DE602004002087D1 - Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistenten krebs - Google Patents
Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistenten krebsInfo
- Publication number
- DE602004002087D1 DE602004002087D1 DE602004002087T DE602004002087T DE602004002087D1 DE 602004002087 D1 DE602004002087 D1 DE 602004002087D1 DE 602004002087 T DE602004002087 T DE 602004002087T DE 602004002087 T DE602004002087 T DE 602004002087T DE 602004002087 D1 DE602004002087 D1 DE 602004002087D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- group
- aryl group
- bonded
- taken together
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 title abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44040603P | 2003-01-15 | 2003-01-15 | |
US440406P | 2003-01-15 | ||
PCT/US2004/001089 WO2004064826A1 (en) | 2003-01-15 | 2004-01-15 | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004002087D1 true DE602004002087D1 (de) | 2006-10-05 |
DE602004002087T2 DE602004002087T2 (de) | 2007-03-08 |
Family
ID=32771813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004002087T Expired - Lifetime DE602004002087T2 (de) | 2003-01-15 | 2004-01-15 | Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistentem krebs |
Country Status (14)
Country | Link |
---|---|
US (1) | US7763658B2 (de) |
EP (1) | EP1583524B1 (de) |
JP (1) | JP4852409B2 (de) |
AT (1) | ATE336991T1 (de) |
AU (1) | AU2004206865B2 (de) |
CA (1) | CA2512797C (de) |
CY (1) | CY1106246T1 (de) |
DE (1) | DE602004002087T2 (de) |
DK (1) | DK1583524T3 (de) |
ES (1) | ES2271839T3 (de) |
HK (1) | HK1084024A1 (de) |
PT (1) | PT1583524E (de) |
TW (1) | TWI330079B (de) |
WO (1) | WO2004064826A1 (de) |
Families Citing this family (41)
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TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
WO2005094322A2 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
JP5362986B2 (ja) | 2004-06-23 | 2013-12-11 | シンタ ファーマスーティカルズ コーポレイション | 癌治療のためのビス(チオ‐ヒドラジドアミド)塩 |
WO2006033913A2 (en) * | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
US8148426B2 (en) * | 2004-11-19 | 2012-04-03 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
WO2006062732A2 (en) * | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
CA2603314A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
JP2008536875A (ja) | 2005-04-15 | 2008-09-11 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオヒドラジド)アミド化合物による併用癌療法 |
BRPI0611262A2 (pt) | 2005-05-16 | 2010-08-24 | Synta Pharmaceuticals Corp | mÉtodos de preparaÇço de um di-sal de bis (tio-hidrazida amida) |
AU2006279891B2 (en) * | 2005-08-16 | 2010-03-11 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amide) formulation |
WO2008024298A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
AU2007288336B2 (en) * | 2006-08-21 | 2011-04-21 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
WO2008024299A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
US8497272B2 (en) | 2006-08-21 | 2013-07-30 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
SG174087A1 (en) | 2006-08-21 | 2011-09-29 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
WO2008024305A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
EP2076254A2 (de) | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Kombination mit bis(thiohydrazidamiden) zur behandlung von krebs |
WO2008033300A2 (en) * | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
US8618170B2 (en) * | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
WO2009073148A2 (en) * | 2007-11-28 | 2009-06-11 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
WO2009105257A1 (en) * | 2008-02-21 | 2009-08-27 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2009123704A2 (en) * | 2008-03-31 | 2009-10-08 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
CN102256949B (zh) | 2008-10-22 | 2014-09-24 | 辛塔医药品有限公司 | 双[硫代酰肼酰胺]化合物的过渡金属络合物 |
AU2009308502B2 (en) | 2008-10-22 | 2013-08-01 | Synta Pharmaceuticals Corp. | Transition metal complexes of bis[thiohydrazide amide] compounds |
US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
WO2010065512A2 (en) | 2008-12-01 | 2010-06-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
CA2854186A1 (en) * | 2011-11-10 | 2013-05-16 | Jim SANG | Administration of a bis(thiohydrazide amide) compound for treating cancers |
US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
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WO2006033913A2 (en) | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
WO2006062732A2 (en) | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
US8148426B2 (en) | 2004-11-19 | 2012-04-03 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
JP5123671B2 (ja) | 2005-02-17 | 2013-01-23 | シンタ ファーマシューティカルズ コーポレーション | 増殖性疾患の治療のための化合物 |
CA2603314A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
JP2008536875A (ja) | 2005-04-15 | 2008-09-11 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオヒドラジド)アミド化合物による併用癌療法 |
WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
BRPI0611262A2 (pt) | 2005-05-16 | 2010-08-24 | Synta Pharmaceuticals Corp | mÉtodos de preparaÇço de um di-sal de bis (tio-hidrazida amida) |
AU2006279891B2 (en) | 2005-08-16 | 2010-03-11 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amide) formulation |
CA2653222A1 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
WO2008024305A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
AU2007288336B2 (en) | 2006-08-21 | 2011-04-21 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
US8497272B2 (en) | 2006-08-21 | 2013-07-30 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2008024299A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
SG174087A1 (en) | 2006-08-21 | 2011-09-29 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
EP2076254A2 (de) | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Kombination mit bis(thiohydrazidamiden) zur behandlung von krebs |
WO2008033300A2 (en) | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
EP2059250A2 (de) | 2006-09-14 | 2009-05-20 | Synta Pharmaceuticals Corporation | Verbindungen zur behandlung von angiogenese |
WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
WO2008082579A1 (en) | 2007-01-03 | 2008-07-10 | Synta Pharmaceuticals Corp. | Method for treating cancer |
TW200922550A (en) | 2007-08-07 | 2009-06-01 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
-
2004
- 2004-01-14 TW TW093100878A patent/TWI330079B/zh not_active IP Right Cessation
- 2004-01-15 EP EP04702560A patent/EP1583524B1/de not_active Expired - Lifetime
- 2004-01-15 ES ES04702560T patent/ES2271839T3/es not_active Expired - Lifetime
- 2004-01-15 WO PCT/US2004/001089 patent/WO2004064826A1/en active IP Right Grant
- 2004-01-15 CA CA2512797A patent/CA2512797C/en not_active Expired - Fee Related
- 2004-01-15 JP JP2006500976A patent/JP4852409B2/ja not_active Expired - Fee Related
- 2004-01-15 PT PT04702560T patent/PT1583524E/pt unknown
- 2004-01-15 DE DE602004002087T patent/DE602004002087T2/de not_active Expired - Lifetime
- 2004-01-15 US US10/758,589 patent/US7763658B2/en not_active Expired - Fee Related
- 2004-01-15 AT AT04702560T patent/ATE336991T1/de active
- 2004-01-15 DK DK04702560T patent/DK1583524T3/da active
- 2004-01-15 AU AU2004206865A patent/AU2004206865B2/en not_active Ceased
-
2006
- 2006-04-07 HK HK06104252A patent/HK1084024A1/xx not_active IP Right Cessation
- 2006-11-16 CY CY20061101668T patent/CY1106246T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
TWI330079B (en) | 2010-09-11 |
US20040225016A1 (en) | 2004-11-11 |
DK1583524T3 (da) | 2006-12-27 |
ATE336991T1 (de) | 2006-09-15 |
HK1084024A1 (en) | 2006-07-21 |
US7763658B2 (en) | 2010-07-27 |
DE602004002087T2 (de) | 2007-03-08 |
CA2512797C (en) | 2012-02-21 |
JP2006515626A (ja) | 2006-06-01 |
PT1583524E (pt) | 2006-12-29 |
JP4852409B2 (ja) | 2012-01-11 |
WO2004064826A1 (en) | 2004-08-05 |
AU2004206865A1 (en) | 2004-08-05 |
EP1583524A1 (de) | 2005-10-12 |
CY1106246T1 (el) | 2011-06-08 |
AU2004206865B2 (en) | 2006-07-13 |
EP1583524B1 (de) | 2006-08-23 |
TW200418449A (en) | 2004-10-01 |
ES2271839T3 (es) | 2007-04-16 |
CA2512797A1 (en) | 2004-08-05 |
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