DE602005023308D1 - Stoffwechseltechnisch hergestellte zellen zur produktion mehrfach ungesättigter fettsäuren - Google Patents
Stoffwechseltechnisch hergestellte zellen zur produktion mehrfach ungesättigter fettsäurenInfo
- Publication number
- DE602005023308D1 DE602005023308D1 DE602005023308T DE602005023308T DE602005023308D1 DE 602005023308 D1 DE602005023308 D1 DE 602005023308D1 DE 602005023308 T DE602005023308 T DE 602005023308T DE 602005023308 T DE602005023308 T DE 602005023308T DE 602005023308 D1 DE602005023308 D1 DE 602005023308D1
- Authority
- DE
- Germany
- Prior art keywords
- expression
- pufas
- fatty acids
- heterologous
- metabolically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6431—Linoleic acids [18:2[n-6]]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6481—Phosphoglycerides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57724504P | 2004-06-04 | 2004-06-04 | |
PCT/DK2005/000372 WO2005118814A2 (en) | 2004-06-04 | 2005-06-03 | Metabolically engineered cells for the production of polyunsaturated fatty acids |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005023308D1 true DE602005023308D1 (de) | 2010-10-14 |
Family
ID=34956349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005023308T Active DE602005023308D1 (de) | 2004-06-04 | 2005-06-03 | Stoffwechseltechnisch hergestellte zellen zur produktion mehrfach ungesättigter fettsäuren |
Country Status (14)
Country | Link |
---|---|
US (1) | US7736884B2 (de) |
EP (1) | EP1766023B1 (de) |
JP (1) | JP4955540B2 (de) |
AT (1) | ATE479757T1 (de) |
AU (1) | AU2005250074B2 (de) |
BR (1) | BRPI0511236A (de) |
CA (1) | CA2568689A1 (de) |
DE (1) | DE602005023308D1 (de) |
DK (1) | DK1766023T3 (de) |
ES (1) | ES2351973T3 (de) |
NZ (1) | NZ552254A (de) |
PL (1) | PL1766023T3 (de) |
PT (1) | PT1766023E (de) |
WO (1) | WO2005118814A2 (de) |
Families Citing this family (77)
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US20050233030A1 (en) * | 2004-03-10 | 2005-10-20 | Broin And Associates, Inc. | Methods and systems for producing ethanol using raw starch and fractionation |
MXPA05009553A (es) * | 2003-03-10 | 2006-03-17 | Broin And Associates Inc | Metodo para producir etanol utilizando almidon como materia prima. |
EP1656449B1 (de) | 2003-08-21 | 2009-05-06 | Monsanto Technology LLC | Fettsäuredesaturasen aus primula |
ES2541537T3 (es) | 2004-04-16 | 2015-07-21 | Monsanto Technology, Llc | Expresión de desaturasas de ácido graso en maíz |
EP2363492A3 (de) | 2004-04-22 | 2012-03-14 | Commonwealth Scientific and Industrial Research Organisation | Synthese von langkettigen polyungesättigten Fettsäuren durch rekombinante Zellen |
CN103451246B (zh) | 2004-04-22 | 2018-02-16 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
CA2566252A1 (en) * | 2004-05-13 | 2005-12-01 | Novozymes North America, Inc. | A process of producing a fermentation product |
JP4587451B2 (ja) * | 2004-08-20 | 2010-11-24 | サントリーホールディングス株式会社 | ω3脂肪酸不飽和化活性を有するポリペプチドおよびそのポリペプチドをコードするポリヌクレオチドならびにそれらの利用 |
GB0503657D0 (en) | 2005-02-22 | 2005-03-30 | Fluxome Sciences As | Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof |
DE102005038036A1 (de) * | 2005-08-09 | 2007-02-15 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen |
US7919289B2 (en) | 2005-10-10 | 2011-04-05 | Poet Research, Inc. | Methods and systems for producing ethanol using raw starch and selecting plant material |
GB0603160D0 (en) * | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
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US7695950B2 (en) * | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
