DE60233939D1 - Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält - Google Patents

Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält

Info

Publication number
DE60233939D1
DE60233939D1 DE60233939T DE60233939T DE60233939D1 DE 60233939 D1 DE60233939 D1 DE 60233939D1 DE 60233939 T DE60233939 T DE 60233939T DE 60233939 T DE60233939 T DE 60233939T DE 60233939 D1 DE60233939 D1 DE 60233939D1
Authority
DE
Germany
Prior art keywords
coating containing
advantageous medium
microprojections
microprojection arrangement
containing advantageous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60233939T
Other languages
English (en)
Inventor
Michel J Cormier
Peter E Daddona
Juanita A Johnson
Wendy A Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE60233939D1 publication Critical patent/DE60233939D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
DE60233939T 2001-04-20 2002-04-20 Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält Expired - Lifetime DE60233939D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28557601P 2001-04-20 2001-04-20
PCT/US2002/012730 WO2002085447A2 (en) 2001-04-20 2002-04-20 Microprojection array having a beneficial agent containing coating

Publications (1)

Publication Number Publication Date
DE60233939D1 true DE60233939D1 (de) 2009-11-19

Family

ID=23094848

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60233939T Expired - Lifetime DE60233939D1 (de) 2001-04-20 2002-04-20 Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält

Country Status (16)

Country Link
US (1) US7963935B2 (de)
EP (1) EP1392389B1 (de)
JP (2) JP2004528900A (de)
KR (1) KR20040020889A (de)
CN (2) CN101129327A (de)
AT (1) ATE444773T1 (de)
BR (1) BR0209046A (de)
CA (1) CA2444883A1 (de)
DE (1) DE60233939D1 (de)
ES (1) ES2333849T3 (de)
IL (1) IL158480A0 (de)
MX (1) MXPA03009603A (de)
NO (1) NO20034684L (de)
NZ (1) NZ529029A (de)
WO (1) WO2002085447A2 (de)
ZA (1) ZA200309006B (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0914178B1 (de) * 1996-06-18 2003-03-12 Alza Corporation Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
HUP0303558A2 (en) * 2000-10-13 2004-01-28 Alza Corp Apparatus and method for piercing skin with microprotrusions
BR0114628A (pt) * 2000-10-13 2004-01-20 Alza Corp Membro de retenção em microprojeção para aplicador de impacto
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
EP2085109A3 (de) * 2000-10-26 2009-09-02 Alza Corporation Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
WO2003048031A2 (en) * 2001-11-30 2003-06-12 Alza Corporation Methods and apparatuses for forming microprojection arrays
ES2297056T3 (es) * 2001-12-20 2008-05-01 Alza Corporation Micro-proyecciones para perforacion de la piel que tienen control de la profundidad de perforacion.
GB0201736D0 (en) * 2002-01-25 2002-03-13 Glaxo Group Ltd DNA dosage forms
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
CA2516547A1 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530531A1 (en) 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
EP1638468B1 (de) * 2003-06-30 2007-08-15 Alza Corporation Verfahren zum beschichten von mikrovorsprüngen zum durchstechen der haut
PE20050288A1 (es) * 2003-07-02 2005-04-29 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
CA2534823A1 (en) * 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
US8524272B2 (en) * 2003-08-15 2013-09-03 Mylan Technologies, Inc. Transdermal patch incorporating active agent migration barrier layer
AU2004268616B2 (en) * 2003-08-25 2010-10-07 3M Innovative Properties Company Delivery of immune response modifier compounds
CN101415443A (zh) * 2003-10-23 2009-04-22 阿尔扎公司 涂覆微喷射体的稳定dna组合物
AU2004285484A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
CA2543154A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
WO2005044333A2 (en) 2003-10-31 2005-05-19 Alza Corporation Self-actuating applicator for microprojection array
EP1680178A4 (de) * 2003-10-31 2008-01-02 Alza Corp System und verfahren für die transdermale abgabe einer vakzine
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
JP2007530680A (ja) * 2004-04-01 2007-11-01 アルザ・コーポレーシヨン インフルエンザワクチンの経皮デリバリーのための装置および方法
CN101120101A (zh) * 2004-04-13 2008-02-06 阿尔扎公司 多联疫苗透皮释放的装置和方法
BRPI0509901A (pt) * 2004-04-13 2007-08-07 Alza Corp aparelho e método para liberação transdérmica de agentes com base em fentanila
BRPI0509788A (pt) * 2004-05-13 2007-10-23 Alza Corp aparato e método para liberação transdérmica de agentes de hormÈnio paratireóides
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
CN101014381A (zh) * 2004-09-08 2007-08-08 阿尔扎公司 具有改善的皮肤粘附力和顺应性的微突物阵列
CA2587387C (en) 2004-11-18 2013-06-25 3M Innovative Properties Company Method of contact coating a microneedle array
KR20130026511A (ko) 2004-11-18 2013-03-13 쓰리엠 이노베이티브 프로퍼티즈 컴파니 로우-프로파일 미세 바늘 어레이 인가 장치
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
KR101288725B1 (ko) * 2004-12-10 2013-07-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 의료 장치
CN101160117A (zh) * 2005-02-16 2008-04-09 阿尔扎公司 依泊汀-基药物的透皮释放装置和方法
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1893130A4 (de) 2005-06-17 2015-08-26 Georgia Tech Res Inst Beschichtete mikrostrukturen und verfahren zu ihrer herstellung
EP1904158B1 (de) 2005-06-24 2013-07-24 3M Innovative Properties Company Faltbares Pflaster mit Mikronadelnanordnung
US20080214952A1 (en) * 2005-07-11 2008-09-04 Jose Mir Replaceable Cartridge for Allergy Testing System
CA2614927A1 (en) * 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
JP5006196B2 (ja) 2005-08-01 2012-08-22 久光製薬株式会社 経皮または経粘膜投与のためのアジュバントおよび製剤
WO2007033015A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US7618429B2 (en) * 2005-12-22 2009-11-17 Spamedica International Srl Skin rejuvination resurfacing method
JP2009522288A (ja) * 2005-12-28 2009-06-11 アルザ コーポレイション 安定な治療剤形
EP1992386B1 (de) * 2006-02-10 2011-11-09 Hisamitsu Pharmaceutical Co., Inc. Transdermales arzneiverabreichungsgerät mit mikronadeln
WO2007106597A2 (en) * 2006-03-15 2007-09-20 Alza Corporation Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
WO2007116959A1 (ja) 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
WO2007124411A1 (en) 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
WO2007127815A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US20100100005A1 (en) * 2006-07-11 2010-04-22 Infotonics Technology Center, Inc. Minimally invasive allergy testing system with coated allergens
WO2008011625A2 (en) * 2006-07-21 2008-01-24 Georgia Tech Researh Corporation Microneedle devices and methods of drug delivery or fluid withdrawal
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
WO2008038644A1 (fr) 2006-09-27 2008-04-03 Asahi Kasei Pharma Corporation AGENT de prÉvention de l'apparition d'une dystrophie sympatHique rÉflexe aprÈs une attaque
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
US20100047327A1 (en) 2007-01-31 2010-02-25 Tetsuji Kuwahara Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same
JP5241517B2 (ja) * 2007-02-06 2013-07-17 久光製薬株式会社 アレルギー診断用マイクロニードルデバイス
WO2008115599A1 (en) * 2007-03-21 2008-09-25 Alza Corporation Apparatus and method for transdermal delivery of a 5-hydroxytrytamine antagonist
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090137945A1 (en) * 2007-11-28 2009-05-28 Claire Marquez Electro Collagen Induction Therapy Device
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
WO2009094394A1 (en) * 2008-01-23 2009-07-30 Georgia Tech Research Corporation Microneedle devices and methods of drug delivery or fluid withdrawal
WO2009097660A1 (en) * 2008-02-07 2009-08-13 The University Of Queensland Patch production
KR101383285B1 (ko) 2008-05-21 2014-04-08 테라젝트, 인코포레이티드 고용체 퍼포레이터 패치의 제조 방법 및 그 사용
US7943187B2 (en) * 2008-05-23 2011-05-17 Bakr Rabie Paeoniflorin preparations and uses thereof for fat reduction
AU2009250341A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
US20110177297A1 (en) * 2008-10-02 2011-07-21 Nurim Wellness Co. Ltd. Method of manufacturing solid microstructure and solid microstructure manufactured based on same
US8734697B2 (en) 2008-12-22 2014-05-27 The University Of Queensland Patch production
WO2010074239A1 (ja) 2008-12-26 2010-07-01 久光製薬株式会社 マイクロニードルデバイス
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
TWI576111B (zh) 2011-02-25 2017-04-01 久光製藥股份有限公司 用於經皮或經黏膜投予之佐劑及含有該佐劑之醫藥製劑
US20120222979A1 (en) 2011-03-04 2012-09-06 Elwha LLC, a limited liability company of the State of Delaware Glassy compositions
AU2012323782B2 (en) * 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
WO2013057819A1 (ja) 2011-10-20 2013-04-25 コスメディ製薬株式会社 マイクロニードル溶着法
WO2013082418A1 (en) 2011-11-30 2013-06-06 3M Innovative Properties Company Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
JP2013153959A (ja) * 2012-01-30 2013-08-15 Toppan Printing Co Ltd 針状体の構造
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
ES2743404T3 (es) 2012-12-21 2020-02-19 Corium Inc Matriz para suministro de agente terapéutico y método de fabricación
EP2968887B1 (de) 2013-03-12 2022-05-04 Corium, Inc. Mikroprojektionsapplikatoren
EP2974768A4 (de) * 2013-03-12 2017-05-17 Takeda Pharmaceutical Company Limited Mikronadelpflaster
CA2903459C (en) 2013-03-15 2024-02-20 Corium International, Inc. Multiple impact microprojection applicators and methods of use
EP2968119B1 (de) 2013-03-15 2019-09-18 Corium International, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung
EP2968118B1 (de) 2013-03-15 2022-02-09 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur verwendung
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US20160120628A1 (en) * 2013-06-12 2016-05-05 The Board Of Regents For Oklahoma State University Fluttering ear tag for bovine vaccination
JP6114401B2 (ja) 2013-10-31 2017-04-12 久光製薬株式会社 アジュバント組成物、これを含むアジュバント製剤、及びキット
EP3188714A1 (de) 2014-09-04 2017-07-12 Corium International, Inc. Mikrostrukturanordnung, verfahren zur herstellung und verfahren zur verwendung
EP4218892A1 (de) 2015-02-02 2023-08-02 Vaxxas Pty Limited Mikroprojektionsarrayapplikator
EP4039253A1 (de) 2015-04-29 2022-08-10 Radius Pharmaceuticals, Inc. Verfahren zur behandlung von krebs
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US10172729B2 (en) * 2015-10-12 2019-01-08 Reflow Medical, Inc. Stents having protruding drug-delivery features and associated systems and methods
EP3416618A1 (de) 2016-02-19 2018-12-26 ZP Opco, Inc. Verfahren zum schnellen erreichen therapeutischer konzentrationen von triptanen zur behandlung von migräne
JP2017164308A (ja) * 2016-03-16 2017-09-21 凸版印刷株式会社 穿刺デバイス及びその製造方法
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
JP7034425B2 (ja) * 2016-04-15 2022-03-14 エーディーエムバイオサイエンス インコーポレイテッド 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置
CA3020333A1 (en) 2016-04-18 2017-10-26 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
KR102322802B1 (ko) 2017-01-05 2021-11-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
DK3606760T3 (da) 2017-03-31 2023-11-06 Vaxxas Pty Ltd Indretning og fremgangsmåde til belægning af overflader
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP3661587A4 (de) 2017-08-04 2021-06-09 Vaxxas Pty Limited Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map)
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
KR102340393B1 (ko) 2017-08-23 2021-12-17 조사노 파마 코포레이션 편두통 및 군발성 두통의 치료를 위한 졸미트립탄의 치료적 농도를 신속하게 달성하는 방법
KR102146704B1 (ko) * 2018-04-13 2020-08-21 가천대학교 산학협력단 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
CN112423844A (zh) 2018-07-04 2021-02-26 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3556080A (en) * 1968-04-08 1971-01-19 Lincoln Lab Inc Skin allergy testing device
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
FR2474856A1 (fr) 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
JPS60193925A (ja) 1984-03-13 1985-10-02 Chemo Sero Therapeut Res Inst 凍結乾燥製剤化ワクチン
DE3722775A1 (de) 1987-07-09 1989-01-19 Lohmann Therapie Syst Lts Transdermales therapeutisches system
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5437656A (en) 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
DE4222380A1 (de) 1992-07-08 1994-01-13 Ernst Peter Prof Dr M Strecker In den Körper eines Patienten perkutan implantierbare Endoprothese
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
DE4341444C2 (de) 1993-12-04 1996-03-14 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6586006B2 (en) * 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
WO1996003978A1 (en) * 1994-08-04 1996-02-15 Quadrant Holdings Cambridge Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
DE59505328D1 (de) 1994-12-09 1999-04-15 Novartis Ag Transdermales system
JP3601102B2 (ja) 1995-03-15 2004-12-15 ブラザー工業株式会社 インクジェット式印刷記録装置と印字システム
DE19514104C2 (de) 1995-04-13 1997-05-28 Behringwerke Ag Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
NZ311175A (en) * 1995-07-03 1999-11-29 Koken Co Gene preparation comprising a gene incorporated into a biocompatible carrier which preferably contains collagen
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
EP0914178B1 (de) 1996-06-18 2003-03-12 Alza Corporation Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
DE69722414T2 (de) 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5738728A (en) 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
ATE231015T1 (de) 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US6197013B1 (en) * 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
KR100453132B1 (ko) * 1996-12-20 2004-10-15 앨자 코포레이션 경피 약제 플럭스를 향상시키기 위한 장치 및 방법
DE19654391A1 (de) 1996-12-27 1998-07-02 Basf Ag Katalysator zur selektiven Herstellung von Propylen aus Propan
ID21673A (id) 1996-12-31 1999-07-08 Shell Internationale Res Maatc Anjungan tiang dengan alur vertikal
US20020009464A1 (en) * 1997-07-03 2002-01-24 Camilo Colaco Modified glycosides, compositions comprised thereof and methods of use thereof
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029365A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6532386B2 (en) * 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
WO2000035530A1 (en) 1998-12-18 2000-06-22 Minimed Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
DE60007290T2 (de) * 1999-01-28 2004-09-23 Cyto Pulse Sciences, Inc. Einbringen von makromolekülen in zellen
US6884427B1 (en) 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
EP1173151B1 (de) 1999-04-16 2003-07-09 Novo Nordisk A/S Trockene formbare arzneistoffformulierung
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
WO2000074767A2 (en) * 1999-06-08 2000-12-14 Altea Technologies, Inc. Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
SE0000363L (sv) * 2000-02-04 2001-08-05 Zoucas Kirurgkonsult Ab Belagd medicinsk anordning
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US20050008683A1 (en) 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
HUP0303558A2 (en) 2000-10-13 2004-01-28 Alza Corp Apparatus and method for piercing skin with microprotrusions
PT1341442E (pt) 2000-10-13 2005-09-30 Alza Corp Aplicador de impacto com um conjunto de microlaminas
BR0114628A (pt) 2000-10-13 2004-01-20 Alza Corp Membro de retenção em microprojeção para aplicador de impacto
EP2085109A3 (de) 2000-10-26 2009-09-02 Alza Corporation Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen
GB0026957D0 (en) * 2000-11-03 2000-12-20 Eastman Kodak Co Processing photographic materal
US6638246B1 (en) * 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
EP1345646A2 (de) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Mikronadel-vorrichtungen und deren herstellung
WO2002074173A1 (en) 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
EP1469903A2 (de) 2001-09-28 2004-10-27 BioValve Technologies, Inc. Mikronadel mit membran
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal

Also Published As

Publication number Publication date
BR0209046A (pt) 2004-11-09
JP5611888B2 (ja) 2014-10-22
CN100349632C (zh) 2007-11-21
WO2002085447A8 (en) 2004-05-13
CN101129327A (zh) 2008-02-27
IL158480A0 (en) 2004-05-12
KR20040020889A (ko) 2004-03-09
ATE444773T1 (de) 2009-10-15
US7963935B2 (en) 2011-06-21
ZA200309006B (en) 2005-02-21
MXPA03009603A (es) 2004-12-06
US20020177839A1 (en) 2002-11-28
NO20034684D0 (no) 2003-10-20
CN1541126A (zh) 2004-10-27
JP2011172968A (ja) 2011-09-08
JP2004528900A (ja) 2004-09-24
EP1392389A2 (de) 2004-03-03
EP1392389B1 (de) 2009-10-07
NO20034684L (no) 2003-12-11
NZ529029A (en) 2005-07-29
WO2002085447A2 (en) 2002-10-31
ES2333849T3 (es) 2010-03-02
CA2444883A1 (en) 2002-10-31
WO2002085447A3 (en) 2003-03-06

Similar Documents

Publication Publication Date Title
DE60233939D1 (de) Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
Bohart et al. How clients make therapy work: The process of active self-healing.
WO2005000161A3 (en) Methods and devices for occluding body lumens and/or for delivering therapeutic agents
FR2810539B1 (fr) Procede et dispositif de traitement,notamment de maquillage, de coloration ou de soin cosmetique,de parties ou de la totalite du corps humain ou animal
DE602004026701D1 (de) Implantierbares medizinprodukt zur selektiven modulation der abgabe von mitteln in situ
ATE432096T1 (de) Beschichtete gefässvorrichtungen
TW200618830A (en) Micorprojection apparatus and system with low infection potential
AR046697A1 (es) Metodo y sistema de administracion transdermica de agente asistido por frecuencia
TW200502017A (en) Active agent delivery device having composite members
DE602005026078D1 (de) Verwendung von Antioxidantien zur Verhinderung von Oxidation und zur Reduzierung von Wirkstoffzersetzung in wirkstoffhaltigen medizinischen Artikeln
DE60124285D1 (de) Beschichtete medizinische geräte
AR048827A1 (es) Aparato y metodo para la administracion transdermica de agentes basados en fentanil
AR046823A1 (es) Sistema y metodo de administracion de vacuna transdermica asistida por ultrasonido
DE60213976D1 (de) Vorrichtung zur manipulation von nadeln oder polierarray
CO5150202A1 (es) Composicion de tisu facial y metodo para usarla para el secuestro de irritantes de la piel de la secrecion nasal
MXPA03003869A (es) Dispositivos medicos revestidos.
BRPI0509493A (pt) aparelho e método para a liberação transdérmica de vacina da influenza
DE60124286D1 (de) Beschichtete medizinische geräte
BRPI0415466A (pt) método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
ATE264672T1 (de) Vorrichtung und verwendung zur steigerung der transdermalen permeation von arzneistoffen
DE60332662D1 (de) Sonophorese-hautpflegevorrichtung
AR001073A1 (es) Benzoilguanidinas basicamente sustituidas procedimientos para su preparación su empleo como medicamento o agente de diagnostico asi como medicamento que las contiene
ES2159983T3 (es) Composicion que contiene urea y sus utilizaciones en el ambito cosmetico y/o dermatologico.
ATE185274T1 (de) Therapeutisches mittel gegen drohenden abortus
EP1752189A3 (de) Mikroprojektionsanordnung mit einem Überzug, der ein vorteilhaftes Mittel enthält

Legal Events

Date Code Title Description
8364 No opposition during term of opposition