DE602005020320D1 - Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten - Google Patents

Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten

Info

Publication number
DE602005020320D1
DE602005020320D1 DE602005020320T DE602005020320T DE602005020320D1 DE 602005020320 D1 DE602005020320 D1 DE 602005020320D1 DE 602005020320 T DE602005020320 T DE 602005020320T DE 602005020320 T DE602005020320 T DE 602005020320T DE 602005020320 D1 DE602005020320 D1 DE 602005020320D1
Authority
DE
Germany
Prior art keywords
implant
attachment
promoting
ifbm
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005020320T
Other languages
English (en)
Inventor
Paul T Hamilton
Mark W Grinstaff
Daniel J Kenan
Dale J Christensen
Wayne Fl Beyer
Robin Hyde-Deruyscher
Ray Edward Benson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affinergy Inc
Original Assignee
Affinergy Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinergy Inc filed Critical Affinergy Inc
Publication of DE602005020320D1 publication Critical patent/DE602005020320D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
DE602005020320T 2004-06-16 2005-06-15 Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten Active DE602005020320D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58001904P 2004-06-16 2004-06-16
US65133805P 2005-02-09 2005-02-09
US65174705P 2005-02-10 2005-02-10
PCT/US2005/021270 WO2006098744A2 (en) 2004-06-16 2005-06-15 Ifbm’s to promote attachment of target analytes

Publications (1)

Publication Number Publication Date
DE602005020320D1 true DE602005020320D1 (de) 2010-05-12

Family

ID=35784316

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005020320T Active DE602005020320D1 (de) 2004-06-16 2005-06-15 Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten

Country Status (8)

