DE60228128D1 - Biokonjugat-nanopartikelsonden - Google Patents

Biokonjugat-nanopartikelsonden

Info

Publication number
DE60228128D1
DE60228128D1 DE60228128T DE60228128T DE60228128D1 DE 60228128 D1 DE60228128 D1 DE 60228128D1 DE 60228128 T DE60228128 T DE 60228128T DE 60228128 T DE60228128 T DE 60228128T DE 60228128 D1 DE60228128 D1 DE 60228128D1
Authority
DE
Germany
Prior art keywords
bioconjugate
probes
nanoparticle probes
nanoparticle
dithiothreitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228128T
Other languages
English (en)
Inventor
Viswanadham Garimella
James J Storhoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosphere LLC
Original Assignee
Nanosphere LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere LLC filed Critical Nanosphere LLC
Application granted granted Critical
Publication of DE60228128D1 publication Critical patent/DE60228128D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
DE60228128T 2001-11-09 2002-11-08 Biokonjugat-nanopartikelsonden Expired - Lifetime DE60228128D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34823901P 2001-11-09 2001-11-09
PCT/US2002/035888 WO2003081202A2 (en) 2001-11-09 2002-11-08 Bioconjugate-nanoparticle probes

Publications (1)

Publication Number Publication Date
DE60228128D1 true DE60228128D1 (de) 2008-09-18

Family

ID=28454565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228128T Expired - Lifetime DE60228128D1 (de) 2001-11-09 2002-11-08 Biokonjugat-nanopartikelsonden

Country Status (8)

