DE60317305D1 - Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen - Google Patents

Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen

Info

Publication number
DE60317305D1
DE60317305D1 DE60317305T DE60317305T DE60317305D1 DE 60317305 D1 DE60317305 D1 DE 60317305D1 DE 60317305 T DE60317305 T DE 60317305T DE 60317305 T DE60317305 T DE 60317305T DE 60317305 D1 DE60317305 D1 DE 60317305D1
Authority
DE
Germany
Prior art keywords
dispensing
liquid
system fluid
communication passageway
dispensing orifice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60317305T
Other languages
English (en)
Other versions
DE60317305T2 (de
Inventor
James E Johnson
Neil R Picha
Craig M Storms
David A Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovadyne Technologies Inc
Original Assignee
Innovadyne Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovadyne Technologies Inc filed Critical Innovadyne Technologies Inc
Publication of DE60317305D1 publication Critical patent/DE60317305D1/de
Application granted granted Critical
Publication of DE60317305T2 publication Critical patent/DE60317305T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/021Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • B01L3/0268Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016Control of the volume dispensed or introduced
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/148Specific details about calibrations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/14Means for pressure control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/02Drop detachment mechanisms of single droplets from nozzles or pins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0666Solenoid valves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • G01N2035/1041Ink-jet like dispensers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • G01N2035/1044Using pneumatic means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00712Automatic status testing, e.g. at start-up or periodic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002Reagent dispensers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/2931Diverse fluid containing pressure systems
    • Y10T137/3003Fluid separating traps or vents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/15Inorganic acid or base [e.g., hcl, sulfuric acid, etc. ]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer
DE2003617305 2002-01-25 2003-01-27 Kontaktloses verfahren zur verteilung geringer flüssigkeitsmengen Expired - Lifetime DE60317305T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35185802P 2002-01-25 2002-01-25
US351858P 2002-01-25
PCT/US2003/002414 WO2003065049A2 (en) 2002-01-25 2003-01-27 Low volume, non-contact liquid dispensing method

Publications (2)

Publication Number Publication Date
DE60317305D1 true DE60317305D1 (de) 2007-12-20
DE60317305T2 DE60317305T2 (de) 2008-08-28

Family

ID=27663031

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2003617305 Expired - Lifetime DE60317305T2 (de) 2002-01-25 2003-01-27 Kontaktloses verfahren zur verteilung geringer flüssigkeitsmengen

Country Status (7)

