DE60219627D1 - Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen - Google Patents

Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen

Info

Publication number
DE60219627D1
DE60219627D1 DE60219627T DE60219627T DE60219627D1 DE 60219627 D1 DE60219627 D1 DE 60219627D1 DE 60219627 T DE60219627 T DE 60219627T DE 60219627 T DE60219627 T DE 60219627T DE 60219627 D1 DE60219627 D1 DE 60219627D1
Authority
DE
Germany
Prior art keywords
therapy
identification
plaque
photodynamic compounds
sensitive plaque
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60219627T
Other languages
English (en)
Other versions
DE60219627T2 (de
Inventor
Michael R Hamblin
Ahmed Tawakol
Tayyaba Hasan
Alan Fischman
James Muller
Rox Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of DE60219627D1 publication Critical patent/DE60219627D1/de
Application granted granted Critical
Publication of DE60219627T2 publication Critical patent/DE60219627T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • A61B18/245—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter for removing obstructions in blood vessels or calculi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00057—Light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00079—Radioactivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00904—Automatic detection of target tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N2005/0602—Apparatus for use inside the body for treatment of blood vessels
DE60219627T 2001-06-04 2002-06-04 Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen Expired - Lifetime DE60219627T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29562701P 2001-06-04 2001-06-04
US295627P 2001-06-04
US36567302P 2002-03-15 2002-03-15
US365673P 2002-03-15
PCT/US2002/018472 WO2003003975A2 (en) 2001-06-04 2002-06-04 Detection and therapy of vulnerable plaque with photodynamic compounds

Publications (2)

Publication Number Publication Date
DE60219627D1 true DE60219627D1 (de) 2007-05-31
DE60219627T2 DE60219627T2 (de) 2008-02-07

Family

ID=27388922

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60219627T Expired - Lifetime DE60219627T2 (de) 2001-06-04 2002-06-04 Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen

Country Status (8)

