DE60330669D1 - Verfahren und vorrichtung zur messung der membranpermeabilität - Google Patents

Verfahren und vorrichtung zur messung der membranpermeabilität

Info

Publication number
DE60330669D1
DE60330669D1 DE60330669T DE60330669T DE60330669D1 DE 60330669 D1 DE60330669 D1 DE 60330669D1 DE 60330669 T DE60330669 T DE 60330669T DE 60330669 T DE60330669 T DE 60330669T DE 60330669 D1 DE60330669 D1 DE 60330669D1
Authority
DE
Germany
Prior art keywords
sink
permeability
membrane retention
double
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60330669T
Other languages
English (en)
Inventor
Alex Avdeef
Per E Nielsen
Chau M Du
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
pION Inc
Original Assignee
pION Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by pION Inc filed Critical pION Inc
Application granted granted Critical
Publication of DE60330669D1 publication Critical patent/DE60330669D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N13/04—Investigating osmotic effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/082—Investigating permeability by forcing a fluid through a sample
    • G01N15/0826—Investigating permeability by forcing a fluid through a sample and measuring fluid flow rate, i.e. permeation rate or pressure change
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/003—Diffusion; diffusivity between liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
DE60330669T 2002-01-31 2003-01-23 Verfahren und vorrichtung zur messung der membranpermeabilität Expired - Fee Related DE60330669D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35391402P 2002-01-31 2002-01-31
PCT/US2003/002095 WO2003065037A2 (en) 2002-01-31 2003-01-23 Method and apparatus for measuring membrane permeability

Publications (1)

Publication Number Publication Date
DE60330669D1 true DE60330669D1 (de) 2010-02-04

Family

ID=27663266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330669T Expired - Fee Related DE60330669D1 (de) 2002-01-31 2003-01-23 Verfahren und vorrichtung zur messung der membranpermeabilität

Country Status (5)

Country Link
US (1) US7022528B2 (de)
EP (1) EP1521962B1 (de)
AT (1) ATE453119T1 (de)
DE (1) DE60330669D1 (de)
WO (1) WO2003065037A2 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
CA2400644C (en) 2000-02-18 2009-07-14 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US6797172B2 (en) * 2000-05-24 2004-09-28 The Texas A&M University System Degumming of edible oils by ultrafiltration
US20100261159A1 (en) 2000-10-10 2010-10-14 Robert Hess Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
AU2001296809A1 (en) * 2000-10-10 2002-04-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US7112443B2 (en) * 2002-10-18 2006-09-26 Symyx Technologies, Inc. High throughput permeability testing of materials libraries
WO2004074818A2 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20050106745A1 (en) * 2003-09-19 2005-05-19 Agy Therapeutics, Inc. Combination of solubility and membrane permeability measurement methods for profiling of chemical compounds
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
EP1730516A1 (de) * 2004-03-30 2006-12-13 Pfizer Products Incorporated Verfahren und vorrichtung zur bewertung pharmazeutischer zusammensetzungen
EP1768784B1 (de) * 2004-06-01 2017-10-25 Pion, Inc. Permeationsvorrichtung und verfahren zur verringerung der dicke wässriger grenzschichten
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
WO2007022026A2 (en) * 2005-08-11 2007-02-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
DE102005044071A1 (de) * 2005-09-07 2007-03-08 Nimbus Biotechnologie Gmbh Verfahren zur Messung der Permeation einer Substanz durch eine Barriere
US8986781B2 (en) * 2005-10-27 2015-03-24 Corning Incorporated Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)
WO2007095366A2 (en) * 2006-02-13 2007-08-23 The Johns Hopkins University System and methods for sampling materials
EP1991864B1 (de) * 2006-02-28 2018-03-21 F.Hoffmann-La Roche Ag Verfahren zur beurteilung der absorptionseigenschaften von verbindungen mit geringer löslichkeit
US8685749B2 (en) 2009-12-02 2014-04-01 Whatman International Limited Methods and systems for processing samples on porous substrates
CN101907549B (zh) * 2010-07-06 2013-03-13 南京工业大学 一种同时获取固体溶质在液相中饱和溶解度和扩散系数的测试方法及测试装置
CN102183393A (zh) * 2011-03-07 2011-09-14 中国海洋大学 一种阴离子表面活性剂土壤提取与测定方法
CN104011197B (zh) * 2011-12-19 2016-08-24 雅马哈发动机株式会社 对象物分选装置以及对象物分选方法
US9423234B2 (en) 2012-11-05 2016-08-23 The Regents Of The University Of California Mechanical phenotyping of single cells: high throughput quantitative detection and sorting
WO2015177811A2 (en) * 2014-05-23 2015-11-26 Indian Institute Of Technology Madras System and method for measuring permeability of drugs/toxic/ chemical compounds
GB2528096A (en) 2014-07-09 2016-01-13 Paraytec Ltd Method
JP2018503065A (ja) * 2014-11-17 2018-02-01 スードダンスク ウニヴァシテーツＳｙｄｄａｎｓｋ Ｕｎｉｖｅｒｓｉｔｅｔ 調整可能な生体模倣特性を備えた薬物透過性評価アセンブリ
WO2016168445A1 (en) 2015-04-17 2016-10-20 Pion Inc. Apparatus and method for the assessment of concentration profiling and permeability rates
US10883978B2 (en) * 2017-01-31 2021-01-05 Agilent Technologies, Inc. Method and device for calibration of biological flux
US11293911B2 (en) 2017-12-28 2022-04-05 Korea Advanced Institute Of Science And Technology Multi-phase liquid composition, device for measuring permeability of drugs, and method for measuring permeability of drugs
CN114279929B (zh) * 2021-12-23 2024-01-12 上海交通大学 几何未知微尺度矩形槽内气溶胶穿透效率确定方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0242326A3 (de) 1986-04-15 1990-04-18 Pharmatronic AG Einrichtung zur Untersuchung der Diffusion einer Substanz und Verfahren zum Betrieb der Einrichtung
EP1250587A1 (de) 2000-01-28 2002-10-23 Pion, Inc. MESSUNG VON LÖSLICHKEITS-pH-PROFILEN
DE10118725C2 (de) 2001-04-12 2003-04-10 Pharmacelsus Gmbh Verfahren zum Testen von Arzneimittelwirkstoffen
EP1399539A2 (de) 2001-06-29 2004-03-24 Wyeth Verfahren und zusammensetzung zur vorhersage der permeabilität der blut-hirn-schranke

Also Published As

Publication number Publication date
EP1521962B1 (de) 2009-12-23
EP1521962A2 (de) 2005-04-13
ATE453119T1 (de) 2010-01-15
WO2003065037A3 (en) 2003-12-18
WO2003065037A2 (en) 2003-08-07
US7022528B2 (en) 2006-04-04
US20030219716A1 (en) 2003-11-27

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