DE60141742D1 - Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten - Google Patents

Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten

Info

Publication number: DE60141742D1
Authority: DE; Germany
Prior art keywords: free; harnic; aggregate; acid oxidase; preparing non
Prior art date: 2000-02-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60141742T

Other languages

English (en)

Inventor

Merry R Sherman

Mark G Saifer

David L Williams

Michael S Hershfield

Susan J Kelly

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mountain View Pharmaceuticals Inc

Duke University

Original Assignee

Mountain View Pharmaceuticals Inc

Duke University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-10

Filing date

2001-02-07

Publication date

2010-05-20

2001-02-07 Application filed by Mountain View Pharmaceuticals Inc, Duke University filed Critical Mountain View Pharmaceuticals Inc

2010-05-20 Application granted granted Critical

2010-05-20 Publication of DE60141742D1 publication Critical patent/DE60141742D1/de

2021-02-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DE60141742T 2000-02-10 2001-02-07 Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten Expired - Lifetime DE60141742D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/501,730 US6783965B1 (en)	2000-02-10	2000-02-10	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
PCT/US2001/040069 WO2001059078A2 (en)	2000-02-10	2001-02-07	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

Publications (1)

Publication Number	Publication Date
DE60141742D1 true DE60141742D1 (de)	2010-05-20

Family

ID=23994789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60141742T Expired - Lifetime DE60141742D1 (de)	2000-02-10	2001-02-07	Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten

Country Status (28)

