DE602004030615D1 - Lateralfluss-testvorrichtungen auf membranbasis unter verwendung von phosphoreszenznachweises - Google Patents

Lateralfluss-testvorrichtungen auf membranbasis unter verwendung von phosphoreszenznachweises

Info

Publication number
DE602004030615D1
DE602004030615D1 DE602004030615T DE602004030615T DE602004030615D1 DE 602004030615 D1 DE602004030615 D1 DE 602004030615D1 DE 602004030615 T DE602004030615 T DE 602004030615T DE 602004030615 T DE602004030615 T DE 602004030615T DE 602004030615 D1 DE602004030615 D1 DE 602004030615D1
Authority
DE
Germany
Prior art keywords
membrane
lateral flow
based lateral
phosphorescence detection
flow testers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004030615T
Other languages
English (en)
Inventor
Xuedong Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kimberly Clark Worldwide Inc
Kimberly Clark Corp
Original Assignee
Kimberly Clark Worldwide Inc
Kimberly Clark Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Worldwide Inc, Kimberly Clark Corp filed Critical Kimberly Clark Worldwide Inc
Publication of DE602004030615D1 publication Critical patent/DE602004030615D1/de
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/805Test papers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/97Test strip or test slide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81Tube, bottle, or dipstick
DE602004030615T 2003-11-21 2004-04-28 Lateralfluss-testvorrichtungen auf membranbasis unter verwendung von phosphoreszenznachweises Active DE602004030615D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/718,989 US20050112703A1 (en) 2003-11-21 2003-11-21 Membrane-based lateral flow assay devices that utilize phosphorescent detection
PCT/US2004/013180 WO2005057215A1 (en) 2003-11-21 2004-04-28 Membrane-based lateral flow assay devices that utilize phosphorescent detection

Publications (1)

Publication Number Publication Date
DE602004030615D1 true DE602004030615D1 (de) 2011-01-27

Family

ID=34591211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004030615T Active DE602004030615D1 (de) 2003-11-21 2004-04-28 Lateralfluss-testvorrichtungen auf membranbasis unter verwendung von phosphoreszenznachweises

Country Status (4)

Country Link
US (3) US20050112703A1 (de)
EP (1) EP1692508B1 (de)
DE (1) DE602004030615D1 (de)
WO (1) WO2005057215A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US8128871B2 (en) 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
JPWO2006075678A1 (ja) * 2005-01-14 2008-06-12 財団法人浜松科学技術研究振興会 光感受性化合物
US10753931B2 (en) 2005-04-22 2020-08-25 Alverix, Inc. Assay test strips with multiple labels and reading same
US20060275920A1 (en) * 2005-06-01 2006-12-07 Petrilla John F Apparatus and method for discriminating among lateral flow assay test indicators
US7829347B2 (en) 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
US8003399B2 (en) * 2005-08-31 2011-08-23 Kimberly-Clark Worldwide, Inc. Nitrite detection technique
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
JP2009523406A (ja) * 2005-11-15 2009-06-25 オクソニカ・インコーポレーテッド 生体剤(bioagents)の検出のためのSERSに基づく方法
WO2007090058A2 (en) * 2006-01-27 2007-08-09 Oxonica, Inc. Lateral flow immunoassay with encapsulated detection modality
US8758989B2 (en) 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
WO2008014223A2 (en) * 2006-07-24 2008-01-31 Becton, Dickinson And Company Assay particle concentration and imaging apparatus and method
US7749775B2 (en) 2006-10-03 2010-07-06 Jonathan Scott Maher Immunoassay test device and method of use
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
DE102008019928A1 (de) * 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Polyelektrolyt-Monoschichten mit kovalenten Bindungsstellen für optische Signalwandler
US11275084B2 (en) * 2010-01-15 2022-03-15 Stanford University Successive sampling device and associated method
GB201010768D0 (en) 2010-06-25 2010-08-11 Isis Innovation Analyte sensor
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
GB201112395D0 (en) * 2011-07-19 2011-08-31 Bio Nano Consulting Immunoassay
US20150177154A1 (en) * 2011-09-06 2015-06-25 Dmitri Boris Papkovsky Dry laminated photoluminescent probe and method of manufacture and use
CN103293303B (zh) * 2012-03-01 2016-12-14 上海鑫谱生物科技有限公司 一种荧光分析方法和装置
US20150079608A1 (en) * 2012-04-06 2015-03-19 Adtec, Inc. Method for detecting or quantifying analyte, kit for detecting or quantifying analyte, and test strip for lateral flow type chromatography method for detecting or quantifying analyte
CN102680702B (zh) * 2012-04-28 2014-12-17 广州鸿琪光学仪器科技有限公司 一种快速定量检测c-反应蛋白的免疫荧光试纸条组件、及其制成的检测卡组件和制备方法
CN102707056B (zh) * 2012-04-28 2015-01-28 广州鸿琪光学仪器科技有限公司 快速定量检测心肌肌酸激酶同工酶的免疫荧光试纸条组件及其制成的检测卡组件和制备方法
CN102692508B (zh) * 2012-04-28 2014-12-17 广州鸿琪光学仪器科技有限公司 一种快速定量检测肌钙蛋白t的免疫荧光试纸条组件及其制成的检测卡组件和制备方法
CN102662055B (zh) * 2012-04-28 2014-12-10 广州鸿琪光学仪器科技有限公司 一种快速定量检测肌钙蛋白i的免疫荧光试纸条组件、及其制成的检测卡组件和制备方法
CN102680704B (zh) * 2012-04-28 2015-02-11 广州鸿琪光学仪器科技有限公司 一种快速定量检测微量白蛋白的免疫荧光试纸条组件及其制成的检测卡组件和制备方法
CN102662065B (zh) * 2012-04-28 2014-12-17 广州鸿琪光学仪器科技有限公司 一种快速定量检测多种蛋白的免疫荧光试纸条组件及其制成的检测卡组件和制备方法
CN102680703B (zh) * 2012-04-28 2014-12-17 广州鸿琪光学仪器科技有限公司 一种快速定量检测肌红蛋白的免疫荧光试纸条组件及其制成的检测卡组件和制备方法
CN102866251A (zh) * 2012-06-19 2013-01-09 深圳市艾瑞生物科技有限公司 基于磷光发光技术的免疫荧光试纸条及其制备方法和应用
CN102866252B (zh) * 2012-08-09 2015-01-21 河南省农业科学院 磷光二氧化硅纳米颗粒标记的定量检测西马特罗的免疫层析试纸条及制备方法
US9939438B2 (en) * 2012-10-23 2018-04-10 Robert Bosch Gmbh Sensor integration in lateral flow immunoassays and its applications
CN104278079A (zh) * 2013-07-08 2015-01-14 嘉兴朝云帆生物科技有限公司 用核酸层析技术检测核酸的试纸条和方法
CN104345148A (zh) * 2013-07-28 2015-02-11 嘉兴朝云帆生物科技有限公司 用免疫层析技术检测蛋白的试纸条和方法
CN104345144A (zh) * 2013-07-28 2015-02-11 嘉兴朝云帆生物科技有限公司 用免疫层析技术检测小分子有机化合物的试纸条和方法
CN105705938B (zh) * 2013-08-19 2020-11-06 休斯敦大学系统 磷光报告物
DE102014219723A1 (de) * 2014-09-29 2016-03-31 Robert Bosch Gmbh Elektrode für eine Batteriezelle und Batteriezelle
CN104360085B (zh) * 2014-12-05 2016-03-16 重庆乾德生物技术有限公司 一种afp检测试剂盒
USD775738S1 (en) * 2015-01-05 2017-01-03 Ge Healthcare Bio-Sciences Ab Membrane card
EP3153230A1 (de) * 2015-10-08 2017-04-12 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin Verfahren zur herstellung von poly(methylmethacrylat) (pmma)-membranen und verwendungen davon
EP3371257A4 (de) * 2015-11-02 2019-03-20 SABIC Global Technologies B.V. Polymerlegierungszusammensetzungen und anwendung für medizinische systeme und verfahren
JP2017181050A (ja) * 2016-03-28 2017-10-05 古河電気工業株式会社 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用標識試薬粒子
CN105929155A (zh) * 2016-07-08 2016-09-07 同济大学 免疫层析试纸及其检测方法
WO2018185672A1 (en) 2017-04-06 2018-10-11 Magbiosense Inc. Bio-assay capture surfaces with bleached autofluorescence
CN108152282B (zh) * 2017-12-14 2020-12-25 吉林省汇酉生物技术股份有限公司 一种检测尿液肌酐的试剂及其应用
US10866192B2 (en) * 2018-10-19 2020-12-15 Endress+Hauser Conducta Gmbh+Co. Kg Optochemical sensor unit and a method for the qualitative and/or quantitative determination of an analyte in a measuring medium with the sensor unit
CN109655625A (zh) * 2019-01-25 2019-04-19 三诺生物传感股份有限公司 一种检测糖化血红蛋白的胶体金试纸条及其制备方法和应用
CN110530831B (zh) * 2019-08-26 2023-02-03 河南师范大学 基于金纳米簇AuNCs@APAP的荧光增强体系及其应用
CN111308079B (zh) * 2020-02-21 2023-09-19 上海艾瑞德生物科技有限公司 一种提高胶体金免疫层析平台定量分析准确度的方法
WO2022254364A1 (en) * 2021-06-01 2022-12-08 Ryshens Ltd. Diagnostic platform device and method

