JPH08500481A
(ja)
*
|
1992-05-11 |
1996-01-23 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
ウイルスの複製を阻害するための方法および薬剤
|
US20030206887A1
(en)
*
|
1992-05-14 |
2003-11-06 |
David Morrissey |
RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
|
US5639647A
(en)
*
|
1994-03-29 |
1997-06-17 |
Ribozyme Pharmaceuticals, Inc. |
2'-deoxy-2'alkylnucleotide containing nucleic acid
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20040219569A1
(en)
*
|
1999-07-06 |
2004-11-04 |
Fruma Yehiely |
Gene identification method
|
US20110003879A1
(en)
*
|
2005-03-11 |
2011-01-06 |
Vincent Mark D |
Antisense oligonucleotides targeted to the coding region of thymidylate synthase and uses thereof
|
ES2374290T3
(es)
|
1998-03-20 |
2012-02-15 |
Commonwealth Scientific And Industrial Research Organisation |
Genes sintéticos y constructos genéticos que comprenden los mismos.
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
JP2003525017A
(ja)
*
|
1998-04-20 |
2003-08-26 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
遺伝子発現を調節しうる新規な化学組成を有する核酸分子
|
AU776150B2
(en)
|
1999-01-28 |
2004-08-26 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for (in vivo) and (in vitro) attenuation of gene expression using double stranded RNA
|
DE19956568A1
(de)
*
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
US7601494B2
(en)
|
1999-03-17 |
2009-10-13 |
The University Of North Carolina At Chapel Hill |
Method of screening candidate compounds for susceptibility to biliary excretion
|
ES2420835T3
(es)
|
1999-04-09 |
2013-08-27 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de las moléculas inmunofuncionales
|
US6656698B1
(en)
*
|
1999-06-30 |
2003-12-02 |
Millennium Pharmaceuticals, Inc. |
12832, a novel human kinase-like molecule and uses thereof
|
US6423885B1
(en)
|
1999-08-13 |
2002-07-23 |
Commonwealth Scientific And Industrial Research Organization (Csiro) |
Methods for obtaining modified phenotypes in plant cells
|
US8128922B2
(en)
*
|
1999-10-20 |
2012-03-06 |
Johns Hopkins University |
Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
|
GB9925459D0
(en)
*
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
DE10160151A1
(de)
*
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
US7829693B2
(en)
*
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
US7179796B2
(en)
*
|
2000-01-18 |
2007-02-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US8202979B2
(en)
*
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
US20050032733A1
(en)
*
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
US20080039414A1
(en)
*
|
2002-02-20 |
2008-02-14 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20070026394A1
(en)
*
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
US20030084471A1
(en)
*
|
2000-03-16 |
2003-05-01 |
David Beach |
Methods and compositions for RNA interference
|
US8202846B2
(en)
|
2000-03-16 |
2012-06-19 |
Cold Spring Harbor Laboratory |
Methods and compositions for RNA interference
|
AU2001245793A1
(en)
|
2000-03-16 |
2001-09-24 |
Cold Spring Harbor Laboratory |
Methods and compositions for rna interference
|
ATE450621T2
(de)
|
2000-03-30 |
2009-12-15 |
Whitehead Biomedical Inst |
Mediatoren von rns-interferenz, die rns- sequenzspezifisch sind
|
DK2360253T3
(da)
*
|
2000-03-30 |
2014-06-16 |
Whitehead Biomedical Inst |
Fremgangsmåde til fremstilling af knockdown-celler eller knockdown-organismer ved hjælp af RNA-sekvensspecifikke formidlere af RNA-interferens og anvendelser deraf
|
US7662791B2
(en)
*
|
2000-08-02 |
2010-02-16 |
University Of Southern California |
Gene silencing using mRNA-cDNA hybrids
|
US20080242627A1
(en)
*
|
2000-08-02 |
2008-10-02 |
University Of Southern California |
Novel rna interference methods using dna-rna duplex constructs
|
CA2417214C
(en)
*
|
2000-08-03 |
2016-06-21 |
Johns Hopkins University |
Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen
|
US20030190635A1
(en)
*
|
2002-02-20 |
2003-10-09 |
Mcswiggen James A. |
RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
|
US20080032942A1
(en)
*
|
2000-08-30 |
2008-02-07 |
Mcswiggen James |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
|
US20020165192A1
(en)
*
|
2000-09-19 |
2002-11-07 |
Kerr William G. |
Control of NK cell function and survival by modulation of ship activity
|
US7691821B2
(en)
|
2001-09-19 |
2010-04-06 |
University Of South Florida |
Inhibition of SHIP to enhance stem cell harvest and transplantation
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
US20040259247A1
(en)
|
2000-12-01 |
2004-12-23 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
CA2369944A1
(en)
|
2001-01-31 |
2002-07-31 |
Nucleonics Inc. |
Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
|
US20050233996A1
(en)
*
|
2002-02-20 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
|
US20070093437A1
(en)
*
|
2001-05-18 |
2007-04-26 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)
|
US20050182007A1
(en)
*
|
2001-05-18 |
2005-08-18 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
US20050196765A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
US7517864B2
(en)
|
2001-05-18 |
2009-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20080161256A1
(en)
*
|
2001-05-18 |
2008-07-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20040019001A1
(en)
*
|
2002-02-20 |
2004-01-29 |
Mcswiggen James A. |
RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
|
US20050124566A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
|
US20050239731A1
(en)
*
|
2001-05-18 |
2005-10-27 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
|
US20050191618A1
(en)
*
|
2001-05-18 |
2005-09-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
|
US20050119212A1
(en)
*
|
2001-05-18 |
2005-06-02 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA)
|
US20050233344A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
|
US20050196781A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of STAT3 gene expression using short interfering nucleic acid (siNA)
|
US20050176024A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA)
|
US20050159378A1
(en)
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
US20050143333A1
(en)
*
|
2001-05-18 |
2005-06-30 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
US20050159379A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc |
RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)
|
US20040219671A1
(en)
*
|
2002-02-20 |
2004-11-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of parkinson disease using short interfering nucleic acid (siNA)
|
US20050159381A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)
|
WO2005014811A2
(en)
*
|
2003-08-08 |
2005-02-17 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF XIAP GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
WO2003070743A1
(en)
*
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF G72 AND D-AMINO ACID OXIDASE (DAAO) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20060211642A1
(en)
*
|
2001-05-18 |
2006-09-21 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
US20070270579A1
(en)
*
|
2001-05-18 |
2007-11-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050048529A1
(en)
*
|
2002-02-20 |
2005-03-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
US20040198682A1
(en)
*
|
2001-11-30 |
2004-10-07 |
Mcswiggen James |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA)
|
US20050124569A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
|
US20060142225A1
(en)
*
|
2001-05-18 |
2006-06-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
|
US20050176666A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)
|
US20050176663A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)
|
US20050196767A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
|
US20050164224A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
US20050159380A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)
|
US20050137155A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA)
|
US20050282188A1
(en)
*
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US9994853B2
(en)
|
2001-05-18 |
2018-06-12 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
US20050267058A1
(en)
*
|
2001-05-18 |
2005-12-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA)
|
US20070042983A1
(en)
*
|
2001-05-18 |
2007-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050209180A1
(en)
*
|
2001-05-18 |
2005-09-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
US20050164967A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
US20050233997A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
US20050014172A1
(en)
|
2002-02-20 |
2005-01-20 |
Ivan Richards |
RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA)
|
US20050287128A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
|
US20050158735A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)
|
US20050187174A1
(en)
*
|
2001-05-18 |
2005-08-25 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
US20050261219A1
(en)
*
|
2001-05-18 |
2005-11-24 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
US20030175950A1
(en)
*
|
2001-05-29 |
2003-09-18 |
Mcswiggen James A. |
RNA interference mediated inhibition of HIV gene expression using short interfering RNA
|
US20050136436A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA)
|
US20050256068A1
(en)
|
2001-05-18 |
2005-11-17 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
|
US7109165B2
(en)
*
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
AU2004266311B2
(en)
*
|
2001-05-18 |
2009-07-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20060148743A1
(en)
*
|
2001-05-18 |
2006-07-06 |
Vasant Jadhav |
RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA)
|
US20050176664A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)
|
US20050203040A1
(en)
*
|
2001-05-18 |
2005-09-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
US20050288242A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA)
|
US20050222066A1
(en)
*
|
2001-05-18 |
2005-10-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050159382A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
US20050079610A1
(en)
*
|
2001-05-18 |
2005-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
US20050153914A1
(en)
*
|
2001-05-18 |
2005-07-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA)
|
US20050054596A1
(en)
*
|
2001-11-30 |
2005-03-10 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20090299045A1
(en)
*
|
2001-05-18 |
2009-12-03 |
Sirna Therapeutics, Inc. |
RNA Interference Mediated Inhibition Of Interleukin and Interleukin Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
US20050176025A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050164968A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)
|
US20080188430A1
(en)
*
|
2001-05-18 |
2008-08-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
US8008472B2
(en)
|
2001-05-29 |
2011-08-30 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
|
EP1390472A4
(de)
*
|
2001-05-29 |
2004-11-17 |
Sirna Therapeutics Inc |
Nukleinsäurebehandlung von krankheiten oder leiden im zusammenhang mit ras-, her2- und hiv-niveaus
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
AU2002315393A1
(en)
|
2001-06-21 |
2003-01-08 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
DE10133858A1
(de)
*
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
IL159756A0
(en)
|
2001-07-12 |
2004-06-20 |
Univ Massachusetts |
IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
|
US10590418B2
(en)
*
|
2001-07-23 |
2020-03-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for RNAi mediated inhibition of gene expression in mammals
|
WO2003010180A1
(en)
|
2001-07-23 |
2003-02-06 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for rnai mediated inhibition of gene expression in mammals
|
US20090247606A1
(en)
*
|
2001-08-28 |
2009-10-01 |
Sirna Therapeutics, Inc. |
RNA Interference Mediated Inhibition of Adenosine A1 Receptor (ADORA1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
US20030198627A1
(en)
*
|
2001-09-01 |
2003-10-23 |
Gert-Jan Arts |
siRNA knockout assay method and constructs
|
US7745418B2
(en)
|
2001-10-12 |
2010-06-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting viral replication
|
DE10163098B4
(de)
*
|
2001-10-12 |
2005-06-02 |
Alnylam Europe Ag |
Verfahren zur Hemmung der Replikation von Viren
|
CN1604783A
(zh)
*
|
2001-10-26 |
2005-04-06 |
里伯药品公司 |
通过rna干扰治疗纤维化疾病的药物
|
DE10230996A1
(de)
*
|
2001-10-26 |
2003-07-17 |
Ribopharma Ag |
Medikament zur Behandlung eines Pankreaskarzinoms
|
WO2003035870A1
(de)
*
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Medikament zur behandlung eines pankreaskarzinoms
|
US20040248835A1
(en)
*
|
2001-10-26 |
2004-12-09 |
Anja Krebs |
Use of a double-stranded ribonucleic acid for treating an infection with a positivestrand rna-virus
|
US20040063654A1
(en)
*
|
2001-11-02 |
2004-04-01 |
Davis Mark E. |
Methods and compositions for therapeutic use of RNA interference
|
AU2002348163A1
(en)
*
|
2001-11-02 |
2003-05-19 |
Intradigm Corporation |
Therapeutic methods for nucleic acid delivery vehicles
|
WO2004033620A2
(en)
*
|
2001-11-02 |
2004-04-22 |
Insert Therapeutics, Inc. |
Methods and compositions for therapeutic use of rna interference
|
CA2467936C
(en)
*
|
2001-11-21 |
2013-11-05 |
Mitsubishi Chemical Corporation |
Method of inhibiting gene expression
|
US20070203333A1
(en)
*
|
2001-11-30 |
2007-08-30 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050075304A1
(en)
*
|
2001-11-30 |
2005-04-07 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20040138163A1
(en)
*
|
2002-05-29 |
2004-07-15 |
Mcswiggen James |
RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US7294504B1
(en)
|
2001-12-27 |
2007-11-13 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Methods and compositions for DNA mediated gene silencing
|
DK1465995T3
(da)
|
2002-01-17 |
2008-10-20 |
Univ British Columbia |
Bispespecifikke antisense-olignukleotider der inhiberer IGFBP-2 og IGFBP og fremgangsmåder til anvendelse deraf
|
DE10202419A1
(de)
*
|
2002-01-22 |
2003-08-07 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
|
GB0201477D0
(en)
*
|
2002-01-23 |
2002-03-13 |
Novartis Forschungsstiftung |
Methods of obtaining isoform specific expression in mammalian cells
|
CA2475003A1
(en)
|
2002-02-01 |
2003-08-07 |
Sequitur, Inc. |
Double-stranded oligonucleotides
|
US20060009409A1
(en)
*
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
US20030166282A1
(en)
*
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
US20050096289A1
(en)
*
|
2002-02-07 |
2005-05-05 |
Hans Prydz |
Methods and compositions for modulating tissue factor
|
US20030157573A1
(en)
*
|
2002-02-12 |
2003-08-21 |
Orna Mor |
Use of Axl receptor for diagnosis and treatment of renal disease
|
AU2003214363A1
(en)
*
|
2002-02-13 |
2003-09-04 |
Axordia Limited |
Method to modify differentiation of pluripotential stem cells
|
EP1483281B2
(de)
|
2002-02-14 |
2012-09-05 |
City of Hope |
Verfahren zur herstellung interferierender rna-moleküle in säugetierzellen und therapeutische anwendungen solcher moleküle
|
US20100240730A1
(en)
*
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
CA2477014A1
(en)
*
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of tnf and tnf receptor superfamily gene expression using short interfering nucleic acid (sina)
|
US20090306182A1
(en)
*
|
2002-02-20 |
2009-12-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MAP KINASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20090093439A1
(en)
*
|
2002-02-20 |
2009-04-09 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7897753B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA)
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US8258288B2
(en)
|
2002-02-20 |
2012-09-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)
|
US7700760B2
(en)
|
2002-02-20 |
2010-04-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
US20050096284A1
(en)
*
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
US20090253773A1
(en)
*
|
2002-02-20 |
2009-10-08 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7893248B2
(en)
|
2002-02-20 |
2011-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
|
ATE519774T1
(de)
|
2002-02-20 |
2011-08-15 |
Sirna Therapeutics Inc |
Durch eine störung der rna vermittelte inhibierung der genexpression des hepatitis c virus (hcv) mit kurzer, störender nukleinsäure (short interfering nucleic acid, sina)
|
US7910724B2
(en)
*
|
2002-02-20 |
2011-03-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
US8232383B2
(en)
*
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US7683165B2
(en)
*
|
2002-02-20 |
2010-03-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
EP1432724A4
(de)
*
|
2002-02-20 |
2006-02-01 |
Sirna Therapeutics Inc |
Durch rna-interferenz vermittelte inhibierung von map-kinase-genen
|
US7691999B2
(en)
*
|
2002-02-20 |
2010-04-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)
|
US7897752B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
|
EP1499631A4
(de)
*
|
2002-02-20 |
2006-01-25 |
Sirna Therapeutics Inc |
Rna-interferenz-vermittelte hemmung von tgf-beta und tgf-beta-rezeptor-genexpression mit kurzinterferenz-nukleinsäure (sina)
|
US20090253774A1
(en)
|
2002-02-20 |
2009-10-08 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF PLATELET DERIVED GROWTH FACTOR (PDGF) AND PLATELET DERIVED GROWTH FACTOR RECEPTOR (PDGFR) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7928220B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)
|
US20090247613A1
(en)
*
|
2002-02-20 |
2009-10-01 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7667030B2
(en)
|
2002-02-20 |
2010-02-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
US7928219B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA)
|
US7683166B2
(en)
*
|
2002-02-20 |
2010-03-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
|
AU2003219818A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Ribozyme Pharmaceuticals, Incorporated |
RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7897757B2
(en)
*
|
2002-02-20 |
2011-03-01 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
|
US7928218B2
(en)
|
2002-02-20 |
2011-04-19 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
US20090233983A1
(en)
*
|
2002-02-20 |
2009-09-17 |
Sirna Therapeutics Inc. |
RNA Interference Mediated Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) Gene Expression Using Short Interfering RNA
|
US20090192105A1
(en)
|
2002-02-20 |
2009-07-30 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA)
|
US7678897B2
(en)
*
|
2002-02-20 |
2010-03-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
US7795422B2
(en)
|
2002-02-20 |
2010-09-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
US20090099117A1
(en)
|
2002-02-20 |
2009-04-16 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MYOSTATIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
WO2003070966A2
(en)
*
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc |
RNA INTERFERENCE MEDIATED TARGET DISCOVERY AND TARGET VALIDATION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US7667029B2
(en)
*
|
2002-02-20 |
2010-02-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
WO2003106476A1
(en)
*
|
2002-02-20 |
2003-12-24 |
Sirna Therapeutics, Inc |
Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity
|
US7662952B2
(en)
*
|
2002-02-20 |
2010-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)
|
AU2003213005A1
(en)
*
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc |
RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20090137509A1
(en)
*
|
2002-02-20 |
2009-05-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF PROLIFERATION CELL NUCLEAR ANTIGEN (PCNA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8067575B2
(en)
|
2002-02-20 |
2011-11-29 |
Merck, Sharp & Dohme Corp. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
US7935812B2
(en)
|
2002-02-20 |
2011-05-03 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US8013143B2
(en)
*
|
2002-02-20 |
2011-09-06 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
|
US20060111312A1
(en)
*
|
2002-02-22 |
2006-05-25 |
The John Hopkins University |
Antigene locks and therapeutic uses thereof
|
CA2476410C
(en)
*
|
2002-03-01 |
2013-09-24 |
Celltech R & D, Inc. |
Methods to increase or decrease bone density
|
US20040005593A1
(en)
*
|
2002-03-06 |
2004-01-08 |
Rigel Pharmaceuticals, Inc. |
Novel method for delivery and intracellular synthesis of siRNA molecules
|
US7274703B2
(en)
*
|
2002-03-11 |
2007-09-25 |
3Com Corporation |
Stackable network units with resiliency facility
|
CA2479530A1
(en)
*
|
2002-03-20 |
2003-10-02 |
Massachusetts Institute Of Technology |
Hiv therapeutic
|
US7357928B2
(en)
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
US20050222061A1
(en)
*
|
2002-04-18 |
2005-10-06 |
Schulte Ralf W |
Means and methods for the specific inhibition of genes in cells and tissue of the cns and/or eye
|
PT1504126E
(pt)
|
2002-05-03 |
2014-06-02 |
Univ Duke |
Um método para regular a expressão génica
|
US20040009946A1
(en)
|
2002-05-23 |
2004-01-15 |
Ceptyr, Inc. |
Modulation of PTP1B expression and signal transduction by RNA interference
|
US7199107B2
(en)
*
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
AU2003237686A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Rna interference mediating small rna molecules
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
WO2003106631A2
(en)
*
|
2002-06-12 |
2003-12-24 |
Ambion, Inc. |
Methods and compositions relating to labeled rna molecules that reduce gene expression
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
US20030235916A1
(en)
*
|
2002-06-14 |
2003-12-25 |
Monahan Sean D. |
Novel methods for the delivery of polynucleotides to cells
|
CN1662652B
(zh)
*
|
2002-06-21 |
2011-05-25 |
北京诺赛基因组研究中心有限公司 |
随机化的dna文库和双链rna文库,其用途及生产方法
|
EP1539245A2
(de)
*
|
2002-06-26 |
2005-06-15 |
The Penn State Research Foundation |
Verfahren und materialien zur behandlung von infektionen mit dem papillomavirus beim menschen
|
ES2354607T3
(es)
|
2002-06-28 |
2011-03-16 |
Protiva Biotherapeutics Inc. |
Procedimiento y aparato para producir liposomas.