Country Link
US (5) US20030103995A1 (de)
EP (2) EP1401479B1 (de)
JP (2) JP2005502618A (de)
AT (1) ATE359806T1 (de)
AU (2) AU2002327180A1 (de)
CA (2) CA2449828A1 (de)
DE (1) DE60219627T2 (de)
WO (2) WO2003003975A2 (de)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7426409B2 (en) * 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
ATE454845T1 (de) 2000-10-30 2010-01-15 Gen Hospital Corp Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
WO2002080756A2 (en) * 2001-04-05 2002-10-17 The Johns Hopkins University Imaging systems for in vivo protocols
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
DE60219627T2 (de) * 2001-06-04 2008-02-07 The General Hospital Corp., Boston Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen
US20030013986A1 (en) * 2001-07-12 2003-01-16 Vahid Saadat Device for sensing temperature profile of a hollow body organ
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US20040073132A1 (en) * 2002-05-07 2004-04-15 Tracy Maahs Systems and methods for detecting vulnerable plaque
EA200401565A1 (ru) * 2002-05-24 2005-04-28 Неофарм, Инк. Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
JP2006518701A (ja) * 2002-05-24 2006-08-17 ネオファーム、インコーポレイティッド カルジオリピン組成物、その製造方法及び使用
US7326238B1 (en) 2002-09-30 2008-02-05 Abbott Cardiovascular Systems Inc. Method and apparatus for treating vulnerable plaque
US7008411B1 (en) * 2002-09-30 2006-03-07 Advanced Cardiovascular Systems, Inc. Method and apparatus for treating vulnerable plaque
US20060265043A1 (en) * 2002-09-30 2006-11-23 Evgenia Mandrusov Method and apparatus for treating vulnerable plaque
US20050277611A1 (en) * 2002-10-16 2005-12-15 Neopharm, Inc. Cationic cardiolipin analoges and its use thereof
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7153299B1 (en) 2003-02-24 2006-12-26 Maxwell Sensors Inc. Optical apparatus for detecting and treating vulnerable plaque
US7297154B2 (en) * 2003-02-24 2007-11-20 Maxwell Sensors Inc. Optical apparatus for detecting and treating vulnerable plaque
JP4805142B2 (ja) 2003-03-31 2011-11-02 ザ ジェネラル ホスピタル コーポレイション 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少
US7515626B2 (en) * 2003-05-29 2009-04-07 Novera Optics, Inc. Light source capable of lasing that is wavelength locked by an injected light signal
KR20130138867A (ko) 2003-06-06 2013-12-19 더 제너럴 하스피탈 코포레이션 파장 동조 소스용 방법 및 장치
US20060078560A1 (en) * 2003-06-23 2006-04-13 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
US20050049228A1 (en) * 2003-09-02 2005-03-03 Ceramoptec Industries Inc. Antimicrobial photodynamic therapy compound and method of use
US20050053590A1 (en) * 2003-09-05 2005-03-10 The Texas A&M University System Endothelium-targeting nanoparticle for reversing endothelial dysfunction
KR101321413B1 (ko) 2003-10-27 2013-10-22 더 제너럴 하스피탈 코포레이션 주파수 영역 간섭법을 이용하여 광 영상화를 수행하는 방법및 장치
DE10354496B4 (de) * 2003-11-21 2011-03-31 Siemens Ag Medizinisches Untersuchungs- und/oder Behandlungssystem
US7258697B1 (en) * 2003-12-22 2007-08-21 Advanced Cardiovascular Systems, Inc. Stent with anchors to prevent vulnerable plaque rupture during deployment
US7474408B2 (en) * 2004-05-14 2009-01-06 Medeikon Corporation Low coherence interferometry utilizing phase
US20050254059A1 (en) * 2004-05-14 2005-11-17 Alphonse Gerard A Low coherence interferometric system for optical metrology
US7242480B2 (en) * 2004-05-14 2007-07-10 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
AU2004320269B2 (en) 2004-05-29 2011-07-21 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
JP4995720B2 (ja) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション ダブルクラッドファイバを有する内視鏡撮像プローブ
US20130040043A1 (en) * 2004-08-04 2013-02-14 Marian L. Larson Method of coating medical devices including application of peptide linker coating
US8081316B2 (en) 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
WO2006024014A2 (en) 2004-08-24 2006-03-02 The General Hospital Corporation Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample
EP2272420B1 (de) 2004-08-24 2013-06-19 The General Hospital Corporation Vorrichtung zur Abbildung von Gefäßsegmenten
CA2578205A1 (en) * 2004-08-25 2006-03-30 The Regents Of The University Of Michigan Partially acetylated dendrimers and related methods of use
JP5215664B2 (ja) 2004-09-10 2013-06-19 ザ ジェネラル ホスピタル コーポレイション 光学コヒーレンス撮像のシステムおよび方法
