DE669128T1 - Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung. - Google Patents
Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung.Info
- Publication number
- DE669128T1 DE669128T1 DE0669128T DE93924827T DE669128T1 DE 669128 T1 DE669128 T1 DE 669128T1 DE 0669128 T DE0669128 T DE 0669128T DE 93924827 T DE93924827 T DE 93924827T DE 669128 T1 DE669128 T1 DE 669128T1
- Authority
- DE
- Germany
- Prior art keywords
- microsphere
- antipsychotic
- biocompatible polymer
- dispense
- microball
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33244192 | 1992-11-17 | ||
PCT/JP1993/001673 WO1994010982A1 (en) | 1992-11-17 | 1993-11-15 | Sustained-release microsphere containing antipsychotic and process for producing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DE669128T1 true DE669128T1 (de) | 1996-03-14 |
Family
ID=18255017
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69327542T Revoked DE69327542T2 (de) | 1992-11-17 | 1993-11-15 | Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung |
DE0669128T Pending DE669128T1 (de) | 1992-11-17 | 1993-11-15 | Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69327542T Revoked DE69327542T2 (de) | 1992-11-17 | 1993-11-15 | Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung |
Country Status (11)
Country | Link |
---|---|
US (2) | US5656299A (de) |
EP (1) | EP0669128B1 (de) |
KR (1) | KR100333115B1 (de) |
AT (1) | ATE188375T1 (de) |
CA (1) | CA2148823C (de) |
DE (2) | DE69327542T2 (de) |
DK (1) | DK0669128T3 (de) |
ES (1) | ES2077547T3 (de) |
GR (2) | GR960300020T1 (de) |
PT (1) | PT669128E (de) |
WO (1) | WO1994010982A1 (de) |
Families Citing this family (96)
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US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
ES2236700T3 (es) * | 1993-11-19 | 2005-07-16 | Janssen Pharmaceutica N.V. | 1,2-benzazoles microencapsulados. |
ES2172574T5 (es) * | 1993-11-19 | 2012-11-29 | Alkermes, Inc. | Preparación de micropartículas biodegradables que contienen un agente biológicamente activo |
EP0733368A1 (de) * | 1995-03-24 | 1996-09-25 | Eli Lilly And Company | Granulatformulierungen von Olanzapin |
FR2748205A1 (fr) * | 1996-05-06 | 1997-11-07 | Debio Rech Pharma Sa | Compositions pharmaceutiques pour la liberation controlee de principes actifs insolubles |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
ATE357218T1 (de) * | 1996-05-07 | 2007-04-15 | Alkermes Inc | Micropartikel |
ATE302599T1 (de) * | 1996-05-24 | 2005-09-15 | Angiotech Pharm Inc | Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege |
EP0839525B1 (de) * | 1996-10-31 | 2004-08-04 | Takeda Chemical Industries, Ltd. | Zubereitung mit verzögerter Freisetzung |
IL123716A (en) * | 1997-03-27 | 2001-03-19 | Akzo Nobel Nv | Therapeutic combinations of mirtazapine and an antipsychotic agent |
GB9718986D0 (en) * | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
US6854841B1 (en) * | 1998-04-17 | 2005-02-15 | Elesys, Inc. | Point-of-incidence ink-curing mechanisms for radial printing |
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GB9817078D0 (en) * | 1998-08-05 | 1998-10-07 | Habib Nagy A | Device for liver surgery |
UA66872C2 (uk) * | 1998-09-30 | 2004-06-15 | Елі Ліллі Енд Компані | Сполука, яка є памоатом оланзапіну або його сольватом, та спосіб лікування психотичних розладів |
US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
WO2000018374A1 (en) * | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
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US6705757B2 (en) | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
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US6599532B2 (en) * | 2000-01-13 | 2003-07-29 | Osmotica Corp. | Osmotic device containing alprazolam and an antipsychotic agent |
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US7666445B2 (en) * | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
AU2002233239B2 (en) * | 2000-12-13 | 2006-05-11 | Merckle Gmbh | Microparticles with an improved release profile and method for the production thereof |
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EP1275378B1 (de) | 2001-07-10 | 2009-04-15 | Canon Kabushiki Kaisha | Partikel auf Basis von Polyhydroxyalkanoat und Verfahren zu deren Herstellung |
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PT3566696T (pt) | 2011-04-25 | 2021-01-11 | Nanjing Luye Pharmaceutical Co Ltd | Composição de microesfera para libertação sustentada de risperidona |
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CN115804749A (zh) | 2013-03-11 | 2023-03-17 | 度瑞公司 | 包含高粘度液体载体的可注射控制释放组合物 |
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US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
KR20240042548A (ko) | 2015-06-03 | 2024-04-02 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
MA53353A (fr) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation |
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IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
IT1216570B (it) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione. |
-
1993
- 1993-11-15 KR KR1019950701853A patent/KR100333115B1/ko not_active IP Right Cessation
- 1993-11-15 AT AT93924827T patent/ATE188375T1/de not_active IP Right Cessation
- 1993-11-15 EP EP93924827A patent/EP0669128B1/de not_active Revoked
- 1993-11-15 DE DE69327542T patent/DE69327542T2/de not_active Revoked
- 1993-11-15 PT PT93924827T patent/PT669128E/pt unknown
- 1993-11-15 ES ES93924827T patent/ES2077547T3/es not_active Expired - Lifetime
- 1993-11-15 WO PCT/JP1993/001673 patent/WO1994010982A1/ja not_active Application Discontinuation
- 1993-11-15 CA CA002148823A patent/CA2148823C/en not_active Expired - Fee Related
- 1993-11-15 DE DE0669128T patent/DE669128T1/de active Pending
- 1993-11-15 DK DK93924827T patent/DK0669128T3/da active
-
1995
- 1995-05-17 US US08/443,021 patent/US5656299A/en not_active Expired - Fee Related
-
1996
- 1996-03-31 GR GR960300020T patent/GR960300020T1/el unknown
-
1997
- 1997-03-07 US US08/812,544 patent/US5871778A/en not_active Expired - Fee Related
-
2000
- 2000-03-21 GR GR20000400702T patent/GR3033016T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2148823A1 (en) | 1994-05-26 |
EP0669128A1 (de) | 1995-08-30 |
US5656299A (en) | 1997-08-12 |
GR960300020T1 (en) | 1996-03-31 |
ES2077547T1 (es) | 1995-12-01 |
EP0669128B1 (de) | 2000-01-05 |
WO1994010982A1 (en) | 1994-05-26 |
ATE188375T1 (de) | 2000-01-15 |
ES2077547T3 (es) | 2000-06-16 |
PT669128E (pt) | 2000-06-30 |
DK0669128T3 (da) | 2000-06-19 |
DE69327542D1 (de) | 2000-02-10 |
KR100333115B1 (ko) | 2002-12-02 |
CA2148823C (en) | 1999-03-09 |
US5871778A (en) | 1999-02-16 |
GR3033016T3 (en) | 2000-08-31 |
EP0669128A4 (de) | 1996-09-25 |
DE69327542T2 (de) | 2000-07-06 |
KR950703936A (ko) | 1995-11-17 |
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