|
EP1520022B1
(de)
*
|
2002-07-10 |
2015-07-22 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Rna-interferenz durch rna-einzelstrangmoleküle
|
US7148342B2
(en)
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
ES2389024T3
(es)
|
2002-08-05 |
2012-10-22 |
Silence Therapeutics Aktiengesellschaft |
Moléculas de RNA interferentes de extremos romos
|
PT2258847T
(pt)
*
|
2002-08-05 |
2017-06-22 |
Silence Therapeutics Gmbh |
Outras novas formas de moléculas de arn de interferência
|
AU2015264957B2
(en)
*
|
2002-08-05 |
2017-10-26 |
Silence Therapeutics Gmbh |
Further novel forms of interfering rna molecules
|
US20040241854A1
(en)
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
AU2012216354B2
(en)
*
|
2002-08-05 |
2016-01-14 |
Silence Therapeutics Gmbh |
Further novel forms of interfering RNA molecules
|
EP1857547B2
(de)
*
|
2002-08-05 |
2020-12-02 |
Silence Therapeutics GmbH |
Weitere neue Formen von interferierenden RNA-Molekülen
|
WO2004017997A1
(ja)
*
|
2002-08-06 |
2004-03-04 |
Toray Industries, Inc. |
腎疾患治療又は予防剤及び腎疾患の診断方法
|
AU2003258100A1
(en)
*
|
2002-08-06 |
2004-02-23 |
Intradigm Corporation |
Methods of down regulating target gene expression in vivo by introduction of interfering rna
|
US8729036B2
(en)
|
2002-08-07 |
2014-05-20 |
University Of Massachusetts |
Compositions for RNA interference and methods of use thereof
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
CN1674929B
(zh)
*
|
2002-08-14 |
2013-07-17 |
赛伦斯治疗公司 |
蛋白激酶Nβ的应用
|
US8252918B2
(en)
*
|
2002-08-21 |
2012-08-28 |
The University Of British Columbia |
RNAi probes targeting cancer-related proteins
|
US7956176B2
(en)
*
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20080260744A1
(en)
|
2002-09-09 |
2008-10-23 |
Omeros Corporation |
G protein coupled receptors and uses thereof
|
US20060287269A1
(en)
*
|
2002-09-09 |
2006-12-21 |
The Regents Of The University Of California |
Short interfering nucleic acid hybrids and methods thereof
|
US20040138119A1
(en)
*
|
2002-09-18 |
2004-07-15 |
Ingo Tamm |
Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis
|
WO2004027063A1
(en)
*
|
2002-09-19 |
2004-04-01 |
Institut National De La Sante Et De La Recherche Medicale-Inserm |
Use of sirnas for gene silencing in antigen presenting cells
|
EP1556402B1
(de)
|
2002-09-25 |
2011-06-22 |
University of Massachusetts |
Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna
|
US20060160759A1
(en)
*
|
2002-09-28 |
2006-07-20 |
Jianzhu Chen |
Influenza therapeutic
|
MXPA05003287A
(es)
*
|
2002-09-28 |
2005-07-05 |
Massachusetts Inst Technology |
Influenza terapeutica.
|
US20040242518A1
(en)
*
|
2002-09-28 |
2004-12-02 |
Massachusetts Institute Of Technology |
Influenza therapeutic
|
US20060240425A1
(en)
*
|
2002-09-30 |
2006-10-26 |
Oncotherapy Science, Inc |
Genes and polypeptides relating to myeloid leukemia
|
US7422853B1
(en)
*
|
2002-10-04 |
2008-09-09 |
Myriad Genetics, Inc. |
RNA interference using a universal target
|
US7521431B2
(en)
|
2002-11-01 |
2009-04-21 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for siRNA inhibition of HIF-1 alpha
|
US7892793B2
(en)
|
2002-11-04 |
2011-02-22 |
University Of Massachusetts |
Allele-specific RNA interference
|
EP1563070A4
(de)
*
|
2002-11-05 |
2008-05-28 |
Isis Pharmaceuticals Inc |
2'-substituierte oligomere verbindungen und zusammensetzungen zur verwendung bei genmodulationen
|
US7696345B2
(en)
|
2002-11-05 |
2010-04-13 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
CA2504929C
(en)
|
2002-11-05 |
2014-07-22 |
Charles Allerson |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
DE10322662A1
(de)
*
|
2002-11-06 |
2004-10-07 |
Grünenthal GmbH |
Wirksame und stabile DNA-Enzyme
|
US7691998B2
(en)
*
|
2002-11-14 |
2010-04-06 |
Dharmacon, Inc. |
siRNA targeting nucleoporin 62kDa (Nup62)
|
US10011836B2
(en)
|
2002-11-14 |
2018-07-03 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US9839649B2
(en)
|
2002-11-14 |
2017-12-12 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US20090227780A1
(en)
*
|
2002-11-14 |
2009-09-10 |
Dharmacon, Inc. |
siRNA targeting connexin 43
|
US7655785B1
(en)
|
2002-11-14 |
2010-02-02 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
US20090005548A1
(en)
*
|
2002-11-14 |
2009-01-01 |
Dharmacon, Inc. |
siRNA targeting nuclear receptor interacting protein 1 (NRIP1)
|
ES2440284T3
(es)
|
2002-11-14 |
2014-01-28 |
Thermo Fisher Scientific Biosciences Inc. |
ARNip dirigido a tp53
|
US7781575B2
(en)
|
2002-11-14 |
2010-08-24 |
Dharmacon, Inc. |
siRNA targeting tumor protein 53 (p53)
|
US7619081B2
(en)
*
|
2002-11-14 |
2009-11-17 |
Dharmacon, Inc. |
siRNA targeting coatomer protein complex, subunit beta 2 (COPB2)
|
US7592442B2
(en)
|
2002-11-14 |
2009-09-22 |
Dharmacon, Inc. |
siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2)
|
US7977471B2
(en)
*
|
2002-11-14 |
2011-07-12 |
Dharmacon, Inc. |
siRNA targeting TNFα
|
US20080268457A1
(en)
*
|
2002-11-14 |
2008-10-30 |
Dharmacon, Inc. |
siRNA targeting forkhead box P3 (FOXP3)
|
US20100113307A1
(en)
*
|
2002-11-14 |
2010-05-06 |
Dharmacon, Inc. |
siRNA targeting vascular endothelial growth factor (VEGF)
|
US7612196B2
(en)
*
|
2002-11-14 |
2009-11-03 |
Dharmacon, Inc. |
siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
|
US8198427B1
(en)
|
2002-11-14 |
2012-06-12 |
Dharmacon, Inc. |
SiRNA targeting catenin, beta-1 (CTNNB1)
|
US7951935B2
(en)
|
2002-11-14 |
2011-05-31 |
Dharmacon, Inc. |
siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
|
US9879266B2
(en)
|
2002-11-14 |
2018-01-30 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US10920226B2
(en)
*
|
2002-11-14 |
2021-02-16 |
Thermo Fisher Scientific Inc. |
siRNA targeting LDHA
|
WO2006006948A2
(en)
*
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
US8163896B1
(en)
|
2002-11-14 |
2012-04-24 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
US7635770B2
(en)
*
|
2002-11-14 |
2009-12-22 |
Dharmacon, Inc. |
siRNA targeting protein kinase N-3 (PKN-3)
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
US9719094B2
(en)
|
2002-11-14 |
2017-08-01 |
Thermo Fisher Scientific Inc. |
RNAi targeting SEC61G
|
US9719092B2
(en)
|
2002-11-14 |
2017-08-01 |
Thermo Fisher Scientific Inc. |
RNAi targeting CNTD2
|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
US9771586B2
(en)
|
2002-11-14 |
2017-09-26 |
Thermo Fisher Scientific Inc. |
RNAi targeting ZNF205
|
EP1613724A4
(de)
|
2002-11-18 |
2010-09-01 |
Us Gov Health & Human Serv |
Zellinien und wirtsnukleinsäuresequenzen in verbindung mit infektionskrankheiten
|
US7064337B2
(en)
|
2002-11-19 |
2006-06-20 |
The Regents Of The University Of California |
Radiation detection system for portable gamma-ray spectroscopy
|
DE10254214A1
(de)
*
|
2002-11-20 |
2004-06-09 |
Beiersdorf Ag |
Oligoribonukleotide zur Behandlung von degenerativen Hauterscheinungen durch RNA-Interferenz
|
AU2003298718A1
(en)
*
|
2002-11-22 |
2004-06-18 |
University Of Massachusetts |
Modulation of hiv replication by rna interference
|
JP4526228B2
(ja)
*
|
2002-11-22 |
2010-08-18 |
隆 森田 |
RNAiによる新規治療法および治療剤
|
US20060275762A1
(en)
*
|
2002-11-22 |
2006-12-07 |
Bio- Think Tank Co., Ltd., |
Method of detecting target base sequence of rna interference, method of designing polynucleotide base sequence causing rna interference, method of constructing double-stranded polynucleotide, method of regulating gene expression, base sequence processing apparatus, program for running base sequence processing method on comp
|
US7618948B2
(en)
|
2002-11-26 |
2009-11-17 |
Medtronic, Inc. |
Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
|
US7217807B2
(en)
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
WO2004048545A2
(en)
*
|
2002-11-26 |
2004-06-10 |
University Of Massachusetts |
DELIVERY OF siRNAs______________________________________________
|
US7696334B1
(en)
|
2002-12-05 |
2010-04-13 |
Rosetta Genomics, Ltd. |
Bioinformatically detectable human herpesvirus 5 regulatory gene
|
US7605249B2
(en)
|
2002-11-26 |
2009-10-20 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
US20130130231A1
(en)
|
2002-11-26 |
2013-05-23 |
Isaac Bentwich |
Bioinformatically detectable group of novel viral regulatory genes and uses thereof
|
US7829694B2
(en)
|
2002-11-26 |
2010-11-09 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
CN1301263C
(zh)
|
2002-12-18 |
2007-02-21 |
北京昭衍新药研究中心 |
一组抗hiv感染及防治艾滋病的核苷酸序列及其应用
|
SI1575517T1
(sl)
|
2002-12-24 |
2012-06-29 |
Rinat Neuroscience Corp |
Protitelesa proti ĺ˝iväśnemu rastnemu dejavniku in metode njihove uporabe
|
US9498530B2
(en)
|
2002-12-24 |
2016-11-22 |
Rinat Neuroscience Corp. |
Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
|
CA2512337A1
(en)
*
|
2003-01-03 |
2004-07-29 |
Gencia Corporation |
Sirna mediated post-transcriptional gene silencing of genes involved in alopecia
|
MXPA05007651A
(es)
|
2003-01-16 |
2005-10-26 |
Univ Pennsylvania |
Composiciones y metodos para la inhibicion por arnsi de la molecula de adhesion intercelular-1.
|
US7629323B2
(en)
*
|
2003-01-21 |
2009-12-08 |
Northwestern University |
Manipulation of neuronal ion channels
|
US20060178297A1
(en)
*
|
2003-01-28 |
2006-08-10 |
Troy Carol M |
Systems and methods for silencing expression of a gene in a cell and uses thereof
|
US20040147027A1
(en)
*
|
2003-01-28 |
2004-07-29 |
Troy Carol M. |
Complex for facilitating delivery of dsRNA into a cell and uses thereof
|
US7994149B2
(en)
|
2003-02-03 |
2011-08-09 |
Medtronic, Inc. |
Method for treatment of Huntington's disease through intracranial delivery of sirna
|
US7732591B2
(en)
|
2003-11-25 |
2010-06-08 |
Medtronic, Inc. |
Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
|
EP1589931A2
(de)
*
|
2003-02-05 |
2005-11-02 |
University of Massachusetts |
Rnai targeting von viren
|
FR2850971B1
(fr)
*
|
2003-02-10 |
2006-08-11 |
Aventis Pharma Sa |
Oligonucleotide antisens inhibant l'expression de la proteine ob-rgrp et procede de detection de composes modifiant l'interaction entre la famille de la proteine ob-rgrp et le recepteur de la leptine
|
US20070104688A1
(en)
|
2003-02-13 |
2007-05-10 |
City Of Hope |
Small interfering RNA mediated transcriptional gene silencing in mammalian cells
|
US20040162235A1
(en)
*
|
2003-02-18 |
2004-08-19 |
Trubetskoy Vladimir S. |
Delivery of siRNA to cells using polyampholytes
|
PL379983A1
(pl)
|
2003-02-19 |
2006-11-27 |
Rinat Neuroscience Corp. |
Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje
|
CA2516425A1
(en)
*
|
2003-02-21 |
2005-02-24 |
The Penn State Research Foundation |
Rna interference compositions and methods
|
WO2004076664A2
(en)
*
|
2003-02-21 |
2004-09-10 |
University Of South Florida |
Vectors for regulating gene expression
|
EP1605043A1
(de)
*
|
2003-02-27 |
2005-12-14 |
National Institute of Advanced Industrial Science and Technology |
INDUKTION DER METHYLIERUNG EINER CPG-SEQUENZ MITTELS dsRNA IN SÄUGERZELLEN
|
CA2517235A1
(en)
*
|
2003-02-27 |
2004-09-10 |
Nucleonics Inc. |
Methods and constructs for evaluation of rnai targets and effector molecules
|
JP2006520611A
(ja)
*
|
2003-03-05 |
2006-09-14 |
セネスコ テクノロジーズ,インコーポレイティド |
eIF−5A1の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はsiRNAの使用
|
WO2004078941A2
(en)
*
|
2003-03-06 |
2004-09-16 |
Oligo Engine, Inc. |
Modulation of gene expression using dna-rna hybrids
|
ATE479752T1
(de)
|
2003-03-07 |
2010-09-15 |
Alnylam Pharmaceuticals Inc |
Therapeutische zusammensetzungen
|
AU2004220525B2
(en)
*
|
2003-03-12 |
2011-03-31 |
Vasgene Therapeutics, Inc. |
Nucleic acid compounds for inhibiting angiogenesis and tumor growth
|
CA2519860C
(en)
†
|
2003-03-21 |
2018-01-16 |
Santaris Pharma A/S |
Short interfering rna (sirna) analogues
|
EP1608733B1
(de)
*
|
2003-04-02 |
2011-12-07 |
Dharmacon, Inc. |
Modifizierte polynukleotide zur verwendung bei rna-interferenz
|
US20040198640A1
(en)
*
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
ATE536408T1
(de)
*
|
2003-04-02 |
2011-12-15 |
Dharmacon Inc |
Modifizierte polynukleotide zur verwendung bei rna-interferenz
|
AU2004229519B2
(en)
|
2003-04-09 |
2011-07-21 |
Alnylam Pharmaceuticals, Inc. |
iRNA conjugates
|
JP4789208B2
(ja)
|
2003-04-09 |
2011-10-12 |
バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド |
タンパク質発現に向けられた渦巻型組成物
|
US20070270360A1
(en)
*
|
2003-04-15 |
2007-11-22 |
Sirna Therapeutics, Inc. |
Rna Interference Mediated Inhibition of Severe Acute Respiratory Syndrome (Sars) Gene Expression Using Short Interfering Nucleic Acid
|
US8796436B2
(en)
|
2003-04-17 |
2014-08-05 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
WO2004094595A2
(en)
|
2003-04-17 |
2004-11-04 |
Alnylam Pharmaceuticals Inc. |
MODIFIED iRNA AGENTS
|
US8017762B2
(en)
|
2003-04-17 |
2011-09-13 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
JP4991288B2
(ja)
|
2003-04-17 |
2012-08-01 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
二本鎖iRNA剤、および二本鎖iRNA剤の対合の安定性を調節する方法。
|
US7723509B2
(en)
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
MXPA05011221A
(es)
*
|
2003-04-18 |
2006-02-17 |
Univ Pennsylvania |
Composiciones y metodos para la inhibicion de angiopoyetina 1 y 2 y su receptor tie2 por arnsi.