Country Link
US (3) US6983636B2 (de)
EP (1) EP1470427B1 (de)
JP (3) JP2005516220A (de)
AT (1) ATE377763T1 (de)
CA (1) CA2473860A1 (de)
DE (1) DE60317305T2 (de)
WO (1) WO2003065049A2 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1354211A1 (de) * 2001-01-25 2003-10-22 Tecan Trading AG Pipettiervorrichtung
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
US6865425B2 (en) * 2002-01-07 2005-03-08 Siemens Energy & Automation, Inc. State machine for a pulse output function
US7410615B2 (en) * 2002-01-24 2008-08-12 Perkinelmer Las, Inc. Precision liquid dispensing system
US7288228B2 (en) * 2002-02-12 2007-10-30 Gilson, Inc. Sample injection system
CN100392587C (zh) 2002-06-03 2008-06-04 西门子能量及自动化公司 用于编程智能模块的向导
DE10255595A1 (de) * 2002-11-26 2004-06-03 Cybio Ag Mehrkanaldosiervorrichtung mit automatischer Kalibrierung
US6746966B1 (en) * 2003-01-28 2004-06-08 Taiwan Semiconductor Manufacturing Company Method to solve alignment mark blinded issues and a technology for application of semiconductor etching at a tiny area
JP3972012B2 (ja) * 2003-03-19 2007-09-05 株式会社日立ハイテクノロジーズ 試料分注機構及びそれを備えた自動分析装置
US7543720B2 (en) * 2003-05-05 2009-06-09 The Lee Company Method and apparatus for dispensing small volumes of fluid
WO2005019360A1 (en) 2003-08-25 2005-03-03 Dip Tech. Ltd. Ink for ceramic surfaces
US8211214B2 (en) * 2003-10-02 2012-07-03 Molecular Imprints, Inc. Single phase fluid imprint lithography method
US7396512B2 (en) * 2003-11-04 2008-07-08 Drummond Scientific Company Automatic precision non-contact open-loop fluid dispensing
US20050203482A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical dispensing apparatus and method
WO2005124366A1 (en) * 2004-06-14 2005-12-29 Parker-Hannifin Corporation Robotic handling system and method with independently operable detachable tools
US8161020B2 (en) * 2004-11-15 2012-04-17 Zi Corporation Of Canada, Inc. Searching for and providing objects using byte-by-byte comparison
US8057756B2 (en) * 2005-01-28 2011-11-15 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US20060258011A1 (en) * 2005-04-22 2006-11-16 Igor Shvets Cleaning of system for dispensing of liquid droplets
US20070116608A1 (en) * 2005-11-23 2007-05-24 Birdsell Michael P Vented ceramic tip arrangement for use with a microarray
US20080314412A1 (en) * 2005-12-05 2008-12-25 Grippo Paul M Self-Cleaning Injection Port for Analytical Applications
US20090032065A1 (en) * 2005-12-08 2009-02-05 Bantz Daniel L Syringe wash station for analytical applications
US20090188630A1 (en) * 2006-02-06 2009-07-30 Kanji Takada Laminated Microcapsule Sheet Producing Apparatus
JP4906416B2 (ja) * 2006-07-11 2012-03-28 日本碍子株式会社 物体の通過検出装置
WO2008038812A1 (fr) * 2006-09-28 2008-04-03 Shimadzu Corporation Procédé permettant de préparer un échantillon pour la spectrométrie de masse à désorption-ionisation laser assistée par matrice et procédé de spectrométrie de masse à désorption-ionisation laser assistée par matrice
KR101065571B1 (ko) * 2006-09-28 2011-09-19 가부시키가이샤 시마즈세이사쿠쇼 파라핀 포매 표본의 탈파라핀법 및 파라핀 포매 표본의 해석법
US7832252B2 (en) * 2006-10-05 2010-11-16 Watson Gary W Precise droplet injection for calibrating a gas chromatography instrument
US7628085B2 (en) * 2006-11-17 2009-12-08 Sru Biosystems, Inc. Simultaneous aspirator and dispenser for multiwell plates and similar devices
US7861581B2 (en) * 2006-12-01 2011-01-04 Gamida For Life B.V. Fluidic volume dispense verification tool
