DE60219627D1 - Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen - Google Patents
Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungenInfo
- Publication number
- DE60219627D1 DE60219627D1 DE60219627T DE60219627T DE60219627D1 DE 60219627 D1 DE60219627 D1 DE 60219627D1 DE 60219627 T DE60219627 T DE 60219627T DE 60219627 T DE60219627 T DE 60219627T DE 60219627 D1 DE60219627 D1 DE 60219627D1
- Authority
- DE
- Germany
- Prior art keywords
- therapy
- identification
- plaque
- photodynamic compounds
- sensitive plaque
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
- A61B18/245—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter for removing obstructions in blood vessels or calculi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
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- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
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- A—HUMAN NECESSITIES
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00079—Radioactivity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00904—Automatic detection of target tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0602—Apparatus for use inside the body for treatment of blood vessels
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29562701P | 2001-06-04 | 2001-06-04 | |
US295627P | 2001-06-04 | ||
US36567302P | 2002-03-15 | 2002-03-15 | |
US365673P | 2002-03-15 | ||
PCT/US2002/018472 WO2003003975A2 (en) | 2001-06-04 | 2002-06-04 | Detection and therapy of vulnerable plaque with photodynamic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60219627D1 true DE60219627D1 (de) | 2007-05-31 |
DE60219627T2 DE60219627T2 (de) | 2008-02-07 |
Family
ID=27388922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60219627T Expired - Lifetime DE60219627T2 (de) | 2001-06-04 | 2002-06-04 | Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen |
Country Status (8)
Country | Link |
---|---|
US (5) | US20030103995A1 (de) |
EP (2) | EP1401479B1 (de) |
JP (2) | JP2005502618A (de) |
AT (1) | ATE359806T1 (de) |
AU (2) | AU2002327180A1 (de) |
CA (2) | CA2449828A1 (de) |
DE (1) | DE60219627T2 (de) |
WO (2) | WO2003003975A2 (de) |
Families Citing this family (185)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7426409B2 (en) * | 1999-06-25 | 2008-09-16 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
WO2002036015A1 (en) | 2000-10-30 | 2002-05-10 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
WO2002080756A2 (en) * | 2001-04-05 | 2002-10-17 | The Johns Hopkins University | Imaging systems for in vivo protocols |
DE10297689B4 (de) | 2001-05-01 | 2007-10-18 | The General Hospital Corp., Boston | Verfahren und Gerät zur Bestimmung von atherosklerotischem Belag durch Messung von optischen Gewebeeigenschaften |
EP1401479B1 (de) * | 2001-06-04 | 2007-04-18 | The General Hospital Corporation | Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen |
US20030013986A1 (en) * | 2001-07-12 | 2003-01-16 | Vahid Saadat | Device for sensing temperature profile of a hollow body organ |
US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US20040073132A1 (en) * | 2002-05-07 | 2004-04-15 | Tracy Maahs | Systems and methods for detecting vulnerable plaque |
JP2006518701A (ja) * | 2002-05-24 | 2006-08-17 | ネオファーム、インコーポレイティッド | カルジオリピン組成物、その製造方法及び使用 |
EA200401565A1 (ru) * | 2002-05-24 | 2005-04-28 | Неофарм, Инк. | Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты) |
US20060265043A1 (en) * | 2002-09-30 | 2006-11-23 | Evgenia Mandrusov | Method and apparatus for treating vulnerable plaque |
US7008411B1 (en) * | 2002-09-30 | 2006-03-07 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for treating vulnerable plaque |
US7326238B1 (en) | 2002-09-30 | 2008-02-05 | Abbott Cardiovascular Systems Inc. | Method and apparatus for treating vulnerable plaque |
US20050277611A1 (en) * | 2002-10-16 | 2005-12-15 | Neopharm, Inc. | Cationic cardiolipin analoges and its use thereof |
US8054468B2 (en) | 2003-01-24 | 2011-11-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US7297154B2 (en) * | 2003-02-24 | 2007-11-20 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
US7153299B1 (en) | 2003-02-24 | 2006-12-26 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
CA2519937C (en) * | 2003-03-31 | 2012-11-20 | Guillermo J. Tearney | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
US7515626B2 (en) * | 2003-05-29 | 2009-04-07 | Novera Optics, Inc. | Light source capable of lasing that is wavelength locked by an injected light signal |
EP2008579B1 (de) * | 2003-06-06 | 2016-11-09 | The General Hospital Corporation | Verfahren und Vorrichtung für eine Lichtquelle mit Abstimmung der Wellenlänge |
US20060078560A1 (en) * | 2003-06-23 | 2006-04-13 | Neopharm, Inc. | Method of inducing apoptosis and inhibiting cardiolipin synthesis |