|
WO2005032595A2
(en)
*
|
2003-04-23 |
2005-04-14 |
Georgetown University |
Methods and compositions for the inhibition of stat5 in prostate cancer cells
|
WO2004098526A2
(en)
*
|
2003-05-05 |
2004-11-18 |
Johns Hopkins University |
Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
|
CA2523785A1
(en)
|
2003-05-09 |
2004-11-25 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Small interfering rna libraries and methods of synthesis and use
|
US7619068B2
(en)
|
2003-05-09 |
2009-11-17 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
US7964714B2
(en)
*
|
2003-05-12 |
2011-06-21 |
Potomac Pharmaceuticals Inc. |
Gene expression suppression agents
|
WO2004104199A2
(en)
*
|
2003-05-15 |
2004-12-02 |
Oligo Engine, Inc. |
Modulation of gene expression using dna-dna hybrids
|
EP1628993A4
(de)
*
|
2003-05-16 |
2010-04-07 |
Rosetta Inpharmatics Llc |
Verfahren und zusammensetzungen zur rna-interfrenz
|
EP1625853B1
(de)
*
|
2003-05-19 |
2015-07-08 |
Genecare Research Institute Co., Ltd |
Apoptose-auslöser für krebszelle
|
AU2005212433B2
(en)
*
|
2003-05-23 |
2010-12-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using multifunctional short interfering nucleic acid (multifunctional sINA)
|
CA2527301A1
(en)
*
|
2003-05-30 |
2004-12-09 |
Nippon Shinyaku Co., Ltd. |
Oligonucleic acid-bearing composite and pharmaceutical composition containing the composite
|
JP4505749B2
(ja)
|
2003-05-30 |
2010-07-21 |
日本新薬株式会社 |
Bcl−2の発現抑制をするオリゴ二本鎖RNAとそれを含有する医薬組成物
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
EP2314692B1
(de)
*
|
2003-06-02 |
2021-02-24 |
University of Massachusetts |
Verfahren und Zusammensetzungen zur Verbesserung der RNAi-Wirksamkeit und -Spezifizität
|
CA2528012C
(en)
*
|
2003-06-02 |
2015-11-24 |
University Of Massachusetts |
Methods and compositions for controlling efficacy of rna silencing
|
US20050019918A1
(en)
*
|
2003-06-03 |
2005-01-27 |
Hidetoshi Sumimoto |
Treatment of cancer by inhibiting BRAF expression
|
BRPI0410886A
(pt)
*
|
2003-06-03 |
2006-07-04 |
Isis Pharmaceuticals Inc |
composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
|
US7595306B2
(en)
*
|
2003-06-09 |
2009-09-29 |
Alnylam Pharmaceuticals Inc |
Method of treating neurodegenerative disease
|
US8575327B2
(en)
|
2003-06-12 |
2013-11-05 |
Alnylam Pharmaceuticals, Inc. |
Conserved HBV and HCV sequences useful for gene silencing
|
EP1486564A1
(de)
*
|
2003-06-13 |
2004-12-15 |
Ribopharma AG |
SiRNA mit erhöhter Stabilität in Serum
|
EP1633770B1
(de)
*
|
2003-06-13 |
2015-04-29 |
Alnylam Europe AG |
Doppelsträngige ribonukleinsäure mit verbesserter wirksamkeit in einem organismus
|
US7790691B2
(en)
*
|
2003-06-20 |
2010-09-07 |
Isis Pharmaceuticals, Inc. |
Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
|
EP1636342A4
(de)
*
|
2003-06-20 |
2008-10-08 |
Isis Pharmaceuticals Inc |
Oligomere verbindungen zur verwendung bei der modulation von genen
|
AU2004257167B2
(en)
*
|
2003-07-03 |
2012-03-29 |
The Trustees Of The University Of Pennsylvania |
Inhibition of Syk kinase expression
|
EP1649019A2
(de)
*
|
2003-07-15 |
2006-04-26 |
California Institute Of Technology |
Verbesserte inhibitor-nukleinsäuren
|
US20050256071A1
(en)
*
|
2003-07-15 |
2005-11-17 |
California Institute Of Technology |
Inhibitor nucleic acids
|
CN101291653B
(zh)
*
|
2003-07-16 |
2012-06-27 |
普洛体维生物治疗公司 |
脂质包封的干扰rna
|
US20050079614A1
(en)
*
|
2003-07-21 |
2005-04-14 |
Reinhart Brenda J. |
RNAs able to modulate chromatin silencing
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
NZ545544A
(en)
*
|
2003-08-13 |
2009-04-30 |
Univ Illinois |
Silencing of TGF-beta receptor type II expression by sirna
|
US7888497B2
(en)
|
2003-08-13 |
2011-02-15 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
US7825235B2
(en)
*
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
WO2005035759A2
(en)
*
|
2003-08-20 |
2005-04-21 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HYPOXIA INDUCIBLE FACTOR 1 (HIF1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20050136437A1
(en)
*
|
2003-08-25 |
2005-06-23 |
Nastech Pharmaceutical Company Inc. |
Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
|
JP2007503803A
(ja)
*
|
2003-08-28 |
2007-03-01 |
ノバルティス アクチエンゲゼルシャフト |
平滑末端および3’修飾を有する干渉性rna二本鎖
|
US8501705B2
(en)
*
|
2003-09-11 |
2013-08-06 |
The Board Of Regents Of The University Of Texas System |
Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
EP1670518B1
(de)
*
|
2003-09-12 |
2014-05-21 |
University of Massachusetts |
Rna-interferenz zur behandlung von funktionszunahmestörungen
|
US7425544B2
(en)
|
2003-09-18 |
2008-09-16 |
Eli Lilly And Company |
Modulation of eIF4E expression
|
AU2004276823A1
(en)
*
|
2003-09-22 |
2005-04-07 |
Merck And Co., Inc |
Synthetic lethal screen using RNA interference
|
WO2005033310A1
(de)
*
|
2003-10-01 |
2005-04-14 |
Grünenthal GmbH |
Pim-1-spezifische dsrna-verbindungen
|
CA2541852A1
(en)
*
|
2003-10-07 |
2005-05-12 |
Quark Biotech, Inc. |
Bone morphogenetic protein (bmp) 2a and uses thereof
|
US20060218673A9
(en)
|
2003-10-09 |
2006-09-28 |
E.I. Du Pont De Nemours And Company |
Gene silencing
|
WO2005045032A2
(en)
*
|
2003-10-20 |
2005-05-19 |
Sima Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF EARLY GROWTH RESPONSE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
JP2007527709A
(ja)
*
|
2003-10-23 |
2007-10-04 |
サーナ・セラピューティクス・インコーポレイテッド |
短鎖干渉核酸(siNA)を用いた、RNA干渉を介したGPRA及び/又はAAA1遺伝子発現の阻害
|
EP1682661A2
(de)
*
|
2003-10-23 |
2006-07-26 |
Sirna Therapeutics, Inc. |
Durch rna-interferenz vermittelte hemmung der genxpression unter verwendung von sina (short interfering nucleic acid)
|
JP4790619B2
(ja)
|
2003-10-27 |
2011-10-12 |
ロゼッタ インファーマティクス エルエルシー |
遺伝子サイレンシングのためのsiRNAを設計する方法
|
US8227434B1
(en)
|
2003-11-04 |
2012-07-24 |
H. Lee Moffitt Cancer Center & Research Institute, Inc. |
Materials and methods for treating oncological disorders
|
US20070275918A1
(en)
*
|
2003-11-07 |
2007-11-29 |
The Board Of Trustees Of The University Of Illinois |
Induction of Cellular Senescence by Cdk4 Disruption for Tumor Suppression and Regression
|
US20070258993A1
(en)
*
|
2003-11-12 |
2007-11-08 |
The Austin Research Institute |
Dna-Carrier Conjugate
|
US7807646B1
(en)
*
|
2003-11-20 |
2010-10-05 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
JP2005168485A
(ja)
*
|
2003-11-20 |
2005-06-30 |
Tsutomu Suzuki |
siRNAの設計方法
|
US7763592B1
(en)
*
|
2003-11-20 |
2010-07-27 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
US20050208658A1
(en)
*
|
2003-11-21 |
2005-09-22 |
The University Of Maryland |
RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
|
US20100145038A1
(en)
*
|
2003-11-24 |
2010-06-10 |
Merck & Co., Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
JP2007513611A
(ja)
*
|
2003-11-26 |
2007-05-31 |
ザ クイーンズ ユニヴァーシティ オブ ベルファスト |
癌治療
|
AU2004294567A1
(en)
|
2003-11-26 |
2005-06-16 |
University Of Massachusetts |
Sequence-specific inhibition of small RNA function
|
CA2548150A1
(en)
|
2003-12-04 |
2005-06-23 |
University Of South Florida |
Polynucleotides for reducing respiratory syncytial virus gene expression
|
CA2548972A1
(en)
*
|
2003-12-12 |
2005-06-30 |
Wisconsin Alumni Research Foundation |
Treatment of mammals by sirna delivery into mammalian nerve cells
|
WO2005068630A1
(ja)
*
|
2003-12-16 |
2005-07-28 |
National Institute Of Advanced Industrial Science And Technology |
干渉用二重鎖rna
|
US20060134787A1
(en)
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
AU2004308484A1
(en)
*
|
2003-12-23 |
2005-07-14 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for combined therapy of disease
|
WO2005067971A1
(ja)
*
|
2004-01-16 |
2005-07-28 |
Takeda Pharmaceutical Company Limited |
動脈硬化の予防・治療用医薬
|
DK1713912T3
(da)
*
|
2004-01-30 |
2013-12-16 |
Santaris Pharma As |
Modificerede Korte Interfererende RNA (Modificerede siRNA)
|
ATE491715T1
(de)
|
2004-01-30 |
2011-01-15 |
Quark Pharmaceuticals Inc |
Oligoribonukleotide und verfahren zu deren anwendung bei der behandlung von fibrotischen leiden und anderen krankheiten
|
ATE447024T1
(de)
*
|
2004-02-06 |
2009-11-15 |
Dharmacon Inc |
Stabilisierte rnas als transfektionskontrollen und silencing-reagentien
|
WO2005078848A2
(en)
|
2004-02-11 |
2005-08-25 |
University Of Tennessee Research Foundation |
Inhibition of tumor growth and invasion by anti-matrix metalloproteinase dnazymes
|
WO2005079533A2
(en)
*
|
2004-02-17 |
2005-09-01 |
University Of Massachusetts |
Methods and compositions for mediating gene silencing
|
WO2005079532A2
(en)
*
|
2004-02-17 |
2005-09-01 |
University Of Massachusetts |
Methods and compositions for enhancing risc activity in vitro and in vivo
|
EP1718367A1
(de)
*
|
2004-02-23 |
2006-11-08 |
Genzyme Corporation |
Muc1-antagonisten-verstärkung von durch todes-rezeptor-ligand ausgelöster apoptose
|
EP1566202A1
(de)
*
|
2004-02-23 |
2005-08-24 |
Sahltech I Göteborg AB |
Verwendung von resistin-antagonisten zur behandlung von Rheumatoider arthritis
|
JP2008506356A
(ja)
|
2004-02-24 |
2008-03-06 |
アメリカ合衆国 |
Rab9a、rab11a、および感染症に関するこれらのモジュレーター
|
US7691823B2
(en)
*
|
2004-03-05 |
2010-04-06 |
University Of Massachusetts |
RIP140 regulation of glucose transport
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US20050202075A1
(en)
*
|
2004-03-12 |
2005-09-15 |
Pardridge William M. |
Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers
|
EP1735009A4
(de)
|
2004-03-12 |
2011-03-30 |
Alnylam Pharmaceuticals Inc |
Irna mittel targeting vegf
|
AU2005222965B8
(en)
|
2004-03-15 |
2010-07-01 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
US20070265220A1
(en)
*
|
2004-03-15 |
2007-11-15 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
US20050208090A1
(en)
*
|
2004-03-18 |
2005-09-22 |
Medtronic, Inc. |
Methods and systems for treatment of neurological diseases of the central nervous system
|
US20050272682A1
(en)
*
|
2004-03-22 |
2005-12-08 |
Evers Bernard M |
SiRNA targeting PI3K signal transduction pathway and siRNA-based therapy
|
US7851452B2
(en)
*
|
2004-03-22 |
2010-12-14 |
The Trustees Of The University Of Pennsylvania |
Methods of use of bcl-6-derived nucleotides to induce apoptosis
|
US7872117B2
(en)
*
|
2004-03-26 |
2011-01-18 |
Van Andel Research Institute |
c-met siRNA adenovirus vectors inhibit cancer cell growth, invasion and tumorigenicity
|
DK1730280T3
(en)
*
|
2004-03-26 |
2019-02-04 |
Curis Inc |
RNA interference modulators for hedgehog signaling and applications thereof
|
JP2005312428A
(ja)
*
|
2004-03-31 |
2005-11-10 |
Keio Gijuku |
Skp−2発現抑制を利用した癌の治療
|
WO2005095647A1
(ja)
*
|
2004-03-31 |
2005-10-13 |
Takara Bio Inc. |
siRNAのスクリーニング方法
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
US20050267300A1
(en)
|
2004-04-05 |
2005-12-01 |
Muthiah Manoharan |
Processes and reagents for oligonucleotide synthesis and purification
|
KR101234281B1
(ko)
|
2004-04-09 |
2013-02-18 |
가부시키가이샤 진케어켄큐쇼 |
염색체 안정화에 관한 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제
|
US20060078902A1
(en)
*
|
2004-04-15 |
2006-04-13 |
Michaeline Bunting |
Method and compositions for RNA interference
|
WO2006019430A2
(en)
*
|
2004-04-20 |
2006-02-23 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
WO2005105157A2
(en)
|
2004-04-23 |
2005-11-10 |
The Trustees Of Columbia University In The City Ofnew York |
INHIBITION OF HAIRLESS PROTEIN mRNA
|
WO2006078278A2
(en)
|
2004-04-27 |
2006-07-27 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
|
US8029815B2
(en)
|
2004-04-28 |
2011-10-04 |
Elford Howard L |
Methods for treating or preventing restenosis and other vascular proliferative disorders
|
AU2005323437B2
(en)
|
2004-04-30 |
2011-10-06 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a C5-modified pyrimidine
|
US20060040882A1
(en)
*
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US20050260214A1
(en)
*
|
2004-05-12 |
2005-11-24 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
US7605250B2
(en)
*
|
2004-05-12 |
2009-10-20 |
Dharmacon, Inc. |
siRNA targeting cAMP-specific phosphodiesterase 4D
|
US20060030003A1
(en)
*
|
2004-05-12 |
2006-02-09 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
US20110117088A1
(en)
*
|
2004-05-12 |
2011-05-19 |
Simon Michael R |
Composition and method for introduction of rna interference sequences into targeted cells and tissues
|
US7687616B1
(en)
|
2004-05-14 |
2010-03-30 |
Rosetta Genomics Ltd |
Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
WO2005110464A2
(en)
*
|
2004-05-14 |
2005-11-24 |
Oregon Health & Science University |
Irx5 inhibition as treatment for hyperproliferative disorders
|
US10508277B2
(en)
|
2004-05-24 |
2019-12-17 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
EP1773303A2
(de)
*
|
2004-05-25 |
2007-04-18 |
Chimeracore, Inc. |
Selbstmontierendes nanopartikel-wirkstofffreisetzungssystem
|
US7795419B2
(en)
|
2004-05-26 |
2010-09-14 |
Rosetta Genomics Ltd. |
Viral and viral associated miRNAs and uses thereof
|
EP2471921A1
(de)
*
|
2004-05-28 |
2012-07-04 |
Asuragen, Inc. |
Verfahren und Zusammensetzungen mit microRNA
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
EP1602926A1
(de)
|
2004-06-04 |
2005-12-07 |
University of Geneva |
Neue Mittel und Verfahren zur Behandlung von Gehörverlust oder Tinnitus
|
WO2005121348A1
(en)
*
|
2004-06-07 |
2005-12-22 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
CA2569645C
(en)
*
|
2004-06-07 |
2014-10-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
US20060008907A1
(en)
*
|
2004-06-09 |
2006-01-12 |
The Curators Of The University Of Missouri |
Control of gene expression via light activated RNA interference
|
WO2006085942A2
(en)
*
|
2004-06-17 |
2006-08-17 |
The Regents Of The University Of California |
Compositions and methods for regulating gene transcription
|
US20060051815A1
(en)
*
|
2004-06-25 |
2006-03-09 |
The J. David Gladstone Institutes |
Methods of treating smooth muscle cell disorders
|
JP2008504840A
(ja)
|
2004-06-30 |
2008-02-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
非リン酸骨格結合を含むオリゴヌクレオチド
|
CA2572439A1
(en)
*
|
2004-07-02 |
2006-01-12 |
Protiva Biotherapeutics, Inc. |
Immunostimulatory sirna molecules and uses therefor
|
WO2006038208A2
(en)
*
|
2004-07-12 |
2006-04-13 |
Medical Research Fund Of Tel Aviv Sourasky Medical Center |
Agents capable of downregulating an msf-a - dependent hif-1α and use thereof in cancer treatment
|
CA2574572A1
(en)
*
|
2004-07-19 |
2006-10-26 |
Baylor College Of Medicine |
Modulation of cytokine signaling regulators and applications for immunotherapy
|
US7767652B2
(en)
*
|
2004-07-21 |
2010-08-03 |
Medtronic, Inc. |
Medical devices and methods for reducing localized fibrosis
|
US20060030538A1
(en)
*
|
2004-07-21 |
2006-02-09 |
Medtronic, Inc. |
Methods for reducing or preventing localized fibrosis using SiRNA
|
CA2574088C
(en)
|
2004-07-21 |
2013-09-17 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a modified or non-natural nucleobase
|
EP1782321A4
(de)
|
2004-07-23 |
2009-11-04 |
Univ North Carolina |
Verfahren und materialien zur bestimmung von schmerzempfindlichkeit und vorhersage und behandlung zugehöriger störungen
|
EP1913011B1
(de)
|
2004-08-04 |
2016-11-02 |
Alnylam Pharmaceuticals Inc. |
Oligonukleotide mit einem an einer modifizierten oder nicht-natürlichen nukleobase angebundenen liganden
|
WO2006020557A2
(en)
*
|
2004-08-10 |
2006-02-23 |
Immusol, Inc. |
Methods of using or identifying agents that inhibit cancer growth
|
AU2005272816B2
(en)
|
2004-08-10 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides
|
EP1789592A4
(de)
*
|
2004-08-13 |
2009-12-23 |
Univ Delaware |
Verfahren zur identifizierung und quantifizierung von kurzen oder kleinen rna-molekülen
|
CN101123994B
(zh)
|
2004-08-16 |
2012-11-14 |
夸克医药公司 |
Rtp801的抑制剂的治疗性用途
|
ES2632913T3
(es)
*
|
2004-08-23 |
2017-09-18 |
Sylentis S.A.U. |
Tratamiento con ARNpi de trastornos oculares caracterizados por una presión intraocular elevada
|
US20070021366A1
(en)
*
|
2004-11-19 |
2007-01-25 |
Srivastava Satish K |
Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
|
MX2007002423A
(es)
*
|
2004-08-31 |
2007-08-07 |
Sylentis Sau |
Metodos y composiciones para inhibir la expresion del receptor p2x7.
|
US7323310B2
(en)
|
2004-08-31 |
2008-01-29 |
Qiagen North American Holdings, Inc. |
Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
|
US7884086B2
(en)
*
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
US20090170794A1
(en)
*
|
2004-09-10 |
2009-07-02 |
Somagenics Inc. |
Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
|
FI20041204A0
(fi)
|
2004-09-16 |
2004-09-16 |
Riikka Lund |
Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
|
WO2006033965A2
(en)
*
|
2004-09-16 |
2006-03-30 |
The Trustees Of The University Of Pennsylvania |
Nadph oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities
|
CA2580707C
(en)
*
|
2004-09-24 |
2014-07-08 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of apob and uses thereof
|
BRPI0516177B8
(pt)
|
2004-09-28 |
2021-05-25 |
Quark Biotech Inc |
oligorribonucleotídeos, uso dos mesmos, uso de um composto sirna eficaz para inibir 0 p53 humano e composição farmacêutica que os contém, bem como método para diminuição da expressão do gene p53
|
WO2006039343A2
(en)
*
|
2004-09-30 |
2006-04-13 |
Centocor, Inc. |
Emmprin antagonists and uses thereof
|
CN101107362A
(zh)
|
2004-10-21 |
2008-01-16 |
文甘扎公司 |
用于赋予对植物病害生物和植物病原体抗性的方法和材料
|
US7790878B2
(en)
*
|
2004-10-22 |
2010-09-07 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
|
AU2004324236B2
(en)
*
|
2004-10-22 |
2010-12-09 |
Neuregenix Limited |
Neuron regeneration
|
US20060110440A1
(en)
*
|
2004-10-22 |
2006-05-25 |
Kiminobu Sugaya |
Method and system for biasing cellular development
|
US20060089324A1
(en)
*
|
2004-10-22 |
2006-04-27 |
Sailen Barik |
RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
|
US7964346B2
(en)
|
2004-10-27 |
2011-06-21 |
Rubin Donald H |
Mammalian genes involved in infection
|
JP2008517629A
(ja)
*
|
2004-10-27 |
2008-05-29 |
シェーリング コーポレイション |
Nav1.8の短い干渉核酸阻害のための組成物および方法
|
EP1804771A2
(de)
*
|
2004-10-28 |
2007-07-11 |
Idexx Laboratories, Inc. |
Zusammensetzungen zur kontrollierten verabreichung pharmazeutisch aktiver zusammensetzungen
|
US20060094676A1
(en)
*
|
2004-10-29 |
2006-05-04 |
Ronit Lahav |
Compositions and methods for treating cancer using compositions comprising an inhibitor of endothelin receptor activity
|
US9492400B2
(en)
|
2004-11-04 |
2016-11-15 |
Massachusetts Institute Of Technology |
Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
|
EP2302054B1
(de)
*
|
2004-11-12 |
2014-07-16 |
Asuragen, Inc. |
Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind
|
US20060105052A1
(en)
*
|
2004-11-15 |
2006-05-18 |
Acar Havva Y |
Cationic nanoparticle having an inorganic core
|
WO2006055635A2
(en)
*
|
2004-11-15 |
2006-05-26 |
Mount Sinai School Of Medicine Of New York University |
Compositions and methods for altering wnt autocrine signaling
|
AU2005306533B2
(en)
*
|
2004-11-17 |
2012-05-31 |
Arbutus Biopharma Corporation |
siRNA silencing of apolipoprotein B
|
EP1814899A4
(de)
*
|
2004-11-18 |
2008-09-03 |
Univ Illinois |
Multicistronische sirna-konstrukte zur tumorhemmung
|
WO2006054625A1
(ja)
*
|
2004-11-19 |
2006-05-26 |
Genecare Research Institute Co., Ltd. |
癌細胞特異的細胞増殖抑制剤
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
US7935811B2
(en)
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
US20060166234A1
(en)
*
|
2004-11-22 |
2006-07-27 |
Barbara Robertson |
Apparatus and system having dry control gene silencing compositions
|
WO2006073602A2
(en)
*
|
2004-11-24 |
2006-07-13 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of the bcr-abl fusion gene and uses thereof
|
JP2008521909A
(ja)
*
|
2004-12-02 |
2008-06-26 |
ビー−ブリッジ インターナショナル,インコーポレーテッド |
短鎖干渉rna、アンチセンスポリヌクレオチド、および他のハイブリッド形成化ポリヌクレオチドの設計方法
|
WO2006060779A2
(en)
*
|
2004-12-03 |
2006-06-08 |
Case Western Reserve University |
Novel methods, compositions and devices for inducing neovascularization
|
US7361752B2
(en)
*
|
2004-12-14 |
2008-04-22 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of MLL-AF4 and uses thereof
|
EP1838838B1
(de)
|
2004-12-17 |
2010-09-01 |
Beth Israel Deaconess Medical Center |
Zusammensetzungen für bakteriell vermitteltes gen-silencing sowie verfahren zur verwendung davon
|
GB0427916D0
(en)
*
|
2004-12-21 |
2005-01-19 |
Astrazeneca Ab |
Method
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
TWI386225B
(zh)
|
2004-12-23 |
2013-02-21 |
Alcon Inc |
用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術
|
BRPI0519468A2
(pt)
|
2004-12-27 |
2009-01-27 |
Silence Therapeutics Ag |
complexos de lipÍdeos revestido e seu uso
|
EP1838875A4
(de)
*
|
2004-12-30 |
2010-08-25 |
Todd M Hauser |
Zusammensetzungen und verfahren zur modulation der genexpression unter verwendung selbstgeschützer oligonukleotide
|
AU2005322960A1
(en)
*
|
2005-01-06 |
2006-07-13 |
The Johns Hopkins University |
RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines
|
DE602006013275D1
(de)
|
2005-01-07 |
2010-05-12 |
Diadexus Inc |
Ovr110-antikörperzusammensetzungen und verwendungsverfahren dafür
|
EA017847B1
(ru)
*
|
2005-01-07 |
2013-03-29 |
Элнилэм Фармасьютикалз, Инк. |
Композиция для лечения респираторных синцитиальных вирусов
|
CA2594919A1
(en)
*
|
2005-01-24 |
2006-08-03 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of the nogo-l or nogo-r gene and uses thereof
|
WO2006081323A2
(en)
*
|
2005-01-26 |
2006-08-03 |
The Johns Hopkins University |
Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin
|
TW200639253A
(en)
*
|
2005-02-01 |
2006-11-16 |
Alcon Inc |
RNAi-mediated inhibition of ocular targets
|
WO2006085700A2
(en)
*
|
2005-02-14 |
2006-08-17 |
Hvc Stragetic Research Institute, Inc. |
Pharmaceutical agents for preventing metastasis of cancer
|
CN103920142A
(zh)
|
2005-02-14 |
2014-07-16 |
爱荷华大学研究基金会 |
治疗和诊断年龄相关性黄斑变性的方法和试剂
|
WO2006102970A2
(en)
*
|
2005-03-08 |
2006-10-05 |
Qiagen Gmbh |
Modified short interfering rna
|
JP2008533050A
(ja)
|
2005-03-11 |
2008-08-21 |
アルコン,インコーポレイテッド |
緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害
|
GB0505081D0
(en)
*
|
2005-03-14 |
2005-04-20 |
Genomica Sau |
Downregulation of interleukin-12 expression by means of rnai technology
|
WO2006130201A1
(en)
*
|
2005-03-14 |
2006-12-07 |
Board Of Regents, The University Of Texas System |
Antigene oligomers inhibit transcription
|
JP4585342B2
(ja)
*
|
2005-03-18 |
2010-11-24 |
株式会社資生堂 |
不全角化を抑制する物質のスクリーニング方法、同方法によりスクリーニングされた物質及び不全角化を抑制する方法
|
EP1877556B1
(de)
*
|
2005-03-25 |
2011-09-14 |
Medtronic, Inc. |
Verwendung von anti-tnf oder anti-il1-rnai zur unterdrückung der wirkung entzündungsfördernder cytokine zur lokalen schmerzbehandlung
|
EP1866414B9
(de)
*
|
2005-03-31 |
2012-10-03 |
Calando Pharmaceuticals, Inc. |
Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen
|
US20090203055A1
(en)
*
|
2005-04-18 |
2009-08-13 |
Massachusetts Institute Of Technology |
Compositions and methods for RNA interference with sialidase expression and uses thereof
|
WO2006121960A2
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
WO2006130560A2
(en)
*
|
2005-05-31 |
2006-12-07 |
The Trustees Of The University Of Pennsylvania |
Manipulation of pten in t cells as a strategy to modulate immune responses
|
EP1891141B1
(de)
*
|
2005-05-31 |
2016-11-16 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Triblockcopolymere zur zytoplasmatischen zuführung von arzneistoffen auf genbasis
|
CN101213300B
(zh)
*
|
2005-06-01 |
2013-01-23 |
聚加转染股份有限公司 |
用于rna干扰的寡核苷酸及其生物学应用
|
JP2008545749A
(ja)
*
|
2005-06-01 |
2008-12-18 |
デューク ユニバーシティ |
血管内膜過形成を阻害する方法
|
US20100266574A1
(en)
*
|
2005-06-10 |
2010-10-21 |
Orna Mor |
Oligoribonucleotides and Methods of Use Thereof for Treatment of Fibrotic Conditions and Other Diseases
|
CN100445381C
(zh)
*
|
2005-06-10 |
2008-12-24 |
中国人民解放军军事医学科学院基础医学研究所 |
带有单链polyA尾巴的siRNA分子制备方法和应用
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
US7838503B2
(en)
*
|
2005-06-15 |
2010-11-23 |
Children's Medical Center Corporation |
Methods for extending the replicative lifespan of cells
|
FI20050640A0
(fi)
*
|
2005-06-16 |
2005-06-16 |
Faron Pharmaceuticals Oy |
Yhdisteitä amiinioksidaasista riippuvien sairauksien tai häiriöiden hoitoon tai estoon
|
US7868159B2
(en)
*
|
2005-06-23 |
2011-01-11 |
Baylor College Of Medicine |
Modulation of negative immune regulators and applications for immunotherapy
|
WO2007002718A2
(en)
*
|
2005-06-27 |
2007-01-04 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of hif-1 and theraputic uses thereof
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
CA2614531C
(en)
*
|
2005-07-07 |
2015-06-16 |
Avraham Hochberg |
Nucleic acid agents for downregulating h19, and methods of using same
|
WO2007011702A2
(en)
|
2005-07-15 |
2007-01-25 |
The University Of North Carolina At Chapel Hill |
Use of egfr inhibitors to prevent or treat obesity
|
DE502006007749D1
(de)
*
|
2005-07-25 |
2010-10-07 |
Riboxx Gmbh |
Verfahren und Kit zur Amplifikation von heteropolymerer oder poly(C)- RNA
|
WO2007014370A2
(en)
*
|
2005-07-28 |
2007-02-01 |
University Of Delaware |
Small regulatory rnas and methods of use
|
US7919583B2
(en)
|
2005-08-08 |
2011-04-05 |
Discovery Genomics, Inc. |
Integration-site directed vector systems
|
US20070213257A1
(en)
*
|
2005-08-12 |
2007-09-13 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for complexes of nucleic acids and peptides
|
US20070105803A1
(en)
|
2005-08-18 |
2007-05-10 |
Muthiah Manoharan |
Methods and compositions for treating neurological disease
|
US20070054873A1
(en)
*
|
2005-08-26 |
2007-03-08 |
Protiva Biotherapeutics, Inc. |
Glucocorticoid modulation of nucleic acid-mediated immune stimulation
|
EP1937312B1
(de)
|
2005-08-30 |
2016-06-29 |
Ionis Pharmaceuticals, Inc. |
Chimere oligomere verbindungen zur modulation von splicing
|
US20090018097A1
(en)
*
|
2005-09-02 |
2009-01-15 |
Mdrna, Inc |
Modification of double-stranded ribonucleic acid molecules
|
US20090221673A1
(en)
*
|
2005-09-13 |
2009-09-03 |
Rigby William F C |
Compositions and Methods for Regulating RNA Translation via CD154 CA-Dinucleotide Repeat
|
CA2620387C
(en)
|
2005-09-20 |
2018-09-18 |
Basf Plant Science Gmbh |
Methods for controlling gene expression using ta-sirna
|
FR2890859B1
(fr)
*
|
2005-09-21 |
2012-12-21 |
Oreal |
Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
|
WO2007041213A2
(en)
*
|
2005-09-30 |
2007-04-12 |
St. Jude Children's Research Hospital |
Methods for regulation of p53 translation and function
|
US8168584B2
(en)
|
2005-10-08 |
2012-05-01 |
Potentia Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
WO2007048046A2
(en)
*
|
2005-10-20 |
2007-04-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of filovirus gene expression
|
GB0521351D0
(en)
*
|
2005-10-20 |
2005-11-30 |
Genomica Sau |
Modulation of TRPV expression levels
|
GB0521716D0
(en)
*
|
2005-10-25 |
2005-11-30 |
Genomica Sau |
Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
|
WO2007049690A1
(ja)
*
|
2005-10-27 |
2007-05-03 |
National University Corporation NARA Institute of Science and Technology |
Singarの発現または機能の抑制による神経軸索の形成・伸長と神経再生への応用
|
JP5111385B2
(ja)
*
|
2005-10-28 |
2013-01-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ハンチンチン遺伝子の発現を抑制するための組成物および方法
|
CN101346393B
(zh)
|
2005-11-02 |
2015-07-22 |
普洛体维生物治疗公司 |
修饰的siRNA分子及其应用
|
CA2626584A1
(en)
*
|
2005-11-04 |
2007-05-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of nav1.8 gene
|
WO2007051316A1
(en)
*
|
2005-11-07 |
2007-05-10 |
British Columbia Cancer Agency |
Inhibition of autophagy genes in cancer chemotherapy
|
AU2006311730B2
(en)
|
2005-11-09 |
2010-12-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Factor V Leiden mutant gene
|
US7709456B2
(en)
*
|
2005-11-17 |
2010-05-04 |
Board Of Regents, The University Of Texas System |
Modulation of gene expression by oligomers targeted to chromosomal DNA
|
US8916530B2
(en)
*
|
2005-11-18 |
2014-12-23 |
Gradalis, Inc. |
Individualized cancer therapy
|
US8603991B2
(en)
|
2005-11-18 |
2013-12-10 |
Gradalis, Inc. |
Individualized cancer therapy
|
US20080125384A1
(en)
*
|
2005-11-21 |
2008-05-29 |
Shuewi Yang |
Simultaneous silencing and restoration of gene function
|
US8153362B2
(en)
*
|
2005-11-24 |
2012-04-10 |
Jichi Medical University |
Mitochondrial function of prohibitin 2 (PHB2)
|
WO2007070682A2
(en)
|
2005-12-15 |
2007-06-21 |
Massachusetts Institute Of Technology |
System for screening particles
|
ATE466081T1
(de)
*
|
2005-12-22 |
2010-05-15 |
Opko Ophthalmics Llc |
Zusammensetzungen und verfahren zur regulierung eines komplementsystems
|
AR057252A1
(es)
*
|
2005-12-27 |
2007-11-21 |
Alcon Mfg Ltd |
Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares
|
US8673873B1
(en)
*
|
2005-12-28 |
2014-03-18 |
Alcon Research, Ltd. |
RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders
|
JP5713377B2
(ja)
|
2005-12-28 |
2015-05-07 |
ザ スクリプス リサーチ インスティテュート |
薬物標的としての天然アンチセンスおよび非コードrna転写物
|
EP1973574B1
(de)
*
|
2005-12-30 |
2014-04-02 |
Institut Gustave Roussy |
Verwendung von hemmern von scinderin und/oder ephrin-a1 zur behandlung von tumoren
|
BRPI0707290A2
(pt)
*
|
2006-01-17 |
2011-08-16 |
Biolex Therapeutics Inc |
composições e métodos para humanização e otimização de n-glicanas em plantas
|
US20090060921A1
(en)
*
|
2006-01-17 |
2009-03-05 |
Biolex Therapeutics, Inc. |
Glycan-optimized anti-cd20 antibodies
|
US7825099B2
(en)
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
EP1973946B1
(de)
|
2006-01-20 |
2015-03-25 |
Cell Signaling Technology, Inc. |
Translokation und mutations-ros-kinase bei menschlichem nicht-kleinzelligem lungenkrebs
|
NL2000439C2
(nl)
|
2006-01-20 |
2009-03-16 |
Quark Biotech |
Therapeutische toepassingen van inhibitoren van RTP801.
|
US20120208824A1
(en)
|
2006-01-20 |
2012-08-16 |
Cell Signaling Technology, Inc. |
ROS Kinase in Lung Cancer
|
WO2007087451A2
(en)
*
|
2006-01-25 |
2007-08-02 |
University Of Massachusetts |
Compositions and methods for enhancing discriminatory rna interference
|
CA2638837A1
(en)
*
|
2006-01-27 |
2007-08-02 |
Santaris Pharma A/S |
Lna modified phosphorothiolated oligonucleotides
|
US8229398B2
(en)
*
|
2006-01-30 |
2012-07-24 |
Qualcomm Incorporated |
GSM authentication in a CDMA network
|
US8362229B2
(en)
*
|
2006-02-08 |
2013-01-29 |
Quark Pharmaceuticals, Inc. |
Tandem siRNAS
|
US7910566B2
(en)
|
2006-03-09 |
2011-03-22 |
Quark Pharmaceuticals Inc. |
Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
|
FI20060246A0
(fi)
*
|
2006-03-16 |
2006-03-16 |
Jukka Westermarck |
Uusi kasvua stimuloiva proteiini ja sen käyttö
|
WO2007109609A2
(en)
*
|
2006-03-17 |
2007-09-27 |
The Board Of Trustees Of The University Of Illinois |
Method for inhibiting angiogenesis
|
WO2007107162A2
(en)
|
2006-03-23 |
2007-09-27 |
Santaris Pharma A/S |
Small internally segmented interfering rna
|
FR2898908A1
(fr)
|
2006-03-24 |
2007-09-28 |
Agronomique Inst Nat Rech |
Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence
|
WO2007111998A2
(en)
*
|
2006-03-24 |
2007-10-04 |
Novartis Ag |
Dsrna compositions and methods for treating hpv infection
|
WO2007115047A2
(en)
*
|
2006-03-29 |
2007-10-11 |
Senesco Technologies, Inc. |
Inhibition of hiv replication and expression of p24 with eif-5a
|
EP2527354A1
(de)
|
2006-03-31 |
2012-11-28 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur Hemmung der Expression des Eg5-Gens
|
CA2648099C
(en)
|
2006-03-31 |
2012-05-29 |
The Brigham And Women's Hospital, Inc |
System for targeted delivery of therapeutic agents
|
WO2007113331A2
(en)
*
|
2006-04-06 |
2007-10-11 |
Dkfz Deutsches Krebsforschungszentrum |
Method to inhibit the propagation of an undesired cell population
|
DE602007005366D1
(de)
*
|
2006-04-07 |
2010-04-29 |
Chimeros Inc |
Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen
|
JP5524610B2
(ja)
|
2006-04-07 |
2014-06-18 |
ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク |
トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法
|
US9044461B2
(en)
|
2006-04-07 |
2015-06-02 |
The Research Foundation Of State University Of New York |
Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
|
WO2007120883A2
(en)
*
|
2006-04-12 |
2007-10-25 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hepcidin
|
WO2007120842A2
(en)
*
|
2006-04-13 |
2007-10-25 |
Cornell Research Foundation, Inc. |
Methods and compositions for targeting c-rel
|
HUE035732T2
(en)
|
2006-04-14 |
2018-05-28 |
Cell Signaling Technology Inc |
Gene defects and mutant ALK kinase in human solid tumors
|
JP2009533458A
(ja)
*
|
2006-04-14 |
2009-09-17 |
マサチューセッツ インスティテュート オブ テクノロジー |
神経系の可塑性を媒介する分子経路の同定および変調
|
US7691824B2
(en)
*
|
2006-04-28 |
2010-04-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the JC virus
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
EP3872179A1
(de)
|
2006-05-11 |
2021-09-01 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der pcsk9-genexpression
|
WO2007133807A2
(en)
|
2006-05-15 |
2007-11-22 |
Massachusetts Institute Of Technology |
Polymers for functional particles
|
US20090130212A1
(en)
*
|
2006-05-15 |
2009-05-21 |
Physical Pharmaceutica, Llc |
Composition and improved method for preparation of small particles
|
US20070269892A1
(en)
*
|
2006-05-18 |
2007-11-22 |
Nastech Pharmaceutical Company Inc. |
FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
|
EP2021352A4
(de)
*
|
2006-05-19 |
2009-10-28 |
Scripps Research Inst |
Behandlung von protein-missfaltung
|
CA2652770A1
(en)
*
|
2006-05-19 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of aha and therapeutic uses thereof
|
WO2007137220A2
(en)
*
|
2006-05-22 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
US9273356B2
(en)
|
2006-05-24 |
2016-03-01 |
Medtronic, Inc. |
Methods and kits for linking polymorphic sequences to expanded repeat mutations
|
US20070275923A1
(en)
*
|
2006-05-25 |
2007-11-29 |
Nastech Pharmaceutical Company Inc. |
CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY
|
US8598333B2
(en)
*
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
GB0610542D0
(en)
*
|
2006-05-26 |
2006-07-05 |
Medical Res Council |
Screening method
|
US9506056B2
(en)
|
2006-06-08 |
2016-11-29 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
WO2007141796A2
(en)
|
2006-06-09 |
2007-12-13 |
Quark Pharmaceuticals, Inc. |
Therapeutic uses of inhibitors of rtp801l
|
US7915399B2
(en)
*
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
EP2383341A1
(de)
*
|
2006-06-12 |
2011-11-02 |
Exegenics, Inc., D/b/a Opko Health, Inc. |
Zusammensetzungen und Verfahren zur SiRNA-Hemmung von Angiogenese
|
US9200275B2
(en)
*
|
2006-06-14 |
2015-12-01 |
Merck Sharp & Dohme Corp. |
Methods and compositions for regulating cell cycle progression
|
WO2007150030A2
(en)
|
2006-06-23 |
2007-12-27 |
Massachusetts Institute Of Technology |
Microfluidic synthesis of organic nanoparticles
|
WO2008008719A2
(en)
*
|
2006-07-10 |
2008-01-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the myc gene
|
GB0613753D0
(en)
|
2006-07-11 |
2006-08-23 |
Norwegian Radium Hospital Res |
Method
|
CA2659392A1
(en)
|
2006-07-13 |
2008-01-17 |
University Of Iowa Research Foundation |
Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration
|
JP4756271B2
(ja)
*
|
2006-07-18 |
2011-08-24 |
独立行政法人産業技術総合研究所 |
ガン細胞の老化、アポトーシス誘導剤
|
AU2007276388A1
(en)
|
2006-07-21 |
2008-01-24 |
Silence Therapeutics Ag |
Means for inhibiting the expression of protein kinase 3
|
US20080039415A1
(en)
*
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
US20100330105A1
(en)
*
|
2006-08-22 |
2010-12-30 |
John Hopkins University |
Anticancer Combination Therapies
|
DE102006039479A1
(de)
|
2006-08-23 |
2008-03-06 |
Febit Biotech Gmbh |
Programmierbare Oligonukleotidsynthese
|
US7872118B2
(en)
*
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
AU2007299804A1
(en)
*
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
MiR-200 regulated genes and pathways as targets for therapeutic intervention
|
CA2663962A1
(en)
*
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
|
AU2007299629C1
(en)
|
2006-09-21 |
2012-05-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the HAMP gene
|
CA2663601C