EP1804638B1 (de) 2004-09-29 2012-12-19 The General Hospital Corporation System und verfahren zur abbildung optischer kohärenz
US20080260650A1 (en) * 2004-10-28 2008-10-23 The General Hospital Corporation Methods of Detection and Therapy of Inflamed Tissues Using Immune Modulation
US20080193376A1 (en) * 2004-10-28 2008-08-14 The General Hospital Corporation Methods of Enhanced Detection and Therapy of Inflamed Tissues Using Immune Modulation
JP2008521516A (ja) 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション サンプル上の複数の地点を同時に照射し検出することによって光学画像生成を実行する構成、装置、内視鏡、カテーテル、及び方法
KR20070112194A (ko) * 2005-02-17 2007-11-22 라이트 사이언시즈 온콜로지, 인코포레이티드 죽상동맥경화증의 예방치료를 위한 광반응성 시스템과 방법
US7560227B2 (en) * 2005-02-28 2009-07-14 University Of Massachusetts Biomarkers of vulnerable atherosclerotic plaques and methods of use
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
ES2337497T3 (es) 2005-04-28 2010-04-26 The General Hospital Corporation Evaluacion de caracteristicas de la imagen de una estructura anatomica en imagenes de tomografia de coherencia optica.
WO2006128016A2 (en) * 2005-05-25 2006-11-30 Prescient Medical, Inc. Methods and systems for treating vulnerable plaques
WO2007117572A2 (en) * 2005-05-27 2007-10-18 Board Of Regents, University Of Texas System Optical coherence tomographic detection of cells and killing of the same
US8454511B2 (en) 2005-05-27 2013-06-04 Board Of Regents, The University Of Texas System Magneto-motive ultrasound detection of magnetic nanoparticles
US8355776B2 (en) 2005-05-27 2013-01-15 Board Of Regents, The University Of Texas System Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus
WO2006128167A2 (en) * 2005-05-27 2006-11-30 Board Of Regents, The University Of Texas System Optical coherence tomographic detection of cells and compositions
JP5702049B2 (ja) 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション 位相分解光学周波数領域画像化を行うための装置、方法及びシステム
US7874975B2 (en) * 2005-07-20 2011-01-25 Clear Vascular, Inc. Methods and compositions for treating luminal inflammatory disease
CN101238347B (zh) 2005-08-09 2011-05-25 通用医疗公司 执行光学相干层析术中的基于偏振的正交解调的设备、方法和存储介质
US20070073364A1 (en) * 2005-09-29 2007-03-29 Siemens Aktiengesellschaft Combined OCT catheter device and method for combined optical coherence tomography (OCT) diagnosis and photodynamic therapy (PDT)
CN101360447B (zh) 2005-09-29 2012-12-05 通用医疗公司 通过光谱编码进行光学成像的方法和装置
JP2007091673A (ja) * 2005-09-29 2007-04-12 Toshiba Corp 血液循環促進剤、血液循環装置および血液循環促進医療システム
WO2007047690A1 (en) 2005-10-14 2007-04-26 The General Hospital Corporation Spectral- and frequency- encoded fluorescence imaging
JP5680826B2 (ja) 2006-01-10 2015-03-04 ザ ジェネラル ホスピタル コーポレイション １以上のスペクトルを符号化する内視鏡技術によるデータ生成システム
US7842465B2 (en) * 2006-01-17 2010-11-30 Palo Alto Research Center Incorporated Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection
WO2007084995A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US7418169B2 (en) * 2006-02-01 2008-08-26 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
EP1983921B1 (de) 2006-02-01 2016-05-25 The General Hospital Corporation Systeme zur bereitstellung elektromagnetischer strahlung für mindestens einen teil einer probe mittels konformer lasertherapieverfahren
US9186066B2 (en) 2006-02-01 2015-11-17 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
EP1988825B1 (de) 2006-02-08 2016-12-21 The General Hospital Corporation Anordnungen und systeme zum abrufen von informationen im zusammenhang mit einer anatomischen probe mithilfe eines optischen mikroskops
JP2007223966A (ja) * 2006-02-24 2007-09-06 Pentax Corp 細胞表面又は組織表面染色剤組成物及びこれを用いた染色方法
EP2982929A1 (de) 2006-02-24 2016-02-10 The General Hospital Corporation Verfahren und systeme zur durchführung von winkelaufgelöster optischer kohärenztomografie im fourier-bereich
US8435276B2 (en) * 2006-02-27 2013-05-07 Thomas Perez Method and apparatus for the combined application of light therapy, optic diagnosis, and fluid to tissue
US20070208400A1 (en) * 2006-03-01 2007-09-06 The General Hospital Corporation System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages
EP2004041B1 (de) 2006-04-05 2013-11-06 The General Hospital Corporation Verfahren, anordnungen und systeme für polarisationsempfindliche optische frequenzbereichsabbildung einer probe
US8187189B2 (en) 2006-04-28 2012-05-29 The Invention Science Fund I, Llc Imaging via blood vessels
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20070299431A1 (en) * 2006-05-02 2007-12-27 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
JP2009536740A (ja) 2006-05-10 2009-10-15 ザ ジェネラル ホスピタル コーポレイション サンプルの周波数領域画像形成を提供するためのプロセス、構成およびシステム
US20080275432A1 (en) * 2006-05-11 2008-11-06 Ceramoptec Industries, Inc. Photodynamic foam composition and sclerosis treatment
US7782464B2 (en) 2006-05-12 2010-08-24 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
US7572625B2 (en) * 2006-05-18 2009-08-11 Boston Scientific Scimed, Inc. Medical devices coated with drug carrier macromolecules
US7488930B2 (en) * 2006-06-02 2009-02-10 Medeikon Corporation Multi-channel low coherence interferometer
EP2061518A4 (de) * 2006-08-29 2011-05-11 Molecular Insight Pharm Inc An peptidase-bindende teile gekoppelte radiodarstellende teile zur bilddarstellung von geweben und organen, die peptidasen exprimieren
US8882674B2 (en) * 2006-09-28 2014-11-11 Research Foundation Of The City University Of New York System and method for in vivo imaging of blood vessel walls to detect microcalcifications
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
US8108030B2 (en) 2006-10-20 2012-01-31 Board Of Regents, The University Of Texas System Method and apparatus to identify vulnerable plaques with thermal wave imaging of heated nanoparticles
WO2008067079A2 (en) * 2006-10-20 2008-06-05 Cardiospectra, Inc. Method and apparatus to identify vulnerable plaques with thermal wave imaging of heated nanoparticles
US8155730B2 (en) * 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
US8000774B2 (en) * 2007-01-03 2011-08-16 Infraredx, Inc. Method and system for intra luminal thrombus detection
WO2008086376A2 (en) * 2007-01-08 2008-07-17 Light Sciences Oncology, Inc. Therapeutic devices for the treatment of varicosity
JP2010517080A (ja) 2007-01-19 2010-05-20 ザ ジェネラル ホスピタル コーポレイション 分散広帯域光の高速波長スキャンのための回転ディスク反射
JP5507258B2 (ja) * 2007-01-19 2014-05-28 ザ ジェネラル ホスピタル コーポレイション 光周波数領域イメージングにおける測定深度を制御するための装置及び方法
JP5558839B2 (ja) 2007-03-23 2014-07-23 ザ ジェネラル ホスピタル コーポレイション 角度走査及び分散手順を用いて波長掃引レーザを利用するための方法、構成及び装置
WO2008121844A1 (en) 2007-03-30 2008-10-09 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
WO2008122056A2 (en) * 2007-04-02 2008-10-09 Case Western Reserve University Medical apparatus and method associated therewith
EP3473093B1 (de) 2007-04-12 2020-10-28 The General Hospital Corporation Biomimetisches gefässnetz
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
EP2173254A2 (de) 2007-07-31 2010-04-14 The General Hospital Corporation System und verfahren zur bereitstellung von strahlerfassungsmustern für hochgeschwindigkeits-abbildungen optischer dopplerfrequenzdomänen
IL185128A0 (en) * 2007-08-08 2008-01-06 Kerber Tom Irradiating strip catheter
US7682089B2 (en) * 2007-08-15 2010-03-23 Rohlen Brooks H System and method for positioning a probe
US8480662B2 (en) * 2007-08-22 2013-07-09 Cardiac Pacemakers, Inc. Systems and devices for photoablation
US8040608B2 (en) 2007-08-31 2011-10-18 The General Hospital Corporation System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith
EP2207469A4 (de) * 2007-10-12 2012-07-11 Gen Hospital Corp Systeme und verfahren zur optischen bildgebung von luminalen anatomischen strukturen
WO2009059034A1 (en) 2007-10-30 2009-05-07 The General Hospital Corporation System and method for cladding mode detection
GB0803076D0 (en) * 2008-02-20 2008-03-26 Univ Ghent Mucosal Membrane Receptor and uses thereof
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US8593619B2 (en) 2008-05-07 2013-11-26 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
US9042967B2 (en) 2008-05-20 2015-05-26 University Health Network Device and method for wound imaging and monitoring
EP2288948A4 (de) 2008-06-20 2011-12-28 Gen Hospital Corp Anordnung aus kondensierten glasfaserkopplern und verfahren zu ihrer verwendung
US9254089B2 (en) * 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
US9204925B2 (en) * 2008-08-14 2015-12-08 The Cleveland Clinic Foundation Apparatus and method for treating a neuromuscular defect
KR20100030195A (ko) * 2008-09-09 2010-03-18 서울대학교산학협력단 방사성 표지된 형광 실리카 나노파티클 및 이를 이용한 ｐｅｔ 및 형광 복합영상 측정방법
FR2935924B1 (fr) * 2008-09-18 2010-11-12 Sidel Participations Dispositif et procede de mesure de la temperature de paroi d'une ebauche de recipient
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010062557A2 (en) * 2008-10-27 2010-06-03 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to lox-1
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
ES2957932T3 (es) 2008-12-10 2024-01-30 Massachusetts Gen Hospital Sistemas, aparatos y procedimientos para ampliar el rango de profundidad de imagen de tomografía de coherencia óptica mediante submuestreo óptico
JP5355074B2 (ja) * 2008-12-26 2013-11-27 キヤノン株式会社 ３次元形状データ処理装置、３次元形状データ処理方法及びプログラム
EP2389093A4 (de) 2009-01-20 2013-07-31 Gen Hospital Corp Endoskopische biopsievorrichtung sowie entsprechendes system und verfahren
US8097864B2 (en) 2009-01-26 2012-01-17 The General Hospital Corporation System, method and computer-accessible medium for providing wide-field superresolution microscopy
CA2749670A1 (en) 2009-02-04 2010-08-12 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
US20100312312A1 (en) * 2009-06-09 2010-12-09 Gary Wayne Jones Method for selective photodynamic therapy and light source for implementation thereof
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
HU230008B1 (hu) * 2009-09-01 2015-05-28 Szegedi Tudományegyetem Javított tonometriás eszköz a szervezet légzési elégtelenségének és regionális perfúzió-zavarának vizsgálatára
CA2777682C (en) 2009-10-13 2015-02-24 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
US9211283B2 (en) * 2009-12-11 2015-12-15 Biolitec Pharma Marketing Ltd Nanoparticle carrier systems based on human serum albumin for photodynamic therapy
US20120022380A1 (en) * 2010-01-19 2012-01-26 Chernomorsky Ary S Methods and apparatus for assesment and treatment of body cavities
HUE052561T2 (hu) 2010-03-05 2021-05-28 Massachusetts Gen Hospital Készülék elektromágneses sugárzás biztosítására egy mintához
US20130289520A1 (en) * 2010-04-23 2013-10-31 Children's Hospital Boston Targeted and light-activated cytosolic drug delivery
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
JP5778762B2 (ja) 2010-05-25 2015-09-16 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィー画像のスペクトル解析のための装置及び方法
EP2575597B1 (de) 2010-05-25 2022-05-04 The General Hospital Corporation Vorrichtung zur bereitstellung einer optischen bildgebung für strukturen und zusammensetzungen
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
WO2012058381A2 (en) 2010-10-27 2012-05-03 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US20120265062A1 (en) * 2011-04-13 2012-10-18 St. Jude Medical, Inc. Optical coherence tomography catheter for elastographic property mapping of lumens utilizing micropalpation
US8721077B2 (en) 2011-04-29 2014-05-13 The General Hospital Corporation Systems, methods and computer-readable medium for determining depth-resolved physical and/or optical properties of scattering media by analyzing measured data over a range of depths
US9492113B2 (en) 2011-07-15 2016-11-15 Boston Scientific Scimed, Inc. Systems and methods for monitoring organ activity
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
EP2748587B1 (de) 2011-08-25 2021-01-13 The General Hospital Corporation Verfahren und anordnungen zur bereitstellung mikrooptischer kohärenztomographieverfahren
US9265459B2 (en) 2011-10-07 2016-02-23 Boston Scientific Scimed, Inc. Methods and systems for detection and thermal treatment of lower urinary tract conditions
US20130090640A1 (en) * 2011-10-07 2013-04-11 University Of Surrey Methods and systems for detection and thermal treatment of lower urinary tract conditions
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
WO2013085718A1 (en) 2011-12-08 2013-06-13 The Regents Of The University Of Michigan Multifunctional small molecules
WO2013148306A1 (en) 2012-03-30 2013-10-03 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
JP6398093B2 (ja) * 2012-04-13 2018-10-03 ベイカー ハート アンド ダイアベーツ インスティテュート アテローム斑の検出
US10512691B2 (en) * 2012-04-23 2019-12-24 The Regents Of The University Of Michigan Systems and methods for targeted imaging and ablation of cardiac cells
US11490797B2 (en) 2012-05-21 2022-11-08 The General Hospital Corporation Apparatus, device and method for capsule microscopy
US9415550B2 (en) 2012-08-22 2016-08-16 The General Hospital Corporation System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography
CA2882388C (en) 2012-08-31 2020-10-20 Sloan-Kettering Institute For Cancer Research Particles, methods and uses thereof
CN103721257B (zh) * 2012-10-16 2016-12-21 无锡兆真辐射技术有限公司 光敏素催化分解过氧化氢系列药物
EP2908759B1 (de) * 2012-10-16 2018-05-09 Boston Scientific Scimed, Inc. Chirurgisches lasersystem und laserfaser
CN105073142B (zh) 2012-12-19 2019-12-10 索隆-基特林癌症研究协会 多模态粒子、其方法和用途
EP2948758B1 (de) 2013-01-28 2024-03-13 The General Hospital Corporation Vorrichtung zur bereitstellung von gemeinsam mit optischer frequenzdomänenbildgebung aufgezeichneter diffuser spektroskopie
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
EP2958481A4 (de) 2013-02-20 2017-03-08 Sloan-Kettering Institute for Cancer Research Ramanbildgebungsvorrichtung mit weitem sichtfeld und zugehörige verfahren
WO2014144709A2 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Methods and systems for characterizing an object
WO2014186353A1 (en) 2013-05-13 2014-11-20 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
WO2015010133A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
EP3692887B1 (de) 2013-07-19 2024-03-06 The General Hospital Corporation Bildgebungsvorrichtung mithilfe von endoskopie mit multidirektionalem sichtfeld
ES2893237T3 (es) 2013-07-26 2022-02-08 Massachusetts Gen Hospital Aparato con una disposición láser que utiliza dispersión óptica para aplicaciones en la tomografía de coherencia óptica en el dominio de Fourier
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
EP3099325A4 (de) * 2014-01-31 2017-10-04 The General Hospital Corporation Dba Massachusetts General Hospital Verfahren zur behandlung und bildgebung von tumormikrometastasen mittels lichtaktivierbarer immunkonjugate
US10912947B2 (en) 2014-03-04 2021-02-09 Memorial Sloan Kettering Cancer Center Systems and methods for treatment of disease via application of mechanical force by controlled rotation of nanoparticles inside cells
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
PT3171765T (pt) 2014-07-24 2021-10-27 Univ Health Network Recolha e análise de dados para fins diagnósticos
KR102513779B1 (ko) * 2014-07-25 2023-03-24 더 제너럴 하스피탈 코포레이션 생체 내 이미징 및 진단을 위한 장치, 디바이스 및 방법
US10175219B2 (en) * 2014-07-28 2019-01-08 The Board Of Trustees Of The Leland Stanford Junior University Method to sort cells on the basis of radionuclide uptake
CN106687146A (zh) 2014-07-28 2017-05-17 纪念斯隆-凯特琳癌症中心 作为医学同位素的通用结合剂的(类)金属硫族纳米粒子
US20160058502A1 (en) * 2014-08-27 2016-03-03 Boston Scientific Scimed, Inc. Devices for damaging nerves and related methods of use
US10111936B2 (en) 2015-01-19 2018-10-30 Theralase Technologies, Inc. Metal-glycoprotein complexes and photodynamic therapy of immune privileged sites with same
EP3247397B1 (de) 2015-01-19 2021-05-19 Theralase Technologies Inc. Metallglycoproteinkomplexe und deren verwendung als chemotherapeutische verbindungen
EP3317035A1 (de) 2015-07-01 2018-05-09 Memorial Sloan Kettering Cancer Center Anisotrope partikel, verfahren und verwendungen dafür
US20220012877A1 (en) * 2015-08-14 2022-01-13 Elucid Bioimaging Inc. Quantitative imaging for detecting histopathologically defined plaque fissure non-invasively
US20230368365A9 (en) * 2015-08-14 2023-11-16 Elucid Bioimaging Inc. Quantitative imaging for detecting histopathologically defined plaque erosion non-invasively
US11094058B2 (en) * 2015-08-14 2021-08-17 Elucid Bioimaging Inc. Systems and method for computer-aided phenotyping (CAP) using radiologic images
EP3370634B1 (de) 2015-11-04 2019-09-18 Boston Scientific Scimed Inc. Medizinische vorrichtung und zugehörige verfahren
KR101880613B1 (ko) * 2017-09-29 2018-07-20 박우태 조명기능을 갖는 치아거울
CN108956564B (zh) * 2018-06-21 2020-12-29 深圳市优迈医学科技有限公司 光敏剂浓度检测装置、系统以及方法
JP2022503657A (ja) * 2018-10-22 2022-01-12 カリフォルニア インスティチュート オブ テクノロジー ３ｄ工学材料に基づくカラー及びマルチスペクトルイメージセンサ
US11239276B2 (en) 2019-10-18 2022-02-01 California Institute Of Technology CMOS color image sensors with metamaterial color splitting
CN111707664A (zh) * 2020-05-19 2020-09-25 西安交通大学 一种适用于超疏水表面的观测实验装置
WO2021258069A2 (en) * 2020-06-19 2021-12-23 The General Hospital Corporation Near-infrared autofluorescence imaging systems and methods
TWI815720B (zh) * 2022-11-03 2023-09-11 財團法人金屬工業研究發展中心 訊號傳輸元件

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US618402A (en) * 1899-01-31 Flat stripping motion for carding engines
US4141347A (en) * 1976-09-21 1979-02-27 Sri International Real-time ultrasonic B-scan imaging and Doppler profile display system and method
US4577636A (en) * 1982-11-23 1986-03-25 The Beth Israel Hospital Association Method for diagnosis of atherosclerosis
US4512762A (en) 1982-11-23 1985-04-23 The Beth Israel Hospital Association Method of treatment of atherosclerosis and a balloon catheter for same
US5693043A (en) 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5104392A (en) * 1985-03-22 1992-04-14 Massachusetts Institute Of Technology Laser spectro-optic imaging for diagnosis and treatment of diseased tissue
US4920143A (en) 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
CA1340977C (en) * 1988-11-15 2000-04-25 Monty Krieger Scavenger receptor protein and antibody thereto
US4995396A (en) 1988-12-08 1991-02-26 Olympus Optical Co., Ltd. Radioactive ray detecting endoscope
DE68925586T2 (de) * 1988-12-21 1996-10-24 Massachusetts Inst Technology Verfahren für laserinduzierte fluoreszenz von gewebe
US5046501A (en) * 1989-01-18 1991-09-10 Wayne State University Atherosclerotic identification
US5008546A (en) 1990-06-18 1991-04-16 The Regents Of The University Of California Intraoperative beta probe and method of using the same
US5197470A (en) 1990-07-16 1993-03-30 Eastman Kodak Company Near infrared diagnostic method and instrument
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5116864A (en) * 1991-04-09 1992-05-26 Indiana University Foundation Method for preventing restenosis following reconfiguration of body vessels
US5169395A (en) 1991-04-26 1992-12-08 Pdt Cardiovascular, Inc. Laser delivery system
JP3154742B2 (ja) * 1991-04-30 2001-04-09 日本石油化学株式会社 哺乳類の動脈硬化症治療剤
US5364612A (en) 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
WO1993018751A1 (en) * 1992-03-23 1993-09-30 Georgetown University Liposome encapsulated taxol and a method of using the same
WO1993021940A1 (en) * 1992-05-06 1993-11-11 Immunomedics, Inc. Intraoperative, intravascular and endoscopic tumor and lesion detection and therapy
JPH05330716A (ja) * 1992-05-25 1993-12-14 Eastman Kodak Japan Kk 排紙集積装置
US5776966A (en) * 1992-05-27 1998-07-07 University Of British Columbia Selective cell inactivation in blood
US5807881A (en) 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
US5298018A (en) 1992-08-14 1994-03-29 Pdt Cardiovascular, Inc. Method for treating cardiovascular disease through adjunctive photodynamic therapy
ATE201596T1 (de) * 1992-09-21 2001-06-15 Quadra Logic Tech Inc Transkutane in-vivo aktivierung von photoempfindlichen mitteln im blut
US5409710A (en) * 1993-04-20 1995-04-25 Endocon, Inc. Foam cell drug delivery
WO1995000605A1 (fr) 1993-06-18 1995-01-05 Aktsionernoe Obschestvo Otkrytogo Tipa 'yaroslavnefteorgsintez' Procede permettant d'obtenir des benzenes a l'aide d'un catalyseur
US5422362A (en) 1993-07-29 1995-06-06 Quadra Logic Technologies, Inc. Method to inhibit restenosis
US5798349A (en) 1994-03-14 1998-08-25 The General Hospital Corporation Use of green porphyrins to treat neovasculature in the eye
AU685661B2 (en) 1994-07-22 1998-01-22 Duke University Human serum albumin-porphyrin complexes with the ability to bind oxygen and therapeutic uses thereof
US5639600A (en) 1994-08-05 1997-06-17 The Regents Of The University Of California Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
US5568532A (en) 1994-08-12 1996-10-22 Southeastern Universities Research Association, Inc. Examination system utilizing ionizing radiation and a flexible, miniature radiation detector probe
US5891108A (en) * 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5789433A (en) * 1995-01-17 1998-08-04 Quadra Logic Technologies, Inc. Green porphyrins as immunomodulators
US6008211A (en) * 1995-07-27 1999-12-28 Pdt Pharmaceuticals, Inc. Photoactivatable compounds comprising benzochlorin and furocoumarin
US5760674A (en) * 1995-11-28 1998-06-02 International Business Machines Corporation Fusible links with improved interconnect structure
US5952329A (en) * 1996-01-23 1999-09-14 The General Hospital Corporation Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors
US5811814A (en) * 1996-02-12 1998-09-22 Cordis Corporation Radiation measuring catheter apparatus and method
US20030138411A1 (en) * 1996-05-02 2003-07-24 Glaxo Wellcome Inc. Gene expression in monocytes and macrophages
US5932879A (en) 1996-05-07 1999-08-03 Regents Of The University Of Michigan Solid state beta-sensitive surgical probe
US6076009A (en) 1997-05-05 2000-06-13 The University Of Michigan Solid state beta-sensitive surgical probe
US5744805A (en) 1996-05-07 1998-04-28 University Of Michigan Solid state beta-sensitive surgical probe
US5834503A (en) * 1996-06-14 1998-11-10 Qlt Phototherapeutics, Inc. Methods to treat arterial plaque
US5924997A (en) * 1996-07-29 1999-07-20 Campbell; Thomas Henderson Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US6286514B1 (en) * 1996-11-05 2001-09-11 Jerome Lemelson System and method for treating select tissue in a living being
US6180402B1 (en) * 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
US5919135A (en) * 1997-02-28 1999-07-06 Lemelson; Jerome System and method for treating cellular disorders in a living being
US6238348B1 (en) * 1997-07-22 2001-05-29 Scimed Life Systems, Inc. Miniature spectrometer system and method
US5864141A (en) 1997-07-23 1999-01-26 Southeastern Univ. Research Assn. Compact, high-resolution, gamma ray imaging for scintimammography and other medical diagostic applications
HUP0004412A3 (en) * 1997-08-14 2003-06-30 Hoffmann La Roche Use of heterocyclic vinylethers for the preparation of pharmaceutical compositions treating neurological disorders
CA2302837A1 (en) 1997-09-08 1999-03-18 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
US6033436A (en) * 1998-02-17 2000-03-07 Md3, Inc. Expandable stent
US6295680B1 (en) * 1998-07-05 2001-10-02 The Regents Of The University Of Michigan Method for detecting early atherosclerosis and vascular damage using radioactive tracers and intravascular radiation detection devices
US20020115649A1 (en) * 1998-07-06 2002-08-22 Pharmacyclics, Inc. Use of texaphyrins in macrophage-mediated disease
AU6417599A (en) * 1998-10-08 2000-04-26 University Of Kentucky Research Foundation, The Methods and apparatus for (in vivo) identification and characterization of vulnerable atherosclerotic plaques
US6211349B1 (en) * 1998-12-30 2001-04-03 Oligos Etc., Inc. Protonated/acidified nucleic acids and methods of use
US6167297A (en) * 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
US6782289B1 (en) * 1999-10-08 2004-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for characterizing lesions in blood vessels and other body lumens
US6716410B1 (en) 1999-10-26 2004-04-06 The Regents Of The University Of California Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
JP2003513027A (ja) * 1999-10-26 2003-04-08 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア アテローム性動脈硬化症の診断、結像、治療用の薬剤及びその方法
US6750037B2 (en) * 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US7373197B2 (en) 2000-03-03 2008-05-13 Intramedical Imaging, Llc Methods and devices to expand applications of intraoperative radiation probes
GB0121171D0 (en) * 2001-08-31 2001-10-24 Glaxosmithkline Biolog Sa Vaccine
JP4238476B2 (ja) * 2000-12-08 2009-03-18 株式会社デンソー 中間歯車付スタータ
US6547812B1 (en) * 2000-12-29 2003-04-15 Advanced Cardiovascular Systems, Inc. Radiation therapy using a radioactive implantable device and a radiosensitizer agent
MXPA03007534A (es) * 2001-02-23 2003-12-04 Bristol Myers Squibb Pharma Co Antagonistas del receptor depurador de macrofago etiquetado para formacion de imagenes de aterosclerosis y placa vulnerable.
US6894161B2 (en) * 2001-03-27 2005-05-17 The University Of British Columbia Methods and compositions for photo-cross linking photoactive compounds to target tissue
US6764501B2 (en) * 2001-04-10 2004-07-20 Robert A. Ganz Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US6906050B2 (en) * 2001-05-31 2005-06-14 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis
DE60219627T2 (de) * 2001-06-04 2008-02-07 The General Hospital Corp., Boston Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen
DE60230046D1 (de) * 2001-08-10 2009-01-08 Novartis Ag Peptide, die atherosklerotische schädigungen binden
US20030152513A1 (en) * 2001-09-06 2003-08-14 Imetrix, Inc. Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector
DE10226420A1 (de) * 2002-06-13 2004-01-15 Eucro European Contract Research Gmbh & Co Kg Verfahren zur Behandlung der Artherosklerose
CA2527196C (en) * 2003-05-30 2012-10-16 Purdue Research Foundation Diagnostic method for atherosclerosis

Also Published As

Publication number Publication date
US20030082105A1 (en) 2003-05-01
US20030055307A1 (en) 2003-03-20
JP2005538751A (ja) 2005-12-22
US20060073100A1 (en) 2006-04-06
WO2003003975A2 (en) 2003-01-16
US20030103995A1 (en) 2003-06-05
EP1575414A4 (de) 2008-02-20
AU2002360488A1 (en) 2003-09-29
AU2002327180A1 (en) 2003-01-21
WO2003077723A2 (en) 2003-09-25
AU2002360488A8 (en) 2003-09-29
US7809428B2 (en) 2010-10-05
EP1401479A2 (de) 2004-03-31
JP2005502618A (ja) 2005-01-27
WO2003077723A3 (en) 2007-07-12
CA2449828A1 (en) 2003-01-16
EP1401479B1 (de) 2007-04-18
ATE359806T1 (de) 2007-05-15
WO2003003975A3 (en) 2003-12-11
DE60219627T2 (de) 2008-02-07
EP1575414A2 (de) 2005-09-21
US20070258906A1 (en) 2007-11-08
CA2478248A1 (en) 2003-09-25
EP1401479A4 (de) 2005-03-16

Similar Documents

Publication Publication Date Title
DE60219627D1 (de) Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen
BR0007527A (pt) Fenilfenantridinas com atividade inibitória depde-iv
DK0889886T3 (da) Hidtil ukendte, i 6-stilling substituerede phenanthridiner
DE60218458D1 (de) Isochinolinon derivate als parp inhibitoren
BR9806752A (pt) Ftalazinonas.
BR9707233A (pt) Fenantridinas
ID21526A (id) 4-hidroksiquinolin-3-karboksamida dan hidrazida sebagai bahan anti-virus
DE50310516D1 (de) Fredericamycin-derivate
SE0102315D0 (sv) Compounds
ATE466014T1 (de) Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
DE60030741D1 (de) Chinazoline verbindungen als heilmittel
DE60045751D1 (de) Therapeutische Behandlung androgenrezeptorbedingter Leiden
ES2189235T3 (es) 6-fenilfenantridinas sustituidas.
DK1556021T3 (da) Farmaceutiske sammensætninger omfattende flavonoider og menthol samt fremgangsmåder til behandling med brug af nævnte sammensætninger
DE60137337D1 (de) Vorbeugende und therapeutsche monoklonale antikörper gegen vacciniavirusantigene
NO20034204D0 (no) Farmasöytiske kombinasjoner til behandling av kreft
EA200000911A1 (ru) Новые кристаллические формы антивирусного соединения бензимидазола
NO20035025L (no) Anvendelse av osteopontin for behandling og/eller for a hindre nevrologiske sykdommer, samt farmasoytisk sammensetning omfattende osteopontin eller en antagonist med osteopontinaktivitet.
PT998460E (pt) Novos derivados de tetrazole
ATE393917T1 (de) Identifikation von therapeutische verbindungen.
ATE404550T1 (de) Chemische verbindungen
ATE407702T1 (de) Liposomale einkapselung von alphastrahlern, und deren verwendung
DK1011329T3 (da) 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler
ATE517108T1 (de) 9-(1',5'-dimethyl-1'-vinyl-4'-hexenyl)-4-hydrox - 7h-furoä3,2-güä1übenzopyran-7-on als antibakterielles mittel
DE60102704D1 (de) Trioxepan verbindungen

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: HAMBLIN, MICHAEL, R., BOSTON, MA 02114, US

Inventor name: TAWAKOL, AHMED, BOSTON, MA 02114, US

Inventor name: HASAN, TAYYABA, BOSTON, MA 02114, US

Inventor name: FISCHMAN, ALAN, BOSTON, MA 02114, US

Inventor name: MULLER, JAMES, BOSTON, MA 02114, US

Inventor name: ANDERSON, ROX, BOSTON, MA 02114, US

8364 No opposition during term of opposition