US20080134806A1 (en) * 2006-12-06 2008-06-12 Agamatrix, Inc. Container system for dispensing a liquid
EP2136911A2 (de) 2007-01-19 2009-12-30 Biodot, Inc. Systeme und verfahren für hochgeschwindigkeitsarraydruck und -hybridisierung
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
JP4952470B2 (ja) * 2007-09-19 2012-06-13 和光純薬工業株式会社 分注装置および分注装置における吐出状態判定方法
CH712572B1 (de) * 2007-11-28 2017-12-15 Integra Biosciences Ag Handpipettiergerät.
JP2009146241A (ja) * 2007-12-17 2009-07-02 Fuji Koki Corp 弁制御装置及び弁制御方法
US8808625B2 (en) * 2008-01-11 2014-08-19 National Institute Of Advanced Industrial Science And Technology Dispensing apparatus and a dispensing method
US8100293B2 (en) * 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
JP2010223638A (ja) * 2009-03-19 2010-10-07 Beckman Coulter Inc 分注装置、自動分析装置及び分注装置の分注監視方法
US8444935B2 (en) * 2009-06-12 2013-05-21 Bose Corporation Multiple-specimen device testing with particle measurement
KR20110046935A (ko) * 2009-10-29 2011-05-06 포항공과대학교 산학협력단 액적 토출 장치
CN102656464A (zh) * 2009-12-22 2012-09-05 通用电气健康护理生物科学股份公司 具有改进混合的分析方法
JP4919119B2 (ja) * 2010-01-19 2012-04-18 株式会社日立プラントテクノロジー 試薬分注ノズルによる分取・分注方法および試薬分取・分注機構
CH702769B1 (de) * 2010-02-22 2019-07-31 Reseachem Gmbh Dosiervorrichtung und Verfahren zur Dosierung eines Fluids in ein Reaktionsgefäss.
US8969098B2 (en) * 2010-04-08 2015-03-03 Siemens Healthcare Diagnostics Inc. Methods and systems providing reagent mixing
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012100205A2 (en) 2011-01-21 2012-07-26 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
FR2978064B1 (fr) * 2011-07-18 2016-02-19 Interlab Procede et dispositif de distribution gravimetrique et en serie de solution.
CN103998144A (zh) * 2011-10-28 2014-08-20 惠普发展公司,有限责任合伙企业 并行寻址方法
US8671733B2 (en) * 2011-12-13 2014-03-18 Intermolecular, Inc. Calibration procedure considering gas solubility
CN104321634B (zh) * 2012-04-12 2017-12-12 生物辐射实验室股份有限公司 颗粒分配装置和方法
WO2013156408A1 (en) * 2012-04-18 2013-10-24 Sias Ag Pipetting arrangement and method of controlling pipetting
EP2986704B1 (de) 2013-04-19 2019-04-03 Siemens Healthcare Diagnostics Inc. Kontaktloser mikrotropfenspender
US9410977B2 (en) 2013-08-08 2016-08-09 Illumina, Inc. Fluidic system for reagent delivery to a flow cell
CA2955172C (en) 2014-07-14 2021-07-20 President And Fellows Of Havard College Systems and methods for improved performance of fluidic and microfluidic systems
PL3279618T3 (pl) * 2016-08-01 2021-09-13 Harro Höfliger Verpackungsmaschinen GmbH Urządzenie kalibrujące i sposób dozowania jednostek dawkowania
ES2922878T3 (es) * 2016-10-28 2022-09-21 Becton Dickinson Co Sensor de verificación de dispensación positiva
DE112019001892T5 (de) * 2018-04-10 2021-02-04 Elemental Scientific, Inc. System zum Sammeln von Flüssigkeitsproben und zum Transportieren über Strecken, während ein Flüssigkeitsprobenabschnitt aufrechterhalten wird
CN108636469A (zh) * 2018-06-14 2018-10-12 成都瀚辰光翼科技有限责任公司 一种非接触式移液装置及移液方法
EP3823758A4 (de) 2018-07-20 2022-04-06 Brighton Technologies LLC Verfahren und vorrichtung zur bestimmung der masse eines tröpfchens aus von einem flüssigkeitströpfchenausgabesystem gesammelten probendaten
JP7433821B2 (ja) * 2019-09-24 2024-02-20 東芝テック株式会社 薬液滴下装置
US11919241B1 (en) * 2021-02-25 2024-03-05 Xerox Corporation Optimized nozzle design for drop-on-demand printers and methods thereof
CN114965310B (zh) * 2022-04-26 2023-05-26 上海亚新城市建设有限公司 水质在线监测系统量程自切换控制方法及系统

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1428878A (fr) 1965-03-24 1966-02-18 Ct D Etudes Des Matieres Plast Dispositif émetteur et compteur de gouttes
US3405734A (en) 1966-12-01 1968-10-15 London Concrete Machinery Comp Self-draining valve
BE758245A (fr) 1969-11-03 1971-04-30 Hoffmann La Roche Pipette de precision
GB1354486A (en) 1970-05-20 1974-06-05 Unilever Ltd Plate valve
US3796239A (en) 1971-07-22 1974-03-12 Instrumentation Labor Inc Dispenser system
US3832579A (en) * 1973-02-07 1974-08-27 Gould Inc Pulsed droplet ejecting system
US3868970A (en) 1973-06-04 1975-03-04 Phillips Petroleum Co Multipositional selector valve
US3994423A (en) * 1973-06-28 1976-11-30 American Hospital Supply Corporation Drop dispensing apparatus for laboratory reagents
US3963148A (en) * 1974-01-10 1976-06-15 Coulter Electronics, Inc. Apparatus for drawing, measuring and discharging proportional amounts of fluid
US4013413A (en) * 1975-07-10 1977-03-22 The United States Of America As Represented By The Secretary Of Agriculture Apparatus and method for rapid analyses of plurality of samples
JPS53111782A (en) 1977-03-03 1978-09-29 Jeol Ltd Sampling and metering system
FR2463920A1 (fr) 1979-08-17 1981-02-27 Commissariat Energie Atomique Dispositif microdoseur de liquides
EP0028478B1 (de) * 1979-10-31 1985-02-20 The University Of Birmingham Pipettenmittel
DE3367661D1 (en) 1982-02-04 1987-01-02 Toray Industries Rotary valve
US4461328A (en) * 1982-06-04 1984-07-24 Drummond Scientific Company Pipette device
US4818706A (en) * 1983-04-19 1989-04-04 American Monitor Corporation Reagent-dispensing system and method
US4623008A (en) 1983-08-12 1986-11-18 Sakata Shokai, Ltd. Automatic dispensing system
FR2550990B1 (fr) 1983-08-22 1987-01-30 Colgate Palmolive Co Procede de fabrication d'un corps creux par extrusion et soufflage de matiere plastique et installation pour la mise en oeuvre de ce procede
CH674580A5 (de) 1983-10-06 1990-06-15 Contraves Ag
US4625569A (en) 1984-01-17 1986-12-02 Toyo Soda Manufacturing Co., Ltd. Liquid injection device
DE3586244T2 (de) * 1984-12-26 2000-04-20 Toshiba Kawasaki Kk Vorrichtung zur Erzeugung von Weich-Röntgenstrahlen durch ein Hochenergiebündel.
US4702889A (en) 1986-01-16 1987-10-27 Coulter Electronics Inc. Liquid sampling valve
US5104621A (en) * 1986-03-26 1992-04-14 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
US4694861A (en) 1986-12-22 1987-09-22 Beckman Instruments, Inc. Rotary pinch valve
JP2659954B2 (ja) * 1987-05-27 1997-09-30 キヤノン株式会社 インクジェット記録装置
US4917351A (en) * 1989-03-15 1990-04-17 Micro-Flo Technologies, Inc. Metering valve
US4948565A (en) 1989-04-25 1990-08-14 Fisher Scientific Company Analytical system
DE69133185D1 (de) * 1990-10-25 2003-01-30 Univ Columbia Entwicklung von dns-sonden und immunologischen reagenzien von menschlichen tumor-assoziierten antigenen
EP0484278B1 (de) 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
US5207109A (en) 1991-02-07 1993-05-04 Rheodyne, Inc. Internal-external sample injector
US5312757A (en) 1991-05-02 1994-05-17 Olympus Optical Co., Ltd. Sample distributing method
US6096276A (en) 1991-08-14 2000-08-01 Trustees Of Boston University Apparatus for effecting sequential chemical syntheses
JP2913984B2 (ja) * 1992-03-11 1999-06-28 株式会社ニコン 傾斜角測定装置
GB9208386D0 (en) 1992-04-16 1992-06-03 Amersham Int Plc Storage and dispensing device for liquids
DE69302692T2 (de) 1992-07-06 1996-10-02 Beckman Instruments Inc Flüssigkeitsversorgungssystem mit Mehrwegventil
US5324480A (en) * 1992-12-04 1994-06-28 Hamilton Company Liquid handling system
US5525515A (en) 1993-02-03 1996-06-11 Blattner; Frederick R. Process of handling liquids in an automated liquid handling apparatus
