DE60140748D1 - Thiazol-derivate zur verwendung als entzündungshemmende mittel - Google Patents
Thiazol-derivate zur verwendung als entzündungshemmende mittelInfo
- Publication number
- DE60140748D1 DE60140748D1 DE60140748T DE60140748T DE60140748D1 DE 60140748 D1 DE60140748 D1 DE 60140748D1 DE 60140748 T DE60140748 T DE 60140748T DE 60140748 T DE60140748 T DE 60140748T DE 60140748 D1 DE60140748 D1 DE 60140748D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- inflammatory agents
- unsubstituted alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000198074 | 2000-06-30 | ||
| PCT/JP2001/005540 WO2002002542A1 (en) | 2000-06-30 | 2001-06-28 | Five-membered-ring compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60140748D1 true DE60140748D1 (de) | 2010-01-21 |
Family
ID=18696291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60140748T Expired - Lifetime DE60140748D1 (de) | 2000-06-30 | 2001-06-28 | Thiazol-derivate zur verwendung als entzündungshemmende mittel |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6919361B2 (de) |
| EP (2) | EP1669070A3 (de) |
| JP (1) | JP3785397B2 (de) |
| KR (2) | KR100758775B1 (de) |
| CN (2) | CN100369903C (de) |
| AT (1) | ATE451102T1 (de) |
| AU (2) | AU2001266345B2 (de) |
| CA (1) | CA2413000C (de) |
| CY (1) | CY1109863T1 (de) |
| DE (1) | DE60140748D1 (de) |
| DK (1) | DK1300401T3 (de) |
| ES (1) | ES2336425T3 (de) |
| PT (1) | PT1300401E (de) |
| TW (1) | TWI313266B (de) |
| WO (1) | WO2002002542A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002361117A1 (en) * | 2001-12-28 | 2003-07-24 | Sumitomo Pharmaceuticals Co., Ltd. | 5-membered cyclic compounds |
| EP1348433A1 (de) * | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | Thiazol-5-yl-imine als PDE7-Inhibitoren |
| DE10254336A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
| JPWO2005000825A1 (ja) * | 2003-06-27 | 2006-08-03 | 住友製薬株式会社 | チアゾールイミン類およびオキサゾールイミン類 |
| KR100848437B1 (ko) * | 2003-10-10 | 2008-07-28 | 샤프 가부시키가이샤 | 콘텐츠 재생 장치, 콘텐츠 재생 장치의 제어 방법, 콘텐츠 기록 매체, 및 컴퓨터 판독 가능한 기록 매체 |
| MY162179A (en) * | 2004-04-01 | 2017-05-31 | Elan Pharm Inc | Steroid sparing agents and methods of using same |
| JPWO2006051704A1 (ja) * | 2004-11-15 | 2008-05-29 | 大正製薬株式会社 | イミン化合物 |
| CA2603060A1 (en) * | 2005-04-28 | 2006-11-09 | Dainippon Sumitomo Pharma Co., Ltd. | Therapeutic agent for chronic obstructive pulmonary disease |
| JP2007015999A (ja) * | 2005-07-11 | 2007-01-25 | Sumitomo Chemical Co Ltd | イミノチアゾール化合物の製造方法 |
| CN101505758A (zh) * | 2006-05-11 | 2009-08-12 | 大日本住友制药株式会社 | 含有噻唑衍生物作为活性成分的药物 |
| WO2007140439A2 (en) | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
| US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
| WO2008121558A1 (en) | 2007-03-28 | 2008-10-09 | Abbott Laboratories | 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands |
| US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| JP2010527929A (ja) | 2007-05-18 | 2010-08-19 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての新規な化合物 |
| KR100863239B1 (ko) | 2007-05-23 | 2008-10-15 | 한국과학기술연구원 | 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는ｔ-형 칼슘 채널 저해제 |
| US9193713B2 (en) * | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| EP2272844A4 (de) * | 2008-04-25 | 2012-02-22 | Dainippon Sumitomo Pharma Co | Fünfgliedrige ringverbindung |
| WO2009131171A1 (ja) | 2008-04-25 | 2009-10-29 | 大日本住友製薬株式会社 | 新規５員環化合物 |
| US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US8859596B2 (en) | 2008-09-16 | 2014-10-14 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