US20050049228A1 (en) * | 2003-09-02 | 2005-03-03 | Ceramoptec Industries Inc. | Antimicrobial photodynamic therapy compound and method of use |
US20050053590A1 (en) * | 2003-09-05 | 2005-03-10 | The Texas A&M University System | Endothelium-targeting nanoparticle for reversing endothelial dysfunction |
EP3009815B1 (de) | 2003-10-27 | 2022-09-07 | The General Hospital Corporation | Verfahren und vorrichtung zur durchführung optischer abbildung mit frequenzdomäneninterferometrie |
DE10354496B4 (de) * | 2003-11-21 | 2011-03-31 | Siemens Ag | Medizinisches Untersuchungs- und/oder Behandlungssystem |
US7258697B1 (en) * | 2003-12-22 | 2007-08-21 | Advanced Cardiovascular Systems, Inc. | Stent with anchors to prevent vulnerable plaque rupture during deployment |
US20050254059A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometric system for optical metrology |
US7242480B2 (en) * | 2004-05-14 | 2007-07-10 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US7474408B2 (en) * | 2004-05-14 | 2009-01-06 | Medeikon Corporation | Low coherence interferometry utilizing phase |
WO2005117534A2 (en) | 2004-05-29 | 2005-12-15 | The General Hospital Corporation | Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging |
WO2006014392A1 (en) * | 2004-07-02 | 2006-02-09 | The General Hospital Corporation | Endoscopic imaging probe comprising dual clad fibre |
US20130040043A1 (en) * | 2004-08-04 | 2013-02-14 | Marian L. Larson | Method of coating medical devices including application of peptide linker coating |
JP5053845B2 (ja) | 2004-08-06 | 2012-10-24 | ザ ジェネラル ホスピタル コーポレイション | 光学コヒーレンス断層撮影法を使用して試料中の少なくとも1つの位置を決定するための方法、システムおよびソフトウェア装置 |
WO2006024015A1 (en) | 2004-08-24 | 2006-03-02 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
ATE538714T1 (de) | 2004-08-24 | 2012-01-15 | Gen Hospital Corp | Verfahren, system und software-anordnung zur bestimmung des elastizitätsmoduls |
CA2578205A1 (en) * | 2004-08-25 | 2006-03-30 | The Regents Of The University Of Michigan | Partially acetylated dendrimers and related methods of use |
EP1787105A2 (de) | 2004-09-10 | 2007-05-23 | The General Hospital Corporation | System und verfahren zur optischen kohärenzabbildung |
WO2006037132A1 (en) | 2004-09-29 | 2006-04-06 | The General Hospital Corporation | System and method for optical coherence imaging |
WO2006050058A2 (en) * | 2004-10-28 | 2006-05-11 | The General Hospital Corporation | Methods of detection and therapy of inflamed tissues using immune modulation |
US20080193376A1 (en) * | 2004-10-28 | 2008-08-14 | The General Hospital Corporation | Methods of Enhanced Detection and Therapy of Inflamed Tissues Using Immune Modulation |
EP1816949A1 (de) | 2004-11-29 | 2007-08-15 | The General Hospital Corporation | Anordnungen, vorrichtungen, endoskope, katheter und verfahren für die optische bilddarstellung durch gleichzeitige beleuchtung und nachweis von mehreren punkten auf einer probe |
AU2006214202A1 (en) * | 2005-02-17 | 2006-08-24 | Light Sciences Oncology, Inc. | Photoreactive system and methods for prophylactic treatment of atherosclerosis |
US7560227B2 (en) * | 2005-02-28 | 2009-07-14 | University Of Massachusetts | Biomarkers of vulnerable atherosclerotic plaques and methods of use |
US20060222592A1 (en) * | 2005-04-05 | 2006-10-05 | Clemens Burda | Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications |
EP2085929A1 (de) | 2005-04-28 | 2009-08-05 | The General Hospital Corporation | Beurteilung von optischen Kohärenztomographieinformationen für eine anatomische Struktur |
US20060271154A1 (en) * | 2005-05-25 | 2006-11-30 | Prescient Medical, Inc. | Methods and systems for treating vulnerable plaque |
US8355776B2 (en) | 2005-05-27 | 2013-01-15 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US8454511B2 (en) | 2005-05-27 | 2013-06-04 | Board Of Regents, The University Of Texas System | Magneto-motive ultrasound detection of magnetic nanoparticles |
CA2609965A1 (en) * | 2005-05-27 | 2006-11-30 | Board Of Regents, The University Of Texas System | Optical coherence tomographic detection of cells and compositions |
WO2007117572A2 (en) * | 2005-05-27 | 2007-10-18 | Board Of Regents, University Of Texas System | Optical coherence tomographic detection of cells and killing of the same |
JP5702049B2 (ja) | 2005-06-01 | 2015-04-15 | ザ ジェネラル ホスピタル コーポレイション | 位相分解光学周波数領域画像化を行うための装置、方法及びシステム |
US7874975B2 (en) * | 2005-07-20 | 2011-01-25 | Clear Vascular, Inc. | Methods and compositions for treating luminal inflammatory disease |
EP2207008A1 (de) | 2005-08-09 | 2010-07-14 | The General Hospital Corporation | Gerät und Verfahren zur Durchführung von polarisationsbasierter Quadraturdemulation bei optischer Kohärenztomographie |
EP1928306B1 (de) | 2005-09-29 | 2021-01-13 | General Hospital Corporation | OPTISCHES KOHÄRENZTOMOGRAFIESYSTEME UND VERFAHREN MIT MIKROSKOPISCHER Fluoreszensbildgebung VON EINER ODER MEHR BIOLOGISCHEN STRUKTUREN |
