) 2012-10-15 2021-04-20 Medimmune Ltd Antikörper gegen amyloid beta
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
US9121859B2 (en) 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
WO2014165061A1 (en) 2013-03-13 2014-10-09 Meso Scale Technologies, Llc. Improved assay methods
WO2014142831A1 (en) 2013-03-13 2014-09-18 Illumina, Inc. Methods and systems for aligning repetitive dna elements
EP3919617A1 (de) 2013-03-13 2021-12-08 Illumina, Inc. Verfahren und zusammensetzungen zur nukleinsäuresequenzierung
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
ES2747634T3 (es) 2013-05-14 2020-03-11 Siemens Healthcare Diagnostics Inc Formulaciones líquidas estabilizadas que contienen receptores
WO2015088913A1 (en) 2013-12-09 2015-06-18 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
WO2015089172A1 (en) 2013-12-13 2015-06-18 Siemens Healthcare Diagnostics Inc. Pretreatment agent in non-agglutination assays
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
EP3084437B1 (de) 2013-12-18 2018-02-28 Siemens Healthcare Diagnostics Inc. Detektion von endothelialer erkrankung
EP3957750A1 (de) 2013-12-20 2022-02-23 Illumina, Inc. Konservierung von genomverbindungsinformationen in fragmentierten genomischen dna-proben
KR102001554B1 (ko) 2014-01-16 2019-07-18 일루미나, 인코포레이티드 고형 지지체 상에서의 앰플리콘 제조 방법 및 시퀀싱
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
WO2015175856A1 (en) 2014-05-15 2015-11-19 Meso Scale Technologies, Llc. Improved assay methods
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
CN106879252B (zh) 2014-06-10 2020-07-17 德克斯特里蒂诊断公司 用于收集和稳定生物样品的装置及方法
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
US10443087B2 (en) 2014-06-13 2019-10-15 Illumina Cambridge Limited Methods and compositions for preparing sequencing libraries
AU2015284464B2 (en) 2014-06-30 2021-06-17 Illumina, Inc. Methods and compositions using one-sided transposition
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
WO2016044233A1 (en) 2014-09-18 2016-03-24 Illumina, Inc. Methods and systems for analyzing nucleic acid sequencing data
RU2709655C2 (ru) 2014-10-17 2019-12-19 Иллумина Кембридж Лимитед Транспозиция с сохранением сцепления генов
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
CA2967224C (en) 2014-12-11 2023-08-22 Inbiomotion S.L. Binding members for human c-maf
US20170362305A1 (en) 2014-12-17 2017-12-21 Siemens Healthcare Diagnostics Inc. Sandwich assay design for small molecules
CN107532205B (zh) 2015-03-31 2021-06-08 伊卢米纳剑桥有限公司 模板的表面连环化
US20180258467A1 (en) 2015-04-07 2018-09-13 Polyskope Labs Detection of one or more pathogens
CN107922966B (zh) 2015-07-06 2022-06-28 伊卢米纳剑桥有限公司 用于核酸扩增的样品制备
WO2017074703A1 (en) 2015-10-29 2017-05-04 Siemens Healthcare Diagnostics Inc. Sandwich assay for small molecules
EP3377226B1 (de) 2016-03-28 2021-02-17 Illumina, Inc. Mikroarrays in mehreren ebenen
KR20230003255A (ko) 2016-07-22 2023-01-05 오레곤 헬스 앤드 사이언스 유니버시티 단일 세포 전체 게놈 라이브러리 및 이의 제조를 위한 조합 인덱싱 방법
EP3615691B1 (de) 2017-04-23 2021-05-26 Illumina, Inc. Zusammensetzungen und verfahren zur verbesserung der probenidentifikation in indizierten nukleinsäurebibliotheken
EP3615671B1 (de) 2017-04-23 2021-07-21 Illumina Cambridge Limited Zusammensetzungen und verfahren zur verbesserung der probenidentifikation in indizierten nukleinsäurebibliotheken
CA3060979C (en) 2017-04-23 2023-07-11 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