Country Link
US (15) US20060051396A1 (de)
EP (4) EP2138195A3 (de)
JP (1) JP2008504850A (de)
AT (1) ATE462451T1 (de)
CA (1) CA2569864A1 (de)
DE (1) DE602005020320D1 (de)
ES (1) ES2342551T3 (de)
WO (2) WO2006098744A2 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007819A2 (en) 2003-07-09 2005-01-27 Wisconsin Alumni Research Foundation Charge-dynamic polymers and delivery of anionic compounds
DK1661910T3 (da) * 2003-07-30 2013-12-16 Japan Science & Tech Agency Peptider, der er i stand til at binde til titan, sølv og silicium
EP2138195A3 (de) 2004-06-16 2010-07-21 Affinergy Inc. Grenzflächenbiomaterialien zur Förderung der Anhaftung von Zielanalyten
US20070099245A1 (en) * 2005-09-29 2007-05-03 Boris Gorovits Assays for neutralizing antibodies
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
US20080015138A1 (en) * 2006-07-17 2008-01-17 Affinergy, Inc. Metal binding compounds, metal binding compositions, and their uses
EP2089072B1 (de) * 2006-09-06 2014-06-04 Boston Scientific Limited Medizinprodukte mit einer beschichtung zur förderung der adhäsion von endothelzellen
US8834918B2 (en) * 2007-01-22 2014-09-16 Wisconsin Alumni Research Foundation Modified multilayered film
KR20100014404A (ko) * 2007-02-13 2010-02-10 폴 에이치 나이 개인용 어펙터 기계
US20090018642A1 (en) * 2007-03-15 2009-01-15 Boston Scientific Scimed, Inc. Methods to improve the stability of celluar adhesive proteins and peptides
US7977313B2 (en) * 2007-04-27 2011-07-12 Affinergy, Inc. Methods and compositions for promoting localization of pharmaceutically active agents to bone
WO2008150375A1 (en) * 2007-06-01 2008-12-11 Arrow International, Inc. Combined fibrinolytic and antimicrobial catheter and uses thereof
JP2009051773A (ja) * 2007-08-27 2009-03-12 Toyobo Co Ltd 細胞接着能を有するｈｓｐ７０ファミリータンパク質
US8067021B2 (en) 2007-09-04 2011-11-29 Affinergy, Inc. Methods and compositions for delivery of growth factor to fibrous connective tissue
WO2009049092A1 (en) * 2007-10-09 2009-04-16 Wisconsin Alumni Research Foundation Covalent assembly of ultrathin polymeric films
US20090105375A1 (en) * 2007-10-09 2009-04-23 Lynn David M Ultrathin Multilayered Films for Controlled Release of Anionic Reagents
US8637455B2 (en) 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
WO2009054967A2 (en) * 2007-10-22 2009-04-30 Synthes (U.S.A.) Compositions for delivery of glycopeptide antibiotics
WO2009055313A1 (en) * 2007-10-22 2009-04-30 Affinergy Inc. Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
US20090246249A1 (en) * 2008-03-27 2009-10-01 Affinergy Coating compositions having improved performance
US8324333B2 (en) * 2008-06-05 2012-12-04 Wisconsin Alumni Research Foundation Anionic charge-dynamic polymers for release of cationic agents
KR20110042107A (ko) 2008-08-07 2011-04-22 바이오엑티브 써지컬, 아이엔씨. 의료 장치 및 이식물을 위한 줄기 세포 포획 및 고정화 코팅
US7700923B2 (en) * 2008-09-20 2010-04-20 Varian Medical Systems, Inc. Apparatus of photoconductor crystal growth
EP3670524A1 (de) 2008-09-24 2020-06-24 Tel HaShomer Medical Research Infrastructure and Services Ltd. Peptide und zusammensetzungen zur verhinderung der zelladhäsion und verfahren zur verwendung davon
US20100098737A1 (en) * 2008-10-17 2010-04-22 Affinergy, Inc. methods and compositions for delivery of glycopeptide antibiotics to medical device surfaces
EP2387376A4 (de) * 2009-01-19 2014-04-23 Cochlear Ltd Oberflächenveränderung für implantierbare medizinische vorrichtung
WO2010085510A1 (en) 2009-01-20 2010-07-29 Zadeh Homayoun H Antibody mediated osseous regeneration
US8545459B2 (en) * 2009-02-25 2013-10-01 Teleflex Medical Incorporated Stabilized enzyme compositions
US9333280B2 (en) 2009-02-25 2016-05-10 Teleflex Medical Incorporated Stabilized enzyme compositions
US8574612B2 (en) * 2009-03-04 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having a coating of biologic macromolecules
US20100249783A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Drug-eluting implant cover
US9414864B2 (en) 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
US9078712B2 (en) * 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US8079737B2 (en) * 2009-04-20 2011-12-20 Harvatek Corporation Reflection-type light-emitting module with high heat-dissipating and high light-generating efficiency
WO2011060076A1 (en) * 2009-11-10 2011-05-19 Amgen Inc. Anti-c-mpl antibodies
WO2011063140A2 (en) * 2009-11-18 2011-05-26 Affinergy, Inc. Implantable bone graft materials
WO2011115812A2 (en) * 2010-03-16 2011-09-22 Advanced Technologies And Regenerative Medicine, Llc Affinity peptides toward bmp-2
US8707950B1 (en) * 2010-08-04 2014-04-29 Darren Rubin Universal medical gas delivery system
US11628267B2 (en) 2010-08-04 2023-04-18 Medline Industries, Lp Universal medical gas delivery system
US9186243B2 (en) * 2011-05-31 2015-11-17 Novartis Ag Accommodative intraocular lens and method of implantation
US9586381B1 (en) 2013-10-25 2017-03-07 Steriplate, LLC Metal plated object with biocidal properties
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016176146A1 (en) * 2015-04-26 2016-11-03 The Trustees Of Princeton University Surfaces comprising attached quorum sensing modulators
US9999899B2 (en) 2016-11-01 2018-06-19 International Business Machines Corporation Controlled exposure of in-vivo sensors
WO2019232280A1 (en) * 2018-05-30 2019-12-05 Purdue Research Foundation Targeting anabolic drugs for accelerated fracture repair
EP3810637A1 (de) * 2018-06-20 2021-04-28 DWI - Leibniz-Institut für Interaktive Materialien e.V. Fusionspeptide oder -proteine, deren verwendung und darauf basierende systeme und kits zur trennung und/oder zum nachweis von kunststoffen, insbesondere von mikrokunststoffen
KR20210066006A (ko) 2018-10-12 2021-06-04 세러댑티브, 인크. 베타-인산삼칼슘 결합 서열을 포함하는 폴리펩티드 및 이의 용도
EP3952881A4 (de) * 2019-04-12 2023-01-04 Azura Ophthalmics Ltd. Zusammensetzungen und verfahren zur behandlung von kontaktlinsenbeschwerden
US20210154403A1 (en) * 2019-11-25 2021-05-27 Thomas Leroy Schmitz Joint capsule fluid delivery
JP2023510499A (ja) 2020-01-10 2023-03-14 アズーラ オフサルミックス エルティーディー． 組成物および過敏症のための指示
US20230174814A1 (en) * 2020-04-27 2023-06-08 Board Of Trustees Of The University Of Arkansas Cellulose Based Anti-Viral Anti-Microbial Spray Coating
US11141528B1 (en) 2020-12-14 2021-10-12 Thomas Leroy Schmitz Therapeutic fluid delivery cartridge