| CA2756178A1 (en) | 2009-03-27 | 2010-09-30 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| US9650369B2 (en) * | 2012-09-28 | 2017-05-16 | Xavier University Of Louisiana | Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE941288C (de) * | 1950-10-31 | 1956-04-05 | Goodrich Co B F | Verfahren zur Herstellung substituierter 2-Imino-4-thiazoline oder von Salzen derselben bzw. von substituierten 2-Aminothiazolen |
| EP0848059A1 (de) | 1996-12-12 | 1998-06-17 | Vetigen | ICYP (Iodocyanopindolol) Rezeptor von Säugetieren und dessen Anwendungen |
| US7076307B2 (en) * | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
| FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
| CA2389773A1 (en) * | 1999-11-05 | 2001-05-10 | Robert Glen | Activators of soluble guanylate cyclase |
| US20030208212A1 (en) * | 1999-12-07 | 2003-11-06 | Valerio Cigaina | Removable gastric band |
| DE19959825C1 (de) * | 1999-12-10 | 2001-07-26 | Dorma Gmbh & Co Kg | Schiebewand mit mehreren seitlich verschiebbaren Wandelementen |
| US6885888B2 (en) * | 2000-01-20 | 2005-04-26 | The Cleveland Clinic Foundation | Electrical stimulation of the sympathetic nerve chain |
| US6708064B2 (en) * | 2000-02-24 | 2004-03-16 | Ali R. Rezai | Modulation of the brain to affect psychiatric disorders |
| US6639077B2 (en) * | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
| US6684105B2 (en) * | 2001-08-31 | 2004-01-27 | Biocontrol Medical, Ltd. | Treatment of disorders by unidirectional nerve stimulation |
| US7054686B2 (en) * | 2001-08-30 | 2006-05-30 | Biophan Technologies, Inc. | Pulsewidth electrical stimulation |
| US7831308B2 (en) * | 2002-02-01 | 2010-11-09 | The Cleveland Clinic Foundation | Neural stimulation delivery device with independently moveable delivery structures |
| US7715924B2 (en) * | 2002-02-01 | 2010-05-11 | The Cleveland Clinic Foundation | Adjustable simulation device and method of using same |
| AU2003210752A1 (en) * | 2002-02-01 | 2003-09-02 | The Cleveland Clinic Foundation | Modulation of the pain circuitry to affect chronic pain |
| US7689276B2 (en) * | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
| US20040015205A1 (en) * | 2002-06-20 | 2004-01-22 | Whitehurst Todd K. | Implantable microstimulators with programmable multielectrode configuration and uses thereof |
| US7292890B2 (en) * | 2002-06-20 | 2007-11-06 | Advanced Bionics Corporation | Vagus nerve stimulation via unidirectional propagation of action potentials |
| US20040210270A1 (en) * | 2002-07-26 | 2004-10-21 | John Erickson | High frequency pulse generator for an implantable neurostimulator |
| US7209790B2 (en) * | 2002-09-30 | 2007-04-24 | Medtronic, Inc. | Multi-mode programmer for medical device communication |
| US20040172084A1 (en) * | 2003-02-03 | 2004-09-02 | Knudson Mark B. | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
| US7613515B2 (en) * | 2003-02-03 | 2009-11-03 | Enteromedics Inc. | High frequency vagal blockage therapy |
| US7167750B2 (en) * | 2003-02-03 | 2007-01-23 | Enteromedics, Inc. | Obesity treatment with electrically induced vagal down regulation |
| US7844338B2 (en) * | 2003-02-03 | 2010-11-30 | Enteromedics Inc. | High frequency obesity treatment |
| US7444184B2 (en) * | 2003-05-11 | 2008-10-28 | Neuro And Cardial Technologies, Llc | Method and system for providing therapy for bulimia/eating disorders by providing electrical pulses to vagus nerve(s) |
| US7149574B2 (en) * | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| US7263405B2 (en) * | 2003-08-27 | 2007-08-28 | Neuro And Cardiac Technologies Llc | System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities |
| US7617002B2 (en) * | 2003-09-15 | 2009-11-10 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using decision trees |
| US7184837B2 (en) * | 2003-09-15 | 2007-02-27 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using bayesian networks |
| US7252090B2 (en) * | 2003-09-15 | 2007-08-07 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using neural network |
| US7239926B2 (en) * | 2003-09-15 | 2007-07-03 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using genetic algorithms |
| US7418292B2 (en) * | 2003-10-01 | 2008-08-26 | Medtronic, Inc. | Device and method for attenuating an immune response |
| EP1781372A1 (de) * | 2004-07-20 | 2007-05-09 | Medtronic, Inc. | Therapie-programmierführung auf basis von gespeicherter programmierhistorie |
-
2001
- 2001-06-28 ES ES01943850T patent/ES2336425T3/es not_active Expired - Lifetime
- 2001-06-28 DE DE60140748T patent/DE60140748D1/de not_active Expired - Lifetime
- 2001-06-28 AT AT01943850T patent/ATE451102T1/de active
- 2001-06-28 AU AU2001266345A patent/AU2001266345B2/en not_active Ceased
- 2001-06-28 CA CA002413000A patent/CA2413000C/en not_active Expired - Fee Related
- 2001-06-28 DK DK01943850.6T patent/DK1300401T3/da active
- 2001-06-28 US US10/312,692 patent/US6919361B2/en not_active Expired - Fee Related
- 2001-06-28 KR KR1020027017947A patent/KR100758775B1/ko not_active IP Right Cessation
- 2001-06-28 WO PCT/JP2001/005540 patent/WO2002002542A1/ja active Application Filing
- 2001-06-28 EP EP05025661A patent/EP1669070A3/de not_active Withdrawn
- 2001-06-28 CN CNB018146139A patent/CN100369903C/zh not_active Expired - Fee Related
- 2001-06-28 JP JP2002507796A patent/JP3785397B2/ja not_active Expired - Fee Related
- 2001-06-28 CN CNA2006100818928A patent/CN1944417A/zh active Pending
- 2001-06-28 EP EP01943850A patent/EP1300401B1/de not_active Expired - Lifetime
- 2001-06-28 KR KR1020077015693A patent/KR100824156B1/ko not_active IP Right Cessation
- 2001-06-28 AU AU6634501A patent/AU6634501A/xx active Pending
- 2001-06-28 PT PT01943850T patent/PT1300401E/pt unknown
- 2001-06-29 TW TW090115944A patent/TWI313266B/zh not_active IP Right Cessation
-
2005
- 2005-04-22 US US11/111,845 patent/US7396842B2/en not_active Expired - Fee Related
-
2010
- 2010-03-02 CY CY20101100202T patent/CY1109863T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2413000A1 (en) | 2002-01-10 |
| PT1300401E (pt) | 2010-01-25 |
| KR100824156B1 (ko) | 2008-04-21 |
| CA2413000C (en) | 2010-01-19 |
| US6919361B2 (en) | 2005-07-19 |
| KR20030011377A (ko) | 2003-02-07 |
| EP1669070A3 (de) | 2007-05-23 |
| ATE451102T1 (de) | 2009-12-15 |
| EP1300401A4 (de) | 2004-07-21 |
| CY1109863T1 (el) | 2014-09-10 |
| DK1300401T3 (da) | 2010-02-01 |
| US20040072827A1 (en) | 2004-04-15 |
| ES2336425T3 (es) | 2010-04-13 |
| EP1300401B1 (de) | 2009-12-09 |
| US7396842B2 (en) | 2008-07-08 |
| KR20070086998A (ko) | 2007-08-27 |
| KR100758775B1 (ko) | 2007-09-14 |
| CN1620442A (zh) | 2005-05-25 |
| AU2001266345B2 (en) | 2006-03-02 |
| WO2002002542A1 (en) | 2002-01-10 |
| CN1944417A (zh) | 2007-04-11 |
| EP1669070A2 (de) | 2006-06-14 |
| CN100369903C (zh) | 2008-02-20 |
| EP1300401A1 (de) | 2003-04-09 |
| US20050222226A1 (en) | 2005-10-06 |
| JP3785397B2 (ja) | 2006-06-14 |
| TWI313266B (en) | 2009-08-11 |
| AU6634501A (en) | 2002-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |