DE602005009322D1 - Verfahren zur bestimmung der auswirkungen einer substanz auf ein organ - Google Patents

Verfahren zur bestimmung der auswirkungen einer substanz auf ein organ

Info

Publication number
DE602005009322D1
DE602005009322D1 DE602005009322T DE602005009322T DE602005009322D1 DE 602005009322 D1 DE602005009322 D1 DE 602005009322D1 DE 602005009322 T DE602005009322 T DE 602005009322T DE 602005009322 T DE602005009322 T DE 602005009322T DE 602005009322 D1 DE602005009322 D1 DE 602005009322D1
Authority
DE
Germany
Prior art keywords
organ
substance
hypothermic
transport
storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005009322T
Other languages
English (en)
Inventor
John Brassil
Douglas Schein
Christopher G Curtis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organ Recovery Systems Inc
Original Assignee
Organ Recovery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organ Recovery Systems Inc filed Critical Organ Recovery Systems Inc
Publication of DE602005009322D1 publication Critical patent/DE602005009322D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0236Mechanical aspects
    • A01N1/0242Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
DE602005009322T 2004-02-02 2005-01-27 Verfahren zur bestimmung der auswirkungen einer substanz auf ein organ Active DE602005009322D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/768,167 US7749693B2 (en) 1998-09-29 2004-02-02 Method of determining that an organ is not suitable for transplantation and using it for testing substances
PCT/US2005/003008 WO2005074681A2 (en) 2004-02-02 2005-01-27 Apparatus and method for determining effects of a substance on an organ

Publications (1)

Publication Number Publication Date
DE602005009322D1 true DE602005009322D1 (de) 2008-10-09

Family

ID=34837790

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005009322T Active DE602005009322D1 (de) 2004-02-02 2005-01-27 Verfahren zur bestimmung der auswirkungen einer substanz auf ein organ

Country Status (9)