JP2007091673A (ja) * | 2005-09-29 | 2007-04-12 | Toshiba Corp | 血液循環促進剤、血液循環装置および血液循環促進医療システム |
US20070073364A1 (en) * | 2005-09-29 | 2007-03-29 | Siemens Aktiengesellschaft | Combined OCT catheter device and method for combined optical coherence tomography (OCT) diagnosis and photodynamic therapy (PDT) |
WO2007047690A1 (en) | 2005-10-14 | 2007-04-26 | The General Hospital Corporation | Spectral- and frequency- encoded fluorescence imaging |
JP5680826B2 (ja) | 2006-01-10 | 2015-03-04 | ザ ジェネラル ホスピタル コーポレイション | 1以上のスペクトルを符号化する内視鏡技術によるデータ生成システム |
US7842465B2 (en) * | 2006-01-17 | 2010-11-30 | Palo Alto Research Center Incorporated | Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection |
US8145018B2 (en) | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
EP2289398A3 (de) * | 2006-01-19 | 2011-04-06 | The General Hospital Corporation | Verfahren und Systeme zur optischen Bildgebung von epithelialen Luminalorganen durch Strahlenabtastung dieser |
JP5524487B2 (ja) | 2006-02-01 | 2014-06-18 | ザ ジェネラル ホスピタル コーポレイション | コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。 |
JP2009537024A (ja) * | 2006-02-01 | 2009-10-22 | ザ ジェネラル ホスピタル コーポレイション | 少なくとも一つのファイバの少なくとも二つの部位の少なくとも一つを制御する装置 |
EP2659851A3 (de) | 2006-02-01 | 2014-01-15 | The General Hospital Corporation | Vorrichtung zur Anwendung mehrerer elektromagnetischer Strahlungen auf einer Probe |
EP1988825B1 (de) | 2006-02-08 | 2016-12-21 | The General Hospital Corporation | Anordnungen und systeme zum abrufen von informationen im zusammenhang mit einer anatomischen probe mithilfe eines optischen mikroskops |
JP2007223966A (ja) * | 2006-02-24 | 2007-09-06 | Pentax Corp | 細胞表面又は組織表面染色剤組成物及びこれを用いた染色方法 |
EP1987318B1 (de) | 2006-02-24 | 2015-08-12 | The General Hospital Corporation | Verfahren und systeme zur durchführung von winkelaufgelöster optischer kohärenztomografie im fourier-bereich |
US8435276B2 (en) * | 2006-02-27 | 2013-05-07 | Thomas Perez | Method and apparatus for the combined application of light therapy, optic diagnosis, and fluid to tissue |
US20070208400A1 (en) * | 2006-03-01 | 2007-09-06 | The General Hospital Corporation | System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages |
CN101466298B (zh) | 2006-04-05 | 2011-08-31 | 通用医疗公司 | 用于样本的偏振敏感光频域成像的方法、装置和系统 |
US8187189B2 (en) | 2006-04-28 | 2012-05-29 | The Invention Science Fund I, Llc | Imaging via blood vessels |
WO2007130465A2 (en) * | 2006-05-02 | 2007-11-15 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
US7465312B2 (en) | 2006-05-02 | 2008-12-16 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
EP3150110B1 (de) | 2006-05-10 | 2020-09-02 | The General Hospital Corporation | Verfahren, anordnungen und systeme zur bereitstellung von frequenzbereichsabbildung einer probe |
US20080275432A1 (en) * | 2006-05-11 | 2008-11-06 | Ceramoptec Industries, Inc. | Photodynamic foam composition and sclerosis treatment |
US7782464B2 (en) | 2006-05-12 | 2010-08-24 | The General Hospital Corporation | Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images |
US7572625B2 (en) * | 2006-05-18 | 2009-08-11 | Boston Scientific Scimed, Inc. | Medical devices coated with drug carrier macromolecules |
US7488930B2 (en) * | 2006-06-02 | 2009-02-10 | Medeikon Corporation | Multi-channel low coherence interferometer |
AU2007289168A1 (en) * | 2006-08-29 | 2008-03-06 | Molecular Insight Pharmaceuticals, Inc. | Radioimaging moieties coupled to peptidase-binding moieties for imaging tissues and organs that express peptidases |
US8882674B2 (en) * | 2006-09-28 | 2014-11-11 | Research Foundation Of The City University Of New York | System and method for in vivo imaging of blood vessel walls to detect microcalcifications |
WO2008049118A2 (en) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s) |
WO2008067079A2 (en) * | 2006-10-20 | 2008-06-05 | Cardiospectra, Inc. | Method and apparatus to identify vulnerable plaques with thermal wave imaging of heated nanoparticles |
US8108030B2 (en) | 2006-10-20 | 2012-01-31 | Board Of Regents, The University Of Texas System | Method and apparatus to identify vulnerable plaques with thermal wave imaging of heated nanoparticles |
WO2008060833A2 (en) | 2006-10-24 | 2008-05-22 | The Research Foundation Of State University Of New York | Composition, method, system, and kit for optical electrophysiology |
US8000774B2 (en) * | 2007-01-03 | 2011-08-16 | Infraredx, Inc. | Method and system for intra luminal thrombus detection |
WO2008086376A2 (en) * | 2007-01-08 | 2008-07-17 | Light Sciences Oncology, Inc. | Therapeutic devices for the treatment of varicosity |
EP2102583A2 (de) * | 2007-01-19 | 2009-09-23 | The General Hospital Corporation | Vorrichtung und verfahren zur steuerung der entfernungsmessungstiefe bei der bildgebung im optischen frequenzbereich |
US7949019B2 (en) | 2007-01-19 | 2011-05-24 | The General Hospital | Wavelength tuning source based on a rotatable reflector |
WO2008118781A2 (en) | 2007-03-23 | 2008-10-02 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
US10534129B2 (en) | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
WO2008122056A2 (en) * | 2007-04-02 | 2008-10-09 | Case Western Reserve University | Medical apparatus and method associated therewith |
EP3473093B1 (de) | 2007-04-12 | 2020-10-28 | The General Hospital Corporation | Biomimetisches gefässnetz |
US8045177B2 (en) | 2007-04-17 | 2011-10-25 | The General Hospital Corporation | Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy |
US8115919B2 (en) | 2007-05-04 | 2012-02-14 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy |
US9375158B2 (en) | 2007-07-31 | 2016-06-28 | The General Hospital Corporation | Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging |
IL185128A0 (en) * | 2007-08-08 | 2008-01-06 | Kerber Tom | Irradiating strip catheter |
US7682089B2 (en) * | 2007-08-15 | 2010-03-23 | Rohlen Brooks H | System and method for positioning a probe |
US8480662B2 (en) * | 2007-08-22 | 2013-07-09 | Cardiac Pacemakers, Inc. | Systems and devices for photoablation |
JP5536650B2 (ja) | 2007-08-31 | 2014-07-02 | ザ ジェネラル ホスピタル コーポレイション | 自己干渉蛍光顕微鏡検査のためのシステムと方法、及び、それに関連するコンピュータがアクセス可能な媒体 |
US20090131801A1 (en) * | 2007-10-12 | 2009-05-21 | The General Hospital Corporation | Systems and processes for optical imaging of luminal anatomic structures |
WO2009059034A1 (en) | 2007-10-30 | 2009-05-07 | The General Hospital Corporation | System and method for cladding mode detection |
GB0803076D0 (en) * | 2008-02-20 | 2008-03-26 | Univ Ghent | Mucosal Membrane Receptor and uses thereof |
US7898656B2 (en) | 2008-04-30 | 2011-03-01 | The General Hospital Corporation | Apparatus and method for cross axis parallel spectroscopy |
WO2009137701A2 (en) | 2008-05-07 | 2009-11-12 | The General Hospital Corporation | System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy |
CN104939806B (zh) | 2008-05-20 | 2021-12-10 | 大学健康网络 | 用于基于荧光的成像和监测的装置和方法 |
WO2009155536A2 (en) | 2008-06-20 | 2009-12-23 | The General Hospital Corporation | Fused fiber optic coupler arrangement and method for use thereof |
EP2309923B1 (de) * | 2008-07-14 | 2020-11-25 | The General Hospital Corporation | Vorrichtung und verfahren für eine farbendoskopie |
US9204925B2 (en) * | 2008-08-14 | 2015-12-08 | The Cleveland Clinic Foundation | Apparatus and method for treating a neuromuscular defect |
KR20100030195A (ko) * | 2008-09-09 | 2010-03-18 | 서울대학교산학협력단 | 방사성 표지된 형광 실리카 나노파티클 및 이를 이용한 pet 및 형광 복합영상 측정방법 |
FR2935924B1 (fr) * | 2008-09-18 | 2010-11-12 | Sidel Participations | Dispositif et procede de mesure de la temperature de paroi d'une ebauche de recipient |
WO2010039861A2 (en) | 2008-09-30 | 2010-04-08 | The Regents Of The University Of Michigan | Dendrimer conjugates |
US8440167B2 (en) * | 2008-10-27 | 2013-05-14 | University Of Virginia Patent Foundation | Multimodal imaging of atherosclerotic plaque targeted to LOX-1 |
WO2010054321A2 (en) | 2008-11-07 | 2010-05-14 | The Regents Of The University Of Michigan | Methods of treating autoimmune disorders and/or inflammatory disorders |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
JP5355074B2 (ja) * | 2008-12-26 | 2013-11-27 | キヤノン株式会社 | 3次元形状データ処理装置、3次元形状データ処理方法及びプログラム |
US9615748B2 (en) | 2009-01-20 | 2017-04-11 | The General Hospital Corporation | Endoscopic biopsy apparatus, system and method |
JP2012515930A (ja) | 2009-01-26 | 2012-07-12 | ザ ジェネラル ホスピタル コーポレーション | 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体 |
CN104134928A (zh) | 2009-02-04 | 2014-11-05 | 通用医疗公司 | 利用高速光学波长调谐源的设备和方法 |
WO2010105197A2 (en) | 2009-03-12 | 2010-09-16 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s) |
WO2010144531A1 (en) * | 2009-06-09 | 2010-12-16 | Gary Wayne Jones | Method for selective photodynamic therapy and light source for implementation thereof |
CN102469943A (zh) | 2009-07-14 | 2012-05-23 | 通用医疗公司 | 用于测量脉管内流动和压力的设备、系统和方法 |
HU230008B1 (hu) * | 2009-09-01 | 2015-05-28 | Szegedi Tudományegyetem | Javított tonometriás eszköz a szervezet légzési elégtelenségének és regionális perfúzió-zavarának vizsgálatára |
CA2777682C (en) | 2009-10-13 | 2015-02-24 | The Regents Of The University Of Michigan | Dendrimer compositions and methods of synthesis |
WO2011059586A2 (en) | 2009-10-30 | 2011-05-19 | The Regents Of The University Of Michigan | Multifunctional small molecules |
US9211283B2 (en) * | 2009-12-11 | 2015-12-15 | Biolitec Pharma Marketing Ltd | Nanoparticle carrier systems based on human serum albumin for photodynamic therapy |
US20120022380A1 (en) * | 2010-01-19 | 2012-01-26 | Chernomorsky Ary S | Methods and apparatus for assesment and treatment of body cavities |
PT2542154T (pt) | 2010-03-05 | 2020-11-25 | Massachusetts Gen Hospital | Aparelho para proporcionar radiação eletromagnética a uma amostra |