Country	Link
US (3)	US6783965B1 (de)
EP (3)	EP1254237B1 (de)
JP (2)	JP5165826B2 (de)
KR (3)	KR101054247B1 (de)
CN (2)	CN101735991B (de)
AT (1)	ATE463576T1 (de)
AU (3)	AU2001249975B2 (de)
BE (1)	BE2013C045I2 (de)
BR (1)	BRPI0108386B8 (de)
CA (1)	CA2398679C (de)
CY (3)	CY1110142T1 (de)
CZ (1)	CZ304864B6 (de)
DE (1)	DE60141742D1 (de)
DK (3)	DK1254237T3 (de)
ES (2)	ES2524153T3 (de)
FR (1)	FR13C0036I2 (de)
HK (4)	HK1056742A1 (de)
HU (1)	HU227127B1 (de)
IL (3)	IL151065A0 (de)
LU (1)	LU92237I2 (de)
MX (1)	MXPA02007545A (de)
NZ (1)	NZ520434A (de)
PL (1)	PL208064B1 (de)
PT (2)	PT2305819E (de)
RU (3)	RU2352354C2 (de)
TW (2)	TW200914617A (de)
WO (1)	WO2001059078A2 (de)
ZA (1)	ZA200207206B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DK2158923T3 (da) *	1998-08-06	2013-03-25	Mountain View Pharmaceuticals	Peg-uratoxidase-konjugater og anvendelse deraf
US20060188971A1 (en) *	1998-08-06	2006-08-24	Duke University	Urate oxidase
PL220873B1 (pl) *	1998-08-06	2016-01-29	Mountain View Pharmaceuticals	Roztwór chromatograficznie oczyszczonej tetramerycznej urykazy
US6783965B1 (en) *	2000-02-10	2004-08-31	Mountain View Pharmaceuticals, Inc.	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
IL141221A0 (en)	1998-08-06	2002-03-10	Univ Duke	Urate oxidase
WO2003002716A2 (en)	2001-06-28	2003-01-09	Mountain View Pharmaceuticals, Inc.	Polymer stabilized proteinases
US6913915B2 (en)	2001-08-02	2005-07-05	Phoenix Pharmacologics, Inc.	PEG-modified uricase
DK2311432T3 (en) *	2002-06-07	2015-02-02	Dyax Corp	Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
US8129330B2 (en) *	2002-09-30	2012-03-06	Mountain View Pharmaceuticals, Inc.	Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en)	2002-09-30	2004-04-01	Mountain View Pharmaceuticals, Inc.	Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
PT1667708E (pt) *	2002-12-26	2012-09-14	Mountain View Pharmaceuticals	Conjugados de interferão-beta-1b e polietileno glicol apresentando uma potência biológica in vitro aumentada
MXPA05012314A (es) *	2003-05-12	2006-04-18	Affymax Inc	Radical separador para peptido modificado con polietilenglicol.
EA010099B1 (ru) *	2003-05-12	2008-06-30	Афимакс, Инк.	Пептиды, которые связываются с рецептором к эритропоэтину, и способы их применения
WO2004101600A2 (en) *	2003-05-12	2004-11-25	Affymax, Inc.	Novel poly(ethylene glycol) modified compounds and uses thereof
CA2536873C (en) *	2003-08-29	2019-09-10	Dyax Corp.	Poly-pegylated protease inhibitors
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EP1814910A4 (de) *	2004-11-11	2009-04-29	Affymax Inc	Neue am erythropoietinrezeptor bindende peptide
WO2006062685A2 (en) *	2004-11-11	2006-06-15	Affymax, Inc.	Novel peptides that bind to the erythropoietin receptor
JP2008534640A (ja) *	2005-04-05	2008-08-28	イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー	タンパク質の機能部位またはエピトープの遮蔽方法
US8188224B2 (en)	2005-04-11	2012-05-29	Savient Pharmaceuticals, Inc.	Variant forms of urate oxidase and use thereof
US8148123B2 (en) *	2005-04-11	2012-04-03	Savient Pharmaceuticals, Inc.	Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
CZ2007700A3 (cs)	2005-04-11	2008-02-27	Savient Pharmaceuticals, Inc.	Variantní forma urátoxidázy a její použití
US20080159976A1 (en) *	2005-04-11	2008-07-03	Jacob Hartman	Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
JP2008545665A (ja) *	2005-05-23	2008-12-18	ユニベルシテドゥジュネーブ	高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用
US7550433B2 (en) *	2005-06-03	2009-06-23	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
US7919461B2 (en)	2005-06-03	2011-04-05	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) *	2005-06-03	2012-12-04	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
KR101288027B1 (ko) *	2006-04-12	2013-07-22	새비언트 파마수티컬즈 인크.	양이온 계면활성제를 이용한 단백질 정제 방법
WO2009026334A2 (en) *	2007-08-21	2009-02-26	Genzyme Corporation	Treatment with kallikrein inhibitors
US8637454B2 (en)	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
CN102803954A (zh)	2009-06-25	2012-11-28	萨文特制药公司	通过监测peg化尿酸酶治疗期间的血清尿酸预测输液反应风险和抗体介导的响应丧失的方法和试剂盒