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA92121A (en) 1904-11-07 1905-03-14 William Waid Paddock Pressure filter
US4244946A (en) 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
FR2501680A1 (fr) 1981-03-12 1982-09-17 Elf Aquitaine Synthese de tetra mercaptides stanniques
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4526909A (en) 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US5079342A (en) * 1986-01-22 1992-01-07 Institut Pasteur Cloned DNA sequences related to the entire genomic RNA of human immunodeficiency virus II (HIV-2), polypeptides encoded by these DNA sequences and use of these DNA clones and polypeptides in diagnostic kits
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5543394A (en) 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5344654A (en) 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US6261271B1 (en) 1989-01-18 2001-07-17 Becton Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
JPH0327172A (ja) 1989-06-19 1991-02-05 Nissan Chem Ind Ltd 布の漂白方法
US5635482A (en) * 1989-08-14 1997-06-03 The Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
DE4002897A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
AP237A (en) 1990-05-29 1993-04-29 Cedars Sinai Medical Center Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use.
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5520664A (en) 1991-03-01 1996-05-28 Spire Corporation Catheter having a long-lasting antimicrobial surface treatment
US5652118A (en) 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
DK0591392T3 (da) 1991-06-21 1996-09-30 Genetics Inst Farmaceutiske formuleringer af osteogene proteiner
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
US5681575A (en) 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
ATE187494T1 (de) * 1992-12-11 1999-12-15 Dow Chemical Co Multivalente einkettige antikörper
WO1995000547A1 (en) * 1993-06-22 1995-01-05 E.I. Du Pont De Nemours And Company Antimicrobial composition of a polymer and a peptide forming amphiphilic helices of the magainin-type
US6361526B1 (en) 1993-11-01 2002-03-26 Medtronic Xomed, Inc. Antimicrobial tympanostomy tube
EP0754756B1 (de) * 1994-03-04 2005-11-09 Ajinomoto Co., Inc. Verfahren für die herstellung von l-lysin
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
JPH07313169A (ja) * 1994-05-26 1995-12-05 Nippon Ham Kk 骨形成因子受容体改変体の遺伝子
DE69526665T2 (de) 1994-09-21 2002-11-21 Cytogen Corp Antigen bindende peptide (abtides) aus peptidbibliotheken
US6746482B2 (en) * 1994-10-17 2004-06-08 Baxter International Inc. Method for producing medical devices and devices so produced
WO1996013583A2 (en) * 1994-10-20 1996-05-09 Morphosys Gesellschaft Für Proteinoptimierung Mbh Targeted hetero-association of recombinant proteins to multi-functional complexes
DE4441124C2 (de) 1994-11-18 1997-03-27 Heraeus Kulzer Gmbh Verfahren zur Erzeugung eines haftfesten, feuchtigkeitsdichten Überzugs aus Kunststoff auf einer Unterlage und dessen Verwendung
US6071890A (en) 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
AUPN024994A0 (en) * 1994-12-23 1995-01-27 Ludwig Institute For Cancer Research Assay and peptides for use therein
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX
US5624704A (en) 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US5702892A (en) 1995-05-09 1997-12-30 The United States Of America As Represented By The Department Of Health And Human Services Phage-display of immunoglobulin heavy chain libraries
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
US5709672A (en) 1995-11-01 1998-01-20 Texas Tech University Health Sciences Center Silastic and polymer-based catheters with improved antimicrobial/antifungal properties
IE80466B1 (en) * 1995-11-10 1998-07-29 Elan Corp Plc Peptides which enhance transport across tissues and methods of identifying and using the same
FR2741892B1 (fr) 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US6031071A (en) 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
EP0800901B1 (de) 1996-04-10 2003-07-02 Dieffenbacher Schenck Panel GmbH Verfahren zur Herstellung eines Vlieses und Vorrichtung
NZ334517A (en) * 1996-09-04 2000-03-27 Mogen Internat Nv Antifungal plant proteins and method of inhibiting fungal growth with carbohydrate oxidising activity and DNA coding sequences thereof
US6617114B1 (en) * 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
US5756332A (en) * 1996-12-26 1998-05-26 Incyte Pharmaceuticals, Inc. Guanosine monophosphate reductase
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
EP0983095B1 (de) 1997-05-22 2004-09-29 Biomet Deutschland GmbH Peptid-beschichtete implantate und verfahren zu ihrer herstellung
AU2783899A (en) * 1998-02-26 1999-09-15 Human Genome Sciences, Inc. 36 human secreted proteins
US6281331B1 (en) 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6121236A (en) * 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6428579B1 (en) * 1998-07-01 2002-08-06 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
AU5390699A (en) * 1998-07-24 2000-02-14 Pharmacal Biotechnologies, Inc. Osseous tissue reconstruction system and method
US20030236190A1 (en) * 1998-09-02 2003-12-25 Renuka Pillutla Isulin and IGF-1 receptor agonists and antagonists
US7176275B2 (en) * 1998-09-04 2007-02-13 Samuel Bogoch Anthrax and small pox replikins and methods of use
US6410713B1 (en) * 1998-11-20 2002-06-25 Vincent Guerriero DNA encoding proteins that inhibit Hsp70 function
US7090973B1 (en) * 1999-04-09 2006-08-15 Oscient Pharmaceuticals Corporation Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics
US6884628B2 (en) * 1999-04-28 2005-04-26 Eidgenossische Technische Hochschule Zurich Multifunctional polymeric surface coatings in analytic and sensor devices
US6544768B1 (en) * 1999-05-11 2003-04-08 Cornell Research Foundation, Inc. Mammalian soluble adenylyl cyclase
EP1203016A2 (de) * 1999-08-09 2002-05-08 Incyte Genomics, Inc. Protease und proteaseinhibitoren
US7304127B2 (en) * 1999-08-27 2007-12-04 United States Of America As Represented By The Secretary, Department Of Health And Human Services Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
CA2385480A1 (en) * 1999-09-24 2001-03-29 Human Genome Sciences, Inc. 32 human secreted proteins
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
WO2001056627A1 (en) * 2000-01-12 2001-08-09 Am-Pharma B.V. Medical device coated with antimicrobial peptides
WO2001068158A1 (en) * 2000-03-15 2001-09-20 Orbus Medical Technologies Inc. Coating that promotes endothelial cell adherence
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
WO2001075179A2 (en) * 2000-03-31 2001-10-11 Ludwig Institute For Cancer Research Preprocalcitonin as tumor rejection antigen precursor and uses thereof
EP1142596A1 (de) * 2000-04-03 2001-10-10 Universiteit Gent Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
US6716811B1 (en) * 2000-07-20 2004-04-06 Affymax, Inc. Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses
WO2002012271A2 (en) * 2000-08-04 2002-02-14 Jeffrey Howard Treatment of microbial infections with bacterial proteins and peptides
DE10040105A1 (de) * 2000-08-17 2002-02-28 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
WO2002016587A2 (en) * 2000-08-21 2002-02-28 Incyte Genomics, Inc. Microtubule-associated proteins and tubulins
IL155204A0 (en) * 2000-10-02 2003-11-23 Arizeke Pharmaceuticals Inc Compositions and methods for the transport of biologically active agents across cellular barriers
WO2002088375A2 (en) * 2000-10-27 2002-11-07 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
US20030003440A1 (en) * 2001-03-14 2003-01-02 Lucia Lopalco Novel CCR5 epitope and antibodies against it
JP2004536818A (ja) * 2001-06-08 2004-12-09 スミス　アンド　ネフュー　ピーエルシー 骨または軟骨再生における使用のためのｂｍｐ結合タンパク質
EP1421111A2 (de) * 2001-08-08 2004-05-26 Incyte Genomics, Inc. Mit zellwachstum, -differenzierung und -tod assoziierte proteine
DE60230046D1 (de) 2001-08-10 2009-01-08 Novartis Ag Peptide, die atherosklerotische schädigungen binden
JP4933708B2 (ja) 2001-08-31 2012-05-16 善彦 西村 骨形成作用を有する新規なペプチドおよびこれを固定化してなる骨形成促進剤
US6596338B2 (en) 2001-10-24 2003-07-22 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
JP2005518442A (ja) * 2001-11-20 2005-06-23 デューク・ユニバーシティー 界面バイオマテリアル
US7381426B2 (en) * 2002-01-24 2008-06-03 Southwest Research Institute Targeted delivery of bioactive factors to the systemic skeleton
US7355022B2 (en) * 2002-02-12 2008-04-08 Licentia Ltd. Gene functionally related to dyslexia
AU2003213246A1 (en) * 2002-02-21 2003-09-09 University Of Virginia Patent Foundation Bone targeting peptides
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
EP2073013B1 (de) * 2002-04-12 2016-01-06 Omeros Corporation Verfahren zur Identifizierung transmembraner Protein-interagierender Verbindungen
WO2003093314A2 (en) 2002-05-03 2003-11-13 Millenium Biologix Inc. Connective tissue stimulating peptides
US7635752B2 (en) * 2002-05-03 2009-12-22 Mayo Foundation For Medical Education And Research Ablated SLAM-Dependent Entry
US7449480B2 (en) * 2002-05-14 2008-11-11 Baylor College Of Medicine Small molecule inhibitors of HER2 expression
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
US7166574B2 (en) 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
WO2004035612A2 (en) * 2002-09-04 2004-04-29 Board Of Regents, University Of Texas System Composition, method and use of bi-functional biomaterials
US7238669B2 (en) 2002-09-11 2007-07-03 The Curators Of The University Of Missouri Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae
US7282214B2 (en) 2002-12-19 2007-10-16 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
US7163920B2 (en) * 2003-09-30 2007-01-16 Ethicon, Inc. Peptide with osteogenic activity
US8188219B2 (en) 2004-01-28 2012-05-29 The Regents Of The University Of California Bone morphogenic protein binding peptide
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
KR101013999B1 (ko) 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
EP2138195A3 (de) 2004-06-16 2010-07-21 Affinergy Inc. Grenzflächenbiomaterialien zur Förderung der Anhaftung von Zielanalyten
US7807624B2 (en) 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices

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US7795383B2 (en) 2010-09-14
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US8022184B2 (en) 2011-09-20
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US20100324262A1 (en) 2010-12-23
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US8022183B2 (en) 2011-09-20
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US7812119B2 (en) 2010-10-12
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US7968677B2 (en) 2011-06-28
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