US20130289520A1 (en) * | 2010-04-23 | 2013-10-31 | Children's Hospital Boston | Targeted and light-activated cytosolic drug delivery |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
WO2011150069A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
WO2011149972A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
EP2632324A4 (de) | 2010-10-27 | 2015-04-22 | Gen Hospital Corp | Vorrichtungen, systeme und verfahren zur blutdruckmessung in mindestens einem gefäss |
US9138148B2 (en) * | 2011-04-13 | 2015-09-22 | St. Jude Medical, Inc. | High speed elastographic property mapping of lumens utilizing micropalpation delivered from an OCT-equipped catheter tip |
JP6240064B2 (ja) | 2011-04-29 | 2017-11-29 | ザ ジェネラル ホスピタル コーポレイション | 散乱媒質の深さ分解した物理的及び/又は光学的特性を決定する方法 |
US9492113B2 (en) | 2011-07-15 | 2016-11-15 | Boston Scientific Scimed, Inc. | Systems and methods for monitoring organ activity |
WO2013013049A1 (en) | 2011-07-19 | 2013-01-24 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
US10241028B2 (en) | 2011-08-25 | 2019-03-26 | The General Hospital Corporation | Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures |
WO2013052848A1 (en) * | 2011-10-07 | 2013-04-11 | Boston Scientific Scimed, Inc. | Methods for detection and thermal treatment of lower urinary tract conditions |
US9265459B2 (en) | 2011-10-07 | 2016-02-23 | Boston Scientific Scimed, Inc. | Methods and systems for detection and thermal treatment of lower urinary tract conditions |
WO2013066631A1 (en) | 2011-10-18 | 2013-05-10 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US9402911B2 (en) | 2011-12-08 | 2016-08-02 | The Regents Of The University Of Michigan | Multifunctional small molecules |
EP2833776A4 (de) | 2012-03-30 | 2015-12-09 | Gen Hospital Corp | Abbildungssystem, verfahren und distaler anschluss zur multidirektionalen sichtfeldendoskopie |
WO2013152395A1 (en) * | 2012-04-13 | 2013-10-17 | Baker Idi Heart & Diabetes Institute Holdings Limited | Atherosclerotic plaque detection |
WO2013163187A1 (en) | 2012-04-23 | 2013-10-31 | The Regents Of The University Of Michigan | Systems and methods for targeted imaging and ablation of cardiac cells |
WO2013177154A1 (en) | 2012-05-21 | 2013-11-28 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
EP2888616A4 (de) | 2012-08-22 | 2016-04-27 | Gen Hospital Corp | System, verfahren, und über computer zugängliches medium zur herstellung eines miniaturendoskops mit weicher lithografie |
WO2014036470A1 (en) | 2012-08-31 | 2014-03-06 | Sloan-Kettering Institute For Cancer Research | Particles, methods and uses thereof |
CN103721257B (zh) * | 2012-10-16 | 2016-12-21 | 无锡兆真辐射技术有限公司 | 光敏素催化分解过氧化氢系列药物 |
US9968403B2 (en) * | 2012-10-16 | 2018-05-15 | Boston Scientific Scimed, Inc. | Surgical laser system and laser fiber |
JP6465811B2 (ja) | 2012-12-19 | 2019-02-06 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 多様式の粒子、方法およびその使用 |
EP2948758B1 (de) | 2013-01-28 | 2024-03-13 | The General Hospital Corporation | Vorrichtung zur bereitstellung von gemeinsam mit optischer frequenzdomänenbildgebung aufgezeichneter diffuser spektroskopie |
WO2014120791A1 (en) | 2013-01-29 | 2014-08-07 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
WO2014121082A1 (en) | 2013-02-01 | 2014-08-07 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
EP2958481A4 (de) | 2013-02-20 | 2017-03-08 | Sloan-Kettering Institute for Cancer Research | Ramanbildgebungsvorrichtung mit weitem sichtfeld und zugehörige verfahren |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
WO2014186353A1 (en) | 2013-05-13 | 2014-11-20 | The General Hospital Corporation | Detecting self-interefering fluorescence phase and amplitude |
US10117576B2 (en) | 2013-07-19 | 2018-11-06 | The General Hospital Corporation | System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina |
EP4349242A2 (de) | 2013-07-19 | 2024-04-10 | The General Hospital Corporation | Bildgebungsvorrichtung und verfahren mit multidirektionaler sichtfeldendoskopie |
WO2015013651A2 (en) | 2013-07-26 | 2015-01-29 | The General Hospital Corporation | System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography |
WO2015105870A1 (en) | 2014-01-08 | 2015-07-16 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
US11547300B2 (en) * | 2014-01-31 | 2023-01-10 | The General Hospital Corporation | Methods of treating and imaging tumor micrometastases using photoactive immunoconjugates |
WO2015116986A2 (en) | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
US10912947B2 (en) | 2014-03-04 | 2021-02-09 | Memorial Sloan Kettering Cancer Center | Systems and methods for treatment of disease via application of mechanical force by controlled rotation of nanoparticles inside cells |
WO2015153982A1 (en) | 2014-04-04 | 2015-10-08 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
ES2894912T3 (es) | 2014-07-24 | 2022-02-16 | Univ Health Network | Recopilación y análisis de datos con fines de diagnóstico |
ES2907287T3 (es) | 2014-07-25 | 2022-04-22 | Massachusetts Gen Hospital | Aparato para imagenología y diagnóstico in vivo |
US10175219B2 (en) * | 2014-07-28 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method to sort cells on the basis of radionuclide uptake |
CN106687146A (zh) | 2014-07-28 | 2017-05-17 | 纪念斯隆-凯特琳癌症中心 | 作为医学同位素的通用结合剂的(类)金属硫族纳米粒子 |
US20160058502A1 (en) * | 2014-08-27 | 2016-03-03 | Boston Scientific Scimed, Inc. | Devices for damaging nerves and related methods of use |
US10111936B2 (en) | 2015-01-19 | 2018-10-30 | Theralase Technologies, Inc. | Metal-glycoprotein complexes and photodynamic therapy of immune privileged sites with same |
US9737565B2 (en) | 2015-01-19 | 2017-08-22 | Theralase Technologies, Inc. | Metal-glycoprotein complexes and their use as chemotherapeutic compounds |
CA2990223A1 (en) | 2015-07-01 | 2017-01-05 | Memorial Sloan Kettering Cancer Center | Anisotropic particles, methods and uses thereof |
US20230368365A9 (en) * | 2015-08-14 | 2023-11-16 | Elucid Bioimaging Inc. | Quantitative imaging for detecting histopathologically defined plaque erosion non-invasively |
US20220012877A1 (en) * | 2015-08-14 | 2022-01-13 | Elucid Bioimaging Inc. | Quantitative imaging for detecting histopathologically defined plaque fissure non-invasively |
US11094058B2 (en) * | 2015-08-14 | 2021-08-17 | Elucid Bioimaging Inc. | Systems and method for computer-aided phenotyping (CAP) using radiologic images |
JP6785301B2 (ja) | 2015-11-04 | 2020-11-18 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 医療デバイス及びそれと関連する方法 |
KR101880613B1 (ko) * | 2017-09-29 | 2018-07-20 | 박우태 | 조명기능을 갖는 치아거울 |
CN108956564B (zh) * | 2018-06-21 | 2020-12-29 | 深圳市优迈医学科技有限公司 | 光敏剂浓度检测装置、系统以及方法 |
KR20210064240A (ko) * | 2018-10-22 | 2021-06-02 | 캘리포니아 인스티튜트 오브 테크놀로지 | 3d 엔지니어링된 재료에 기반한 컬러 및 다중-스펙트럼 이미지 센서 |
US11239276B2 (en) | 2019-10-18 | 2022-02-01 | California Institute Of Technology | CMOS color image sensors with metamaterial color splitting |
CN111707664A (zh) * | 2020-05-19 | 2020-09-25 | 西安交通大学 | 一种适用于超疏水表面的观测实验装置 |
US20230238135A1 (en) * | 2020-06-19 | 2023-07-27 | The General Hospital Corporation | Near-infrared autofluorescence imaging systems and methods |
TWI815720B (zh) * | 2022-11-03 | 2023-09-11 | 財團法人金屬工業研究發展中心 | 訊號傳輸元件 |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US618402A (en) * | 1899-01-31 | Flat stripping motion for carding engines | ||
US4141347A (en) * | 1976-09-21 | 1979-02-27 | Sri International | Real-time ultrasonic B-scan imaging and Doppler profile display system and method |
US4577636A (en) * | 1982-11-23 | 1986-03-25 | The Beth Israel Hospital Association | Method for diagnosis of atherosclerosis |
US4512762A (en) | 1982-11-23 | 1985-04-23 | The Beth Israel Hospital Association | Method of treatment of atherosclerosis and a balloon catheter for same |
US5104392A (en) * | 1985-03-22 | 1992-04-14 | Massachusetts Institute Of Technology | Laser spectro-optic imaging for diagnosis and treatment of diseased tissue |
US5693043A (en) * | 1985-03-22 | 1997-12-02 | Massachusetts Institute Of Technology | Catheter for laser angiosurgery |
US4920143A (en) | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
CA1340977C (en) * | 1988-11-15 | 2000-04-25 | Monty Krieger | Scavenger receptor protein and antibody thereto |
US4995396A (en) * | 1988-12-08 | 1991-02-26 | Olympus Optical Co., Ltd. | Radioactive ray detecting endoscope |
EP0449883B1 (de) * | 1988-12-21 | 1996-01-31 | Massachusetts Institute Of Technology | Verfahren für laserinduzierte fluoreszenz von gewebe |
US5046501A (en) * | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
US5008546A (en) * | 1990-06-18 | 1991-04-16 | The Regents Of The University Of California | Intraoperative beta probe and method of using the same |
US5197470A (en) * | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5116864A (en) * | 1991-04-09 | 1992-05-26 | Indiana University Foundation | Method for preventing restenosis following reconfiguration of body vessels |
US5169395A (en) * | 1991-04-26 | 1992-12-08 | Pdt Cardiovascular, Inc. | Laser delivery system |
JP3154742B2 (ja) * | 1991-04-30 | 2001-04-09 | 日本石油化学株式会社 | 哺乳類の動脈硬化症治療剤 |
US5364612A (en) * | 1991-05-06 | 1994-11-15 | Immunomedics, Inc. | Detection of cardiovascular lesions |
PT706373E (pt) * | 1992-03-23 | 2000-11-30 | Univ Georgetown | Taxol encapsulado num liposoma e um metodo |
EP0643583B1 (de) * | 1992-05-06 | 2000-07-26 | Immunomedics, Inc. | Intraoperative, intravaskulare und endoskopische bestimmung und behandlung von verletzungen und tumoren |
JPH05330716A (ja) * | 1992-05-25 | 1993-12-14 | Eastman Kodak Japan Kk | 排紙集積装置 |
US5807881A (en) | 1992-05-27 | 1998-09-15 | Quadra Logic Technologies, Inc. | Method for selectively reducing activated leukocyte cell population |