Country Link
US (1) US7749693B2 (de)
EP (1) EP1711816B1 (de)
JP (1) JP5329760B2 (de)
CN (1) CN1985170A (de)
AT (1) ATE406576T1 (de)
CA (1) CA2554872C (de)
DE (1) DE602005009322D1 (de)
ES (1) ES2314627T3 (de)
WO (1) WO2005074681A2 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US8741555B2 (en) * 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
NZ614472A (en) 2004-10-07 2015-03-27 Transmedics Inc Systems and methods for ex-vivo organ care
US7956752B2 (en) 2005-01-14 2011-06-07 Matthew Henderson Transponder bolt seal and a housing for a transponder
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US20070048725A1 (en) * 2005-08-25 2007-03-01 Arrington Ben O'mar Machine perfusion of tissue grafts for transplantation
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
US8834399B2 (en) * 2010-12-07 2014-09-16 Zoll Lifebridge Gmbh Cardiopulmonary apparatus and methods for preserving organ viability
CA2881613C (en) 2006-04-19 2017-11-14 Stanley Kyi Systems and methods for ex vivo organ care
CA2679827C (en) * 2007-03-01 2014-11-25 Lifeline Scientific, Inc. Perfusion regulation
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
US8765364B2 (en) * 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
US9814230B2 (en) 2008-01-31 2017-11-14 Transmedics, Inc. Systems and methods for ex vivo lung care
FR2937500B1 (fr) 2008-10-23 2010-12-24 Maco Pharma Sa Ensemble pour la preparation d'organes a transplanter
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
WO2011140241A2 (en) 2010-05-04 2011-11-10 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US8882693B2 (en) * 2010-12-07 2014-11-11 Zoll Lifebridge Gmbh Cardiopulmonary apparatus and methods for preserving life
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8835158B2 (en) 2011-03-15 2014-09-16 Paragonix Technologics, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
AU2012242578B2 (en) 2011-04-14 2016-07-21 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
CA2838537C (en) * 2011-06-09 2020-09-29 Lifeline Scientific, Inc. Data record for organ transport and/or storage, comprising biomarker and events information
US9057712B1 (en) 2011-10-27 2015-06-16 Copilot Ventures Fund Iii Llc Methods of delivery of encapsulated perfluorocarbon taggants
US9402389B2 (en) 2012-07-10 2016-08-02 Lifeline Scientific, Inc. Organ transport apparatus with sample compartments
US20140017666A1 (en) 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Filtration in organ perfusion apparatus
US9357766B2 (en) 2012-07-10 2016-06-07 Lifeline Scientific, Inc. Organ transport apparatus with a document compartment and a tamper evident seal
US11439143B2 (en) 2012-07-10 2022-09-13 Lifeline Scientific, Inc. Temperature sensing in organ preservation apparatus
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
CN102813559B (zh) * 2012-08-27 2014-11-05 山东大学 一种全自动灌流装置
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue
US9629358B2 (en) * 2013-03-15 2017-04-25 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids
US20140278468A1 (en) 2013-03-15 2014-09-18 I.D. Therapeutics Llc Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor
CN103519931B (zh) * 2013-10-30 2015-03-11 安徽英特电子有限公司 水浴槽自动进排水结构
US10918102B2 (en) 2014-03-13 2021-02-16 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
BR112016021971B1 (pt) * 2014-03-26 2022-05-17 Tevosol, Inc. Sistema portátil para perfusar corações extirpados de doadores
WO2015182019A1 (ja) * 2014-05-30 2015-12-03 Sbiファーマ株式会社 臓器保存液
CN113287600B (zh) 2014-06-02 2022-08-19 特兰斯迈迪茨公司 对离体肝脏灌注的灌注回路和系统以及对其保存的系统
DK3154656T3 (da) * 2014-06-16 2022-02-28 Siemens Healthcare Diagnostics Inc Fluid indretning og fremgangsmåde til afgasning
USD765874S1 (en) 2014-10-10 2016-09-06 Paragonix Technologies, Inc. Transporter for a tissue transport system
AU2015366148B2 (en) * 2014-12-19 2020-03-19 Institut D'investigacions Biomèdiques August Pi I Sunyer (Idibaps) Preservation and transport of an ex vivo biological sample comprising ultrasound application
CN112933394B (zh) 2015-09-09 2023-10-24 特兰斯迈迪茨公司 用于在离体器官护理系统中使用的主动脉插管
US10091986B2 (en) * 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
CN106508890A (zh) * 2016-10-28 2017-03-22 中山大学附属第医院 多器官保存装置
US10695157B2 (en) * 2017-01-10 2020-06-30 Musculoskeletal Transplant Foundation Packaging system for tissue grafts
US11375710B2 (en) * 2017-01-10 2022-07-05 Musculoskeletal Transplant Foundation Packaging system for tissue grafts
EP3634127A4 (de) 2017-06-07 2021-03-17 Paragonix Technologies Inc. Vorrichtung zum transport und zur konservierung von gewebe
CN106990077A (zh) * 2017-06-15 2017-07-28 福建师范大学 一种基于多光子显微与微流控芯片技术的高通量筛选系统
US11399536B2 (en) 2017-09-15 2022-08-02 The Cleveland Clinic Foundation Device for support of an organ ex vivo
US10582994B2 (en) 2018-03-06 2020-03-10 Musculoskeletal Transplant Foundation Implant packaging assembly
CN110511866A (zh) * 2018-05-21 2019-11-29 深圳华大生命科学研究院 一种多器官芯片及其制备方法和应用
JP2020002062A (ja) * 2018-06-28 2020-01-09 株式会社Screenホールディングス 灌流装置および灌流方法
CN110663680A (zh) * 2019-10-25 2020-01-10 上海长海医院 一种供肾的机器灌注保存及转运仪器
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
ES2869454A1 (es) * 2020-04-24 2021-10-25 Ebers Medical Tech S L Dispositivo de perfusion normotermica adaptado para mantener en condiciones fisiologicas optimas un higado o un rinon
USD954993S1 (en) 2020-06-17 2022-06-14 Musculoskeletal Transplant Foundation Tissue graft retainer
US20230284613A1 (en) * 2022-03-17 2023-09-14 Deka Products Limited Partnership System and method for tissue maintenance, assessment, maturation, and rehabilitation

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1682344A (en) * 1928-08-28 lesieur
FR545332A (fr) 1921-12-29 1922-10-10 Cie Ingersoll Rand Raccord à montage instantané pour tuyauteries
US1916658A (en) * 1931-10-09 1933-07-04 Louis R Davidson Pneumothorax apparatus
US3406531A (en) * 1964-08-25 1968-10-22 Emil S. Swenson Apparatus for maintaining organs in a completely viable state
US3545221A (en) * 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
FR1577356A (de) * 1968-04-04 1969-08-08
SE323475B (de) * 1968-11-26 1970-05-04 Aga Ab
US3772153A (en) * 1969-04-02 1973-11-13 Air Liquide Apparatus for the preservation of animal or human organs in living condition
US3632473A (en) * 1969-04-21 1972-01-04 Univ California Method and apparatus for preserving human organs extracorporeally
BE755423A (fr) * 1969-10-06 1971-02-01 Baxter Laboratories Inc Procede et appareil pour la conservation d'organes
US3892628A (en) * 1969-10-06 1975-07-01 Baxter Laboratories Inc Preservation of organs
US3660241A (en) * 1970-01-12 1972-05-02 Baxter Laboratories Inc Container for organ perfusion or the like
US3639084A (en) * 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
US3810367A (en) * 1970-07-16 1974-05-14 W Peterson Container for cooling, storage, and shipping of human organ for transplant
US3712583A (en) 1971-01-25 1973-01-23 Ametek Inc Valved for lines carrying extreme temperature fluids
US3753865A (en) * 1971-03-12 1973-08-21 Univ California Method and apparatus for preserving human organs extracorporeally
AT313466B (de) 1971-06-09 1974-02-25 Waagner Biro Ag Organperfusionsapparat
DE2241698C2 (de) * 1971-09-02 1982-08-26 Roland Dr.med. Zürich Doerig Verfahren zur Organerhaltung sowie Vorrichtung zum Durchführen dieses Verfahrens
US3935065A (en) * 1971-09-02 1976-01-27 Roland Karl Doerig Procedure for conservation of living organs and apparatus for the execution of this procedure
US3881990A (en) * 1971-11-24 1975-05-06 Waters Instr Inc Method of transporting and storing organs while retaining the organs in a viable condition
US3777507A (en) 1971-11-24 1973-12-11 Waters Instr Inc Renal preservation system
FR2169488A5 (de) * 1972-01-27 1973-09-07 Air Liquide
US3843455A (en) * 1972-09-13 1974-10-22 M Bier Apparatus and technique for preservation of isolated organs through perfusion
US3877843A (en) * 1973-05-21 1975-04-15 Baxter Laboratories Inc Pulsatile pumping system
GB1442356A (en) 1973-09-21 1976-07-14 Vos Nii Ogneupornoi Promy Solid electrolytes
JPS5331209B2 (de) * 1973-10-05 1978-09-01
US3995444A (en) 1974-11-08 1976-12-07 American Hospital Supply Corporation Organ perfusion system
SU760972A1 (ru) 1976-03-18 1980-09-07 Ir G Med Inst Устройство для гипотермии 1
US4186565A (en) * 1978-05-19 1980-02-05 Henry Ford Hospital Perfusion system for organ preservation
US4231354A (en) * 1978-07-14 1980-11-04 Howmedica, Incorporated Pulsatile blood pumping apparatus and method
US4243883A (en) * 1979-01-19 1981-01-06 Midwest Cardiovascular Institute Foundation Blood hematocrit monitoring system
US4242883A (en) * 1979-04-02 1981-01-06 Henry Ford Hospital Liver preservation
US4445500A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4657532A (en) * 1985-07-19 1987-04-14 Thomas Jefferson University Intra-peritoneal perfusion of oxygenated fluorocarbon
US4378797A (en) * 1980-04-14 1983-04-05 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4393863A (en) * 1980-04-14 1983-07-19 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US5085630A (en) * 1980-04-14 1992-02-04 Thomas Jefferson University Oxygenated fluorocarbon nutrient solution
US4717548A (en) * 1980-06-09 1988-01-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analytically controlled blood perfusion system
US4629686A (en) 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
US4451251A (en) * 1982-03-03 1984-05-29 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
DE3366419D1 (en) 1982-06-04 1986-10-30 Hoxan Kk Method of preserving organ and apparatus for preserving the same
US4473637A (en) * 1982-11-10 1984-09-25 Guibert, Colman & Associates System for processing an organ preparatory to transplant