Country Link
US (1) US7186814B2 (de)
EP (1) EP1466015B1 (de)
JP (1) JP4220397B2 (de)
AT (1) ATE403751T1 (de)
AU (1) AU2002367817B2 (de)
CA (1) CA2466656C (de)
DE (1) DE60228128D1 (de)
WO (1) WO2003081202A2 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
JP2004501340A (ja) * 2000-01-13 2004-01-15 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
WO2002004681A2 (en) * 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
CA2563510A1 (en) 2001-07-13 2005-11-17 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US20060177852A1 (en) * 2001-12-12 2006-08-10 Do-Coop Technologies Ltd. Solid-fluid composition
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
EP1540006B1 (de) * 2002-07-02 2009-01-07 Nanosphere, Inc. Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
WO2005001143A2 (en) * 2003-02-27 2005-01-06 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7226636B2 (en) * 2003-07-31 2007-06-05 Los Alamos National Security, Llc Gold-coated nanoparticles for use in biotechnology applications
JP4207754B2 (ja) * 2003-10-31 2009-01-14 和光純薬工業株式会社 磁性体を用いた免疫学的測定方法
US7396677B2 (en) * 2003-11-07 2008-07-08 Nanosphere, Inc. Method of preparing nucleic acids for detection
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
JP4557973B2 (ja) * 2004-03-31 2010-10-06 塩野義製薬株式会社 金属微粒子を用いた質量分析方法
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
EP1771583A2 (de) * 2004-07-26 2007-04-11 Nanosphere, Inc. Verfahren zur unterscheidung von methicillin-resistentem s. aureus von methicillin-sensitivem s. aureus in einer mischkultur
US20060134694A1 (en) * 2004-12-22 2006-06-22 Intel Corporation Methods of protein profiling by thiolation
JP4791867B2 (ja) * 2005-03-31 2011-10-12 日立マクセル株式会社 貴金属コート磁性粒子を用いた被検物質の検出方法
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
EP1915466B1 (de) * 2005-08-19 2010-11-24 Nanosphere, Inc. Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
AU2007203960A1 (en) * 2006-01-04 2007-07-12 Do-Coop Technologies Ltd. Antiseptic compositions and methods of using same
US20090004296A1 (en) * 2006-01-04 2009-01-01 Do-Coop Technologies Ltd. Antiseptic Compositions and Methods of Using Same
US20090253613A1 (en) * 2006-01-04 2009-10-08 Do-Coop Technologies Ltd. Solid-Fluid Composition
WO2008091364A2 (en) * 2006-06-30 2008-07-31 Intel Corporation Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance
KR100828936B1 (ko) 2006-08-01 2008-05-20 김성천 단일가닥핵산 압타머와 금-나노입자를 이용한 생체분자분석방법
JP2010515432A (ja) * 2007-01-04 2010-05-13 ドゥ−コープ テクノロジーズ リミテッド 細胞増殖および細胞融合を高めるための組成物および方法
EP2122350A4 (de) * 2007-01-04 2010-10-27 Do Coop Technologies Ltd Nachweis von analyten
AU2008222678B2 (en) 2007-03-07 2013-01-17 The General Hospital Corporation Compositions and methods for the prevention and treatment of autoimmune conditions
US9222936B2 (en) 2007-04-18 2015-12-29 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
US8597959B2 (en) * 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
US20100209946A1 (en) * 2007-04-19 2010-08-19 Naiyong Jing Uses of water-dispersible silica nanoparticles for attaching biomolecules
AU2008279042B2 (en) * 2007-07-26 2014-03-13 Agamatrix, Inc. Electrochemical analyte detection apparatus and method
US9863939B2 (en) 2007-09-20 2018-01-09 Magarray, Inc. Analyte detection with magnetic sensors
US20090185113A1 (en) * 2008-01-22 2009-07-23 Industrial Technology Research Institute Color Filter Module and Device of Having the Same
EP2419733A4 (de) 2009-04-13 2013-12-25 Univ Leland Stanford Junior Verfahren und vorrichtungen zur erkennung des vorhandenseins eines analyts in einer probe
WO2010129666A1 (en) * 2009-05-05 2010-11-11 Altermune Technologies, Llc Chemically programmable immunity
US20100291541A1 (en) * 2009-05-14 2010-11-18 Evoy Stephane Bacteriophage immobilization for biosensors
CN106198715B (zh) 2010-03-12 2020-01-10 小利兰·斯坦福大学托管委员会 基于磁性传感器的定量结合动力学分析
HUE035000T2 (en) 2010-09-29 2018-03-28 Uti Lp A method of treating autoimmune disease using biocompatible bioabsorbable nanospheres
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
US9851308B2 (en) * 2010-11-19 2017-12-26 Wisconsin Alumni Research Foundation (Warf) Visible detection of microorganisms
WO2012071428A2 (en) * 2010-11-22 2012-05-31 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for assays and detections
JP6101215B2 (ja) 2011-03-09 2017-03-22 マグアレイ,インコーポレイテッド サンプル中の分析対象物に対するハイスループット検出を行うシステム及び方法
US8946389B2 (en) 2011-04-25 2015-02-03 University Of Washington Compositions and methods for multiplex biomarker profiling
US9982292B2 (en) 2012-09-28 2018-05-29 Src, Inc. Detecting chemical and biological agents using textile-based sensors
US9512468B2 (en) 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
US10267871B2 (en) 2013-03-15 2019-04-23 Magarray, Inc. Magnetic tunnel junction sensors and methods for using the same
KR102325668B1 (ko) * 2013-10-23 2021-11-12 켐진스 코포레이션 고체 표면에 생체분자의 강한 고정용 디티올란 기능화된 뉴클레오시드 아미디트 및 지지체
KR101718867B1 (ko) * 2014-06-02 2017-03-22 한국과학기술연구원 생체적합성 형광 나노입자 및 이의 용도
CN104909463A (zh) * 2015-05-09 2015-09-16 浙江省农业科学院 一种核壳结构净水菌胶囊及其制备方法
CN104894097B (zh) * 2015-05-09 2018-11-06 浙江省农业科学院 一种长效净水菌胶囊及其制备方法
KR102489353B1 (ko) 2015-06-01 2023-01-17 캘리포니아 인스티튜트 오브 테크놀로지 특정 집단에 대한 항원으로 t 세포를 스크리닝하기 위한 조성물 및 방법
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN113311047B (zh) * 2021-05-06 2022-06-21 复旦大学 一种纳米金颗粒修饰的伪mos生化分子传感器及其制备方法