US5776966A (en) * | 1992-05-27 | 1998-07-07 | University Of British Columbia | Selective cell inactivation in blood |
US5298018A (en) | 1992-08-14 | 1994-03-29 | Pdt Cardiovascular, Inc. | Method for treating cardiovascular disease through adjunctive photodynamic therapy |
CA2144327C (en) * | 1992-09-21 | 2002-08-06 | Anna M. Richter | Transcutaneous in vivo activation of photosensitive agents in blood |
US5409710A (en) * | 1993-04-20 | 1995-04-25 | Endocon, Inc. | Foam cell drug delivery |
WO1995000605A1 (fr) | 1993-06-18 | 1995-01-05 | Aktsionernoe Obschestvo Otkrytogo Tipa 'yaroslavnefteorgsintez' | Procede permettant d'obtenir des benzenes a l'aide d'un catalyseur |
US5422362A (en) * | 1993-07-29 | 1995-06-06 | Quadra Logic Technologies, Inc. | Method to inhibit restenosis |
US5798349A (en) * | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
EP0775157B1 (de) | 1994-07-22 | 2001-10-31 | Duke University | Komplexe aus porphyrin und menschlichem serumalbumin mit der fähigkeit, sauerstoff zu binden, und deren therapeutische verwendungen |
US5639600A (en) | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
US5568532A (en) * | 1994-08-12 | 1996-10-22 | Southeastern Universities Research Association, Inc. | Examination system utilizing ionizing radiation and a flexible, miniature radiation detector probe |
US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US5789433A (en) * | 1995-01-17 | 1998-08-04 | Quadra Logic Technologies, Inc. | Green porphyrins as immunomodulators |
US6008211A (en) * | 1995-07-27 | 1999-12-28 | Pdt Pharmaceuticals, Inc. | Photoactivatable compounds comprising benzochlorin and furocoumarin |
US5760674A (en) * | 1995-11-28 | 1998-06-02 | International Business Machines Corporation | Fusible links with improved interconnect structure |
US5952329A (en) * | 1996-01-23 | 1999-09-14 | The General Hospital Corporation | Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors |
US5811814A (en) * | 1996-02-12 | 1998-09-22 | Cordis Corporation | Radiation measuring catheter apparatus and method |
US20030138411A1 (en) * | 1996-05-02 | 2003-07-24 | Glaxo Wellcome Inc. | Gene expression in monocytes and macrophages |
US6076009A (en) * | 1997-05-05 | 2000-06-13 | The University Of Michigan | Solid state beta-sensitive surgical probe |
US5932879A (en) * | 1996-05-07 | 1999-08-03 | Regents Of The University Of Michigan | Solid state beta-sensitive surgical probe |
US5744805A (en) * | 1996-05-07 | 1998-04-28 | University Of Michigan | Solid state beta-sensitive surgical probe |
US5834503A (en) | 1996-06-14 | 1998-11-10 | Qlt Phototherapeutics, Inc. | Methods to treat arterial plaque |
US5924997A (en) * | 1996-07-29 | 1999-07-20 | Campbell; Thomas Henderson | Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body |
US5829448A (en) * | 1996-10-30 | 1998-11-03 | Photogen, Inc. | Method for improved selectivity in photo-activation of molecular agents |
US6286514B1 (en) * | 1996-11-05 | 2001-09-11 | Jerome Lemelson | System and method for treating select tissue in a living being |
US6180402B1 (en) | 1996-11-20 | 2001-01-30 | Qlt Inc. | Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor |
US5919135A (en) * | 1997-02-28 | 1999-07-06 | Lemelson; Jerome | System and method for treating cellular disorders in a living being |
US6238348B1 (en) * | 1997-07-22 | 2001-05-29 | Scimed Life Systems, Inc. | Miniature spectrometer system and method |
US5864141A (en) * | 1997-07-23 | 1999-01-26 | Southeastern Univ. Research Assn. | Compact, high-resolution, gamma ray imaging for scintimammography and other medical diagostic applications |
CN1154489C (zh) * | 1997-08-14 | 2004-06-23 | 弗·哈夫曼-拉罗切有限公司 | 抗神经学疾病的杂环乙烯基醚 |
CA2302837A1 (en) | 1997-09-08 | 1999-03-18 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
US6033436A (en) * | 1998-02-17 | 2000-03-07 | Md3, Inc. | Expandable stent |
US6295680B1 (en) * | 1998-07-05 | 2001-10-02 | The Regents Of The University Of Michigan | Method for detecting early atherosclerosis and vascular damage using radioactive tracers and intravascular radiation detection devices |
US20020115649A1 (en) * | 1998-07-06 | 2002-08-22 | Pharmacyclics, Inc. | Use of texaphyrins in macrophage-mediated disease |
WO2000019889A1 (en) * | 1998-10-08 | 2000-04-13 | University Of Kentucky Research Foundation | Methods and apparatus for in vivo identification and characterization of vulnerable atherosclerotic plaques |
US6211349B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc., Inc. | Protonated/acidified nucleic acids and methods of use |
US6167297A (en) * | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
US6782289B1 (en) * | 1999-10-08 | 2004-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and apparatus for characterizing lesions in blood vessels and other body lumens |
US6716410B1 (en) * | 1999-10-26 | 2004-04-06 | The Regents Of The University Of California | Reagents and methods for diagnosing, imaging and treating atherosclerotic disease |
EP1224461B1 (de) * | 1999-10-26 | 2011-04-20 | The Regents of The University of California | Reagenzien und verfahren für diagnose, 'imaging' und behandlung von atherosklerotischen krankheiten |
US6750037B2 (en) * | 1999-12-27 | 2004-06-15 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
US7373197B2 (en) * | 2000-03-03 | 2008-05-13 | Intramedical Imaging, Llc | Methods and devices to expand applications of intraoperative radiation probes |
GB0121171D0 (en) * | 2001-08-31 | 2001-10-24 | Glaxosmithkline Biolog Sa | Vaccine |
JP4238476B2 (ja) * | 2000-12-08 | 2009-03-18 | 株式会社デンソー | 中間歯車付スタータ |
US6547812B1 (en) * | 2000-12-29 | 2003-04-15 | Advanced Cardiovascular Systems, Inc. | Radiation therapy using a radioactive implantable device and a radiosensitizer agent |
WO2002067761A2 (en) * | 2001-02-23 | 2002-09-06 | Bristol-Myers Squibb Pharma Company | Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque |
US6894161B2 (en) * | 2001-03-27 | 2005-05-17 | The University Of British Columbia | Methods and compositions for photo-cross linking photoactive compounds to target tissue |
US6764501B2 (en) * | 2001-04-10 | 2004-07-20 | Robert A. Ganz | Apparatus and method for treating atherosclerotic vascular disease through light sterilization |
WO2002096417A1 (en) * | 2001-05-31 | 2002-12-05 | Miravant Pharmaceuticals, Inc. | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis |
EP1401479B1 (de) | 2001-06-04 | 2007-04-18 | The General Hospital Corporation | Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen |
US20070264194A1 (en) * | 2001-08-10 | 2007-11-15 | The Scripps Research Institute | Peptides That Bind To Atherosclerotic Lesions |
US20030152513A1 (en) * | 2001-09-06 | 2003-08-14 | Imetrix, Inc. | Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector |
DE10226420A1 (de) * | 2002-06-13 | 2004-01-15 | Eucro European Contract Research Gmbh & Co Kg | Verfahren zur Behandlung der Artherosklerose |
CA2527196C (en) * | 2003-05-30 | 2012-10-16 | Purdue Research Foundation | Diagnostic method for atherosclerosis |
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2002
- 2002-06-04 EP EP02763205A patent/EP1401479B1/de not_active Expired - Lifetime
- 2002-06-04 DE DE60219627T patent/DE60219627T2/de not_active Expired - Lifetime
- 2002-06-04 JP JP2003509989A patent/JP2005502618A/ja active Pending
- 2002-06-04 US US10/163,744 patent/US20030103995A1/en not_active Abandoned
- 2002-06-04 AT AT02763205T patent/ATE359806T1/de not_active IP Right Cessation
- 2002-06-04 AU AU2002327180A patent/AU2002327180A1/en not_active Abandoned
- 2002-06-04 CA CA002449828A patent/CA2449828A1/en not_active Abandoned
- 2002-06-04 WO PCT/US2002/018472 patent/WO2003003975A2/en active Search and Examination
- 2002-08-09 US US10/215,958 patent/US20030082105A1/en not_active Abandoned
- 2002-08-09 US US10/215,600 patent/US7809428B2/en not_active Expired - Fee Related
- 2002-08-09 US US10/216,026 patent/US20060073100A1/en not_active Abandoned
- 2002-12-03 WO PCT/US2002/038852 patent/WO2003077723A2/en active Search and Examination
- 2002-12-03 EP EP02795747A patent/EP1575414A4/de not_active Withdrawn
- 2002-12-03 JP JP2003575782A patent/JP2005538751A/ja active Pending
- 2002-12-03 AU AU2002360488A patent/AU2002360488A1/en not_active Abandoned
- 2002-12-03 CA CA002478248A patent/CA2478248A1/en not_active Abandoned
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WO2003077723A3 (en) | 2007-07-12 |
AU2002327180A1 (en) | 2003-01-21 |
WO2003003975A2 (en) | 2003-01-16 |
DE60219627T2 (de) | 2008-02-07 |
AU2002360488A1 (en) | 2003-09-29 |
US20060073100A1 (en) | 2006-04-06 |
ATE359806T1 (de) | 2007-05-15 |
EP1401479A4 (de) | 2005-03-16 |
JP2005502618A (ja) | 2005-01-27 |
US20030082105A1 (en) | 2003-05-01 |
EP1401479A2 (de) | 2004-03-31 |
AU2002360488A8 (en) | 2003-09-29 |
US20030055307A1 (en) | 2003-03-20 |
WO2003077723A2 (en) | 2003-09-25 |
CA2478248A1 (en) | 2003-09-25 |
EP1575414A4 (de) | 2008-02-20 |
CA2449828A1 (en) | 2003-01-16 |
WO2003003975A3 (en) | 2003-12-11 |
US7809428B2 (en) | 2010-10-05 |
JP2005538751A (ja) | 2005-12-22 |
EP1575414A2 (de) | 2005-09-21 |
US20070258906A1 (en) | 2007-11-08 |
EP1401479B1 (de) | 2007-04-18 |
US20030103995A1 (en) | 2003-06-05 |
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8381 | Inventor (new situation) |
Inventor name: HAMBLIN, MICHAEL, R., BOSTON, MA 02114, US Inventor name: TAWAKOL, AHMED, BOSTON, MA 02114, US Inventor name: HASAN, TAYYABA, BOSTON, MA 02114, US Inventor name: FISCHMAN, ALAN, BOSTON, MA 02114, US Inventor name: MULLER, JAMES, BOSTON, MA 02114, US Inventor name: ANDERSON, ROX, BOSTON, MA 02114, US |
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