Family Cites Families (344)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1366241A (en) * 1919-10-03 1921-01-18 Frederick W Burch Ratchet mechanism for camp-beds
US3604927A (en) 1966-11-16 1971-09-14 Block Engineering Total reflection fluorescence spectroscopy
US3772076A (en) 1970-01-26 1973-11-13 Hercules Inc Reaction products of epihalohydrin and polymers of diallylamine and their use in paper
US3700623A (en) 1970-04-22 1972-10-24 Hercules Inc Reaction products of epihalohydrin and polymers of diallylamine and their use in paper
DE2222852A1 (de) 1971-05-11 1973-12-13 Image Analysing Computers Ltd Feldbeleuchtung fuer die bildanalyse
US4006360A (en) * 1974-08-21 1977-02-01 Block Engineering, Inc. Method of discriminating between dyed particles and background fluorescence of the dye
CS179075B1 (en) * 1974-11-26 1977-10-31 Stoy Vladimir Mode of manufacture of spherical particles from polymer
SE388694B (sv) 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
USRE30267E (en) * 1975-06-20 1980-05-06 Eastman Kodak Company Multilayer analytical element
US4341957A (en) * 1975-11-26 1982-07-27 Analytical Radiation Corporation Fluorescent antibody composition for immunofluorometric assay
US4094647A (en) * 1976-07-02 1978-06-13 Thyroid Diagnostics, Inc. Test device
US4210723A (en) * 1976-07-23 1980-07-01 The Dow Chemical Company Method of coupling a protein to an epoxylated latex
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4374925A (en) * 1978-11-24 1983-02-22 Syva Company Macromolecular environment control in specific receptor assays
US4441373A (en) * 1979-02-21 1984-04-10 American Hospital Supply Corporation Collection tube for drawing samples of biological fluids
US4312228A (en) * 1979-07-30 1982-01-26 Henry Wohltjen Methods of detection with surface acoustic wave and apparati therefor
US4259574A (en) * 1979-11-06 1981-03-31 International Business Machines Corporation Microanalysis by pulse laser emission spectroscopy
US4533629A (en) * 1981-04-17 1985-08-06 Syva Company Simultaneous calibration heterogeneous immunoassay
US4843000A (en) * 1979-12-26 1989-06-27 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US5432057A (en) * 1979-12-26 1995-07-11 Syva Company Simultaneous calibration heterogeneous immunoassay
US5156953A (en) 1979-12-26 1992-10-20 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4849338A (en) * 1982-07-16 1989-07-18 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4540659A (en) 1981-04-17 1985-09-10 Syva Company Simultaneous calibration heterogeneous immunoassay
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
FR2478086A1 (fr) * 1980-02-14 1981-09-18 Ciba Geigy Ag Procede pour la preparation de composes du triarylmethane
US4336459A (en) * 1980-06-11 1982-06-22 Union Carbide Corporation Method and apparatus for detecting fluorescence under ambient light conditions
US4427836A (en) * 1980-06-12 1984-01-24 Rohm And Haas Company Sequential heteropolymer dispersion and a particulate material obtainable therefrom, useful in coating compositions as a thickening and/or opacifying agent
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4357311A (en) 1980-10-03 1982-11-02 Warner-Lambert Company Substrate for immunoassay and means of preparing same
US4385126A (en) * 1980-11-19 1983-05-24 International Diagnostic Technology, Inc. Double tagged immunoassay
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4442204A (en) * 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
US4444592A (en) * 1981-06-02 1984-04-24 The Sherwin-Williams Company Pigment compositions and processes therefor
US4363874A (en) 1981-08-07 1982-12-14 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer
EP0073593A1 (de) 1981-09-01 1983-03-09 E.I. Du Pont De Nemours And Company Grössendiskriminierende heterogene Immunzusammensetzung
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4477635A (en) 1982-01-04 1984-10-16 Minnesota Mining And Manufacturing Company Polymeric triarylmethane dyes
US4435504A (en) 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4534356A (en) * 1982-07-30 1985-08-13 Diamond Shamrock Chemicals Company Solid state transcutaneous blood gas sensors
US4632559A (en) 1982-11-29 1986-12-30 Miles Laboratories, Inc. Optical readhead
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
EP0127797B1 (de) 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
CH662421A5 (de) 1983-07-13 1987-09-30 Suisse Horlogerie Rech Lab Piezoelektrischer kontaminationsdetektor.
US4537657A (en) * 1983-08-26 1985-08-27 Hercules Incorporated Wet strength resins
US4552458A (en) 1983-10-11 1985-11-12 Eastman Kodak Company Compact reflectometer
US4595661A (en) * 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
US4703017C1 (en) * 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
US4698262A (en) 1984-04-27 1987-10-06 Becton, Dickinson And Company Fluorescently labeled microbeads
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4586695A (en) * 1984-06-22 1986-05-06 Miller Charlie D Continuous tube extractor
FI842992A0 (fi) * 1984-07-26 1984-07-26 Labsystems Oy Immunologiskt definitionsfoerfarande.
US4661235A (en) * 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
US4596697A (en) * 1984-09-04 1986-06-24 The United States Of America As Represented By The Secretary Of The Army Chemical sensor matrix
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
EP0184600B1 (de) * 1984-12-10 1990-03-14 Prutec Limited Verfahren zum optischen Nachweis von Parametern von Substanzen in einem flüssigen Analyt
US4680275A (en) * 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US4722889A (en) * 1985-04-02 1988-02-02 Leeco Diagnostics, Inc. Immunoassays using multiple monoclonal antibodies and scavenger antibodies
US5026653A (en) * 1985-04-02 1991-06-25 Leeco Diagnostic, Inc. Scavenger antibody mixture and its use for immunometric assay
US5879881A (en) 1985-04-04 1999-03-09 Hybritech, Incorporated Solid phase system for use in ligand-receptor assays
US4743542A (en) * 1985-04-11 1988-05-10 Ortho Diagnostic Method for forestalling the hook effect in a multi-ligand immunoassay system
GB8509492D0 (en) 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
US4877965A (en) 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5238815A (en) 1985-08-30 1993-08-24 Toyo Soda Manufacturing Co., Ltd. Enzymatic immunoassay involving detecting fluorescence while oscillating magnetic beads
US5500350A (en) * 1985-10-30 1996-03-19 Celltech Limited Binding assay device
US4917503A (en) * 1985-12-02 1990-04-17 Lifelines Technology, Inc. Photoactivatable leuco base time-temperature indicator
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5585279A (en) 1986-01-23 1996-12-17 Davidson; Robert S. Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium
US4916056A (en) * 1986-02-18 1990-04-10 Abbott Laboratories Solid-phase analytical device and method for using same
US5482830A (en) * 1986-02-25 1996-01-09 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5468606A (en) 1989-09-18 1995-11-21 Biostar, Inc. Devices for detection of an analyte based upon light interference
US4776944A (en) 1986-03-20 1988-10-11 Jiri Janata Chemical selective sensors utilizing admittance modulated membranes
US5591581A (en) 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
EP0272320B1 (de) 1986-06-17 1994-03-23 Baxter Diagnostics Inc. Homogenes fluortestverfahren mit abstoss des fluorzenten hintergrundes.
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
JPH0692969B2 (ja) * 1986-07-30 1994-11-16 株式会社シノテスト 免疫的測定方法
US5182135A (en) * 1986-08-12 1993-01-26 Bayer Aktiengesellschaft Process for improving the adherency of metallic coatings deposited without current on plastic surfaces
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4791310A (en) 1986-10-02 1988-12-13 Syracuse University Fluorescence microscopy
GB2197065A (en) * 1986-11-03 1988-05-11 Stc Plc Optical sensor device
ATE98020T1 (de) * 1986-12-15 1993-12-15 British Tech Group Usa Monomere phthalocyanin-reagenzien.
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
US4842783A (en) * 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
SE8703682L (sv) 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
EP0400086B1 (de) * 1988-02-08 1993-01-27 University College Cardiff Consultants Ltd. Nachweis von diaminen in biologischen flüssigkeiten
US5268306A (en) 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
US5145784A (en) 1988-05-04 1992-09-08 Cambridge Biotech Corporation Double capture assay method employing a capillary flow device
DE68907519T2 (de) 1988-05-10 1993-10-21 Amersham Int Plc Biosensoren.
EP0341928A1 (de) * 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Oberflächen-Resonanzplasmawellen-Sensoren
GB8811919D0 (en) * 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
GB8813307D0 (en) 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
US4877586A (en) 1988-07-27 1989-10-31 Eastman Kodak Company Sliding test device for assays
US5075077A (en) 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
AT390517B (de) * 1988-08-04 1990-05-25 Avl Verbrennungskraft Messtech Optischer sensor und verfahren zu dessen herstellung
US4973670A (en) 1988-08-12 1990-11-27 The Dow Chemical Company Method for preparing hollow latexes
US5252459A (en) 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
EP0363504A1 (de) * 1988-10-10 1990-04-18 Dräger Nederland B.V. Verfahren zur Herstellung einer ein Polyvinylhydrogel und ein biochemisch aktives Material enthaltenden Schicht auf einem Substrat
US6448091B1 (en) 1988-11-03 2002-09-10 Igen International, Inc. Method and apparatus for improved luminescence assays using particle concentration chemiluminescence detection
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
SE8902043L (sv) 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
US5003178A (en) * 1988-11-14 1991-03-26 Electron Vision Corporation Large-area uniform electron source
US5063081A (en) 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
ATE115982T1 (de) * 1988-11-23 1995-01-15 Cytec Tech Corp Poröse polymerperlen und verfahren.
US4940734A (en) * 1988-11-23 1990-07-10 American Cyanamid Process for the preparation of porous polymer beads
US4895017A (en) * 1989-01-23 1990-01-23 The Boeing Company Apparatus and method for early detection and identification of dilute chemical vapors
US5096671A (en) * 1989-03-15 1992-03-17 Cordis Corporation Fiber optic chemical sensors incorporating electrostatic coupling
JP2853745B2 (ja) 1989-04-12 1999-02-03 株式会社日立製作所 光検出電気泳動装置
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5234813A (en) 1989-05-17 1993-08-10 Actimed Laboratories, Inc. Method and device for metering of fluid samples and detection of analytes therein
US5770416A (en) 1989-05-26 1998-06-23 Upfront Chromatography A/S Permeable hollow particles having an outer shell of mechanically rigid porous material
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
GB9008261D0 (en) 1990-04-11 1990-06-13 Ares Serono Res & Dev Ltd Method of improving assay sensitivity
US5166079A (en) 1989-07-19 1992-11-24 Pb Diagnostic Systems, Inc. Analytical assay method
