DE60314282D1 - Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe - Google Patents

Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe

Info

Publication number
DE60314282D1
DE60314282D1 DE60314282T DE60314282T DE60314282D1 DE 60314282 D1 DE60314282 D1 DE 60314282D1 DE 60314282 T DE60314282 T DE 60314282T DE 60314282 T DE60314282 T DE 60314282T DE 60314282 D1 DE60314282 D1 DE 60314282D1
Authority
DE
Germany
Prior art keywords
tissue
raman signal
detection unit
signal
instrument
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60314282T
Other languages
English (en)
Other versions
DE60314282T2 (de
Inventor
Gerwin Jan Puppels
Rolf Wolthuis
Senada Koljenovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
River Diagnostics BV
Original Assignee
River Diagnostics BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by River Diagnostics BV filed Critical River Diagnostics BV
Publication of DE60314282D1 publication Critical patent/DE60314282D1/de
Application granted granted Critical
Publication of DE60314282T2 publication Critical patent/DE60314282T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
DE60314282T 2002-12-02 2003-12-02 Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe Expired - Lifetime DE60314282T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02080032 2002-12-02
EP02080032 2002-12-02
PCT/NL2003/000815 WO2004051242A1 (en) 2002-12-02 2003-12-02 Use of high wavenumber raman spectroscopy for measuring tissue

Publications (2)

Publication Number Publication Date
DE60314282D1 true DE60314282D1 (de) 2007-07-19
DE60314282T2 DE60314282T2 (de) 2008-03-20

Family

ID=32405739

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60314282T Expired - Lifetime DE60314282T2 (de) 2002-12-02 2003-12-02 Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe

Country Status (10)