(en)
|
2006-09-22 |
2014-11-25 |
Dharmacon, Inc. |
Duplex oligonucleotide complexes and methods for gene silencing by rna interference
|
EP2087110A2
(de)
*
|
2006-10-11 |
2009-08-12 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Influenza-ziele
|
US8299040B2
(en)
*
|
2006-10-18 |
2012-10-30 |
Board Of Regents, The University Of Texas System |
Methods for treating cancer targeting transglutaminase
|
JP2010507387A
(ja)
*
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
WO2008052774A2
(en)
|
2006-10-31 |
2008-05-08 |
Noxxon Pharma Ag |
Methods for detection of a single- or double-stranded nucleic acid molecule
|
CA2667971C
(en)
|
2006-11-01 |
2017-04-18 |
Gary Weisinger |
Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
|
US8324367B2
(en)
|
2006-11-03 |
2012-12-04 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
US9375440B2
(en)
|
2006-11-03 |
2016-06-28 |
Medtronic, Inc. |
Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
|
US8758998B2
(en)
|
2006-11-09 |
2014-06-24 |
Gradalis, Inc. |
Construction of bifunctional short hairpin RNA
|
US8252526B2
(en)
|
2006-11-09 |
2012-08-28 |
Gradalis, Inc. |
ShRNA molecules and methods of use thereof
|
US8906874B2
(en)
|
2006-11-09 |
2014-12-09 |
Gradalis, Inc. |
Bi-functional shRNA targeting Stathmin 1 and uses thereof
|
US7819842B2
(en)
|
2006-11-21 |
2010-10-26 |
Medtronic, Inc. |
Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
|
US8034921B2
(en)
*
|
2006-11-21 |
2011-10-11 |
Alnylam Pharmaceuticals, Inc. |
IRNA agents targeting CCR5 expressing cells and uses thereof
|
US7988668B2
(en)
|
2006-11-21 |
2011-08-02 |
Medtronic, Inc. |
Microsyringe for pre-packaged delivery of pharmaceuticals
|
EP2087912B1
(de)
*
|
2006-11-22 |
2017-05-10 |
The University of Tokyo |
Sirna-träger mit disulfid-überbrückter polymer-mizelle
|
EP2962697A1
(de)
|
2006-11-27 |
2016-01-06 |
diaDexus, Inc. |
Ovr110-antikörperzusammensetzungen und verfahren zur verwendung
|
AU2007355108B2
(en)
|
2006-11-27 |
2013-07-11 |
Patrys Limited |
Novel glycosylated peptide target in neoplastic cells
|
WO2008067373A2
(en)
*
|
2006-11-28 |
2008-06-05 |
Alcon Research, Ltd. |
RNAi-MEDIATED INHIBITION OF AQUAPORIN 1 FOR TREATMENT OF IOP-RELATED CONDITIONS
|
WO2008067560A2
(en)
*
|
2006-11-30 |
2008-06-05 |
University Of Southern California |
Compositions and methods of sphingosine kinase inhibitors for use thereof in cancer therapy
|
EP2104737B1
(de)
*
|
2006-12-08 |
2013-04-10 |
Asuragen, INC. |
Funktionen und ziele von let-7-mikro-rnas
|
EP2104735A2
(de)
*
|
2006-12-08 |
2009-09-30 |
Asuragen, INC. |
Mir-21-regulierte gene und pfade als ziele für therapeutische interventionen
|
EA201101361A1
(ru)
*
|
2006-12-14 |
2012-11-30 |
Новартис Аг |
Композиции и способы, предназначенные для лечения мышечных и сердечно-сосудистых нарушений
|
CA2671270A1
(en)
*
|
2006-12-29 |
2008-07-17 |
Asuragen, Inc. |
Mir-16 regulated genes and pathways as targets for therapeutic intervention
|
US7754698B2
(en)
*
|
2007-01-09 |
2010-07-13 |
Isis Pharmaceuticals, Inc. |
Modulation of FR-alpha expression
|
US9896511B2
(en)
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
US9068003B2
(en)
|
2007-01-10 |
2015-06-30 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
CA2674683A1
(en)
*
|
2007-01-16 |
2008-07-24 |
The Burnham Institute For Medical Research |
Compositions and methods for treatment of colorectal cancer
|
US20080171906A1
(en)
*
|
2007-01-16 |
2008-07-17 |
Everaerts Frank J L |
Tissue performance via hydrolysis and cross-linking
|
AU2007344641B2
(en)
|
2007-01-16 |
2014-05-22 |
The University Of Queensland |
Method of inducing an immune response
|
ATE548454T1
(de)
*
|
2007-01-16 |
2012-03-15 |
Yissum Res Dev Co |
Nukleinsäurewirkstoffe zur stilllegung von h19 zwecks behandlung rheumatoider arthritis
|
US8361988B2
(en)
*
|
2007-01-17 |
2013-01-29 |
Institut De Recherches Cliniques De Montreal |
Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use
|
JP2010516786A
(ja)
|
2007-01-26 |
2010-05-20 |
ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション,インコーポレーテッド |
ワクチンとしての使用のためのエキソソーム成分の改変
|
US20100196403A1
(en)
*
|
2007-01-29 |
2010-08-05 |
Jacob Hochman |
Antibody conjugates for circumventing multi-drug resistance
|
US20100183696A1
(en)
*
|
2007-01-30 |
2010-07-22 |
Allergan, Inc |
Treating Ocular Diseases Using Peroxisome Proliferator-Activated Receptor Delta Antagonists
|
KR101488800B1
(ko)
|
2007-02-09 |
2015-02-04 |
노오쓰웨스턴 유니버시티 |
세포내 타겟 검출용 입자
|
WO2008098165A2
(en)
|
2007-02-09 |
2008-08-14 |
Massachusetts Institute Of Technology |
Oscillating cell culture bioreactor
|
DE102007008596B4
(de)
*
|
2007-02-15 |
2010-09-02 |
Friedrich-Schiller-Universität Jena |
Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
|
CN101646769A
(zh)
|
2007-02-20 |
2010-02-10 |
孟山都技术公司 |
无脊椎动物微rna
|
US7872119B2
(en)
|
2007-02-26 |
2011-01-18 |
Quark Pharmaceuticals, Inc. |
Inhibitors of RTP801 and their use in disease treatment
|
WO2008104978A2
(en)
*
|
2007-02-28 |
2008-09-04 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
WO2008109518A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting wnt gene expression and uses thereof
|
WO2008109357A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting apob gene expression and uses thereof
|
WO2008109034A2
(en)
*
|
2007-03-02 |
2008-09-12 |
The Trustees Of The University Of Pennsylvania |
Modulating pdx-1 with pcif1, methods and uses thereof
|
US9085638B2
(en)
|
2007-03-07 |
2015-07-21 |
The Johns Hopkins University |
DNA vaccine enhancement with MHC class II activators
|
US20080260765A1
(en)
*
|
2007-03-15 |
2008-10-23 |
Johns Hopkins University |
HPV DNA Vaccines and Methods of Use Thereof
|
US7812002B2
(en)
|
2007-03-21 |
2010-10-12 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer
|
HUE027018T2
(en)
|
2007-03-21 |
2016-08-29 |
Brookhaven Science Ass Llc |
Combination hairpin antisense compositions and methods for modulating expression
|
PE20090064A1
(es)
*
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
AU2008232891B2
(en)
|
2007-03-29 |
2012-01-12 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the Ebola
|
WO2008124634A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Polymer-encapsulated reverse micelles
|
WO2008124632A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Amphiphilic compound assisted nanoparticles for targeted delivery
|
WO2008124165A2
(en)
*
|
2007-04-09 |
2008-10-16 |
Chimeros, Inc. |
Self-assembling nanoparticle drug delivery system
|
US8252535B2
(en)
|
2007-04-10 |
2012-08-28 |
Qiagen Gmbh |
RNA interference tags
|
AU2008242842B2
(en)
*
|
2007-04-17 |
2014-06-05 |
Baxter Healthcare Sa |
Nucleic acid microparticles for pulmonary delivery
|
AU2008242583B2
(en)
*
|
2007-04-23 |
2013-10-10 |
Alnylam Pharmaceuticals, Inc. |
Glycoconjugates of RNA interference agents
|
WO2008143774A2
(en)
*
|
2007-05-01 |
2008-11-27 |
University Of Massachusetts |
Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy
|
EP2607477B1
(de)
|
2007-05-03 |
2020-09-23 |
The Brigham and Women's Hospital, Inc. |
Multipotente stammzellen und ihre verwendung
|
JP5296328B2
(ja)
*
|
2007-05-09 |
2013-09-25 |
独立行政法人理化学研究所 |
1本鎖環状rnaおよびその製造方法
|
CA2684879A1
(en)
*
|
2007-05-15 |
2008-11-27 |
Helicon Therapeutics, Inc. |
Methods of identifying genes involved in memory formation using small interfering rna (sirna)
|
AU2008254905A1
(en)
*
|
2007-05-15 |
2008-11-27 |
Helicon Therapeutics, Inc. |
Methods of treating cognitive disorders by inhibition of Gpr12
|
KR101750640B1
(ko)
|
2007-05-22 |
2017-06-23 |
아크투루스 쎄라퓨틱스, 인크. |
치료제를 위한 올리고머
|
US20090131354A1
(en)
*
|
2007-05-22 |
2009-05-21 |
Bader Andreas G |
miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
|
EP2166843A4
(de)
|
2007-06-01 |
2010-08-11 |
Univ Princeton |
Behandlung von virusinfektionen durch modulation von hostzellen-stoffwechselpfaden
|
US9051391B2
(en)
|
2007-06-11 |
2015-06-09 |
Takara Bio Inc. |
Method for expression of specific gene
|
AR066984A1
(es)
*
|
2007-06-15 |
2009-09-23 |
Novartis Ag |
Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
|
US20100273854A1
(en)
*
|
2007-06-15 |
2010-10-28 |
Hagar Kalinski |
Compositions and methods for inhibiting nadph oxidase expression
|
EP2170403B1
(de)
|
2007-06-27 |
2014-04-16 |
Quark Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur Unterdrückung der Expression von pro-apoptotischen Genen
|
EP3456357A1
(de)
|
2007-06-29 |
2019-03-20 |
Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. |
Verfahren zur fixierung und expression einer physiologisch aktiven substanz
|
CN103215269B
(zh)
*
|
2007-07-05 |
2015-01-21 |
诺瓦提斯公司 |
用于治疗病毒感染的dsRNA
|
ES2423182T3
(es)
|
2007-07-10 |
2013-09-18 |
Neurim Pharmaceuticals (1991) Ltd. |
Variantes de unión CD44 en las enfermedades neurodegenerativas
|
US8828960B2
(en)
*
|
2007-07-17 |
2014-09-09 |
Idexx Laboratories, Inc. |
Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
|
JP2009033986A
(ja)
*
|
2007-07-31 |
2009-02-19 |
Sumitomo Chemical Co Ltd |
RNA干渉による遺伝子発現抑制のためのターゲット遺伝子としてのcar遺伝子の使用
|
US9526707B2
(en)
|
2007-08-13 |
2016-12-27 |
Howard L. Elford |
Methods for treating or preventing neuroinflammation or autoimmune diseases
|
US8501929B2
(en)
*
|
2007-08-17 |
2013-08-06 |
Biochrom Pharma Inc. |
PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
|
CN101842381A
(zh)
|
2007-08-27 |
2010-09-22 |
波士顿生物医药公司 |
作为微小rna模拟物或抑制剂的不对称rna双链体的组合物
|
US8637477B2
(en)
*
|
2007-08-30 |
2014-01-28 |
Akshaya Bio Inc. |
Antigenic compositions and use of same in the targeted delivery of nucleic acids
|
US20090081789A1
(en)
*
|
2007-08-31 |
2009-03-26 |
Greenville Hospital System |
Activation of nuclear factor kappa B
|
US8183221B2
(en)
|
2007-09-05 |
2012-05-22 |
Medtronic, Inc. |
Suppression of SCN9A gene expression and/or function for the treatment of pain
|
JP5049713B2
(ja)
*
|
2007-09-14 |
2012-10-17 |
株式会社コナミデジタルエンタテインメント |
ゲームシステム並びにこれを構成するゲーム装置及び課題報知装置
|
US8361714B2
(en)
|
2007-09-14 |
2013-01-29 |
Asuragen, Inc. |
Micrornas differentially expressed in cervical cancer and uses thereof
|
JP2010539245A
(ja)
*
|
2007-09-14 |
2010-12-16 |
日東電工株式会社 |
薬物担体
|
CN101849008A
(zh)
|
2007-09-19 |
2010-09-29 |
应用生物系统有限公司 |
用于减少RNAi中的脱靶表型效应的siRNA的不依赖于序列的修饰形式和其稳定形式
|
WO2009042625A1
(en)
*
|
2007-09-25 |
2009-04-02 |
Idexx Laboratories, Inc. |
Pharmaceutical compositions for administering oligonucleotides
|
US20100136026A1
(en)
*
|
2007-09-26 |
2010-06-03 |
Kerr William G |
Ship Inhibition to Direct Hematopoietic Stem Cells and Induce Extramedullary Hematopoiesis
|
SI2644594T1
(sl)
|
2007-09-28 |
2017-10-30 |
Pfizer Inc. |
Ciljanje rakavih celic z uporabo nanodelcev
|
US20120082659A1
(en)
*
|
2007-10-02 |
2012-04-05 |
Hartmut Land |
Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
|
JP5646997B2
(ja)
*
|
2007-10-03 |
2014-12-24 |
クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. |
新規siRNA構造
|
WO2009046397A2
(en)
*
|
2007-10-04 |
2009-04-09 |
Board Of Regents, The University Of Texas System |
Modulating gene expression with agrna and gapmers targeting antisense transcripts
|
EP3424525A1
(de)
|
2007-10-12 |
2019-01-09 |
Massachusetts Institute Of Technology |
Impfstoffnanotechnologie
|
EP2203558B1
(de)
|
2007-10-18 |
2016-05-04 |
Cell Signaling Technology, Inc. |
Translokation und mutations-ros-kinase bei menschlichem nicht-kleinzelligem bronchialkarzinom
|
US8097712B2
(en)
|
2007-11-07 |
2012-01-17 |
Beelogics Inc. |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
|
US20100098664A1
(en)
*
|
2007-11-28 |
2010-04-22 |
Mathieu Jean-Francois Desclaux |
Lentiviral vectors allowing RNAi mediated inhibition of GFAP and vimentin expression
|
EP2222344A4
(de)
*
|
2007-11-30 |
2012-11-07 |
Baylor College Medicine |
Impfstoffzusammensetzungen mit dendritischen zellen und ihre verwendung
|
WO2009070805A2
(en)
*
|
2007-12-01 |
2009-06-04 |
Asuragen, Inc. |
Mir-124 regulated genes and pathways as targets for therapeutic intervention
|
CA2706317C
(en)
|
2007-12-03 |
2017-06-13 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Doc1 compositions and methods for treating cancer
|
AU2008340355B2
(en)
|
2007-12-04 |
2015-01-22 |
Tekmira Pharmaceuticals Corporation |
Targeting lipids
|
US8507455B2
(en)
*
|
2007-12-04 |
2013-08-13 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
JP5530933B2
(ja)
|
2007-12-10 |
2014-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
第vii因子遺伝子発現阻害のための組成物及び方法
|
US20110105584A1
(en)
*
|
2007-12-12 |
2011-05-05 |
Elena Feinstein |
Rtp80il sirna compounds and methods of use thereof
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
JP2011506484A
(ja)
|
2007-12-13 |
2011-03-03 |
アルニラム ファーマシューティカルズ, インコーポレイテッド |
Rsv感染の予防または治療のための方法および組成物
|
US20090176729A1
(en)
*
|
2007-12-14 |
2009-07-09 |
Alnylam Pharmaceuticals, Inc. |
Method of treating neurodegenerative disease
|
US7845686B2
(en)
*
|
2007-12-17 |
2010-12-07 |
S & B Technical Products, Inc. |
Restrained pipe joining system for plastic pipe
|
KR100949791B1
(ko)
*
|
2007-12-18 |
2010-03-30 |
이동기 |
오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도
|
WO2009086156A2
(en)
*
|
2007-12-21 |
2009-07-09 |
Asuragen, Inc. |
Mir-10 regulated genes and pathways as targets for therapeutic intervention
|
WO2009090639A2
(en)
*
|
2008-01-15 |
2009-07-23 |
Quark Pharmaceuticals, Inc. |
Sirna compounds and methods of use thereof
|
AU2009241591A1
(en)
*
|
2008-01-31 |
2009-11-05 |
Alnylam Pharmaceuticals, Inc. |
Optimized methods for delivery of DSRNA targeting the PCSK9 gene
|
WO2009100430A2
(en)
*
|
2008-02-08 |
2009-08-13 |
Asuragen, Inc |
miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
|
CA2715289C
(en)
|
2008-02-11 |
2019-12-24 |
Rxi Pharmaceuticals Corporation |
Modified rnai polynucleotides and uses thereof
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
US7977321B2
(en)
*
|
2008-02-12 |
2011-07-12 |
University Of Tennessee Research Foundation |
Small interfering RNAs targeting feline herpes virus
|
EP2250266A2
(de)
|
2008-02-12 |
2010-11-17 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen und verfahren zur hemmung der cd45-genexpression
|
US20110207796A1
(en)
*
|
2008-02-13 |
2011-08-25 |
Elan Pharma International Limited |
Alpha-synuclein kinase
|
DE102009043743B4
(de)
|
2009-03-13 |
2016-10-13 |
Friedrich-Schiller-Universität Jena |
Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
|
WO2009103067A2
(en)
*
|
2008-02-14 |
2009-08-20 |
The Children's Hospital Of Philadelphia |
Compositions and methods to treat asthma
|
EA019531B1
(ru)
|
2008-03-05 |
2014-04-30 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF
|
WO2009111643A2
(en)
*
|
2008-03-06 |
2009-09-11 |
Asuragen, Inc. |
Microrna markers for recurrence of colorectal cancer
|
US8202848B2
(en)
*
|
2008-03-17 |
2012-06-19 |
Board Of Regents, The University Of Texas System |
Identification of micro-RNAS involved in neuromuscular synapse maintenance and regeneration
|
EP2268316A4
(de)
*
|
2008-03-20 |
2011-05-25 |
Quark Pharmaceuticals Inc |
Neue sirna-verbindungen zur hemmung von rtp801
|
US20090253780A1
(en)
*
|
2008-03-26 |
2009-10-08 |
Fumitaka Takeshita |
COMPOSITIONS AND METHODS RELATED TO miR-16 AND THERAPY OF PROSTATE CANCER
|
EP2105145A1
(de)
*
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Verfahren zur muskelspezifischen Abgabe lipidkonjugierter Oligonukleotide
|
EP2264167B1
(de)
*
|
2008-03-31 |
2016-10-12 |
National Institute of Advanced Industrial Science and Technology |
Doppelsträngige lipid-modifizierte rna mit hohem rna-interferenzeffekt
|
TWI348916B
(en)
*
|
2008-04-03 |
2011-09-21 |
Univ Nat Taiwan |
A novel treatment tool for cancer: rna interference of bcas2
|
WO2009126726A1
(en)
*
|
2008-04-08 |
2009-10-15 |
Asuragen, Inc |
Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
|
AU2009234266B2
(en)
|
2008-04-11 |
2015-08-06 |
Tekmira Pharmaceuticals Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
ES2710463T3
(es)
|
2008-04-11 |
2019-04-25 |
Cedars Sinai Medical Center |
Acido poli(beta málico) con tripéptido colgante Leu-Leu-Leu para la administración eficaz del fármaco citoplasmático
|
JP5475753B2
(ja)
|
2008-04-15 |
2014-04-16 |
プロチバ バイオセラピューティクス インコーポレイティッド |
核酸送達用の脂質製剤
|
EP2285385A4
(de)
*
|
2008-04-15 |
2013-01-16 |
Quark Pharmaceuticals Inc |
siRNA-VERBINDUNGEN ZUR NRF2-HEMMUNG
|
US20090285861A1
(en)
*
|
2008-04-17 |
2009-11-19 |
Tzyy-Choou Wu |
Tumor cell-based cancer immunotherapeutic compositions and methods
|
US7875711B2
(en)
|
2008-04-17 |
2011-01-25 |
Alnylam Pharamaceuticals, Inc. |
Compositions and methods for inhibiting expression of XBP-1 gene
|
USRE48948E1
(en)
|
2008-04-18 |
2022-03-01 |
Warsaw Orthopedic, Inc. |
Clonidine compounds in a biodegradable polymer
|
JP5773366B2
(ja)
|
2008-04-21 |
2015-09-02 |
ティシュー リジェネレイション セラピューティックス、インコーポレイテッド |
生物学的又は化学的作用物質に対する予防又はそれらの治療のために遺伝子改変されたヒト臍帯血管周囲細胞
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
US8173616B2
(en)
*
|
2008-05-02 |
2012-05-08 |
The Brigham And Women's Hospital, Inc. |
RNA-induced translational silencing and cellular apoptosis
|
WO2009137807A2
(en)
|
2008-05-08 |
2009-11-12 |
Asuragen, Inc. |
Compositions and methods related to mirna modulation of neovascularization or angiogenesis
|
US20090291073A1
(en)
*
|
2008-05-20 |
2009-11-26 |
Ward Keith W |
Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same
|
WO2009146417A1
(en)
*
|
2008-05-30 |
2009-12-03 |
Sigma-Aldrich Co. |
Compositions and methods for specifically silencing a target nucleic acid
|
EP2297322A1
(de)
|
2008-06-04 |
2011-03-23 |
The Board of Regents of The University of Texas System |
Modulation der genexpression über das abzielen kleiner endogener rna auf genpromotoren
|
US20090305611A1
(en)
*
|
2008-06-06 |
2009-12-10 |
Flow International Corporation |
Device and method for improving accuracy of a high-pressure fluid jet apparatus
|
WO2009147684A2
(en)
|
2008-06-06 |
2009-12-10 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treatment of ear disorders
|
US20110053226A1
(en)
*
|
2008-06-13 |
2011-03-03 |
Riboxx Gmbh |
Method for enzymatic synthesis of chemically modified rna
|
US8361510B2
(en)
*
|
2008-06-16 |
2013-01-29 |
Georgia Tech Research Corporation |
Nanogels for cellular delivery of therapeutics
|
TWI455944B
(zh)
|
2008-07-01 |
2014-10-11 |
Daiichi Sankyo Co Ltd |
雙股多核苷酸
|
US20110184046A1
(en)
|
2008-07-11 |
2011-07-28 |
Dinah Wen-Yee Sah |
Compositions And Methods For Inhibiting Expression Of GSK-3 Genes
|
WO2010008562A2
(en)
|
2008-07-16 |
2010-01-21 |
Recombinetics |
Methods and materials for producing transgenic animals
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
US8039658B2
(en)
*
|
2008-07-25 |
2011-10-18 |
Air Products And Chemicals, Inc. |
Removal of trace arsenic impurities from triethylphosphate (TEPO)
|
US8212019B2
(en)
*
|
2008-07-30 |
2012-07-03 |
University Of Massachusetts |
Nucleic acid silencing sequences
|
EP2326351B1
(de)
|
2008-08-19 |
2017-12-27 |
Nektar Therapeutics |
Konjugate von kurzen interferierenden nukleinsäuren
|
AU2009275387B2
(en)
|
2008-08-25 |
2010-07-08 |
Excaliard Pharmaceuticals, Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
WO2011028218A1
(en)
|
2009-09-02 |
2011-03-10 |
Alnylam Pharmaceuticals, Inc. |
Process for triphosphate oligonucleotide synthesis
|
CA2737180C
(en)
|
2008-09-15 |
2019-02-19 |
Children's Medical Center Corporation |
Modulation of bcl11a for treatment of hemoglobinopathies
|
CN108165548B
(zh)
|
2008-09-22 |
2022-10-14 |
菲奥医药公司 |
减小大小的自递送RNAi化合物
|
EP2342616A2
(de)
|
2008-09-23 |
2011-07-13 |
Alnylam Pharmaceuticals Inc. |
Chemische modifikationen von monomeren und oligonukleotiden mit cycloaddition
|
EP2334793B1
(de)
|
2008-09-25 |
2016-04-06 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der expression des serumamyloid-a-gens
|
US8592570B2
(en)
|
2008-10-06 |
2013-11-26 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of an RNA from West Nile virus
|
US8802646B2
(en)
*
|
2008-10-08 |
2014-08-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
|
US9149492B2
(en)
|
2008-10-08 |
2015-10-06 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
|
US9388413B2
(en)
|
2008-10-08 |
2016-07-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
WO2010042292A1
(en)
*
|
2008-10-08 |
2010-04-15 |
Trustees Of Dartmouth College |
Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease
|
US9388414B2
(en)
|
2008-10-08 |
2016-07-12 |
Trustees Of Dartmouth College |
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
|
EP2743265B1
(de)
|
2008-10-09 |
2017-03-15 |
Arbutus Biopharma Corporation |
Verbesserte Aminolipide und Verfahren zur Freisetzung von Nukleinsäuren
|
US8591905B2
(en)
|
2008-10-12 |
2013-11-26 |
The Brigham And Women's Hospital, Inc. |
Nicotine immunonanotherapeutics
|
US8343498B2
(en)
|
2008-10-12 |
2013-01-01 |
Massachusetts Institute Of Technology |
Adjuvant incorporation in immunonanotherapeutics
|
US8277812B2
(en)
|
2008-10-12 |
2012-10-02 |
Massachusetts Institute Of Technology |
Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
|
US8343497B2
(en)
|
2008-10-12 |
2013-01-01 |
The Brigham And Women's Hospital, Inc. |
Targeting of antigen presenting cells with immunonanotherapeutics
|
EP2352744B1
(de)
|
2008-10-15 |
2016-09-21 |
Somagenics, Inc. |
Kurze haarnadel-rna zur genexpressionshemmung
|
US9458472B2
(en)
*
|
2008-10-15 |
2016-10-04 |
Massachusetts Institute Of Technology |
Detection and destruction of cancer cells using programmed genetic vectors
|
IL302142B1
(en)
|
2008-10-20 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Compounds and methods for inhibiting transthyretin expression
|
WO2010046889A1
(en)
*
|
2008-10-23 |
2010-04-29 |
Quark Pharmaceuticals, Inc. |
Methods for delivery of sirna to bone marrow cells and uses thereof
|
EP2350277A1
(de)
*
|
2008-10-23 |
2011-08-03 |
Alnylam Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen zur vorbeugung oder behandlung einer rsv-infektion unter verwendung modifizierter duplex-rna-moleküle
|
EP3207944B1
(de)
|
2008-11-10 |
2020-01-15 |
Arbutus Biopharma Corporation |
Neuartige lipide und zusammensetzungen zur verabreichung von therapeutika
|
US20100179213A1
(en)
*
|
2008-11-11 |
2010-07-15 |
Mirna Therapeutics, Inc. |
Methods and Compositions Involving miRNAs In Cancer Stem Cells
|
EP2365804B1
(de)
*
|
2008-11-13 |
2015-05-06 |
Modgene, Llc |
Reduktion der amyloid-beta-belastung in nicht aus dem gehirn stammendem gewebe
|
US9074211B2
(en)
|
2008-11-19 |
2015-07-07 |
Rxi Pharmaceuticals Corporation |
Inhibition of MAP4K4 through RNAI
|
WO2010059575A2
(en)
|
2008-11-21 |
2010-05-27 |
Isis Pharmaceuticals, Inc. |
Combination therapy for the treatment of cancer
|
DK2365803T3
(en)
|
2008-11-24 |
2018-01-22 |
Univ Northwestern |
POLYVALENT RNA NANOPARTICLE COMPOSITIONS
|
EP2191834A1
(de)
*
|
2008-11-26 |
2010-06-02 |
Centre National De La Recherche Scientifique (Cnrs) |
Zusammensetzungen und Verfahren zur Behandlung von Retrovireninfektionen
|
CN102239259A
(zh)
|
2008-12-03 |
2011-11-09 |
玛瑞纳生物技术有限公司 |
UsiRNA复合物
|
WO2010065834A1
(en)
|
2008-12-04 |
2010-06-10 |
Opko Ophthalmics, Llc |
Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms
|
US20100291188A1
(en)
*
|
2008-12-04 |
2010-11-18 |
Musc Foundation For Research Development |
Periostin Inhibitory Compositions for Myocardial Regeneration, Methods of Delivery, and Methods of Using Same
|
CN102245640B
(zh)
|
2008-12-09 |
2014-12-31 |
霍夫曼-拉罗奇有限公司 |
抗-pd-l1抗体及它们用于增强t细胞功能的用途
|
AU2009324534B2
(en)
|
2008-12-10 |
2015-07-30 |
Alnylam Pharmaceuticals, Inc. |
GNAQ targeted dsRNA compositions and methods for inhibiting expression
|
US8664188B2
(en)
*
|
2008-12-11 |
2014-03-04 |
Xiangxue Group (Hong Kong) Company Limited |
siRNA compositions and methods for potently inhibiting viral infection
|
JPWO2010067882A1
(ja)
*
|
2008-12-12 |
2012-05-24 |
株式会社クレハ |
癌及び喘息治療のための医薬組成物
|
EP2370175A2
(de)
*
|
2008-12-16 |
2011-10-05 |
Bristol-Myers Squibb Company |
Verfahren zur unterdrückung von stiller tumorproliferation
|
WO2010080452A2
(en)
|
2008-12-18 |
2010-07-15 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS AND METHODS OF USE THEREOF
|
US20110268772A1
(en)
|
2008-12-26 |
2011-11-03 |
Samyang Corporation |
Pharmaceutical composition containing an anionic drug and a production method thereof
|
WO2010078536A1
(en)
|
2009-01-05 |
2010-07-08 |
Rxi Pharmaceuticals Corporation |
Inhibition of pcsk9 through rnai
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
WO2010083532A1
(en)
*
|
2009-01-19 |
2010-07-22 |
The Research Foundaton Of State University Of New York |
Fatty acid binding proteins as drug targets for modulation of endocannabinoids
|
EP2389196A1
(de)
*
|
2009-01-20 |
2011-11-30 |
Vib Vzw |
Phd2-hemmung zur normalisierung von blutgefässen und anwendung davon
|
WO2010083615A1
(en)
|
2009-01-26 |
2010-07-29 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein c-iii expression
|
AU2010211133A1
(en)
*
|
2009-02-03 |
2011-07-21 |
F. Hoffmann-La Roche Ag |
Compositions and methods for inhibiting expression of PTP1B genes
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
HUE035769T2
(en)
|
2009-02-12 |
2018-05-28 |
Cell Signaling Technology Inc |
Mutant ROS expression in human liver cancer
|
CN102333869A
(zh)
*
|
2009-02-24 |
2012-01-25 |
里博克斯艾克斯有限公司 |
小干扰rna的改进设计
|
WO2010101951A1
(en)
|
2009-03-02 |
2010-09-10 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
EA201171144A1
(ru)
*
|
2009-03-19 |
2012-04-30 |
Мерк Шарп Энд Домэ Корп. |
ОПОСРЕДОВАННОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНА ГОМОЛОГА 1 BTB И CNC, ОСНОВНОГО ФАКТОРА ТРАНСКРИПЦИИ С ЛЕЙЦИНОВОЙ МОЛНИЕЙ 1 (Bach1) С ИСПОЛЬЗОВАНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
|
CN102378766A
(zh)
|
2009-03-23 |
2012-03-14 |
夸克医药公司 |
治疗癌症和纤维化疾病的化合物组合物和方法
|
US20100239632A1
(en)
|
2009-03-23 |
2010-09-23 |
Warsaw Orthopedic, Inc. |
Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
|
WO2010120874A2
(en)
|
2009-04-14 |
2010-10-21 |
Chimeros, Inc. |
Chimeric therapeutics, compositions, and methods for using same
|
EP2421972A2
(de)
*
|
2009-04-24 |
2012-02-29 |
The Board of Regents of The University of Texas System |
Modulation der genexpression mit auf genregionen nach 3-untranslatierten regionen gerichteten oligomeren
|
US8367350B2
(en)
|
2009-04-29 |
2013-02-05 |
Morehouse School Of Medicine |
Compositions and methods for diagnosis, prognosis and management of malaria
|
US8933049B2
(en)
*
|
2009-05-05 |
2015-01-13 |
Medical Diagnostic Laboratories, Llc |
Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
|
BRPI1007708A2
(pt)
|
2009-05-05 |
2020-08-18 |
Beeologics Inc |
agente do ácido nucleico isolado, construção de ácido nucleico, ácido nucleico isolado, composição ingerível pelas abelhas, método para reduzir a susceptibilidade de uma abelha a infecção por nosema e método para reduzir a susceptibilidade das abelhas melíferas à infecçção por nosema
|
US9255266B2
(en)
|
2009-05-06 |
2016-02-09 |
Rutgers, The State University Of New Jersey |
RNA targeting in alpha-synucleinopathies
|
BRPI1012769A2
(pt)
*
|
2009-05-15 |
2018-01-30 |
Hoffmann La Roche |
composições e métodos para inibir expressão de genes de receptor de glicocorticóide (gcr)
|
WO2011005363A2
(en)
*
|
2009-05-18 |
2011-01-13 |
Ensysce Biosciences, Inc. |
Carbon nanotubes complexed with multiple bioactive agents and methods related thereto
|
EP2432499A2
(de)
|
2009-05-20 |
2012-03-28 |
Schering Corporation |
Modulation von pilr-rezeptoren zur behandlung mikrobieller infektionen
|
US20100304995A1
(en)
*
|
2009-05-22 |
2010-12-02 |
Li Shen |
Arrays and Methods for Reverse Genetic Functional Analysis
|
CA2764158A1
(en)
|
2009-06-01 |
2010-12-09 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotides for multivalent rna interference, compositions and methods of use thereof
|
US20120083519A1
(en)
*
|
2009-06-03 |
2012-04-05 |
Djillali Sahali |
Methods For Diagnosing And Treating A Renal Disease In An Individual
|
WO2010141928A2
(en)
|
2009-06-05 |
2010-12-09 |
University Of Florida Research Foundation, Inc. |
Isolation and targeted suppression of lignin biosynthetic genes from sugarcane
|
US8637482B2
(en)
|
2009-06-08 |
2014-01-28 |
Quark Pharmaceuticals, Inc. |
Methods for treating chronic kidney disease
|
US8853493B2
(en)
|
2009-06-10 |
2014-10-07 |
Temasek Life Sciences Laboratory Limited |
Virus induced gene silencing (VIGS) for functional analysis of genes in cotton
|
HUE038796T2
(hu)
|
2009-06-10 |
2018-11-28 |
Arbutus Biopharma Corp |
Továbbfejlesztett lipid készítmény
|
EA201270019A1
(ru)
*
|
2009-06-15 |
2012-06-29 |
Элнилэм Фармасьютикалз, Инк. |
Двуцепочечная рнк, включенная в липидный состав и мишенью которой является ген pcsk9
|
WO2010147992A1
(en)
|
2009-06-15 |
2010-12-23 |
Alnylam Pharmaceuticals, Inc. |
Methods for increasing efficacy of lipid formulated sirna
|
US20100323018A1
(en)
*
|
2009-06-17 |
2010-12-23 |
Massachusetts Institute Of Technology |
Branched DNA/RNA monomers and uses thereof
|
US20100324124A1
(en)
*
|
2009-06-17 |
2010-12-23 |
Massachusetts Institute Of Technology |
Compositions and methods relating to DNA-based particles
|
GB0910723D0
(en)
|
2009-06-22 |
2009-08-05 |
Sylentis Sau |
Novel drugs for inhibition of gene expression
|
ES2613498T3
(es)
|
2009-07-01 |
2017-05-24 |
Protiva Biotherapeutics Inc. |
Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
EP2454371B1
(de)
|
2009-07-13 |
2021-01-20 |
Somagenics, Inc. |
Chemische modifikation kleiner haarnadel-rnas zur genexpressionshemmung
|
WO2011011447A1
(en)
*
|
2009-07-20 |
2011-01-27 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing ebola virus gene expression
|
ES2629167T3
(es)
|
2009-07-20 |
2017-08-07 |
Bristol-Myers Squibb Company |
Combinación de anticuerpo anti-CTLA4 con etopósido para el tratamiento sinérgico de enfermedades proliferativas
|
WO2011020024A2
(en)
|
2009-08-13 |
2011-02-17 |
The Johns Hopkins University |
Methods of modulating immune function
|
EP2464336A4
(de)
|
2009-08-14 |
2013-11-20 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen aus lipidformulierungen und verfahren zur hemmung der expression eines gens aus dem ebolavirus
|
CN102481379A
(zh)
|
2009-08-24 |
2012-05-30 |
菲吉尼克斯公司 |
靶向pax2用于治疗乳腺癌
|
ES2655079T3
(es)
|
2009-09-10 |
2018-02-16 |
Merck Sharp & Dohme Corp. |
Uso de antagonistas de IL-33 para tratar enfermedades fibróticas
|
EP2295543A1
(de)
|
2009-09-11 |
2011-03-16 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Verfahren zur Herstellung von Influenzaviren
|
WO2011032100A1
(en)
|
2009-09-11 |
2011-03-17 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Inhibitors of kshv vil6 and human il6
|
CN102639115A
(zh)
|
2009-09-15 |
2012-08-15 |
阿尔尼拉姆医药品有限公司 |
脂质配制的组合物及抑制eg5和vegf基因的表达的方法
|
US8916693B2
(en)
|
2009-09-17 |
2014-12-23 |
Nektar Therapeutics |
Monoconjugated chitosans as delivery agents for small interfering nucleic acids
|
WO2011038031A1
(en)
|
2009-09-22 |
2011-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dual targeting sirna agents
|
CA2775092A1
(en)
*
|
2009-09-23 |
2011-03-31 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes expressed in cancer
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
US8962584B2
(en)
|
2009-10-14 |
2015-02-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Compositions for controlling Varroa mites in bees
|
US9376690B2
(en)
|
2009-10-30 |
2016-06-28 |
Northwestern University |
Templated nanoconjugates
|
WO2011056883A1
(en)
|
2009-11-03 |
2011-05-12 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (ttr)
|
US9799416B2
(en)
*
|
2009-11-06 |
2017-10-24 |
Terrapower, Llc |
Methods and systems for migrating fuel assemblies in a nuclear fission reactor
|
US8901097B2
(en)
|
2009-11-08 |
2014-12-02 |
Quark Pharmaceuticals, Inc. |
Methods for delivery of siRNA to the spinal cord and therapies arising therefrom
|
CN102770529B
(zh)
|
2009-11-17 |
2018-06-05 |
Musc研究发展基金会 |
针对人核仁素的人单克隆抗体
|
CA2776568A1
(en)
|
2009-11-26 |
2011-06-03 |
Quark Pharmaceuticals, Inc. |
Sirna compounds comprising terminal substitutions
|
WO2011071860A2
(en)
|
2009-12-07 |
2011-06-16 |
Alnylam Pharmaceuticals, Inc. |
Compositions for nucleic acid delivery
|
EP2510098B1
(de)
|
2009-12-09 |
2015-02-11 |
Quark Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen und zur behandlung von erkrankungen, störungen oder läsionen des zns
|
KR101718534B1
(ko)
*
|
2009-12-09 |
2017-03-22 |
닛토덴코 가부시키가이샤 |
Hsp47 발현의 조절
|
WO2011072240A1
(en)
|
2009-12-10 |
2011-06-16 |
Cedars-Sinai Medical Center |
Drug delivery of temozolomide for systemic based treatment of cancer
|
EP2336171A1
(de)
|
2009-12-11 |
2011-06-22 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Neuartige Targets zur Behandlung proliferativer Erkrankungen
|
WO2011084357A1
(en)
|
2009-12-17 |
2011-07-14 |
Schering Corporation |
Modulation of pilr to treat immune disorders
|
US20130017223A1
(en)
|
2009-12-18 |
2013-01-17 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
CN102686729B
(zh)
*
|
2009-12-18 |
2015-09-23 |
箭头研究公司 |
用于治疗hsf1相关疾病的有机组合物
|
SG181823A1
(en)
|
2009-12-23 |
2012-07-30 |
Max Planck Gesellschaft |
Influenza targets
|
AU2010333753B2
(en)
|
2009-12-23 |
2013-06-13 |
Gradalis, Inc. |
Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
|
US20130023578A1
(en)
|
2009-12-31 |
2013-01-24 |
Samyang Biopharmaceuticals Corporation |
siRNA for inhibition of c-Met expression and anticancer composition containing the same
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
TW201124159A
(en)
*
|
2010-01-07 |
2011-07-16 |
Univ Nat Cheng Kung |
Small interference RNA molecule and applications thereof
|
WO2011085347A2
(en)
*
|
2010-01-11 |
2011-07-14 |
Opko Curna, Llc |
Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
|
WO2011088058A1
(en)
*
|
2010-01-12 |
2011-07-21 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expressions of factor vii and pten genes
|
DE102010004957A1
(de)
|
2010-01-14 |
2011-07-21 |
Universitätsklinikum Jena, 07743 |
Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
WO2011100131A2
(en)
|
2010-01-28 |
2011-08-18 |
Alnylam Pharmacuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
US8722641B2
(en)
|
2010-01-29 |
2014-05-13 |
St. Jude Children's Research Hospital |
Oligonucleotides which inhibit p53 induction in response to cellular stress
|
MX2012009318A
(es)
|
2010-02-10 |
2012-09-07 |
Novartis Ag |
Metodos y compuestos para el crecimiento muscular.
|
AU2011227050B2
(en)
|
2010-03-19 |
2016-12-08 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
EP2550001B1
(de)
|
2010-03-24 |
2019-05-22 |
Phio Pharmaceuticals Corp. |
Rna-interferenz bei augenerkrankungen
|
WO2011119852A1
(en)
|
2010-03-24 |
2011-09-29 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering rnai compounds
|
KR20180044433A
(ko)
|
2010-03-24 |
2018-05-02 |
알엑스아이 파마슈티칼스 코포레이션 |
진피 및 섬유증성 적응증에서의 rna 간섭
|
US8455455B1
(en)
|
2010-03-31 |
2013-06-04 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes involved in hemorrhagic fever
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
US20130260460A1
(en)
|
2010-04-22 |
2013-10-03 |
Isis Pharmaceuticals Inc |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
WO2011133658A1
(en)
|
2010-04-22 |
2011-10-27 |
Boston Medical Center Corporation |
Compositions and methods for targeting and delivering therapeutics into cells
|
WO2011133876A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
MX343559B
(es)
|
2010-04-29 |
2016-11-10 |
Ionis Pharmaceuticals Inc |
Modulacion de la expresion de transtiretina.
|
EP2563359A1
(de)
|
2010-04-30 |
2013-03-06 |
Allergan, Inc. |
Neue behandlung für alterbedingte makuladegeneration und okulare ischämie im zusammenhang mit komplementaktivierung mittels abzielung auf 5-lipoxygenase
|
KR20130107203A
(ko)
|
2010-05-04 |
2013-10-01 |
더 브리검 앤드 우먼즈 하스피털, 인크. |
섬유증의 검출 및 치료
|
US8563243B2
(en)
*
|
2010-05-12 |
2013-10-22 |
University Of South Carolina |
Methods for affecting homology-directed DNA double stranded break repair
|
MX2012013713A
(es)
|
2010-05-26 |
2013-01-28 |
Selecta Biosciences Inc |
Composiciones de nanovehiculos con adyuvante no acoplado.