JPH0366384A (ja) 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk 生理活性物質放出制御システム
US5235238A (en) 1989-08-10 1993-08-10 Dainabot Company, Limited Electrode-separated piezoelectric crystal oscillator and method for measurement using the electrode-separated piezoelectric crystal oscillator
AU635314B2 (en) * 1989-09-08 1993-03-18 Terumo Kabushiki Kaisha Measuring apparatus
CA2003942A1 (en) 1989-09-26 1991-03-26 Julie Lia Rudolph Solid assay support systems
JP2979414B2 (ja) * 1989-09-29 1999-11-15 富士レビオ株式会社 磁性粒子およびそれを用いた免疫測定法
US5225935A (en) * 1989-10-30 1993-07-06 Sharp Kabushiki Kaisha Optical device having a microlens and a process for making microlenses
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
GB8927503D0 (en) 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
US5508171A (en) * 1989-12-15 1996-04-16 Boehringer Mannheim Corporation Assay method with enzyme electrode system
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
EP0462376B1 (de) 1990-05-09 1996-07-24 Abbott Laboratories Bindungsnachweisverfahren mit Konjugatrückgewinnung
DE69032425T2 (de) * 1990-05-11 1998-11-26 Microprobe Corp Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden
DK138090D0 (da) * 1990-06-06 1990-06-06 Novo Nordisk As Diagnostisk analysemetode
DE4024476C1 (de) 1990-08-02 1992-02-27 Boehringer Mannheim Gmbh, 6800 Mannheim, De
GB9019123D0 (en) 1990-09-01 1990-10-17 Fisons Plc Analytical device
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5076094A (en) 1990-10-03 1991-12-31 The United States Of America As Represented By The United States Department Of Energy Dual output acoustic wave sensor for molecular identification
US5700636A (en) 1990-10-19 1997-12-23 Becton Dickinson And Company Methods for selectively detecting microorganisms associated with vaginal infections in complex biological samples
US5726064A (en) 1990-11-22 1998-03-10 Applied Research Systems Ars Holding Nv Method of assay having calibration within the assay
US6027944A (en) 1990-11-22 2000-02-22 Applied Research Systems Ars Holding Nv Capillary-fill biosensor device comprising a calibration zone
US5510481A (en) * 1990-11-26 1996-04-23 The Regents, University Of California Self-assembled molecular films incorporating a ligand
US5208535A (en) * 1990-12-28 1993-05-04 Research Development Corporation Of Japan Mr position detecting device
US5834226A (en) 1991-01-31 1998-11-10 Xytronyx, Inc. One-step test for aspartate aminotransferase
GB9102646D0 (en) * 1991-02-07 1991-03-27 Fisons Plc Analytical device
IL97318A0 (en) * 1991-02-20 1992-05-25 Diagnostic Markers Inc Method for the very rapid detection of polyamines
US5489998A (en) * 1991-03-04 1996-02-06 Canon Kabushiki Kaisha Color image processing apparatus having transmitter and receiver which perform color correction in accordance with a common standard color image and method for same
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5795470A (en) 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
US5196350A (en) * 1991-05-29 1993-03-23 Omnigene, Inc. Ligand assay using interference modulation
GB9111912D0 (en) * 1991-06-04 1991-07-24 Fisons Plc Analytical methods
US5179288A (en) * 1991-09-30 1993-01-12 Ortho Pharmaceutical Corporation Apparatus and method for measuring a bodily constituent
US5418136A (en) * 1991-10-01 1995-05-23 Biostar, Inc. Devices for detection of an analyte based upon light interference
ATE161964T1 (de) * 1991-10-15 1998-01-15 Multilyte Ltd Bindungstest unter benutzung eines markierten reagens
US5424219A (en) * 1991-10-25 1995-06-13 Cytech Biomedical, Inc. Method of performing assays for biomolecules and solid supports for use in such methods
AU3439693A (en) 1992-01-22 1993-09-01 Abbott Laboratories Calibration reagents for semi-quantitative binding assays and devices
US6861264B2 (en) 1992-01-27 2005-03-01 Cis Bio International Method of measuring the luminescence emitted in a luminescent assay
US5221454A (en) * 1992-01-31 1993-06-22 Biometric Imaging Inc. Differential separation assay
US5137609A (en) 1992-01-31 1992-08-11 Biometric Imaging Inc. Differential separation assay
US5445971A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
EP0606422B1 (de) * 1992-07-02 1997-09-03 SOINI, Erkki Biospezifisches multiparameter-analyseverfahren
US5395754A (en) * 1992-07-31 1995-03-07 Hybritech Incorporated Membrane-based immunoassay method
US5321492A (en) * 1992-08-07 1994-06-14 Miles Inc. Dual function readhead for a reflectance instrument
GB9217864D0 (en) 1992-08-21 1992-10-07 Unilever Plc Monitoring method
US5356782A (en) 1992-09-03 1994-10-18 Boehringer Mannheim Corporation Analytical test apparatus with on board negative and positive control
EP0588153B1 (de) 1992-09-14 1996-12-27 Siemens Aktiengesellschaft Gassensor
US6399397B1 (en) 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US5358852A (en) 1992-12-21 1994-10-25 Eastman Kodak Company Use of calcium in immunoassay for measurement of C-reactive protein
US6200820B1 (en) 1992-12-22 2001-03-13 Sienna Biotech, Inc. Light scatter-based immunoassay
TW239881B (de) 1992-12-22 1995-02-01 Sienna Biotech Inc
US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
FI932866A0 (fi) 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
US5422726A (en) 1993-02-16 1995-06-06 Tyler; Jonathan M. Solid state spectrofluorimeter and method of using the same
DE4309393A1 (de) 1993-03-23 1994-09-29 Boehringer Mannheim Gmbh Verringerung des Hook-Effekts in Immuntests mit teilchenförmigem Trägermaterial
DE4310142A1 (de) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung
US5424841A (en) * 1993-05-28 1995-06-13 Molecular Dynamics Apparatus for measuring spatial distribution of fluorescence on a substrate
JP3479100B2 (ja) 1993-06-02 2003-12-15 帝国臓器製薬株式会社 免疫化学的簡易半定量方法および装置
US5658443A (en) 1993-07-23 1997-08-19 Matsushita Electric Industrial Co., Ltd. Biosensor and method for producing the same
FR2708348B1 (fr) 1993-07-28 1995-10-06 Stago Diagnostica Procédé de dosage d'une substance immunologique au moyen de particules de latex magnétiques et de particules non-magnétiques.
US5484867A (en) * 1993-08-12 1996-01-16 The University Of Dayton Process for preparation of polyhedral oligomeric silsesquioxanes and systhesis of polymers containing polyhedral oligomeric silsesqioxane group segments
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5464741A (en) 1993-10-08 1995-11-07 Henwell, Inc. Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
KR0177182B1 (ko) 1993-10-20 1999-05-15 최근선 중공구조를 갖는 유화중합체의 제조방법
US5352582A (en) 1993-10-28 1994-10-04 Hewlett-Packard Company Holographic based bio-assay
US5455475A (en) 1993-11-01 1995-10-03 Marquette University Piezoelectric resonant sensor using the acoustoelectric effect
EP0653639B1 (de) * 1993-11-12 2000-03-22 Unilever Plc Analysevorrichtung und deren Anwendung
ATE224053T1 (de) 1993-11-12 2002-09-15 Inverness Medical Switzerland Vorrichtung zum ablesen von teststreifen
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
JP3504750B2 (ja) 1993-12-22 2004-03-08 オルソ−クリニカル ダイアグノスティクス,インコーポレイティド 検量関係式の再校正法及び定量試験キット
US5663213A (en) 1994-02-28 1997-09-02 Rohm And Haas Company Method of improving ultraviolet radiation absorption of a composition
GB9416002D0 (en) 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
US6117090A (en) 1994-08-25 2000-09-12 Caillouette; James C. Method and apparatus for detecting amine producing organisms in the vagina
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
DE69524337T2 (de) 1994-09-23 2002-10-17 Unilever Nv Überwachungsverfahren und dazu verwendbare Vorrichtungen
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5571684A (en) 1994-11-07 1996-11-05 Litmus Concepts, Inc. Assay for proline iminopeptidase and other hydrolytic activities
US5728352A (en) 1994-11-14 1998-03-17 Advanced Care Products Disposable electronic diagnostic instrument
US5866434A (en) 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
KR0151203B1 (ko) 1994-12-08 1998-12-01 이헌조 다중전극형 바이오센서
US5489988A (en) * 1995-01-03 1996-02-06 Motorola Environmental sensor and method therefor
AU4213396A (en) 1995-01-26 1996-08-01 Nippon Paint Co., Ltd. Kit for immunologically assaying biological substance and assay process
US5569608A (en) 1995-01-30 1996-10-29 Bayer Corporation Quantitative detection of analytes on immunochromatographic strips
FR2730810B1 (fr) 1995-02-21 1997-03-14 Thomson Csf Capteur chimique hautement selectif
JP3962789B2 (ja) 1995-02-21 2007-08-22 ダブリュー. シディキー,イクバール 磁性粒子を利用した混合/分離装置及びその方法
US5534132A (en) * 1995-05-04 1996-07-09 Vreeke; Mark Electrode and method for the detection of an affinity reaction
KR0156176B1 (ko) 1995-06-01 1998-12-01 구자홍 전기화학식 면역 바이오센서
AU6378696A (en) 1995-06-05 1996-12-24 Kimberly-Clark Worldwide, Inc. Novel pre-dyes
US6413410B1 (en) 1996-06-19 2002-07-02 Lifescan, Inc. Electrochemical cell
US5518689A (en) * 1995-09-05 1996-05-21 Bayer Corporation Diffused light reflectance readhead
AUPN527995A0 (en) * 1995-09-07 1995-09-28 Agen Biomedical Limited Method and apparatus for semiquantification of an analyte
GB9602323D0 (en) 1996-02-06 1996-04-03 Boehringer Mannheim Gmbh Materials and methods relating to binding assays
US5723294A (en) * 1996-03-05 1998-03-03 Gull Laboratories Methods for detection and discrimination of multiple analytes using fluorescent technology
US6287871B1 (en) 1996-03-19 2001-09-11 University Of Utah Research Foundation System for determining analyte concentration
US5753517A (en) 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
DE69705938D1 (de) 1996-03-29 2001-09-06 Univ British Columbia Bestimmung der plättchenzahl unter verwendung eines plättchen-körnchenproteins
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US5951492A (en) 1996-05-17 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for sampling and analyzing body fluid
US6048352A (en) 1996-05-17 2000-04-11 Mercury Diagnostics, Inc. Disposable element for use in a body fluid sampling device
DE19621133A1 (de) 1996-05-24 1997-11-27 Boehringer Mannheim Gmbh Bestimmungsverfahren mit oligomerisierten Rezeptoren
DE19622458C2 (de) 1996-05-24 1998-03-26 Senslab Ges Zur Entwicklung Un Enzymatisch-elektrochemischer Einschritt-Affinitätssensor zur quantitativen Bestimmung von Analyten in wäßrigen Medien und Affinitätsassay
AU3092597A (en) 1996-05-28 1998-01-05 Novartis Ag Optical detection apparatus for chemical analyses of small volumes of samples
US5852229A (en) 1996-05-29 1998-12-22 Kimberly-Clark Worldwide, Inc. Piezoelectric resonator chemical sensing device
US6004530A (en) 1996-06-04 1999-12-21 Roche Diagnostics Gmbh Use of metallo-porphyrin conjugates for the detection of biological substances
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
US5876944A (en) * 1996-06-10 1999-03-02 Bayer Corporation Method for amplification of the response signal in a sandwich immunoassay
US5780251A (en) 1996-06-27 1998-07-14 Fci Fiberchem, Inc. Ultrasensitive single-step, solid-state competitive immunoassay sensor with interference modifier and/or gel layer
EP0910791B1 (de) 1996-07-10 2010-09-08 Perkinelmer Singapore PTE Ltd. Verbessertes abbildungssystem zur fluoreszenzanalyse
US5660790A (en) 1996-08-13 1997-08-26 Litmus Concepts, Inc. PH and amine test elements
EP1985995A3 (de) 1996-08-16 2009-09-16 GE Healthcare Niagara Inc. Digitales Abbildungssystem für Assays in Bohrplatten, Gelen und Flecken
US5832165A (en) 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays
US6020047A (en) 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
US5798273A (en) * 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
US6194220B1 (en) * 1996-09-25 2001-02-27 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
US5910940A (en) 1996-10-08 1999-06-08 Polaroid Corporation Storage medium having a layer of micro-optical lenses each lens generating an evanescent field
US6165798A (en) 1996-10-10 2000-12-26 University Of British Columbia Optical quantification of analytes in membranes
US5922537A (en) 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US6048623A (en) 1996-12-18 2000-04-11 Kimberly-Clark Worldwide, Inc. Method of contact printing on gold coated films
US5922550A (en) 1996-12-18 1999-07-13 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images
US6407492B1 (en) 1997-01-02 2002-06-18 Advanced Electron Beams, Inc. Electron beam accelerator
US5962995A (en) 1997-01-02 1999-10-05 Applied Advanced Technologies, Inc. Electron beam accelerator
US5827748A (en) 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US6391558B1 (en) 1997-03-18 2002-05-21 Andcare, Inc. Electrochemical detection of nucleic acid sequences
US6180288B1 (en) 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
EP0872736A1 (de) 1997-04-18 1998-10-21 Byk Gulden Italia S.p.A. Nachweistest unter Benutzung von Magnetteilchen
US6103536A (en) 1997-05-02 2000-08-15 Silver Lake Research Corporation Internally referenced competitive assays
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6008892A (en) 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
US6613583B1 (en) 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
US6136611A (en) 1997-07-31 2000-10-24 Research International, Inc. Assay methods and apparatus
US5943129A (en) 1997-08-07 1999-08-24 Cambridge Research & Instrumentation Inc. Fluorescence imaging system
EP0898169B1 (de) 1997-08-11 2002-02-06 F. Hoffmann-La Roche Ag Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu
US20020166764A1 (en) 1997-08-12 2002-11-14 University Of Southern California Electrochemical sensor devices and methods for fast, reliable, and sensitive detection and quantitation of analytes
US6080391A (en) 1997-08-14 2000-06-27 Novo Nordisk A/S Reduction of malodour
AU748215B2 (en) 1997-08-29 2002-05-30 Fertility Acoustics Inc. Method and apparatus for rapid analysis of analytes in biological samples
WO2000006990A2 (en) 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
US5906921A (en) 1997-09-29 1999-05-25 Matsushita Electric Industrial Co., Ltd. Biosensor and method for quantitative measurement of a substrate using the same
AU9673198A (en) 1997-10-02 1999-04-27 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US6617488B1 (en) 1997-10-14 2003-09-09 Indicator Technologies, Inc. Method and apparatus for indicating the conditions in an absorbent article
US6174646B1 (en) 1997-10-21 2001-01-16 Konica Corporation Image forming method
US6087184A (en) 1997-11-10 2000-07-11 Beckman Coulter, Inc. Opposable-element chromatographic assay device for detection of analytes
US6030792A (en) 1997-11-13 2000-02-29 Pfizer Inc Assays for measurement of protein fragments in biological media
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
US6060256A (en) 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
SE9704933D0 (sv) 1997-12-30 1997-12-30 Pharmacia & Upjohn Diag Ab Metod som utnyttjar en ny kalibrator och test kit som innehåller kalibratorn
KR100593712B1 (ko) 1998-01-22 2006-06-30 루미넥스 코포레이션 다수의 형광 시그널을 갖는 마이크로입자
DE19811622A1 (de) 1998-03-17 1999-09-23 Lre Technology Partner Gmbh Meßgerät zur Bestimmung der Konzentration einer Substanz in einer Flüssigkeit
EP1064088B1 (de) 1998-03-19 2002-12-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Herstellung von mit mehrlagen gestrichenen partikeln und hohlen schalen durch elektrostatische selbstorganisierung von nanokompositmehrlagen auf zersetzbaren schablonen
US6368873B1 (en) 1998-04-09 2002-04-09 Applied Biotech, Inc. Identification of human urine for drug testing
US6241863B1 (en) 1998-04-27 2001-06-05 Harold G. Monbouquette Amperometric biosensors based on redox enzymes
US6316466B1 (en) 1998-05-05 2001-11-13 Syntex (U.S.A.) Llc Pyrazole derivatives P-38 MAP kinase inhibitors
US6451607B1 (en) 1998-05-07 2002-09-17 Litmus Concepts, Inc. External dried-reagent control for analytical test devices
AU2697899A (en) 1998-05-18 1999-11-25 Rohm And Haas Company Hollow sphere organic pigment for paper or paper coatings
JPH11326603A (ja) 1998-05-19 1999-11-26 Seiko Epson Corp マイクロレンズアレイ及びその製造方法並びに表示装置
WO1999064864A1 (en) * 1998-06-12 1999-12-16 New Horizons Diagnostics Inc. Optimizing sensitivity in colloidal colorimetric flow through and lateral flow tests
US6030840A (en) 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
US6183972B1 (en) 1998-07-27 2001-02-06 Bayer Corporation Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect
US6171870B1 (en) 1998-08-06 2001-01-09 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US20010036645A1 (en) 1998-09-29 2001-11-01 Mcneirney John C. Analyte detector and analyte detection method
GB9821526D0 (en) 1998-10-02 1998-11-25 Genosis Inc Capture assay
US6284472B1 (en) 1998-10-05 2001-09-04 Dade Behring Inc. Method for extending the range of an immunoassay
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
DE19846928A1 (de) 1998-10-12 2000-04-13 Zeiss Carl Fa Abbildungssystem mit einem Zylinderlinsenarray
JP2000199855A (ja) * 1998-11-02 2000-07-18 Olympus Optical Co Ltd 走査型光学顕微鏡装置
FI982422A0 (fi) * 1998-11-09 1998-11-09 Arctic Diagnostics Oy Porfyriiniyhdisteitä, niiden konjugaatit sekä määritysmenetelmiä pohjautuen näiden konjugaattien käyttöön
US6261779B1 (en) 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
CA2254223A1 (en) 1998-11-16 2000-05-16 Biophys, Inc. Device and method for analyzing a biologic sample
US6455861B1 (en) 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
US6221579B1 (en) 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6579673B2 (en) 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
AU4324900A (en) 1999-02-05 2000-08-25 University Of Maryland At Baltimore Luminescence spectral properties of cds nanoparticles
WO2000050871A1 (en) 1999-02-26 2000-08-31 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
WO2000052456A1 (en) 1999-03-02 2000-09-08 Helix Biopharma Corporation Biosensor device and method
US6287783B1 (en) 1999-03-18 2001-09-11 Biostar, Inc. Optical assay device and method
US6511814B1 (en) 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6815218B1 (en) 1999-06-09 2004-11-09 Massachusetts Institute Of Technology Methods for manufacturing bioelectronic devices
DE19933104A1 (de) 1999-07-15 2001-01-18 Ingo Klimant Phosphoreszierende Mikro- und Nanopartikel als Referenzstandard und Phosphoreszenzmarker
US6294392B1 (en) 1999-07-21 2001-09-25 The Regents Of The University Of California Spatially-encoded analyte detection
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
EP1221616B1 (de) 1999-09-29 2006-05-10 Japan Science and Technology Corporation Hochsensitiver zeitaufgelöster immunofluoreszenzassay zum nachweis von chemokinen
US6306665B1 (en) 1999-10-13 2001-10-23 A-Fem Medical Corporation Covalent bonding of molecules to an activated solid phase material
US6136549A (en) 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
USD450854S1 (en) 1999-11-04 2001-11-20 Therasense, Inc. Glucose strip
US6331438B1 (en) 1999-11-24 2001-12-18 Iowa State University Research Foundation, Inc. Optical sensors and multisensor arrays containing thin film electroluminescent devices
US6670115B1 (en) 1999-11-24 2003-12-30 Biotronic Technologies, Inc. Devices and methods for detecting analytes using electrosensor having capture reagent
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
US6509196B1 (en) 2000-01-04 2003-01-21 Response Biomedical Corp. Compensation for non-specific signals in quantitative immunoassays
US20020004246A1 (en) * 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
US6255066B1 (en) 2000-02-08 2001-07-03 Allan L. Louderback Bacterial vaginosis screening technique and a diagnostic kit for use therein
US20010055776A1 (en) 2000-02-11 2001-12-27 Dale Greenwalt High throughput cell-based assay kits
CA2437298A1 (en) * 2000-02-23 2001-08-30 Besst-Test Aps Method for correlating blood coagulation activity with markers in body fluids, e.g. urine
WO2001063262A1 (en) 2000-02-25 2001-08-30 Cambridge Research & Instrumentation Inc. Multiple label fluorescence polarization assay system and method
AU2001235996B2 (en) 2000-02-28 2004-12-02 Daiichi Pure Chemicals Co., Ltd Measuring method using long life fluorescence of excitation type
US6607922B2 (en) 2000-03-17 2003-08-19 Quantum Design, Inc. Immunochromatographic assay method and apparatus
US6699722B2 (en) * 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
US6436722B1 (en) 2000-04-18 2002-08-20 Idexx Laboratories, Inc. Device and method for integrated diagnostics with multiple independent flow paths
DE10025145A1 (de) * 2000-05-20 2001-11-22 Presens Prec Sensing Gmbh Phosphoreszierende Polyelektrolytaggregate
US20050032051A1 (en) 2000-06-19 2005-02-10 Hayes Mark A Rapid flow-based immunoassay microchip
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE10042023C2 (de) 2000-08-08 2003-04-10 Biognostic Ag Kapseln, die feste Teilchen signalerzeugender Substanzen einkapseln, und deren Verwendung bei Bioassays zum Nachweis von Zielmolekülen in einer Probe
US6720007B2 (en) * 2000-10-25 2004-04-13 Tufts University Polymeric microspheres
DE10054426B4 (de) 2000-10-27 2006-03-09 Iom Innovative Optische Messtechnik Gmbh Verfahren zur Multi-Fluoreszenz-Detektion
US20020164659A1 (en) 2000-11-30 2002-11-07 Rao Galla Chandra Analytical methods and compositions
DE10062062C1 (de) 2000-12-13 2002-02-28 Draegerwerk Ag Elektrochemischer Sensor
US20030162236A1 (en) 2001-03-26 2003-08-28 Response Biomedical Corporation Compensation for variability in specific binding in quantitative assays
JP2002303629A (ja) 2001-04-06 2002-10-18 Matsushita Electric Ind Co Ltd 免疫クロマトデバイス及びそれを用いた被検物質測定方法
CA2383392A1 (en) * 2001-04-27 2002-10-27 Matsushita Electric Industrial Co., Ltd. Bio-device, and quantitative measurement apparatus and method using the same
JP3741051B2 (ja) 2001-05-10 2006-02-01 横河電機株式会社 バイオチップ読取装置
JP4834242B2 (ja) 2001-05-30 2011-12-14 オリンパス株式会社 蛍光読み取り装置
CN100386627C (zh) 2001-07-03 2008-05-07 包刚 过滤型蛋白芯片
US6818456B2 (en) 2001-07-20 2004-11-16 Varian, Inc. Color contrast system for lateral flow immunoassay tests
US6887851B2 (en) * 2001-09-18 2005-05-03 Bioexpertise, Llc IGF-binding protein-derived peptide
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US7214427B2 (en) 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US20040106190A1 (en) 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices

Also Published As

Publication number Publication date
US20050112703A1 (en) 2005-05-26
US20080090253A1 (en) 2008-04-17
US8557604B2 (en) 2013-10-15
US20140004506A1 (en) 2014-01-02
US8703504B2 (en) 2014-04-22
WO2005057215A1 (en) 2005-06-23
EP1692508A1 (de) 2006-08-23
EP1692508B1 (de) 2010-12-15

Similar Documents

Publication Publication Date Title
DE602004030615D1 (de) Lateralfluss-testvorrichtungen auf membranbasis unter verwendung von phosphoreszenznachweises
DE602004010863D1 (de) Leckdetektor unter Verwendung von Pulssignalen
DE602004009960D1 (de) System und verfahren zum erkennen und vergleichen anatomischer strukturen unter verwendung von erscheinungsbild und form
DE602005023766D1 (de) Durchflusszytometer auf der basis von ramandetektion
DE602004028232D1 (de) Gerät zur überwachung von lungenödem
DE602005027478D1 (de) System zum anbringen von etiketten
DE60115653D1 (de) Verfahren zur Detektion von Emotionen, unter Verwendung von Untergruppenspezialisten
DE602005021914D1 (de) Trennmembranträger
SE0302083L (sv) Stödlist för långhålsborr
DE602005022529D1 (de) Vorrichtung zum Erzeugen von Bildschirmen
ATA1902003A (de) Biologische reinigung von wasser
DE602004005369D1 (de) Vorrichtung zum Verlegen von Leitungselementen
DE602004014686D1 (de) Vorrichtung zum Herstellen von Broschüren
DE602004014207D1 (de) System zum Einfüllen von Kraftstoff
DE60321099D1 (de) Gasdurchflussmessung unter Benutzung von Gaskonzentrationmessungen
ATA2632003A (de) Vorrichtung zum vereinzeln von münzen
DE602004024622D1 (de) Ladesystem unter Verwendung von Gitterelementen mit differenzierten Mustern
DE602004026412D1 (de) Vorrichtung zur verhinderung von lasteinsturz
DE602004022472D1 (de) Vorrichtung für Erkennung von Änderungsinformation
DE602004023676D1 (de) Verfahren und System zum Ausrichten von Papier
ATE450538T1 (de) Spiropiperidinderivate zur bekämpfung von schädlingen
DE602004018030D1 (de) Unter mikrofiltration hergestellte pigmentierte tinten
DE602004017919D1 (de) Vorrichtung zum Aufnehmen von Briefumschlägen
DE502004010581D1 (de) Sensor zur detektion von nebelartigen medien
DE502004004068D1 (de) Einrichtung zum Bergen von unter Wasser befindlichen Fremdteilen

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: ZIMMERMANN & PARTNER, 80331 MUENCHEN