Country Link
US (1) US7499153B2 (de)
EP (2) EP1567852B1 (de)
JP (1) JP4870356B2 (de)
CN (1) CN100533127C (de)
AT (1) ATE364173T1 (de)
AU (1) AU2003285815A1 (de)
DE (1) DE60314282T2 (de)
DK (1) DK1567852T3 (de)
ES (1) ES2289344T3 (de)
WO (1) WO2004051242A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080105096A1 (en) * 1999-01-15 2008-05-08 Cutting Edge Designs, Llc Liquid transport cavity saw blade
US8326404B2 (en) 2003-11-28 2012-12-04 British Columbia Cancer Agency Branch Multimodal detection of tissue abnormalities based on raman and background fluorescence spectroscopy
DE102004015946B3 (de) * 2004-03-25 2006-01-12 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Vorrichtung und Verfahren zur Raman-spektroskopischen Charakterisierung eines Prozessmediums
US7697576B2 (en) 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US7292323B2 (en) * 2004-11-12 2007-11-06 Alcon, Inc. Optical fiber detection method and system
GB0426993D0 (en) 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
WO2006119431A2 (en) 2005-04-29 2006-11-09 The Regents Of The University Of Colorado, A Body Corporate Electromagnetic characterization of tissue
JP4675149B2 (ja) * 2005-05-13 2011-04-20 独立行政法人理化学研究所 血管診断用分光プローブ
US8253936B2 (en) 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
US20080045842A1 (en) * 2006-07-21 2008-02-21 Prescient Medical, Inc. Conformable tissue contact catheter
US20080129993A1 (en) * 2006-10-23 2008-06-05 Brennan James F Windowless fiber optic raman spectroscopy probes
US20120059254A1 (en) * 2007-03-14 2012-03-08 Wang Lifan Apparatus and method for phase-space reduction for imaging of fluorescing, scattering and/or absorbing structures
WO2008144600A1 (en) * 2007-05-17 2008-11-27 Prescient Medical, Inc. Multi-channel fiber optic spectroscopy systems employing integrated optics modules
EP2160217A1 (de) 2007-06-08 2010-03-10 Prescient Medical, Inc. Optische katheterkonfigurationen mit einer kombination aus raman-spektroskopie und niederkohärenz-reflektometrie auf faseroptik-basis
WO2009014820A1 (en) * 2007-07-20 2009-01-29 Prescient Medical, Inc. Wall-contacting intravascular ultrasound probe catheters
US20090076395A1 (en) * 2007-09-19 2009-03-19 Prescient Medical, Inc. Optimized intravascular ultrasound probe catherers
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
JP5198037B2 (ja) 2007-11-02 2013-05-15 株式会社 資生堂 皮膚外用剤の有効性評価方法、有効性評価装置、及び有効性評価プログラム
CN102015020A (zh) * 2008-05-09 2011-04-13 休·贝克曼 用于诊断和治疗异常组织的医疗设备及其使用方法
US8416405B2 (en) 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
US20100113906A1 (en) * 2008-11-06 2010-05-06 Prescient Medical, Inc. Hybrid basket catheters
US20100317974A1 (en) * 2009-01-09 2010-12-16 Research Foundation Of The City University Of New York Detection of vulnerable plaques by raman spectroscopy
WO2010114361A1 (en) * 2009-04-01 2010-10-07 River Diagnostic B.V. Method for determination of one or more mutations
JP2013511341A (ja) * 2009-11-17 2013-04-04 ヴェラライト，インコーポレイテッド 冠動脈石灰化又は冠動脈疾患を検出する方法及び装置
US8175423B2 (en) * 2009-12-03 2012-05-08 Marple Eric T Filtered fiber optic probe
US8702321B2 (en) 2009-12-03 2014-04-22 Eric T. Marple Filtered fiber optic probe
US8582096B2 (en) * 2009-12-18 2013-11-12 The Regents Of The University Of California System and method for efficient coherence anti-stokes raman scattering endoscopic and intravascular imaging and multimodal imaging
WO2011088580A1 (en) * 2010-01-22 2011-07-28 British Columbia Cancer Agency Branch Apparatus and methods for characterization of lung tissue by raman spectroscopy
DE102010052434A1 (de) 2010-11-24 2012-05-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Überwachung einer kryokonservierten biologischen Probe
WO2012096689A1 (en) 2011-01-10 2012-07-19 Emvision Llc Fiber optic probes utilizing grin lenses for spatially precise optical spectroscopy
DE102011100507B4 (de) * 2011-04-29 2020-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tragbares optisches Analysegerät
US9814448B2 (en) 2012-05-21 2017-11-14 Precision Biopsy, Inc. Three-dimensional optical imaging and therapy of prostate cancer
US20130310680A1 (en) 2012-05-21 2013-11-21 The Regents Of The University Of Colorado, A Body Corporate Three-dimensional optical imaging and therapy of prostate cancer
US10058284B2 (en) * 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
GB201301280D0 (en) * 2013-01-24 2013-03-06 Univ St Andrews Optical apparatus for use with a medical imager
GB201302886D0 (en) 2013-02-19 2013-04-03 Univ Singapore Diagnostic instrument and method
EP3003177B1 (de) 2013-05-31 2021-03-10 Covidien LP Chirurgische vorrichtung mit einer endeffektorbaugruppe zur gewebeüberwachung bei chirurgischen eingriffen
US20160139051A1 (en) * 2013-07-11 2016-05-19 Henry Ford Health System Apparatus and method for distinguishing between different tissue types using specific raman spectral regions
CN103645170B (zh) * 2013-12-03 2016-03-02 北京航空航天大学 一种利用拉曼光谱检测肿瘤性质的装置
GB201401727D0 (en) * 2014-01-31 2014-03-19 Univ Bristol A low background raman probe for optical biopsy of brain tissue
CN104155002B (zh) * 2014-07-17 2016-03-02 中国科学院遥感与数字地球研究所 扫描成像光谱仪系统
US11304604B2 (en) 2014-10-29 2022-04-19 Spectral Md, Inc. Reflective mode multi-spectral time-resolved optical imaging methods and apparatuses for tissue classification
US11154186B2 (en) 2015-07-31 2021-10-26 University Of Utah Research Foundation Devices, systems, and methods for imaging and treating a selected tissue
US10161870B2 (en) 2015-10-05 2018-12-25 Nxgen Partners Ip, Llc System and method for multi-parameter spectroscopy
CN108471949B (zh) * 2015-10-28 2021-11-12 光谱Md公司 组织分类用反射模式多光谱时间分辨光学成像方法和设备
EP3393355A1 (de) * 2015-12-21 2018-10-31 Erasmus University Medical Center Rotterdam Optische sonde zur messung einer gewebeprobe
CN108780042A (zh) * 2016-01-13 2018-11-09 尼克根合伙Ip有限责任公司 用于多参数光谱的系统和方法
WO2017126955A1 (en) 2016-01-18 2017-07-27 Erasmus University Medical Center Rotterdam Tissue sample analysis
EP3203215B1 (de) 2016-02-08 2019-08-14 Leibniz-Institut für Astrophysik Potsdam (AIP) Optische bildgebende spektroskopie von grossflächigen proben
CN105997000B (zh) * 2016-05-30 2023-04-14 福建师范大学 一种基于纤维内窥镜的拉曼光谱检测装置及其实现方法
WO2018116363A1 (ja) * 2016-12-19 2018-06-28 オリンパス株式会社 ラマンプローブおよびラマンスペクトル測定装置
CN106770176A (zh) * 2016-12-26 2017-05-31 同方威视技术股份有限公司 拉曼光谱检测设备和拉曼光谱检测设备的安全监控方法
EP3576601B1 (de) 2017-02-01 2023-04-19 University of Utah Research Foundation Vorrichtungen zur abbildung von herzgewebe
US20220240783A1 (en) 2017-03-02 2022-08-04 Spectral Md, Inc. Machine learning systems and techniques for multispectral amputation site analysis
US11375897B2 (en) 2017-04-20 2022-07-05 Henry Ford Health System System and method for characterization of a brain tissue sample using Raman marker regions
US10684226B2 (en) 2018-03-09 2020-06-16 Samsung Electronics Co., Ltd. Raman probe, Raman spectrum obtaining apparatus, and method of obtaining Raman spectrum and detecting distribution of target material using Raman probe
WO2020047660A1 (en) 2018-09-04 2020-03-12 Provincial Health Services Authority Image guided micro-raman spectroscopy
CN113260303A (zh) 2018-12-14 2021-08-13 光谱Md公司 用于评估、愈合预测和治疗创伤的机器学习系统和方法
JP7186298B2 (ja) 2018-12-14 2022-12-08 スペクトラル エムディー，インコーポレイテッド 高精度マルチアパーチャスペクトルイメージングのためのシステムおよび方法
US10783632B2 (en) 2018-12-14 2020-09-22 Spectral Md, Inc. Machine learning systems and method for assessment, healing prediction, and treatment of wounds
US10740884B2 (en) 2018-12-14 2020-08-11 Spectral Md, Inc. System and method for high precision multi-aperture spectral imaging
US20210298604A1 (en) * 2020-03-30 2021-09-30 TimeGate Instruments Oy Method and apparatus for measuring spectrum of raman-scattered light using time gated detection
US11821841B2 (en) 2021-03-05 2023-11-21 Cytoveris, Inc. System and method for classification of tissue based on Raman and fluorescence in high-wavenumber Raman spectrum
WO2023008369A1 (ja) * 2021-07-30 2023-02-02 キヤノン株式会社 細胞自家蛍光の画像を用いて細胞を分類する方法及び解析装置
CN116077016A (zh) * 2022-12-22 2023-05-09 四川大学 一种基于拉曼光谱和红外线光谱的便携式信息诊断装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318024A (en) * 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
ATE187315T1 (de) * 1987-09-24 1999-12-15 Massachusetts Inst Technology Kathetersystem zur abbildung
US5638172A (en) * 1994-05-27 1997-06-10 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
US5621522A (en) * 1995-04-05 1997-04-15 The United States Of America As Represented By The Secretary Of The Navy Fiber optic probe for determination of trace levels of organic pollutants using Raman spectroscopy
US5953477A (en) * 1995-11-20 1999-09-14 Visionex, Inc. Method and apparatus for improved fiber optic light management
JP2000510604A (ja) * 1996-03-13 2000-08-15 ヴィジョネックス インコーポレイテッド 改善された光ファイバー光管理のための方法および機器
US5911017A (en) * 1996-07-31 1999-06-08 Visionex, Inc. Fiber optic interface for laser spectroscopic Raman probes
JP2001515597A (ja) 1997-03-14 2001-09-18 ローズマウント アナリティカル インコーポレイテッド 改良されたレイリー後方散乱制御装置および方法
US5864397A (en) * 1997-09-15 1999-01-26 Lockheed Martin Energy Research Corporation Surface-enhanced raman medical probes and system for disease diagnosis and drug testing
US6205272B1 (en) * 1998-02-27 2001-03-20 Equitech Int'l Corp. Fiber optic probe for attenuated total internal reflection spectrophotometry
JP2000131145A (ja) * 1998-10-23 2000-05-12 Jasco Corp 分光分析装置
JP3992090B2 (ja) * 1999-01-11 2007-10-17 日本分光株式会社 ラマン分光用プローブ
US6623977B1 (en) 1999-11-05 2003-09-23 Real-Time Analyzers, Inc. Material for surface-enhanced Raman spectroscopy, and SER sensors and method for preparing same

Also Published As

Publication number Publication date
EP1567852A1 (de) 2005-08-31
JP4870356B2 (ja) 2012-02-08
US7499153B2 (en) 2009-03-03
WO2004051242A1 (en) 2004-06-17
CN1745294A (zh) 2006-03-08
ATE364173T1 (de) 2007-06-15
CN100533127C (zh) 2009-08-26
EP1821097A1 (de) 2007-08-22
ES2289344T3 (es) 2008-02-01
EP1567852B1 (de) 2007-06-06
US20060139633A1 (en) 2006-06-29
AU2003285815A1 (en) 2004-06-23
JP2006508358A (ja) 2006-03-09
DE60314282T2 (de) 2008-03-20
DK1567852T3 (da) 2007-08-06

Similar Documents

Publication Publication Date Title
DE60314282D1 (de) Verwendung von hochwellenzahl-ramanspektroskopie zur messung von gewebe
Stevens et al. Developing fibre optic Raman probes for applications in clinical spectroscopy
JP3737579B2 (ja) 歯の状態の認識装置
US10531790B2 (en) Method and system of spectrally encoded imaging
US6069689A (en) Apparatus and methods relating to optical systems for diagnosis of skin diseases
Latka et al. Fiber optic probes for linear and nonlinear Raman applications–Current trends and future development
US6006001A (en) Fiberoptic assembly useful in optical spectroscopy
US8804115B2 (en) Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe
US6186780B1 (en) Method and device for the recognition of caries, plaque, concretions or bacterial infection on teeth
US20030156788A1 (en) Method and device for recognizing dental caries, plaque, concrements or bacterial attacks
US20150377787A1 (en) Integrated spectral probe for raman, reflectance and fluorescence spectral measurements
JP5519711B2 (ja) 光信号を生体内測定するための光学プローブ
WO2004064627B1 (en) In vivo raman endoscopic probe and methods of use
JP5476547B2 (ja) ラマン散乱測定装置
ATE442079T1 (de) Verfahren zum nicht invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe
FI964263A (fi) Menetelmä ja laite glukoosin analysoimiseksi biologisesta näytteestä
ES2113098T3 (es) Comprobador de glucosa por fluorescencia y procedimiento.
US11635327B2 (en) Optical probe, Raman spectroscopy system, and method of using the same
Ribeiro et al. A preliminary investigation of a spectroscopic technique for the diagnosis of natural caries lesions
Maryam et al. Mobile multi-configuration clinical translational Raman system for oral cancer application
Zeng et al. Raman spectroscopy for in vivo tissue analysis and diagnosis, from instrument development to clinical applications
CN216622169U (zh) 一种基于荧光和拉曼融合技术的皮肤组织光谱检测装置
WO2018116363A1 (ja) ラマンプローブおよびラマンスペクトル測定装置
JP2017153841A (ja) 歯垢検出装置及び歯ブラシ
CN101903762B (zh) 光纤探针

Legal Events

Date Code Title Description
8364 No opposition during term of opposition