JP3365806B2 (ja) * 1993-02-25 2003-01-14 オリンパス光学工業株式会社 自動分注装置
GB9309637D0 (en) * 1993-05-11 1993-06-23 Boc Group Plc Cryogenic liquid dispensers
US6521187B1 (en) * 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
US6203759B1 (en) * 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
JPH08501882A (ja) 1993-07-09 1996-02-27 マイクロスキャン、インコーポレイテッド 液体分注装置および方法
EP0770212A1 (de) * 1994-07-11 1997-05-02 Tekmar Company Modul, bestehend aus einer aus probegefaessen selbsttaetig proben nehmende vorrichtung
CA2202649C (en) 1994-10-31 2000-12-19 Richard A. Domanik Method and apparatus for dispense verification
US5578275A (en) 1995-02-16 1996-11-26 The United States Of America As Represented By The Secretary Of The Army In-line sampling with continuous flushing for friction sensitive liquid nitrate ester compositions
JP3537208B2 (ja) * 1995-03-07 2004-06-14 オリンパス株式会社 吸光度測定方法
US5601115A (en) 1995-05-31 1997-02-11 Vantege Technologies, Inc. Multiport sampling valve
US5649687A (en) * 1995-06-06 1997-07-22 Borg-Warner Automotive, Inc. Pulse width modulated solenoid purge valve
US6158269A (en) 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5763278A (en) 1995-11-01 1998-06-09 Tecan Ag Automated pipetting of small volumes
TW384398B (en) * 1995-12-19 2000-03-11 Toa Medical Electronics Sample agitating and sucking apparatus
US6660233B1 (en) 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US5849598A (en) 1996-03-15 1998-12-15 Washington University Method for transferring micro quantities of liquid samples to discrete locations
JP3572792B2 (ja) * 1996-04-04 2004-10-06 東ソー株式会社 前処理装置
EP0801309A3 (de) 1996-04-08 1998-08-12 SANYO ELECTRIC Co., Ltd. Pipettiervorrichtung
EP0810438B1 (de) 1996-05-31 2004-02-04 Packard Instrument Company, Inc. Vorrichtung zur Handhabung von Mikroflüssigkeitsmengen
US6083762A (en) * 1996-05-31 2000-07-04 Packard Instruments Company Microvolume liquid handling system
US5915284A (en) 1996-07-22 1999-06-22 Cyberlab, Inc. Multiple channel pipetting device
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
JPH10115621A (ja) * 1996-10-14 1998-05-06 Aloka Co Ltd 分注装置
US5833925A (en) * 1996-11-13 1998-11-10 Beckman Instruments, Inc. Automatic chemistry analyzer with improved ion selective electrode assembly
EP1249705A3 (de) * 1996-12-31 2003-11-05 Genometrix Genomics Incorporated Multiplex-Analysevorrichtung zur Analyse von Molekülen und zugehöriges Herstellungsverfahren
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6323035B1 (en) * 1997-09-24 2001-11-27 Glaxo Wellcome, Inc. Systems and methods for handling and manipulating multi-well plates
DK114497A (da) 1997-10-07 1999-04-08 Alka Electronic Aps Optisk flowmåler
US6068393A (en) * 1997-11-05 2000-05-30 Zymark Corporation Robotic system for processing chemical products
US5955373A (en) * 1997-11-05 1999-09-21 Zymark Corporation Environmentally controlled system for processing chemical products
DE19754000A1 (de) 1997-12-05 1999-06-17 Max Planck Gesellschaft Vorrichtung und Verfahren zur elektrisch ausgelösten Mikrotropfenabgabe mit einem Dispensierkopf
NL1008703C1 (nl) 1998-01-08 1999-07-12 Jan Hendrik Fondse Meerwegklep.
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
US6042729A (en) 1998-02-18 2000-03-28 Chau; Yiu Chau Regeneration of water treatment media
US20030215957A1 (en) * 1998-02-20 2003-11-20 Tony Lemmo Multi-channel dispensing system
US6537505B1 (en) * 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
US6033911A (en) 1998-02-27 2000-03-07 Hamilton Company Automated assaying device
JP3543604B2 (ja) * 1998-03-04 2004-07-14 株式会社日立製作所 送液装置および自動分析装置