|
EP2390327A1
(de)
|
2010-05-27 |
2011-11-30 |
Sylentis S.A. |
siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Behandlung und/oder Prävention von Augenleiden
|
DE102010022937A1
(de)
|
2010-06-04 |
2011-12-08 |
Universitätsklinikum Jena |
Zellspezifisch aktivierbare biologisch wirksame Moleküle auf Grundlage von siRNA, Verfahren zu deren Aktivierung sowie Applikationskit zur Verabreichung
|
US20130236968A1
(en)
|
2010-06-21 |
2013-09-12 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
CA2801928C
(en)
|
2010-06-24 |
2018-04-10 |
Quark Pharmaceuticals, Inc. |
Double stranded rna compounds to rhoa and use thereof
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US20120101108A1
(en)
|
2010-08-06 |
2012-04-26 |
Cell Signaling Technology, Inc. |
Anaplastic Lymphoma Kinase In Kidney Cancer
|
EP3372684B1
(de)
|
2010-08-24 |
2020-10-07 |
Sirna Therapeutics, Inc. |
Einsträngige rnai-mittel mit einem internen nukleinsäurefreien spacer
|
US8933051B2
(en)
|
2010-09-30 |
2015-01-13 |
University Of Zurich |
Treatment of B-cell lymphoma with microRNA
|
WO2013052006A1
(en)
*
|
2010-10-07 |
2013-04-11 |
Agency For Science, Technology And Research (A*Star) |
Parp-1 inhibitors
|
WO2012051491A1
(en)
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
ES2732929T3
(es)
*
|
2010-10-22 |
2019-11-26 |
Olix Pharmaceuticals Inc |
Moléculas de ácido nucleico que inducen interferencia de ARN y usos de las mismas
|
EP3327125B1
(de)
|
2010-10-29 |
2020-08-05 |
Sirna Therapeutics, Inc. |
Rna-interferenz-vermittelte inhibition von genexpression unter verwendung kurzer interferierender nukleinsäure (sina)
|
WO2012071436A1
(en)
|
2010-11-24 |
2012-05-31 |
Genentech, Inc. |
Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants
|
WO2012078536A2
(en)
|
2010-12-06 |
2012-06-14 |
Quark Pharmaceuticals, Inc. |
Double stranded oligonucleotide compounds comprising positional modifications
|
WO2012102793A2
(en)
|
2010-12-10 |
2012-08-02 |
Zirus, Inc. |
Mammalian genes involved in toxicity and infection
|
US8575328B2
(en)
*
|
2010-12-14 |
2013-11-05 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Formicidae (ant) control using double-stranded RNA constructs
|
US9623041B2
(en)
|
2010-12-30 |
2017-04-18 |
Cedars-Sinai Medical Center |
Polymalic acid-based nanobiopolymer compositions
|
DE112012000439T5
(de)
|
2011-01-10 |
2014-04-30 |
The Regents Of The University Of Michigan |
Stammzellfaktor-Inhibitor
|
DK2663548T3
(en)
|
2011-01-11 |
2017-07-24 |
Alnylam Pharmaceuticals Inc |
PEGYLED LIPIDS AND THEIR USE FOR PHARMACEUTICAL SUPPLY
|
DE102011009470A1
(de)
|
2011-01-21 |
2012-08-09 |
Friedrich-Schiller-Universität Jena |
Biologisch wirksame Nukleotid-Moleküle zur gezielten Abtötung von Zellen, Verwendung derselben sowie Applikationskit
|
MX365647B
(es)
|
2011-02-02 |
2019-06-10 |
Excaliard Pharmaceuticals Inc |
El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas.
|
EP2670849A1
(de)
|
2011-02-03 |
2013-12-11 |
Mirna Therapeutics, Inc. |
Synthetische mimetika von mir-124
|
US9796979B2
(en)
|
2011-03-03 |
2017-10-24 |
Quark Pharmaceuticals Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
CN103562387A
(zh)
*
|
2011-03-03 |
2014-02-05 |
夸克医药公司 |
Toll样受体途径的寡核苷酸调剂
|
WO2012125554A2
(en)
*
|
2011-03-11 |
2012-09-20 |
Board Of Regents Of The University Of Nebraska |
Compositions and methods for the treatment of cancer
|
US20140303013A1
(en)
|
2011-03-15 |
2014-10-09 |
University Of Utah Research Foundation |
Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
|
US9458456B2
(en)
*
|
2011-04-01 |
2016-10-04 |
University Of South Alabama |
Methods and compositions for the diagnosis, classification, and treatment of cancer
|
JP2014511877A
(ja)
|
2011-04-12 |
2014-05-19 |
ザ・ガバメント・オブ・ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンテッド・バイ・ザ・セクレタリー・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシーズ |
ポロ様キナーゼ1ポロ−ボックスドメインのペプチド模倣リガンド及び使用方法
|
CN105886506A
(zh)
|
2011-04-13 |
2016-08-24 |
Isis制药公司 |
Ptp1b 表达的反义调节
|
WO2012142622A1
(en)
*
|
2011-04-15 |
2012-10-18 |
Molecular Transfer, Inc. |
Agents for improved delivery of nucleic acids to eukaryotic cells
|
US8716257B2
(en)
*
|
2011-04-15 |
2014-05-06 |
Sutter West Bay Hospitals |
CMV gene products promote cancer stem cell growth
|
ES2880291T3
(es)
|
2011-06-02 |
2021-11-24 |
Univ Louisville Res Found Inc |
Nanopartículas conjugadas a un agente antinucleolina
|
CA3191066A1
(en)
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibition of expression of apolipoprotein c-iii (apoc3) genes
|
EP2723351B1
(de)
|
2011-06-21 |
2018-02-14 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der expression von protein-c (proc)-genen
|
WO2012177921A2
(en)
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc |
Compositions and methods for inhibiting hepcidin antimicrobial peptide (hamp) or hamp-related gene expression
|
AU2012272970A1
(en)
|
2011-06-21 |
2014-02-06 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
|
US20140227293A1
(en)
|
2011-06-30 |
2014-08-14 |
Trustees Of Boston University |
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
|
WO2013001372A2
(en)
|
2011-06-30 |
2013-01-03 |
University Of Oslo |
Methods and compositions for inhibition of activation of regulatory t cells
|
EP2729173B1
(de)
|
2011-07-06 |
2016-06-15 |
Sykehuset Sorlandet HF |
Auf egfr zielende therapie
|
WO2013006861A1
(en)
|
2011-07-07 |
2013-01-10 |
University Of Georgia Research Foundation, Inc. |
Sorghum grain shattering gene and uses thereof in altering seed dispersal
|
US8853181B2
(en)
|
2011-07-21 |
2014-10-07 |
Albert Einstein College Of Medicine Of Yeshiva University |
Fidgetin-like 2 as a target to enhance wound healing
|
US9120858B2
(en)
|
2011-07-22 |
2015-09-01 |
The Research Foundation Of State University Of New York |
Antibodies to the B12-transcobalamin receptor
|
DE102011118024A1
(de)
|
2011-08-01 |
2013-02-07 |
Technische Universität Dresden |
Inhibitor der Expression der Pro-Caspase 1
|
ES2651515T3
(es)
|
2011-09-06 |
2018-01-26 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
La familia miARN-212/132 como diana terapéutica
|
WO2013036973A2
(en)
|
2011-09-09 |
2013-03-14 |
Biomed Realty, L.P. |
Methods and compositions for controlling assembly of viral proteins
|
WO2013040251A2
(en)
|
2011-09-13 |
2013-03-21 |
Asurgen, Inc. |
Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
|
US9951349B2
(en)
|
2011-09-27 |
2018-04-24 |
Yale University |
Compositions and methods for transient expression of recombinant RNA
|
US9701623B2
(en)
|
2011-09-27 |
2017-07-11 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
AU2012325997C1
(en)
|
2011-10-18 |
2018-07-05 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
WO2013070821A1
(en)
|
2011-11-08 |
2013-05-16 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the nervous system
|
EP2725103A3
(de)
*
|
2011-11-14 |
2016-01-06 |
Silenseed Ltd |
Verfahren und Zusammensetzungen zur Behandlung von Prostatakrebs
|
HUE048622T2
(hu)
|
2011-11-18 |
2020-08-28 |
Alnylam Pharmaceuticals Inc |
RNSi szerek, készítmények és alkalmazási eljárások transztiretin (TTR) asszociált betegségek kezelésére
|
WO2013082529A1
(en)
|
2011-12-02 |
2013-06-06 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
US20150216998A1
(en)
|
2012-01-01 |
2015-08-06 |
Ramot At Tel-Aviv University Ltd. |
Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
|
US9464291B2
(en)
*
|
2012-01-06 |
2016-10-11 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
CA2860676A1
(en)
|
2012-01-09 |
2013-07-18 |
Novartis Ag |
Organic compositions to treat beta-catenin-related diseases
|
EP2802657B1
(de)
|
2012-01-12 |
2018-05-02 |
Quark Pharmaceuticals, Inc. |
Kombinationstherapie zur behandlung von gehör-und gleichgewichtsstörungen
|
US20150126438A1
(en)
|
2012-01-24 |
2015-05-07 |
Beth Israel Deaconess Medical Center, Inc. |
Novel ChREBP Isoforms and Methods Using the Same
|
WO2013138456A1
(en)
|
2012-03-14 |
2013-09-19 |
University Of Central Florida Research Foundation, Inc. |
Lim kinasemodulating agents for neurofibromatoses therapy and methods for screening for same
|
ES2694592T3
(es)
|
2012-03-15 |
2018-12-21 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado del cerebro (BDNF) por inhibición del transcrito antisentido natural de BDNF
|
HUE037856T2
(hu)
|
2012-04-18 |
2018-09-28 |
Cell Signaling Technology Inc |
EGFR és ROS1 rákban
|
EP3919620A1
(de)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Zusammensetzungen mit kurzer interferierender nukleinsäure (sina)
|
WO2013166043A1
(en)
|
2012-05-02 |
2013-11-07 |
Children's Hospital Medical Center |
Rejuvenation of precursor cells
|
ES2716818T3
(es)
|
2012-05-22 |
2019-06-17 |
Olix Pharmaceuticals Inc |
Molécula de ácido nucleico inductora de interferencias de arn capaz de penetrar en las células y uso de la misma
|
WO2014006227A1
(en)
|
2012-07-06 |
2014-01-09 |
Institut Gustave-Roussy |
Simultaneous detection of cannibalism and senescence as prognostic marker for cancer
|
WO2014018375A1
(en)
|
2012-07-23 |
2014-01-30 |
Xenon Pharmaceuticals Inc. |
Cyp8b1 and uses thereof in therapeutic and diagnostic methods
|
EP3441467A3
(de)
*
|
2012-08-31 |
2019-04-24 |
The General Hospital Corporation |
Biotinkomplexe zur behandlung und diagnose von morbus alzheimer
|
GB201215857D0
(en)
|
2012-09-05 |
2012-10-24 |
Sylentis Sau |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
WO2014037686A1
(en)
|
2012-09-05 |
2014-03-13 |
Sylentis S.A.U. |
Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
ES2704855T3
(es)
|
2012-09-12 |
2019-03-20 |
Quark Pharmaceuticals Inc |
Moléculas de oligonucleótido de doble cadena para p53 y métodos de uso de las mismas
|
WO2014043289A2
(en)
|
2012-09-12 |
2014-03-20 |
Quark Pharmaceuticals, Inc. |
Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof
|
KR101839864B1
(ko)
|
2012-09-21 |
2018-03-20 |
인텐시티 쎄라퓨틱스, 인코포레이티드 |
암을 치료하는 방법
|
EP3795694A3
(de)
*
|
2012-10-02 |
2021-06-23 |
The General Hospital Corporation d/b/a Massachusetts General Hospital |
Verfahren für mit dem dna-erfassungspfad assoziierten leiden
|
WO2014055825A1
(en)
|
2012-10-04 |
2014-04-10 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
A formulation of mycobacterial components as an adjuvant for inducing th17 responses
|
WO2014068072A1
(en)
|
2012-10-31 |
2014-05-08 |
Institut Gustave-Roussy |
Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
|
CA2930339A1
(en)
|
2012-11-13 |
2014-05-22 |
Jan Lotvall |
Delivery of therapeutic agent
|
DE102012022596B4
(de)
|
2012-11-15 |
2017-05-04 |
Friedrich-Schiller-Universität Jena |
Neue zellspezifisch wirksame Nukleotid-Moleküle und Applikationskit zu deren Anwendung
|
DK3660033T5
(da)
|
2012-11-15 |
2022-06-27 |
Apellis Pharmaceuticals Inc |
Langtidsvirkende compstatinanaloger og tilhørende sammensætninger og fremgangsmåder
|
US9822355B2
(en)
|
2012-11-27 |
2017-11-21 |
Children's Medical Center Corporation |
Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
|
WO2014093688A1
(en)
|
2012-12-12 |
2014-06-19 |
1Massachusetts Institute Of Technology |
Compositions and methods for functional nucleic acid delivery
|
AU2013362134B2
(en)
|
2012-12-21 |
2018-07-05 |
Sykehuset Sorlandet Hf |
EGFR targeted therapy of neurological disorders and pain
|
US9206423B2
(en)
*
|
2012-12-30 |
2015-12-08 |
The Regents Of The University Of California |
Methods of modulating compliance of the trabecular meshwork
|
WO2014113541A1
(en)
|
2013-01-16 |
2014-07-24 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Attenuated chlamydia vaccine
|
DE102013003869B4
(de)
|
2013-02-27 |
2016-11-24 |
Friedrich-Schiller-Universität Jena |
Verfahren zur gezielten Abtötung von Zellen durch zur mRNA-Anbindung ausgerichtete Nukleotid-Moleküle sowie Nukleotid-Moleküle und Applikationskit für solche Verwendung
|
EP2968149A4
(de)
|
2013-03-14 |
2017-02-01 |
Dicerna Pharmaceuticals, Inc. |
Verfahren zur herstellung eines anionischen mittels
|
WO2014150751A2
(en)
*
|
2013-03-15 |
2014-09-25 |
Novartis Ag |
Biomarkers associated with brm inhibition
|
CN105050595A
(zh)
*
|
2013-03-15 |
2015-11-11 |
基因泰克公司 |
通过抑制含布罗莫结构域蛋白brd7和brd9治疗th2介导的疾病
|
US10308687B2
(en)
|
2013-03-15 |
2019-06-04 |
Apellis Pharmaceuticals, Inc. |
Cell-penetrating compstatin analogs and uses thereof
|
EP2978446B1
(de)
|
2013-03-27 |
2020-03-04 |
The General Hospital Corporation |
Anti-cd33 antikörper zur behandlung von morbus alzheimer
|
AU2014265142A1
(en)
|
2013-05-17 |
2015-12-24 |
Medimmune, Llc |
Receptors for B7-H4
|
SG11201510369WA
(en)
|
2013-06-25 |
2016-01-28 |
Univ Canberra |
Methods and compositions for modulating cancer stem cells
|
TW201534578A
(zh)
|
2013-07-08 |
2015-09-16 |
Daiichi Sankyo Co Ltd |
新穎脂質
|
WO2015006554A1
(en)
|
2013-07-10 |
2015-01-15 |
The Regents Of The University Of Michigan |
Therapeutic antibodies and uses thereof
|
BR112016000555B1
(pt)
|
2013-07-19 |
2022-12-27 |
Monsanto Technology Llc |
Método para controlar uma infestação da espécie de leptinotarsa em uma planta, composição inseticida e construção de dna recombinante
|
WO2015013510A1
(en)
|
2013-07-25 |
2015-01-29 |
Ecole Polytechnique Federale De Lausanne Epfl |
High aspect ratio nanofibril materials
|
EP3027222A1
(de)
|
2013-07-31 |
2016-06-08 |
QBI Enterprises Ltd. |
Sphingolipid-polyalkylamin-oligonukleotidverbindungen
|
EP3027223A1
(de)
|
2013-07-31 |
2016-06-08 |
QBI Enterprises Ltd. |
Verfahren zur verwendung von sphingolipid-polyalkylamin-oligonukleotidverbindungen
|
ES2790574T3
(es)
|
2013-08-28 |
2020-10-28 |
Ionis Pharmaceuticals Inc |
Modulación de expresión de prekallikrein (PKK)
|
CN105705139B
(zh)
|
2013-09-11 |
2019-07-26 |
伊戈尔生物药品股份有限公司 |
包含水溶性有机染料的液体蛋白质制剂
|
WO2015039187A1
(en)
|
2013-09-18 |
2015-03-26 |
University Of Canberra |
Stem cell modulation ii
|
US10519446B2
(en)
|
2013-10-04 |
2019-12-31 |
Novartis Ag |
Organic compounds to treat hepatitis B virus
|
KR102298475B1
(ko)
|
2013-10-04 |
2021-09-06 |
노파르티스 아게 |
RNA 간섭에 사용하기 위한 RNAi 작용제를 위한 3' 말단 캡
|
EP2865758A1
(de)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des ORAI1-Gens
|
EP2865756A1
(de)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des FLAP-Gens
|
EP2865757A1
(de)
|
2013-10-22 |
2015-04-29 |
Sylentis, S.A.U. |
siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des PDK1-Gens
|
EP3068407A1
(de)
|
2013-11-11 |
2016-09-21 |
Sirna Therapeutics, Inc. |
Systemische verabreichung von myostatin und kurzen interferierenden nukleinsäuren, konjugiert an eine lipophile gruppe
|
WO2015077566A1
(en)
|
2013-11-21 |
2015-05-28 |
Huang Zhen |
Methods for structural determination of selenium derivatized nucleic acid complexes
|
CN106061488B
(zh)
|
2013-12-02 |
2021-04-09 |
菲奥医药公司 |
癌症的免疫治疗
|
CA2932904A1
(en)
|
2013-12-06 |
2015-06-11 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of transthyretin (ttr) by double-stranded rna
|
CN104830906B
(zh)
|
2014-02-12 |
2018-09-04 |
北京维通达生物技术有限公司 |
一种重编程获得功能性人肝脏实质细胞的方法
|
US10011837B2
(en)
|
2014-03-04 |
2018-07-03 |
Sylentis Sau |
SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions
|
HUE048558T2
(hu)
|
2014-03-11 |
2020-07-28 |
Cellectis |
Eljárás allogén transzplantációra kompatibilis T-sejtek létrehozására
|
WO2015140330A1
(en)
*
|
2014-03-20 |
2015-09-24 |
Oommen Varghese |
Improved small interfering ribonucleic acid molecules
|
JP6752151B2
(ja)
|
2014-03-25 |
2020-09-09 |
アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. |
遺伝子サイレンシングにおいて低下したoff−target効果を有するunaオリゴマー
|
US9856475B2
(en)
|
2014-03-25 |
2018-01-02 |
Arcturus Therapeutics, Inc. |
Formulations for treating amyloidosis
|
WO2015148582A1
(en)
|
2014-03-25 |
2015-10-01 |
Arcturus Therapeutics, Inc. |
Transthyretin allele selective una oligomers for gene silencing
|
PT3757214T
(pt)
|
2014-04-01 |
2022-08-26 |
Biogen Ma Inc |
Composições para modulação da expressão de sod-1
|
BR112016022711A2
(pt)
|
2014-04-01 |
2017-10-31 |
Monsanto Technology Llc |
composições e métodos para controle de pragas de inseto
|
CA2946309C
(en)
|
2014-04-25 |
2021-11-09 |
Michael MILSOM |
Synthetic bcl11a micrornas for treating hemoglobinopathies
|
EP3137119B1
(de)
|
2014-04-28 |
2020-07-01 |
Phio Pharmaceuticals Corp. |
Verfahren zur behandlung von krebs mithilfe von einer nukleinsaüre gegen mdm2
|
KR102366078B1
(ko)
|
2014-05-01 |
2022-02-21 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Pkk 발현을 조절하는 조성물 및 방법
|
RU2728703C2
(ru)
|
2014-05-02 |
2020-07-31 |
Рисерч Инститьют Эт Нэшнуайд Чилдрен`С Хоспитал |
Композиции и способы для анти-lyst иммуномодуляции
|
JP6763780B2
(ja)
|
2014-05-12 |
2020-09-30 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
合成脳浸透遺伝子ベクターの操作
|
US10335500B2
(en)
|
2014-05-12 |
2019-07-02 |
The Johns Hopkins University |
Highly stable biodegradable gene vector platforms for overcoming biological barriers
|
WO2015184105A1
(en)
|
2014-05-29 |
2015-12-03 |
Trustees Of Dartmouth College |
Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
|
CN104120127B
(zh)
*
|
2014-07-01 |
2016-09-21 |
清华大学 |
分离的寡核苷酸及其应用
|
RU2021123470A
(ru)
|
2014-07-29 |
2021-09-06 |
Монсанто Текнолоджи Ллс |
Композиции и способы борьбы с насекомыми-вредителями