WO2023172665A2 (en) 2022-03-10 2023-09-14 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4256834A (en) 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US4713348A (en) 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US5137827A (en) 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5360895A (en) 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US4853335A (en) 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
GB8800702D0 (en) 1988-01-13 1988-02-10 Nycomed As Test method & reagent kit therefor
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
US5460831A (en) 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
GB9019512D0 (en) 1990-09-06 1990-10-24 Ici Plc Assay method
WO1992008133A1 (en) * 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
EP0613585A4 (de) 1991-11-22 1995-06-21 Univ California Halbleitende nanokristalle, die durch selbstzusammengesetzte einzelschichten mit festen anorganischen oberflüchen verbunden sind.
US5225064A (en) 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
GB9212164D0 (en) 1992-06-09 1992-07-22 Medical Res Council Preparation of nucleic acids
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5637508A (en) 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
US5384265A (en) 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
ATE165118T1 (de) 1993-06-09 1998-05-15 Gamera Bioscience Corp Magnetische zyklusreaktionen
EP0630974A3 (de) 1993-06-25 1995-11-15 Clinical Diagnostic Syst Verfahren und Testkit zum Nachweis von anorganischen Orthophosphat bei der Amplifizierung von Zielnukleinsäuren.
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH07227299A (ja) 1994-02-14 1995-08-29 Kyoto Daiichi Kagaku:Kk Dnaの特定塩基配列の検出方法及びその装置
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US6121425A (en) * 1994-07-29 2000-09-19 Nanoprobes, Inc. Metal-lipid molecules
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5609907A (en) 1995-02-09 1997-03-11 The Penn State Research Foundation Self-assembled metal colloid monolayers
US6025202A (en) 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
ATE357663T1 (de) * 1996-04-25 2007-04-15 Genicon Sciences Corp Teilchenförmiges markierungsmittel verwendendes analytassay
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
ES2287956T3 (es) 1996-07-29 2007-12-16 Nanosphere Inc. Nanoparticulas que tienen oligonucleotidos unidos a las mismas y usos de las mismas.
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6242264B1 (en) 1996-09-04 2001-06-05 The Penn State Research Foundation Self-assembled metal colloid monolayers having size and density gradients
WO1998017317A2 (de) 1996-10-23 1998-04-30 Skw Trostberg Aktiengesellschaft Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten
US5830986A (en) 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
AUPP004497A0 (en) 1997-10-28 1997-11-20 University Of Melbourne, The Stabilized particles
US6149868A (en) 1997-10-28 2000-11-21 The Penn State Research Foundation Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches
AU1450699A (en) 1997-10-31 1999-05-24 Gen-Probe Incorporated Methods of nucleic acid detection
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5972615A (en) * 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
IL126776A (en) 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
CA2352362C (en) 1998-11-30 2009-02-17 Nanosphere, Inc. Nanoparticles with polymer shells
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
DE60045739D1 (de) 1999-06-25 2011-04-28 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
EP1208663A4 (de) 1999-08-03 2005-07-27 Polycom Inc Vorrichtung und verfahren zur gesicherten datenübertragung in einem drahtlosen kommunikationssystem
JP2004501340A (ja) * 2000-01-13 2004-01-15 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
JP2004515208A (ja) 2000-03-28 2004-05-27 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
WO2001086301A1 (fr) 2000-05-11 2001-11-15 Center For Advanced Science And Technology Incubation, Ltd. Composition polymère pour former la surface d'un biocapteur
WO2002004681A2 (en) 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
JP2004525607A (ja) 2000-08-11 2004-08-26 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
ES2382636T3 (es) 2000-10-31 2012-06-12 Surmodics Pharmaceuticals, Inc. Método para producir composiciones para la administración mejorada de moléculas bioactivas
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
EP1356109A2 (de) 2000-12-08 2003-10-29 Nanosphere, Inc. Nanopartikel an denen oligonukleotide gebunden sind und deren verwendung
US6958216B2 (en) * 2001-01-10 2005-10-25 The Trustees Of Boston College DNA-bridged carbon nanotube arrays
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
JP4347053B2 (ja) 2001-08-03 2009-10-21 ナノスフェアー インコーポレイテッド ナノ粒子撮像システムおよび方法
CA2508359A1 (en) 2002-12-12 2004-06-24 Nanosphere, Inc. Direct snp detection with unamplified dna

Also Published As

Publication number Publication date
JP2005519627A (ja) 2005-07-07
US20030143598A1 (en) 2003-07-31
US7186814B2 (en) 2007-03-06
CA2466656A1 (en) 2003-10-02
WO2003081202A2 (en) 2003-10-02
CA2466656C (en) 2013-07-02
EP1466015A2 (de) 2004-10-13
ATE403751T1 (de) 2008-08-15
EP1466015B1 (de) 2008-08-06
AU2002367817A1 (en) 2003-10-08
JP4220397B2 (ja) 2009-02-04
WO2003081202A3 (en) 2004-07-22
AU2002367817B2 (en) 2008-05-29
EP1466015A4 (de) 2007-02-28

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