JP3582351B2 (ja) * 1998-04-02 2004-10-27 松下電器産業株式会社 スクリーニング装置
JP3584732B2 (ja) * 1998-05-08 2004-11-04 松下電器産業株式会社 分注装置および分注方法ならびに分注チップの装着方法
US6627446B1 (en) * 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US6551557B1 (en) * 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US20040047765A1 (en) * 1998-10-16 2004-03-11 Gordon Steven J. Automated robotic workstation and methods of operation thereof
US20020006359A1 (en) * 1998-11-25 2002-01-17 Affymetrix, Inc. Microplate sample and reagent loading system
US6296811B1 (en) * 1998-12-10 2001-10-02 Aurora Biosciences Corporation Fluid dispenser and dispensing methods
JP2003517581A (ja) * 1999-02-16 2003-05-27 ピーイー コーポレイション (エヌワイ) ビーズ分散システム
US6627157B1 (en) 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
US20020176801A1 (en) * 1999-03-23 2002-11-28 Giebeler Robert H. Fluid delivery and analysis systems
US20020009394A1 (en) * 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6395232B1 (en) 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
DE60028665T2 (de) * 1999-08-09 2007-06-06 Thk Co., Ltd. Vorrichtung zur Herstellung von Mikroarrays
US6322752B1 (en) * 1999-09-08 2001-11-27 Coulter International Corp. Method and apparatus for aspirating and dispensing liquids
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
JP3833024B2 (ja) * 1999-10-06 2006-10-11 ローム株式会社 レーザビームの受光部ユニットおよびインクジェットプリンタ
JP2001113681A (ja) * 1999-10-15 2001-04-24 Canon Inc 記録装置
JP2001113725A (ja) * 1999-10-15 2001-04-24 Canon Inc インクジェットプリンタ装置
AU1201501A (en) 1999-10-15 2001-04-30 Packard Instrument Company Inc. Piezoelectric-drop-on-demand technology
AU1437601A (en) * 1999-10-26 2001-05-08 Genometrix Genomics Incorporated A storage card for hosting a biological specimen
DE10002475C1 (de) * 2000-01-21 2001-05-31 Roche Diagnostics Gmbh Analysegerät zur Analyse von Proben
US6325114B1 (en) * 2000-02-01 2001-12-04 Incyte Genomics, Inc. Pipetting station apparatus
CA2724266C (en) 2000-02-29 2012-12-04 Gen-Probe Incorporated Fluid dispense and liquid surface verification system and method
US6432365B1 (en) * 2000-04-14 2002-08-13 Discovery Partners International, Inc. System and method for dispensing solution to a multi-well container
JP2001324510A (ja) * 2000-05-15 2001-11-22 Toyobo Engineering Kk 吐出容量可変液体分注装置
JP2002001092A (ja) * 2000-06-22 2002-01-08 Shimadzu Corp 排液装置
US7135146B2 (en) * 2000-10-11 2006-11-14 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
US6852291B1 (en) * 2000-10-11 2005-02-08 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
DE10052819B4 (de) * 2000-10-24 2004-02-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pipettensystem und Pipettenarray sowie Verfahren zum Befüllen eines Pipettensystems
DE20018628U1 (de) * 2000-11-01 2002-03-14 Evotec Biosystems Ag Probenabgabevorrichtung
CH695544A5 (de) * 2000-11-17 2006-06-30 Tecan Trading Ag Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben.
US6503454B1 (en) * 2000-11-22 2003-01-07 Xerox Corporation Multi-ejector system for ejecting biofluids
JP2004535572A (ja) 2001-06-13 2004-11-25 ケニス エフ. ウーヘンハイマー, 自動化流体操作システムおよび方法
US7250303B2 (en) * 2001-07-20 2007-07-31 Ortho-Clinical Diagnostics, Inc. Chemistry system for a clinical analyzer
US6846680B2 (en) * 2001-07-31 2005-01-25 Caliper Life Sciences, Inc. Liquid handling system with automatically interchangeable cannula array
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
US7410615B2 (en) 2002-01-24 2008-08-12 Perkinelmer Las, Inc. Precision liquid dispensing system
US7479391B2 (en) * 2004-12-10 2009-01-20 Tecan Trading Ag Pipetting apparatus with integrated liquid level and/or gas bubble detection