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CA2651402C (en) * | 2006-07-19 | 2016-04-05 | Monsanto Technology Llc | Fatty acid desaturases from tetraselmis suecica |
GB0614442D0 (en) | 2006-07-20 | 2006-08-30 | Fluxome Sciences As | Metabolically engineered cells for the production of pinosylvin |
CA2658483A1 (en) | 2006-07-21 | 2008-01-24 | Xyleco, Inc. | Conversion systems for biomass |
WO2008022963A2 (en) * | 2006-08-24 | 2008-02-28 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
US8816106B2 (en) | 2006-08-29 | 2014-08-26 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of fatty acids |
WO2008073275A2 (en) | 2006-12-07 | 2008-06-19 | E. I. Du Pont De Nemours And Company | Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids |
US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
US7943365B2 (en) * | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
US8765422B2 (en) | 2007-07-13 | 2014-07-01 | Dsm Nutritional Products Ag | D4 desaturases and D5 elongases |
BRPI0813547A2 (pt) * | 2007-07-23 | 2014-12-30 | Suntory Holdings Ltd | Composições de ácido graxo tendo uma nova taxa de ácido graxo |
CN101855347B (zh) | 2007-10-26 | 2013-05-15 | 三得利控股株式会社 | 新型atp:柠檬酸裂解酶基因 |
EP2211881A4 (de) * | 2007-11-01 | 2012-01-04 | Wake Forest University School Of Medicine | Zusammensetzungen und verfahren zur prävention und behandlung von krankheiten von säugetieren |
US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
GB0725075D0 (en) * | 2007-12-21 | 2008-01-30 | Fluxome Sciences As | Metabolically engineered fungal cells with increased content of polyunsaturated fatty acids |
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ES2575008T3 (es) | 2008-07-11 | 2016-06-23 | Nstitut National De La Recherche Agronomique (Inra) | Nuevas cepas de levadura mutantes capaces de acumular una gran cantidad de lípidos |
AR074364A1 (es) | 2008-11-18 | 2011-01-12 | Commw Scient Ind Res Org | Enzimas y metodo para producir acidos grasos omega -3 |
WO2010067352A1 (en) * | 2008-12-09 | 2010-06-17 | Ben Gurion University Of The Negev Research And Development Authority | Polyunsaturated fatty acid elongase |
US8450094B1 (en) * | 2009-03-03 | 2013-05-28 | Poet Research, Inc. | System for management of yeast to facilitate the production of ethanol |
WO2010102060A2 (en) * | 2009-03-03 | 2010-09-10 | Poet Research, Inc. | System for pre-treatment of biomass for the production of ethanol |
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EP2327776A1 (de) * | 2009-11-30 | 2011-06-01 | Institut National De La Recherche Agronomique | Verfahren zur Herstellung von sehr langkettigen Fettsäuren durch Gärung mit einer rekombinanten Yarrowia-Spezies |
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CN102220351A (zh) * | 2011-04-04 | 2011-10-19 | 山东农业大学 | 马铃薯致病疫霉△5去饱和酶基因PinD5的功能鉴定与应用 |
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CN105219789B (zh) | 2014-06-27 | 2023-04-07 | 联邦科学技术研究组织 | 包含二十二碳五烯酸的提取的植物脂质 |
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BRPI0511236A (pt) | 2007-11-27 |
US20060051847A1 (en) | 2006-03-09 |
CA2568689A1 (en) | 2005-12-15 |
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WO2005118814A3 (en) | 2006-03-09 |
AU2005250074B2 (en) | 2011-04-14 |
EP1766023A2 (de) | 2007-03-28 |
NZ552254A (en) | 2008-12-24 |
DK1766023T3 (da) | 2010-12-13 |
PT1766023E (pt) | 2010-12-09 |
JP4955540B2 (ja) | 2012-06-20 |
WO2005118814A9 (en) | 2006-02-09 |
WO2005118814A2 (en) | 2005-12-15 |
AU2005250074A1 (en) | 2005-12-15 |
EP1766023B1 (de) | 2010-09-01 |
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