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4474016A (en) * 1983-03-04 1984-10-02 Baxter Travenol Laboratories, Inc. Sterile cooling system
US4618586A (en) * 1983-04-08 1986-10-21 Endotronics, Inc. Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber
US4837390A (en) * 1983-05-11 1989-06-06 Keyes Offshore, Inc. Hyperbaric organ preservation apparatus and method for preserving living organs
US4462215A (en) * 1983-05-31 1984-07-31 Hoxan Corporation Method of preserving organ and apparatus for preserving the same
US4471629A (en) * 1983-05-31 1984-09-18 Mount Carmel Research And Education Corporation Method of freezing and transplant of kidneys and apparatus
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4502295A (en) * 1984-02-21 1985-03-05 Mount Carmel Research And Education Corporation Organ hypothermic storage unit
US4596250A (en) * 1984-11-14 1986-06-24 Genetic Laboratories, Inc. Moldable cooling/heating device with directional cooling/heating
US4723974A (en) * 1985-07-26 1988-02-09 Ammerman Stephen W Transporting container for an amputated extremity
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4666425A (en) * 1985-12-17 1987-05-19 The Dis Corporation Device for perfusing an animal head
US4704029A (en) * 1985-12-26 1987-11-03 Research Corporation Blood glucose monitor
FR2592306A1 (fr) 1985-12-30 1987-07-03 Couegnas Jacques Appareil de perfusion a debit reglable ne provoquant pas de modification du liquide perfuse.
EP0256653A3 (de) 1986-07-10 1990-01-17 Haemonetics Corporation Wärmetauscher für Blut
GB8619437D0 (en) * 1986-08-08 1986-09-17 Bradley L Storage & refrigeration
US4745759A (en) * 1986-12-23 1988-05-24 Bauer Dan O Kidney preservation machine
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
CA1325937C (en) 1987-05-29 1994-01-11 Ingemar H. Lundquist Retroperfusion and retroinfusion control apparatus, system and method
SU1632428A1 (ru) 1987-08-03 1991-03-07 Одесский Медицинский Институт Им.Н.И.Пирогова Способ лечени т желой черепно-мозговой травмы в острый период заболевани
US5051352A (en) * 1987-10-07 1991-09-24 The Regents Of The University Of California Apparatus and method of preserving the viability of animal organs
FR2628077B1 (fr) * 1988-03-07 1990-08-03 Guilhem Jacques Conteneur pour le transport de greffons
DE3808942A1 (de) 1988-03-17 1989-09-28 Bio Med Gmbh Ges Fuer Biotechn Inkubator, insbes. fuer die polymerase-ketten-methode
US5130230A (en) * 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
CA2001553A1 (en) 1988-10-26 1990-04-26 Karen Mckelvey Device for transportation of human organs used for transplantation
US5013303A (en) * 1988-11-03 1991-05-07 Yehuda Tamari Constant pressure infusion device
US4951482A (en) * 1988-12-21 1990-08-28 Gilbert Gary L Hypothermic organ transport apparatus
US5110721A (en) * 1989-02-10 1992-05-05 The Research Foundation Of State University Of New York Method for hypothermic organ protection during organ retrieval
US5326706A (en) * 1989-07-17 1994-07-05 Research Foundation Of State University Of New York Homeostatic organ preservation system
RU2079273C1 (ru) * 1989-07-27 1997-05-20 И.Джост Леонора Транспортабельный контейнер закрытой системы для хранения биологического материала
JPH0653160B2 (ja) * 1989-08-18 1994-07-20 呉羽化学工業株式会社 拍動発生方法及び装置
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5066578A (en) * 1989-12-21 1991-11-19 The Regents Of The University Of California Long-term preservation of organs for transplantation
US5003787A (en) * 1990-01-18 1991-04-02 Savant Instruments Cell preservation system
US5145771A (en) * 1990-04-12 1992-09-08 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
US5047395A (en) * 1990-07-17 1991-09-10 Nagase Co., Ltd. Reduction of oxyradical damage in biomedical applications
FR2667297B1 (fr) * 1990-09-28 1994-05-27 Electrolux Sarl Conteneur medical climatise.
US5149321A (en) * 1990-10-10 1992-09-22 Klatz Ronald M Brain resuscitation device and method for performing the same
US5584804A (en) 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5395314A (en) * 1990-10-10 1995-03-07 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5308320A (en) * 1990-12-28 1994-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method
US5157930A (en) * 1991-04-22 1992-10-27 Mcghee Samuel C Organ preservation apparatus
US5856081A (en) * 1991-07-08 1999-01-05 The American National Red Cross Computer controlled cryoprotectant perfusion apparatus
US5723282A (en) * 1991-07-08 1998-03-03 The American National Red Cross Method of preparing organs for vitrification
US5217860A (en) 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
US5216032A (en) * 1991-09-30 1993-06-01 The University Of North Carolina At Chapel Hill Selective aortic arch perfusion using perfluorochemical and alpha adrenergic agonist to treat cardiac arrest
US5328821A (en) * 1991-12-12 1994-07-12 Robyn Fisher Cold and cryo-preservation methods for human tissue slices
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
DE4301524A1 (de) * 1993-01-21 1994-07-28 Jostra Medizintechnik Medizinisches Aggregat oder Gerät für Operationssäle, insbesondere Herz-Lungen-Maschine
US5362622A (en) * 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
US5599659A (en) * 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
US5356771A (en) * 1993-03-11 1994-10-18 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation organ preservation apparatus
AU6409594A (en) 1993-03-16 1994-10-11 Alliance Pharmaceutical Corporation Preservation solution and method for warm organ preservation
US5437633A (en) * 1994-03-30 1995-08-01 The University Of North Carolina At Chapel Hill Selective aortic arch perfusion
AU2595195A (en) * 1994-05-20 1995-12-18 Vec Tec, Inc. Method and apparatus monitoring viability of transplantable organs
US5643712A (en) * 1994-05-20 1997-07-01 Brasile; Lauren Method for treating and rendering grafts nonthrombogenic and substantially nonimmunogenic using an extracellular matrix coating
US5823986A (en) * 1995-02-08 1998-10-20 Medtronic, Inc. Perfusion system
US5586438A (en) 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
US5681740A (en) * 1995-06-05 1997-10-28 Cytotherapeutics, Inc. Apparatus and method for storage and transporation of bioartificial organs
US5730720A (en) * 1995-08-18 1998-03-24 Ip Scientific, Inc. Perfusion hyperthermia treatment system and method
US5712084A (en) * 1995-09-08 1998-01-27 Research Corporation Technologies, Inc. Donor kidney viability test for improved preservation
US5712583A (en) * 1995-11-13 1998-01-27 International Business Machines Corporation Clock phase alignment using frequency comparison
US5843024A (en) 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US5965433A (en) * 1996-05-29 1999-10-12 Trans D.A.T.A. Service, Inc. Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate
US5716378A (en) * 1996-06-06 1998-02-10 Medtronic, Inc. Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium
WO1998009166A1 (en) * 1996-08-29 1998-03-05 Chiron Corporation Method for analysing absorption, distribution, metabolism, excretion (adme) and pharmacokinetics properties of compound mixtures
US5879329A (en) * 1997-01-22 1999-03-09 Radiant Medical, Inc. Infusion systems and methods for introducing fluids into the body within a desired temperature range
US5928182A (en) * 1997-07-02 1999-07-27 Johnson & Johnson Professional, Inc. Pediatric programmable hydrocephalus valve
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
TW442306B (en) * 1998-09-29 2001-06-23 Life Science Holdings Inc Apparatus and method for maintaining and/or restoring viability of organs
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
KR20020059255A (ko) 1999-06-17 2002-07-12 린다 에스. 스티븐슨 저온 저장을 개선하기 위한 PEG-Hb를 사용하는 연속심장 관류 보존
WO2001015525A1 (fr) 1999-08-31 2001-03-08 Fujisawa Pharmaceutical Co., Ltd. Conservateurs pour organes
CA2397927A1 (en) * 2000-01-19 2001-07-26 University Of North Carolina At Chapel Hill Liver tissue source

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EP1711816B1 (de) 2008-08-27
US20040224298A1 (en) 2004-11-11
ATE406576T1 (de) 2008-09-15
ES2314627T3 (es) 2009-03-16
CA2554872C (en) 2018-07-31
US7749693B2 (en) 2010-07-06
WO2005074681A3 (en) 2005-11-24
JP5329760B2 (ja) 2013-10-30
WO2005074681A2 (en) 2005-08-18
CA2554872A1 (en) 2005-08-18
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CN1985170A (zh) 2007-06-20

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