Also Published As

Publication number Publication date
WO2003065049A3 (en) 2003-10-16
JP4621777B2 (ja) 2011-01-26
US20070155019A1 (en) 2007-07-05
US20030170903A1 (en) 2003-09-11
US6983636B2 (en) 2006-01-10
JP2009162761A (ja) 2009-07-23
EP1470427A2 (de) 2004-10-27
WO2003065049A2 (en) 2003-08-07
US20030167822A1 (en) 2003-09-11
US7169616B2 (en) 2007-01-30
CA2473860A1 (en) 2003-08-07
JP2005516220A (ja) 2005-06-02
DE60317305T2 (de) 2008-08-28
ATE377763T1 (de) 2007-11-15
JP2009168816A (ja) 2009-07-30
EP1470427B1 (de) 2007-11-07

Similar Documents

Publication Publication Date Title
ATE377763T1 (de) Kontaktloses verfahren zur verteilung geringer flüssigkeitsvolumen
DE502004002800D1 (de) Mikrodosiervorrichtung und verfahren zur dosierten abgabe von flüssigkeiten
DE60132909D1 (de) Implantierbare medizinische vorrichtung zum abgeben einer flüssigkeit
WO2004093818A3 (en) Apparatus and methods for repetitive microjet drug delivery
WO2004105827A3 (en) Drug delivery device and method
ATE547251T1 (de) Flüssigkeitsbehälter
TW200605927A (en) Spray diffuser for emptying fluids for medical purposes
TW200501929A (en) Ophthalmic apparatus and method for administering agents to the eye
ATE506532T1 (de) Hochdruckspeicherkörper mit integriertem verteilerblock
ATE390960T1 (de) Spender für fliessfähige medien
MY122718A (en) Gas storage and dispensing system comprising regulator interiorly disposed in fluid containment vessel and adjustable in situ therein.
ATE284033T1 (de) System zur blutzuckerbestimmung
TW200600126A (en) Method and device for targeted delivery of medicinal, cosmetic, and related agents
DE60131735D1 (de) Vorrichtung zur abgabe von genau kontrollierten kleinen flüssigkeitsmengen
ATE422924T1 (de) Gerät zum abgeben von abgemessenen mengen von medikamente beinhaltendem aerosol
GB9800933D0 (en) A dispenser
WO2004011913A3 (en) Metering tip with internal features to control fluid meniscus and fluid oscillation
ATE333650T1 (de) Vorrichtung und verfahren zur ausgabe von flüssigen produkten
ATE391680T1 (de) Spender für viskose flüssigkeit und verfahren zur dessen verwendung
CA2214229A1 (en) Fluid injector pump with interchangeable reservoir
EP1516714A3 (de) Flüssigkeitstransportssystem in eine Vorform
ATE329849T1 (de) Vorrichtung zur dosierten abgabe von flüssigen oder gelförmigen medien
SE9302953L (sv) Tryckluftsdriven vätskespruta med vätskebehållare
ATE308030T1 (de) Vorrichtung und verfahren zur dosierung von fluiden
ATE349235T1 (de) Vorrichtung für die intradermale und subkutane injektion

Legal Events

Date Code Title Description
8364 No opposition during term of opposition