AU2018261007A1 (en) 2017-05-05 2019-11-07 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
SG10202108175RA (en) 2017-06-07 2021-09-29 Univ Oregon Health & Science Single cell whole genome libraries for methylation sequencing
EP3662482A1 (de) 2017-07-31 2020-06-10 Illumina Inc. Sequenzierungssystem mit multiplexierter aggregation biologischer proben
WO2019028166A1 (en) 2017-08-01 2019-02-07 Illumina, Inc. HYDROGEL BALLS FOR NUCLEOTIDE SEQUENCING
US11180752B2 (en) 2018-02-13 2021-11-23 Illumina, Inc. DNA sequencing using hydrogel beads
JP7134186B2 (ja) 2018-03-22 2022-09-09 イルミナ インコーポレイテッド Rnaおよびdnaからの核酸ライブラリーの作製
US20190367909A1 (en) 2018-04-02 2019-12-05 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
KR102481869B1 (ko) 2018-04-20 2022-12-27 일루미나, 인코포레이티드 단일 세포를 캡슐화하는 방법, 캡슐화된 세포 및 이의 용도
EP3810774B1 (de) 2018-06-04 2023-09-13 Illumina, Inc. Verfahren zur herstellung von einzelzelltranskriptombibliotheken mit hohem durchsatz
US11085036B2 (en) 2018-10-26 2021-08-10 Illumina, Inc. Modulating polymer beads for DNA processing
US20220195504A1 (en) 2018-11-30 2022-06-23 Illumina, Inc. Analysis of multiple analytes using a single assay
AU2020232618A1 (en) 2019-03-01 2021-04-08 Illumina, Inc. High-throughput single-nuclei and single-cell libraries and methods of making and of using
JP2022540268A (ja) 2019-07-12 2022-09-15 イルミナ ケンブリッジ リミテッド 固体支持体上で固定化されたcrispr/cas9を使用する核酸シークエンシングライブラリを調製するための組成物及び方法
KR20220031539A (ko) 2019-07-12 2022-03-11 일루미나 케임브리지 리미티드 전기영동을 이용한 핵산 라이브러리 제조
CN114829669A (zh) 2019-10-11 2022-07-29 宽腾矽公司 气相表面改性
EP3927824A2 (de) 2019-12-19 2021-12-29 Illumina, Inc. Einzelzellbibliotheken mit hohem durchsatz und verfahren zur herstellung und verwendung davon
MX2022012184A (es) 2020-03-30 2022-10-27 Illumina Inc Metodos y composiciones para preparar genotecas de acido nucleico.
EP4150065A2 (de) 2020-05-12 2023-03-22 Illumina Inc Erzeugung von nukleinsäuren mit modifizierten basen unter verwendung rekombinanter terminaler deoxynucleotidyltransferase
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
JP2023532231A (ja) 2020-06-30 2023-07-27 イルミナ インコーポレイテッド 傷なしdnaを生成するための触媒的に制御された合成による配列決定
BR112023002051A2 (pt) 2020-08-06 2023-04-18 Illumina Inc Preparação de bibliotecas de sequenciamento de rna e dna usando transpossomos ligados a microesferas
EP4200416A1 (de) 2020-08-18 2023-06-28 Illumina, Inc. Sequenzspezifische gezielte transposition und selektion und sortierung von nukleinsäuren
KR20230069135A (ko) 2020-09-11 2023-05-18 일루미나 케임브리지 리미티드 헤어핀 어댑터를 사용하여 시퀀싱 라이브러리에서 표적 서열을 농축시키는 방법
AU2022215582A1 (en) 2021-02-04 2023-08-24 Illumina, Inc. Long indexed-linked read generation on transposome bound beads
WO2022212269A1 (en) 2021-03-29 2022-10-06 Illumina, Inc. Improved methods of library preparation
BR112023019894A2 (pt) 2021-03-29 2023-11-14 Illumina Inc Composições e métodos para avaliar os danos ao dna em uma biblioteca e normalizar a distorção do tamanho do amplicon
IL307172A (en) 2021-03-30 2023-11-01 Illumina Inc Improved methods of isothermal complementary DNA and library preparation
EP4314283A1 (de) 2021-03-31 2024-02-07 Illumina, Inc. Verfahren zur herstellung von direktionalen tagmentationssequenzierungsbibliotheken mit transposonbasierter technologie mit eindeutigen molekularen identifikatoren zur fehlerkorrektur
CA3223722A1 (en) 2022-04-07 2023-10-12 Illumina, Inc. Altered cytidine deaminases and methods of use

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4423153A (en) * 1981-12-03 1983-12-27 Board Of Regents, The University Of Texas System Methods and compositions for the detection and determination of cellular DNA
US4480040A (en) * 1981-12-03 1984-10-30 The United States Of America As Represented By The Secretary Of Agriculture Sensitive and rapid diagnosis of viroid diseases and viruses
US4490472A (en) * 1982-06-17 1984-12-25 Imreg, Inc. Sensitive tests for malignancies based on DNA detection
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4677054A (en) * 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4647529A (en) * 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
US4675283A (en) * 1984-07-19 1987-06-23 Massachusetts Institute Of Technology Detection and isolation of homologous, repeated and amplified nucleic acid sequences
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
FI72146C (fi) * 1985-01-02 1987-04-13 Orion Yhtymae Oy Foerfarande foer identifiering av nukleinsyror.
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8509367D0 (en) * 1985-04-12 1985-05-15 Amersham Int Plc Nucleic acid hybridisation
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) * 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
GB2225112A (en) * 1988-11-22 1990-05-23 Ici Plc Hybridisation probes

Also Published As

Publication number Publication date
DE68918657T2 (de) 1995-05-18
US5185243A (en) 1993-02-09
CA1340775C (en) 1999-09-28
EP0357336A2 (de) 1990-03-07
JPH02135100A (ja) 1990-05-23
EP0357336A3 (de) 1991-02-27
US5516641A (en) 1996-05-14
EP0357336B1 (de) 1994-10-05

Similar Documents

Publication Publication Date Title
DE68918657D1 (de) Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen.
DE69520330D1 (de) Verfahren zum Nachweis von spezifischen Nukleinsäuresequenzen
DE58903898D1 (de) Verfahren zum nachweis von nukleinsaeuren.
DE68915202T2 (de) Verfahren zur Vermehrung und zum Nachweis von Nukleinsäuresequenzen.
DE3789905T2 (de) Verfahren zum Nachweis von elektrophoretisch getrennten Oligonukleotiden.
DE69003104D1 (de) Verfahren zum nachweis von spezifischen sequenzen von nukleinsäuren und ihre verwendungen.
DE69125441D1 (de) Verfahren zum Gennachweis
DE3854056T2 (de) Verfahren zum Nachweis einer Nukleinsäure-Sequenz in einer Probe.
DE69207580T2 (de) Verfahren zum DNS-Nachweis
DE3669271D1 (de) Verfahren zur entseuchung des bodens.
DE3682928D1 (de) Verfahren zum polymerisieren von aethylen.
DE3888653T2 (de) Verfahren und Testsatz zum Nachweis einer Nukleinsäure-Sequenz.
DE3767747D1 (de) Verfahren zum bestimmen von abmessungen.
DE3765596D1 (de) Verfahren zum sprengplattieren.
DE3485834T2 (de) Verfahren zum bestimmen von nukleinsaeuresequenzen.
DE68904815D1 (de) Verfahren zur rueckgewinnung von methacrolein.
DE3667781D1 (de) Verfahren zum verbinden von keramischen gegenstaenden.
DE3777237D1 (de) Verfahren zum nachweis von metallen.
DE58901845D1 (de) Verfahren zum festlegen.
DE58907299D1 (de) Verfahren zum Nachweis von kohlenhydrathaltigen Verbindungen.
DE3762109D1 (de) Verfahren zum erfassen des schlupfzustandes.
DE3683916D1 (de) Verfahren zum nachweisen von aminosaeurederivaten.
DE3764424D1 (de) Verfahren zum auskleiden von rohren.
DE3768126D1 (de) Verfahren zum erkennen von unterwasserobjekten.
DE3868187D1 (de) Verfahren zum hydroformylieren von bestimmten acrylsaeurederivaten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN