DE60232666D1 - Herstellungsmethoden für Hydrogelpartikel in Nanogrösse - Google Patents

Herstellungsmethoden für Hydrogelpartikel in Nanogrösse

Info

Publication number
DE60232666D1
DE60232666D1 DE60232666T DE60232666T DE60232666D1 DE 60232666 D1 DE60232666 D1 DE 60232666D1 DE 60232666 T DE60232666 T DE 60232666T DE 60232666 T DE60232666 T DE 60232666T DE 60232666 D1 DE60232666 D1 DE 60232666D1
Authority
DE
Germany
Prior art keywords
hydrogel
poly
nanogels
liposomes
isopropylacrylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60232666T
Other languages
English (en)
Inventor
Sergey Kazakov
Marian Kaholek
Kalle Levon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polytechnic Institute of NYU
Original Assignee
Polytechnic Institute of NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polytechnic Institute of NYU filed Critical Polytechnic Institute of NYU
Application granted granted Critical
Publication of DE60232666D1 publication Critical patent/DE60232666D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
DE60232666T 2001-08-16 2002-08-15 Herstellungsmethoden für Hydrogelpartikel in Nanogrösse Expired - Lifetime DE60232666D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31287801P 2001-08-16 2001-08-16
PCT/US2002/026055 WO2003015936A1 (en) 2001-08-16 2002-08-15 Nanogels and their production using liposomes as reactors

Publications (1)

Publication Number Publication Date
DE60232666D1 true DE60232666D1 (de) 2009-07-30

Family

ID=23213406

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60232666T Expired - Lifetime DE60232666D1 (de) 2001-08-16 2002-08-15 Herstellungsmethoden für Hydrogelpartikel in Nanogrösse

Country Status (6)

Country Link
US (3) US7943067B2 (de)
EP (2) EP1425112B1 (de)
AT (1) ATE433744T1 (de)
AU (1) AU2002329761A1 (de)
DE (1) DE60232666D1 (de)
WO (2) WO2003015936A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943067B2 (en) * 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors
US20040005352A1 (en) * 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US20040151691A1 (en) * 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
WO2004089434A1 (ja) * 2003-04-10 2004-10-21 Teijin Limited ハニカム構造を有する生分解性フィルム
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
DE102006015271A1 (de) * 2006-04-01 2007-10-11 Lohmann & Rauscher Gmbh & Co. Kg Biguanidhaltige Liposomen
WO2009021039A1 (en) * 2007-08-06 2009-02-12 University Of Kentucky Research Foundation Device for detection of molecules of interest
US7959861B2 (en) * 2007-09-19 2011-06-14 Stc.Unm Integrated affinity microcolumns and affinity capillary electrophoresis
US20110171309A1 (en) * 2008-04-10 2011-07-14 Board Of Regents, The University Of Texas System Compositions and Methods for Composite Nanoparticle Hydrogels
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US20110319521A1 (en) * 2009-03-16 2011-12-29 Lundgard Richard A Dispersion, and a process for producing the same
WO2011103143A1 (en) 2010-02-16 2011-08-25 The University Of North Carolina At Chapel Hill Array of micromolded structures for sorting adherent cells
US9849089B2 (en) * 2010-10-14 2017-12-26 Amorepacific Corporation Hydrogel particle coated with lipid and method for manufacturing same
US9150598B2 (en) 2011-10-05 2015-10-06 The Regents Of The University Of California Masking apertures enabling automation and solution exchange in sessile bilayers
GB201119032D0 (en) 2011-11-03 2011-12-14 Isis Innovation Multisomes: encapsulated droplet networks
WO2013155493A1 (en) 2012-04-12 2013-10-17 Yale University Methods of treating inflammatory and autoimmune diseases and disorders
FR2993891B1 (fr) * 2012-07-27 2016-11-18 Rhodia Operations Composition de polymeres pour l'inhibition de la formation de depots inorganiques et/ou organiques au sein de formations souterraines
GB201219201D0 (en) 2012-10-25 2012-12-12 Isis Innovation Hydrogel network
GB201219196D0 (en) 2012-10-25 2012-12-12 Isis Innovation Droplet assembly method
JP6416772B2 (ja) 2012-12-07 2018-10-31 オックスフォード ユニヴァーシティ イノヴェーション リミテッド ３ｄプリンティングによる小滴集合
WO2014138278A1 (en) 2013-03-05 2014-09-12 The Regents Of The University Of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
KR20220085840A (ko) 2016-01-08 2022-06-22 더 리전트 오브 더 유니버시티 오브 캘리포니아 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자
CN105603437A (zh) * 2016-01-12 2016-05-25 北京科技大学 一种低pH可控释放的智能缓蚀剂的制备方法
US10894956B2 (en) * 2017-03-03 2021-01-19 West Virginia University Phospholipid nanogel for exoglycosidase enzyme stabilization
GB2561157A (en) * 2017-03-27 2018-10-10 Univ Oxford Innovation Ltd Compartmentalised gel matrix and method of production
CN109942746B (zh) * 2019-03-27 2021-03-16 浙江理工大学 一种温敏光导阀门及其制备方法
CN110407980B (zh) * 2019-08-14 2021-12-14 中国林业科学研究院林产化学工业研究所 一种纤维素高分子表面活性剂基pH和温度双响应型复合水凝胶的制备方法
CN110655606B (zh) * 2019-10-22 2021-12-21 南京工程学院 一种复合光引发制备阳离子聚丙烯酰胺的方法
IT202100002537A1 (it) * 2021-02-05 2022-08-05 Kyme Nanoimaging Srl Processo microfluidico per la preparazione di nanostrutture liposomiche caricate con idrogel

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0070023B1 (de) * 1981-07-15 1987-09-30 Nippon Oil Co. Ltd. Verfahren zur Herstellung von wasserunlöslichen Polymeren von gleicher Form
US5314811A (en) * 1992-07-13 1994-05-24 Merck & Co., Inc. Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5464629A (en) * 1993-11-16 1995-11-07 Georgetown University Method of forming hydrogel particles having a controlled size using liposomes
HUP9802445A3 (en) * 1995-08-01 1999-03-29 Novartis Ag Liposomal oligonucleotide compositions and process for inhibiting the human raf
DK0910412T3 (da) * 1996-07-01 2003-08-11 Univ Utrecht Hydrolyserbare hydrogeler til kontrolleret frigørelse
US6284375B1 (en) * 1996-10-18 2001-09-04 Tuo Jin Lipid vesicle system
US6018033A (en) * 1997-05-13 2000-01-25 Purdue Research Foundation Hydrophilic, hydrophobic, and thermoreversible saccharide gels and forms, and methods for producing same
KR100845769B1 (ko) * 1999-02-03 2008-07-11 파우더젝트 리서치 리미티드 하이드로겔 입자 제제
US7943067B2 (en) * 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors

Also Published As

Publication number Publication date
US20100062054A1 (en) 2010-03-11
WO2003015701A2 (en) 2003-02-27
EP1425112B1 (de) 2009-06-17
EP1511580B1 (de) 2015-03-18
AU2002329761A1 (en) 2003-03-03
US20030044455A1 (en) 2003-03-06
WO2003015701A3 (en) 2004-12-29
WO2003015936A1 (en) 2003-02-27
EP1511580A4 (de) 2005-06-08
US7883648B2 (en) 2011-02-08
US7943067B2 (en) 2011-05-17
WO2003015701A9 (en) 2003-04-24
EP1511580A2 (de) 2005-03-09
EP1425112A4 (de) 2005-06-15
EP1425112A1 (de) 2004-06-09
ATE433744T1 (de) 2009-07-15
US20030035842A1 (en) 2003-02-20
US7618565B2 (en) 2009-11-17

Similar Documents

Publication Publication Date Title
DE60232666D1 (de) Herstellungsmethoden für Hydrogelpartikel in Nanogrösse
Wang et al. Controls on polymer molecular weight may be used to control the size of palmitoyl glycol chitosan polymeric vesicles
Bonini et al. Self-assembly of β-cyclodextrin in water. Part 1: Cryo-TEM and dynamic and static light scattering
Runas et al. Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers
An et al. pH controlled permeability of lipid/protein biomimetic microcapsules
Chen et al. Hollow core− porous shell structure poly (acrylic acid) nanogels with a superhigh capacity of drug loading
Antipov et al. Polyelectrolyte multilayer capsule permeability control
Gao et al. Swelling and shrinking of polyelectrolyte microcapsules in response to changes in temperature and ionic strength
US6699501B1 (en) Polyelectrolyte coverings on biological templates
Liu et al. Stable polymeric nanoballoons: lyophilization and rehydration of cross-linked liposomes
Polozova et al. Contribution of hydrogen bonding to the association of liposomes and an anionic hydrophobically modified poly (N-isopropylacrylamide)
Bordi et al. Complexation of anionic polyelectrolytes with cationic liposomes: evidence of reentrant condensation and lipoplex formation
Rameez et al. Large scale production of vesicles by hollow fiber extrusion: a novel method for generating polymersome encapsulated hemoglobin dispersions
Senarath-Yapa et al. Preparation and characterization of poly (lipid)-coated, fluorophore-doped silica nanoparticles for biolabeling and cellular imaging
Pippa et al. The fractal hologram and elucidation of the structure of liposomal carriers in aqueous and biological media
Petralito et al. Design and development of PEG-DMA gel-in-liposomes as a new tool for drug delivery
Pippa et al. The delineation of the morphology of charged liposomal vectors via a fractal analysis in aqueous and biological media: physicochemical and self-assembly studies
Santos et al. Ultrasonication of insulin-loaded microgel particles produced by internal gelation: Impact on particle's size and insulin bioactivity
Sennato et al. Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density
Hu et al. Polymersomes: preparation and characterization
Yaroslavov et al. Biodegradable containers composed of anionic liposomes and cationic polypeptide vesicles
Bordi et al. Polyions act as an electrostatic glue for mesoscopic particle aggregates
US20090317792A1 (en) Oil emulsions and methods for manufacture and use thereof
MacKinnon et al. Liposome− hydrogel bead complexes prepared via biotin− avidin conjugation
Hara et al. Calcium alginate gel-entrapped liposomes

Legal Events

Date Code Title Description
8364 No opposition during term of opposition