EP2521568B1 (de)	2010-01-06	2018-07-25	Dyax Corp.	Plasmakallikreinbindende proteine
US8940861B2 (en)	2010-04-08	2015-01-27	Georgia Tech Research Corporation	Variants of ancestral uricases and uses thereof
US8816055B2 (en)	2011-01-06	2014-08-26	Dyax Corp.	Plasma kallikrein binding proteins
CN102827073A (zh)	2011-06-17	2012-12-19	安吉奥斯医药品有限公司	治疗活性组合物和它们的使用方法
US9474779B2 (en)	2012-01-19	2016-10-25	Agios Pharmaceuticals, Inc.	Therapeutically active compositions and their methods of use
CA2913476A1 (en) *	2013-06-07	2014-12-11	Allena Pharmaceuticals, Inc.	Compositions, methods, and devices for dialysis
WO2015003360A2 (en)	2013-07-11	2015-01-15	Agios Pharmaceuticals, Inc.	Therapeutically active compounds and their methods of use
US10376510B2 (en)	2013-07-11	2019-08-13	Agios Pharmaceuticals, Inc.	2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
US9579324B2 (en)	2013-07-11	2017-02-28	Agios Pharmaceuticals, Inc	Therapeutically active compounds and their methods of use
WO2015003355A2 (en)	2013-07-11	2015-01-15	Agios Pharmaceuticals, Inc.	Therapeutically active compounds and their methods of use
US20150031627A1 (en)	2013-07-25	2015-01-29	Agios Pharmaceuticals, Inc	Therapeutically active compounds and their methods of use
MX2016011810A (es)	2014-03-14	2017-04-27	Agios Pharmaceuticals Inc	Composiciones farmaceuticas de compuestos terapeuticamente activos y sus metodos de uso.
IL295414A (en)	2014-03-27	2022-10-01	Takeda Pharmaceuticals Co	Compositions and methods for treating macular edema as a result of diabetes
EP3294322A4 (de)	2015-05-15	2018-12-12	Medimmune, LLC	Verbesserte uricasesequenzen und behandlungsverfahren
MA42999A (fr)	2015-10-15	2018-08-22	Agios Pharmaceuticals Inc	Polythérapie pour le traitement de malignités
JP7033061B2 (ja)	2015-10-15	2022-03-09	アジオスファーマシューティカルズ，インコーポレイテッド	悪性腫瘍を処置するため組合せ療法
NZ744233A (en)	2015-12-11	2023-11-24	Takeda Pharmaceuticals Co	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
WO2018089808A1 (en)	2016-11-11	2018-05-17	Horizon Pharma Rheumatology Llc	Combination therapies of prednisone and uricase molecules and uses thereof
CN111373034A (zh)	2017-07-07	2020-07-03	艾乐娜制药有限公司	重组尿酸酶
US20190309269A1 (en)	2018-03-20	2019-10-10	Rubius Therapeutics, Inc.	Therapeutic cell systems and methods for treating hyperuricemia and gout
US10980788B2 (en)	2018-06-08	2021-04-20	Agios Pharmaceuticals, Inc.	Therapy for treating malignancies
CN109055260B (zh) *	2018-08-08	2021-11-09	淮海工学院	弯曲芽孢杆菌alkaAU及产尿酸氧化酶方法、产品与应用
CN114181917B (zh) *	2022-02-14	2022-06-03	潍坊华卓生物科技有限公司	一种改造尿酸酶、基因序列、制备方法及应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE279486C (de)
US3616231A (en)	1968-11-14	1971-10-26	Boehringer Mannheim Gmbh	Process for the production of uricase
US4179337A (en)	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
JPS5599189A (en)	1979-01-22	1980-07-28	Mihama Hisaharu	Modified uricase free from antigenicity and its preparation
JPS55135590A (en)	1979-04-05	1980-10-22	Mihama Hisaharu	Modified asparaginase and uricase and their preparation
CH651308A5 (de)	1980-07-01	1985-09-13	Hoffmann La Roche	Interferone und deren herstellung.
JPS57192435A (en)	1981-05-20	1982-11-26	Toyobo Co Ltd	Modified polypeptide
DE3126759A1 (de)	1981-07-07	1983-01-27	Boehringer Mannheim Gmbh, 6800 Mannheim	Loesliche leber-uricase, verfahren zu ihrer herstellung und verwendung
WO1987000056A1 (en) *	1985-06-26	1987-01-15	Cetus Corporation	Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4766106A (en)	1985-06-26	1988-08-23	Cetus Corporation	Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en)	1985-06-26	1990-04-17	Cetus Corporation	Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US4847079A (en)	1985-07-29	1989-07-11	Schering Corporation	Biologically stable interferon compositions comprising thimerosal
DD279486A1 (de)	1986-03-10	1990-06-06	Akad Wissenschaften Ddr	Verfahren zur aktivierung von hydroxylgruppenhaltigen polymeren verbindungen
JPS6255079A (ja) *	1986-04-23	1987-03-10	Mihama Hisaharu	修飾ウリカ−ゼ
JPH085506B2 (ja) *	1986-08-25	1996-01-24	日東製器株式会社	缶容器
DD279489A1 (de)	1986-12-11	1990-06-06	Leuna Werke Veb	Verfahren zur herstellung optisch transparenter epoxidharzformmassen
US5080891A (en)	1987-08-03	1992-01-14	Ddi Pharmaceuticals, Inc.	Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US4847325A (en)	1988-01-20	1989-07-11	Cetus Corporation	Conjugation of polymer to colony stimulating factor-1
US5955336A (en) *	1988-08-17	1999-09-21	Toyo Boseki Kabushiki Kaisha	DNA sequence for uricase and manufacturing process of uricase
US5349052A (en)	1988-10-20	1994-09-20	Royal Free Hospital School Of Medicine	Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
US5324844A (en)	1989-04-19	1994-06-28	Enzon, Inc.	Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en)	1989-04-19	1992-06-16	Enzon, Inc.	Active carbonates of polyalkylene oxides for modification of polypeptides
NZ234453A (en) *	1989-07-13	1993-01-27	Sanofi Sa	Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
US5382518A (en)	1989-07-13	1995-01-17	Sanofi	Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
US5286637A (en)	1989-08-07	1994-02-15	Debiopharm, S.A.	Biologically active drug polymer derivatives and method for preparing same
JPH03148298A (ja)	1989-11-01	1991-06-25	Sumitomo Pharmaceut Co Ltd	修飾ペプチドおよびその製造方法
US5766897A (en) *	1990-06-21	1998-06-16	Incyte Pharmaceuticals, Inc.	Cysteine-pegylated proteins
US5653974A (en)	1990-10-18	1997-08-05	Board Of Regents,The University Of Texas System	Preparation and characterization of liposomal formulations of tumor necrosis factor
AU1674292A (en) *	1991-03-15	1992-10-21	Synergen, Inc.	Pegylation of polypeptides
JP3230056B2 (ja)	1991-07-02	2001-11-19	インヘイル・インコーポレーテッド	薬剤のエーロゾル化服用量を形成する装置
WO1994019007A1 (en)	1993-02-16	1994-09-01	Enzon, Inc.	Ribosome inactivating protein compositions having reduced antigenicity
WO1994023740A1 (en) *	1993-04-22	1994-10-27	Celtrix Pharmaceuticals, Inc.	Conjugates of growth factor and bone resorption inhibitor
AU7113594A (en)	1993-06-21	1995-01-17	Enzon, Inc.	Site specific synthesis of conjugated peptides
IT1265101B1 (it) *	1993-07-23	1996-10-30	Erba Carlo Spa	Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
US5919455A (en)	1993-10-27	1999-07-06	Enzon, Inc.	Non-antigenic branched polymer conjugates
US5643575A (en)	1993-10-27	1997-07-01	Enzon, Inc.	Non-antigenic branched polymer conjugates
ATE214940T1 (de)	1993-11-10	2002-04-15	Enzon Inc	Verbesserte interferon-polymerkonjugate
US5824784A (en)	1994-10-12	1998-10-20	Amgen Inc.	N-terminally chemically modified protein compositions and methods
EP0796324A1 (de)	1994-12-07	1997-09-24	Novo Nordisk A/S	Polypeptide mit verminderter allergener wirkung
US5932462A (en)	1995-01-10	1999-08-03	Shearwater Polymers, Inc.	Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
JP2758154B2 (ja)	1995-04-06	1998-05-28	エフ・ホフマン−ラロシユアーゲー	インターフェロンを含む液体製剤
FR2733914B1 (fr) *	1995-05-11	1997-08-01	Sanofi Sa	Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation
US5853974A (en)	1995-06-07	1998-12-29	Chiron Corporation	Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
JPH09154581A (ja)	1995-12-05	1997-06-17	Asahi Chem Ind Co Ltd	ウリカーゼを生産する実質上純粋な微生物
CN1168495C (zh)	1997-01-15	2004-09-29	凤凰药理学公司	被修饰的肿瘤坏死因子
DE69919701T2 (de) *	1998-06-01	2005-09-15	Genentech, Inc., South San Francisco	Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie
US6783965B1 (en) *	2000-02-10	2004-08-31	Mountain View Pharmaceuticals, Inc.	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
DK2158923T3 (da)	1998-08-06	2013-03-25	Mountain View Pharmaceuticals	Peg-uratoxidase-konjugater og anvendelse deraf
IL141221A0 (en)	1998-08-06	2002-03-10	Univ Duke	Urate oxidase
PL220873B1 (pl)	1998-08-06	2016-01-29	Mountain View Pharmaceuticals	Roztwór chromatograficznie oczyszczonej tetramerycznej urykazy
US6425448B1 (en)	2001-01-30	2002-07-30	Cdx Gas, L.L.P.	Method and system for accessing subterranean zones from a limited surface area
US6913915B2 (en)	2001-08-02	2005-07-05	Phoenix Pharmacologics, Inc.	PEG-modified uricase
WO2014187953A1 (en)	2013-05-24	2014-11-27	Zentrum Mikroelektronik Dresden Ag	Non pwm digital dc-dc converter

2000
- 2000-02-10 US US09/501,730 patent/US6783965B1/en not_active Expired - Lifetime
2001
- 2001-02-06 TW TW097145974A patent/TW200914617A/zh unknown
- 2001-02-06 TW TW090102540A patent/TWI322184B/zh not_active IP Right Cessation
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- 2001-02-07 JP JP2001558218A patent/JP5165826B2/ja not_active Expired - Lifetime
- 2001-02-07 ES ES10180428.4T patent/ES2524153T3/es not_active Expired - Lifetime
- 2001-02-07 CZ CZ2002-2982A patent/CZ304864B6/cs not_active IP Right Cessation
- 2001-02-07 BR BRPI0108386A patent/BRPI0108386B8/pt not_active Application Discontinuation
- 2001-02-07 EP EP01923265A patent/EP1254237B1/de not_active Expired - Lifetime
- 2001-02-07 RU RU2006107110/13A patent/RU2352354C2/ru active
- 2001-02-07 KR KR1020087024272A patent/KR101054247B1/ko active IP Right Grant
- 2001-02-07 DK DK01923265.1T patent/DK1254237T3/da active
- 2001-02-07 IL IL15106501A patent/IL151065A0/xx unknown
- 2001-02-07 PT PT101804284T patent/PT2305819E/pt unknown
- 2001-02-07 WO PCT/US2001/040069 patent/WO2001059078A2/en active Application Filing
- 2001-02-07 AT AT01923265T patent/ATE463576T1/de active
- 2001-02-07 KR KR1020027010189A patent/KR100884724B1/ko active IP Right Grant
- 2001-02-07 PL PL358539A patent/PL208064B1/pl unknown
- 2001-02-07 CN CN2009101278530A patent/CN101735991B/zh not_active Expired - Lifetime
- 2001-02-07 EP EP10158016.5A patent/EP2196538B1/de not_active Expired - Lifetime
- 2001-02-07 ES ES01923265T patent/ES2343105T3/es not_active Expired - Lifetime
- 2001-02-07 KR KR1020077018682A patent/KR20070092329A/ko active Search and Examination
- 2001-02-07 DK DK10180428.4T patent/DK2305819T3/en active
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- 2001-02-07 AU AU2001249975A patent/AU2001249975B2/en not_active Revoked
- 2001-02-07 DK DK10158016.5T patent/DK2196538T3/en active
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- 2001-02-07 HU HU0204544A patent/HU227127B1/hu active Protection Beyond IP Right Term
- 2001-02-07 RU RU2002120486/13A patent/RU2281954C2/ru not_active IP Right Cessation
- 2001-02-07 AU AU4997501A patent/AU4997501A/xx active Pending
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2002
- 2002-08-05 IL IL151065A patent/IL151065A/en active Protection Beyond IP Right Term
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2003
- 2003-12-11 HK HK03109064.9A patent/HK1056742A1/xx not_active IP Right Cessation
2007
- 2007-08-03 US US11/882,750 patent/US7927852B2/en not_active Expired - Fee Related
2008
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2009
- 2009-02-06 RU RU2009104003/10A patent/RU2557318C9/ru active
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2010
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2011
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Also Published As

Publication number	Publication date
JP5165826B2 (ja)	2013-03-21
ES2524153T3 (es)	2014-12-04
CN1423699A (zh)	2003-06-11
IL151065A0 (en)	2003-04-10
CZ304864B6 (cs)	2014-12-17
US8921064B2 (en)	2014-12-30
RU2006107110A (ru)	2007-09-20
WO2001059078A2 (en)	2001-08-16
CY1110142T1 (el)	2015-01-14
CA2398679C (en)	2015-11-17
TWI322184B (en)	2010-03-21
CZ20022982A3 (cs)	2003-01-15
CN100491532C (zh)	2009-05-27
FR13C0036I2 (fr)	2014-05-16
BR0108386A (pt)	2002-10-29
PL208064B1 (pl)	2011-03-31
RU2281954C2 (ru)	2006-08-20
RU2557318C9 (ru)	2015-09-10
BRPI0108386B8 (pt)	2021-05-25
IL193365A0 (en)	2009-02-11
AU2009212900B2 (en)	2011-12-08
ZA200207206B (en)	2003-05-06
CA2398679A1 (en)	2001-08-16
HK1144701A1 (en)	2011-03-04
ATE463576T1 (de)	2010-04-15
IL151065A (en)	2008-12-29
HUP0204544A2 (en)	2003-05-28
HK1056742A1 (en)	2004-02-27
EP1254237B1 (de)	2010-04-07
KR100884724B1 (ko)	2009-02-19
ES2343105T3 (es)	2010-07-23
ES2343105T8 (es)	2013-07-15
PT1254237E (pt)	2010-06-07
EP2196538A1 (de)	2010-06-16
FR13C0036I1 (fr)	2013-08-09
IL193365A (en)	2011-08-31
US7927852B2 (en)	2011-04-19
AU2001249975B2 (en)	2006-06-08
JP5341945B2 (ja)	2013-11-13
JP2011188861A (ja)	2011-09-29
HK1155203A1 (en)	2012-05-11
NZ520434A (en)	2004-05-28
KR101054247B1 (ko)	2011-08-08
US20080057048A1 (en)	2008-03-06
HK1143989A1 (en)	2011-01-21
AU2009212900A1 (en)	2009-10-01
DK2305819T3 (en)	2015-01-05
HUP0204544A3 (en)	2007-05-02
RU2352354C2 (ru)	2009-04-20
AU4997501A (en)	2001-08-20
MXPA02007545A (es)	2002-12-13
DK1254237T3 (da)	2010-07-19
US6783965B1 (en)	2004-08-31
CN101735991A (zh)	2010-06-16
EP1254237A2 (de)	2002-11-06
CY1117264T1 (el)	2017-04-26
EP2196538B1 (de)	2014-10-01
BR0108386B1 (pt)	2017-10-31
WO2001059078A3 (en)	2002-03-07
PT2305819E (pt)	2015-06-01
DK2196538T3 (en)	2015-01-05
KR20070092329A (ko)	2007-09-12
CY2013028I2 (el)	2015-11-04
KR20020087934A (ko)	2002-11-23
RU2557318C2 (ru)	2015-07-20
CN101735991B (zh)	2013-09-11
EP2305819B1 (de)	2014-11-12
JP2003521937A (ja)	2003-07-22
LU92237I2 (fr)	2013-09-03
RU2009104003A (ru)	2010-08-20
CY2013028I1 (el)	2015-11-04
HU227127B1 (en)	2010-07-28
TW200914617A (en)	2009-04-01
PL358539A1 (en)	2004-08-09
BR0108386C1 (pt)	2011-12-20
BE2013C045I2 (de)	2020-06-24
US20110287466A1 (en)	2011-11-24
EP2305819A1 (de)	2011-04-06
KR20080098686A (ko)	2008-11-11

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