|
US20170348402A1
(en)
|
2014-07-30 |
2017-12-07 |
The Research Foundation For The State University Of New York |
System and method for delivering genetic material or protein to cells
|
WO2016023974A1
(de)
|
2014-08-14 |
2016-02-18 |
Friedrich-Schiller-Universität Jena |
Peptid zur verwendung in der reduktion von nebenwirkungen in form von immunstimulatorischen reaktionen/effekten
|
US10485772B2
(en)
|
2014-08-25 |
2019-11-26 |
EpiAxis Therapeutics Pty Ltd. |
Compositions for modulating cancer stem cells and uses therefor
|
ES2928500T3
(es)
|
2014-08-29 |
2022-11-18 |
Alnylam Pharmaceuticals Inc |
Patisirán para su uso en el tratamiento de amiloidosis mediada por transtiretina
|
EP3188799B1
(de)
|
2014-09-05 |
2022-07-06 |
Phio Pharmaceuticals Corp. |
Verfahren zur behandlung von alterung und hauterkrankungen mit auf tyr oder mmp1 gerichteten nukleinsäuren
|
KR102473092B1
(ko)
|
2014-09-15 |
2022-12-01 |
칠드런'즈 메디컬 센터 코포레이션 |
히스톤 h3-리신 트리메틸화를 제거함으로써 체세포 핵 이식(scnt) 효율을 증가시키는 방법 및 조성물
|
WO2016049110A1
(en)
|
2014-09-25 |
2016-03-31 |
Cold Spring Harbor Laboratory |
Treatment of rett syndrome
|
SG10201902915VA
(en)
|
2014-10-01 |
2019-04-29 |
Eagle Biologics Inc |
Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
|
US20170304459A1
(en)
|
2014-10-10 |
2017-10-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
ES2908056T3
(es)
|
2014-10-10 |
2022-04-27 |
Idera Pharmaceuticals Inc |
Tratamiento del cáncer por agonistas del TLR9 con inhibidores del punto de control
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
US10538762B2
(en)
*
|
2014-10-14 |
2020-01-21 |
The Board Of Regents Of The University Of Texas System |
Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAS targeting the expanded hexanucleotide repeat
|
US20180009903A1
(en)
|
2014-10-22 |
2018-01-11 |
Katholieke Universiteit Leuven Ku Leuven Research & Development |
Modulating adipose tissue and adipogenesis
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
CA2974716A1
(en)
|
2014-11-12 |
2016-05-19 |
Nmc, Inc. |
Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same
|
WO2016081444A1
(en)
|
2014-11-17 |
2016-05-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
WO2016081621A1
(en)
|
2014-11-18 |
2016-05-26 |
Yale University |
Formulations for targeted release of agents under low ph conditions and methods of use thereof
|
CA2968531A1
(en)
|
2014-11-21 |
2016-05-26 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
WO2016094374A1
(en)
*
|
2014-12-09 |
2016-06-16 |
The Board Of Regents Of The University Of Texas System |
Compositions and mentods for treatment of friedreich's ataxia
|
US20180002702A1
(en)
*
|
2014-12-26 |
2018-01-04 |
Nitto Denko Corporation |
Methods and compositions for treating malignant tumors associated with kras mutation
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
US10792299B2
(en)
|
2014-12-26 |
2020-10-06 |
Nitto Denko Corporation |
Methods and compositions for treating malignant tumors associated with kras mutation
|
PL3256589T3
(pl)
|
2015-01-22 |
2022-02-21 |
Monsanto Technology Llc |
Kompozycje i sposoby kontrolowania leptinotarsa
|
EP3277289A4
(de)
|
2015-04-01 |
2018-12-05 |
Arcturus Therapeutics, Inc. |
Therapeutische una-oligomere und verwendungen davon
|
AU2016247922B2
(en)
|
2015-04-13 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
|
WO2016168197A1
(en)
|
2015-04-15 |
2016-10-20 |
Yale University |
Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof
|
US10857237B2
(en)
|
2015-05-05 |
2020-12-08 |
University Of Louisville Research Foundation, Inc. |
Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and MRI and/or X-ray contrast agents
|
EP3294873B1
(de)
|
2015-05-08 |
2020-08-19 |
The Children's Medical Center Corporation |
Abzielung auf funktionelle regionen des bcl11a-enhancers zur reinduktion von fetalem hämoglobin
|
US10933049B2
(en)
|
2015-06-03 |
2021-03-02 |
The University Of Queensland |
Mobilizing agents and uses therefor
|
EP3307890A1
(de)
|
2015-06-10 |
2018-04-18 |
Board of Regents, The University of Texas System |
Verwendung von exosomen zur behandlung von krankheiten
|
JP6983066B2
(ja)
|
2015-06-30 |
2021-12-17 |
忠三 岸本 |
新規な肺疾患治療剤および/またはそのスクリーニング方法
|
WO2017007813A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
PE20180800A1
(es)
|
2015-07-10 |
2018-05-09 |
Ionis Pharmaceuticals Inc |
Moduladores de diaciglicerol aciltransferasa 2 (dgat2)
|
WO2017015671A1
(en)
|
2015-07-23 |
2017-01-26 |
Arcturus Therapeutics, Inc. |
Compositions for treating amyloidosis
|
ES2842300T3
(es)
|
2015-07-31 |
2021-07-13 |
Alnylam Pharmaceuticals Inc |
Composiciones de ARNi de transtiretina (TTR) y métodos para su uso para el tratamiento o la prevención de enfermedades asociadas con TTR
|
CN108366966A
(zh)
|
2015-08-24 |
2018-08-03 |
光环生物干扰疗法公司 |
用于调节基因表达的多核苷酸纳米颗粒及其用途
|
MA44908A
(fr)
|
2015-09-08 |
2018-07-18 |
Sylentis Sau |
Molécules d'arnsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène nrarp
|
GB201516685D0
(en)
*
|
2015-09-21 |
2015-11-04 |
Varghese Oommen P And Oommen Oommen P |
Nucleic acid molecules with enhanced activity
|
US10086063B2
(en)
|
2015-09-23 |
2018-10-02 |
Regents Of The University Of Minnesota |
Methods of making and using live attenuated viruses
|
US10383935B2
(en)
|
2015-09-23 |
2019-08-20 |
Regents Of The University Of Minnesota |
Methods of making and using live attenuated viruses
|
US10548959B2
(en)
|
2015-09-23 |
2020-02-04 |
Massachusetts Institute Of Technology |
Compositions and methods for modified dendrimer nanoparticle delivery
|
EP3356415A1
(de)
|
2015-09-29 |
2018-08-08 |
Amgen Inc. |
Asgr-inhibitoren
|
JOP20210043A1
(ar)
*
|
2015-10-01 |
2017-06-16 |
Arrowhead Pharmaceuticals Inc |
تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
|
DK3359555T3
(da)
|
2015-10-07 |
2024-03-25 |
Apellis Pharmaceuticals Inc |
Doseringsplaner
|
WO2017070151A1
(en)
|
2015-10-19 |
2017-04-27 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
|
US10059949B2
(en)
|
2015-11-16 |
2018-08-28 |
Olix Pharmaceuticals, Inc. |
Treatment of age-related macular degeneration using RNA complexes that target MYD88 or TLR3
|
WO2017095751A1
(en)
|
2015-12-02 |
2017-06-08 |
Partikula Llc |
Compositions and methods for modulating cancer cell metabolism
|
US11299537B2
(en)
|
2015-12-10 |
2022-04-12 |
Fibrogen, Inc. |
Methods for treatment of motor neuron diseases
|
WO2017105138A1
(ko)
|
2015-12-18 |
2017-06-22 |
주식회사 삼양바이오팜 |
음이온성 약물을 함유하는 고분자 미셀의 제조방법
|
BR102017001164A2
(pt)
|
2016-01-26 |
2019-03-06 |
Embrapa - Empresa Brasileira De Pesquisa Agropecuária |
Composições de rna de fita dupla para controle de diaphorina citri e métodos de uso.
|
AU2017210726B2
(en)
|
2016-01-31 |
2023-08-03 |
University Of Massachusetts |
Branched oligonucleotides
|
JP6944942B2
(ja)
|
2016-02-02 |
2021-10-06 |
オリックス ファーマシューティカルズ,インコーポレーテッド |
IL4Rα、TRPA1、またはF2RL1を標的とするRNA複合体を用いたアトピー性皮膚炎および喘息の治療
|
WO2017134526A1
(en)
|
2016-02-02 |
2017-08-10 |
Olix Pharmaceuticals, Inc. |
Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb
|
US20170360815A1
(en)
|
2016-02-25 |
2017-12-21 |
Applied Biological Laboratories, Inc. |
Compositions and methods for protecting against airborne pathogens and irritants
|
SG11201806868TA
(en)
|
2016-02-25 |
2018-09-27 |
Applied Biological Laboratories Inc |
Compositions and methods for protecting against airborne pathogens and irritants
|
JP2019512014A
(ja)
|
2016-02-26 |
2019-05-09 |
イェール ユニバーシティーYale University |
がん診断法および治療法におけるpiRNAを使用する組成物および方法
|
EP3423106B1
(de)
|
2016-03-01 |
2022-07-27 |
Alexion Pharmaceuticals, Inc. |
Biologisch abbaubare aktivierte polymere zur therapeutischen verabreichung
|
US11072777B2
(en)
|
2016-03-04 |
2021-07-27 |
University Of Louisville Research Foundation, Inc. |
Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (VSELs)
|
JOP20170057B1
(ar)
|
2016-03-07 |
2022-03-14 |
Arrowhead Pharmaceuticals Inc |
مركبات ترابطية مستهدفة كمركبات علاجية
|
EP3429693B1
(de)
|
2016-03-15 |
2023-08-23 |
Mersana Therapeutics, Inc. |
Gegen napi2b gerichtete antikörper-wirkstoff-konjugate und verfahren zur verwendung davon
|
US20190117799A1
(en)
|
2016-04-01 |
2019-04-25 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
MA45349A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques egfr et leurs utilisations
|
MA45470A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques kras et leurs utilisations
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
MA45469A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques de bêta-caténine et leurs utilisations
|
CN108602849B
(zh)
|
2016-04-06 |
2022-10-21 |
俄亥俄州国家创新基金会 |
用于通过rna纳米技术将治疗剂特异性递送至细胞的rna配体展示外来体
|
KR102339886B1
(ko)
|
2016-04-11 |
2021-12-17 |
올릭스 주식회사 |
연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법
|
EP3443091A4
(de)
|
2016-04-14 |
2019-11-27 |
Benitec Biopharma Limited |
Reagenzien zur behandlung von okulopharyngealer muskeldystrophie (opmd) und verwendung davon
|
US11410746B2
(en)
|
2016-04-27 |
2022-08-09 |
Massachusetts Institute Of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
WO2017197128A1
(en)
|
2016-05-11 |
2017-11-16 |
Yale University |
Poly(amine-co-ester) nanoparticles and methods of use thereof
|
KR101916652B1
(ko)
|
2016-06-29 |
2018-11-08 |
올릭스 주식회사 |
작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
|
CN109983121A
(zh)
|
2016-06-30 |
2019-07-05 |
昂克诺斯公司 |
治疗性多肽的假型化溶瘤病毒递送
|
RU2627179C1
(ru)
*
|
2016-07-28 |
2017-08-03 |
федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации |
ТЕСТ-СИСТЕМА ДЛЯ ОПРЕДЕЛЕНИЯ РНК ИНТЕРФЕРОНА λ, ИНТЕРЛЕЙКИНА IL23 И ПРОТИВОВИРУСНОГО БЕЛКА MxA
|
US20190367930A1
(en)
|
2016-07-29 |
2019-12-05 |
Danmarks Tekniske Universitet |
Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides
|
AU2017306422A1
(en)
|
2016-08-03 |
2019-01-31 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
TLR9 targeted therapeutics
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
HUE059718T2
(hu)
|
2016-09-02 |
2022-12-28 |
Dicerna Pharmaceuticals Inc |
4'-foszfát analógok és azokat tartalmazó oligonukleotidok
|
CN109462981B
(zh)
|
2016-09-02 |
2023-07-07 |
箭头药业股份有限公司 |
靶向配体
|
US10933081B2
(en)
|
2016-09-21 |
2021-03-02 |
Alnylam Pharmaceuticals, Inc. |
Myostatin iRNA compositions and methods of use thereof
|
WO2018062510A1
(ja)
|
2016-09-29 |
2018-04-05 |
国立大学法人東京医科歯科大学 |
オーバーハングを有する二本鎖核酸複合体
|
WO2018098352A2
(en)
|
2016-11-22 |
2018-05-31 |
Jun Oishi |
Targeting kras induced immune checkpoint expression
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
US11723912B2
(en)
|
2016-12-08 |
2023-08-15 |
University Of Utah Research Foundation |
Staufen1 agents and associated methods
|
US20200085758A1
(en)
|
2016-12-16 |
2020-03-19 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
CN110268060A
(zh)
|
2017-01-10 |
2019-09-20 |
箭头药业股份有限公司 |
α-1抗胰蛋白酶(AAT)RNAi物质、包含AAT RNAi物质的组合物和使用方法
|
CN110770343A
(zh)
*
|
2017-02-10 |
2020-02-07 |
成均馆大学校产学协力团 |
用于rna干扰的长双链rna
|
WO2018152523A1
(en)
*
|
2017-02-20 |
2018-08-23 |
Northwestern University |
Use of trinucleotide repeat rnas to treat cancer
|
DE102017103383A1
(de)
|
2017-02-20 |
2018-08-23 |
aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) |
System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten
|
US20180271996A1
(en)
|
2017-02-28 |
2018-09-27 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
US11261441B2
(en)
|
2017-03-29 |
2022-03-01 |
Bluebird Bio, Inc. |
Vectors and compositions for treating hemoglobinopathies
|
CA3059304A1
(en)
|
2017-04-07 |
2018-10-11 |
Apellis Pharmaceuticals, Inc. |
Dosing regimens and related compositions and methods
|
ES2957464T3
(es)
|
2017-04-14 |
2024-01-19 |
Univ Arizona |
Composiciones y métodos para tratar fibrosis pulmonar
|
US11324820B2
(en)
|
2017-04-18 |
2022-05-10 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
|
US11433131B2
(en)
|
2017-05-11 |
2022-09-06 |
Northwestern University |
Adoptive cell therapy using spherical nucleic acids (SNAs)
|
WO2018218135A1
(en)
|
2017-05-25 |
2018-11-29 |
The Children's Medical Center Corporation |
Bcl11a guide delivery
|
JP7406793B2
(ja)
*
|
2017-06-23 |
2023-12-28 |
ユニバーシティー オブ マサチューセッツ |
2テイル自己デリバリー型siRNAおよび関連方法
|
BR112019023650A2
(pt)
|
2017-07-06 |
2020-06-02 |
Arrowhead Pharmaceuticals, Inc. |
Agentes rnai para inibir a expressão de alfa-enac e métodos de uso
|
JP7337044B2
(ja)
|
2017-07-13 |
2023-09-01 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Hao1(ヒドロキシ酸オキシダーゼ1(グリコール酸オキシダーゼ))遺伝子発現の阻害方法
|
US11104700B2
(en)
|
2017-07-17 |
2021-08-31 |
Oxford University Innovation Limited |
Oligonucleotides
|
US11110114B2
(en)
|
2017-07-17 |
2021-09-07 |
Oxford University Innovation Limited |
Dinucleotides
|
KR20200044013A
(ko)
|
2017-09-11 |
2020-04-28 |
애로우헤드 파마슈티컬스 인코포레이티드 |
아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물
|
KR20200089656A
(ko)
|
2017-09-19 |
2020-07-27 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
|
WO2019068326A1
(en)
|
2017-10-05 |
2019-04-11 |
Université D'aix-Marseille |
INHIBITORS OF LSD1 FOR THE TREATMENT AND PREVENTION OF CARDIOMYOPATHIES
|
MA50264B1
(fr)
|
2017-10-20 |
2023-03-31 |
Dicerna Pharmaceuticals Inc |
Méthodes de traitement des infections de type hépatite b
|
US10953036B2
(en)
|
2017-11-20 |
2021-03-23 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods of modulating HIF-2A to improve muscle generation and repair
|
US11638760B2
(en)
|
2017-11-27 |
2023-05-02 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
JP7297320B2
(ja)
*
|
2017-12-01 |
2023-06-26 |
ザ テキサス エイ・アンド・エム ユニヴァーシティ システム |
アンジェルマン症候群アンチセンス治療
|
KR102527941B1
(ko)
|
2017-12-06 |
2023-05-02 |
어비디티 바이오사이언시스 인크. |
근위축증 및 근긴장성 이영양증을 치료하는 조성물 및 방법
|
CN111757757A
(zh)
|
2017-12-21 |
2020-10-09 |
梅尔莎纳医疗公司 |
吡咯并苯并二氮呯抗体共轭物
|
US11597932B2
(en)
|
2017-12-21 |
2023-03-07 |
Alnylam Pharmaceuticals, Inc. |
Chirally-enriched double-stranded RNA agents
|
US10960086B2
(en)
|
2017-12-28 |
2021-03-30 |
Augusta University Research Institute, Inc. |
Aptamer compositions and methods of use thereof
|
JP2021508477A
(ja)
|
2017-12-29 |
2021-03-11 |
オンコラス, インコーポレイテッド |
治療用ポリペプチドの腫瘍溶解性ウイルス送達
|
EP3697423A4
(de)
|
2018-01-05 |
2021-08-11 |
Dicerna Pharmaceuticals, Inc. |
Verminderung der beta-catenin- und ido-expression zur potenzierung einer immuntherapie
|
US11661603B2
(en)
|
2018-01-16 |
2023-05-30 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting ALDH2 expression
|
PE20211197A1
(es)
|
2018-02-09 |
2021-07-01 |
Genentech Inc |
Oligonucleotidos para modular la expresion de tmem106b
|
WO2019215067A1
(en)
|
2018-05-07 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Massively parallel discovery methods for oligonucleotide therapeutics
|
WO2019215330A1
(en)
|
2018-05-10 |
2019-11-14 |
The University Of Manchester |
Methods for assessing macular degeneration
|
US11946046B2
(en)
*
|
2018-06-14 |
2024-04-02 |
University Of Utah Research Foundation |
Staufen1 regulating agents and associated methods
|
EA202190528A1
(ru)
|
2018-08-13 |
2021-04-23 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ АГЕНТОВ дцРНК ВИРУСА ГЕПАТИТА B (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
WO2020051231A1
(en)
|
2018-09-04 |
2020-03-12 |
H. Lee Moffitt Cancer Center & Research Institute Inc. |
Use of delta-tocotrienol for treating cancer
|
EP3847650A1
(de)
|
2018-09-06 |
2021-07-14 |
The Broad Institute, Inc. |
Nukleinsäureanordnungen zur gezielten verabreichung
|
CA3117050A1
(en)
|
2018-10-29 |
2020-05-07 |
Mersana Therapeutics, Inc. |
Cysteine engineered antibody-drug conjugates with peptide-containing linkers
|
AU2020221892A1
(en)
|
2019-02-12 |
2021-08-19 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for inhibiting expression of CYP27A1
|
JP2022527108A
(ja)
|
2019-03-29 |
2022-05-30 |
ディセルナ ファーマシューティカルズ インコーポレイテッド |
Kras関連疾患または障害の治療のための組成物及び方法
|
SG11202110896WA
(en)
|
2019-04-04 |
2021-10-28 |
Dicerna Pharmaceuticals Inc |
Compositions and methods for inhibiting gene expression in the central nervous system
|
US11814464B2
(en)
|
2019-04-29 |
2023-11-14 |
Yale University |
Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
|
CA3136676A1
(en)
|
2019-05-03 |
2020-11-12 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
US20200369759A1
(en)
|
2019-05-23 |
2020-11-26 |
Fibrogen, Inc. |
Methods of treatment of muscular dystrophies
|
WO2020261227A1
(en)
|
2019-06-26 |
2020-12-30 |
Biorchestra Co., Ltd. |
Micellar nanoparticles and uses thereof
|
JP2022546699A
(ja)
|
2019-08-30 |
2022-11-07 |
イェール ユニバーシティー |
核酸を細胞に送達するための組成物および方法
|
TW202123973A
(zh)
|
2019-09-10 |
2021-07-01 |
日商第一三共股份有限公司 |
用於肝臟遞送之GalNAc-寡核苷酸結合物及製造方法
|
KR20220069103A
(ko)
|
2019-10-02 |
2022-05-26 |
다이서나 파마수이티컬, 인크. |
최소 플루오린 함량을 갖는 작은 간섭 rna의 화학적 변형
|
US11355185B2
(en)
|
2019-11-26 |
2022-06-07 |
Cypress Semiconductor Corporation |
Silicon-oxide-nitride-oxide-silicon multi-level non-volatile memory device and methods of fabrication thereof
|
WO2021130270A1
(en)
|
2019-12-24 |
2021-07-01 |
F. Hoffmann-La Roche Ag |
Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
|
JP2023509870A
(ja)
|
2019-12-24 |
2023-03-10 |
エフ. ホフマン-ラ ロシュ アーゲー |
Hbvの処置のためのhbvを標的とする治療用オリゴヌクレオチドとtlr7アゴニストとの医薬組合せ
|
CN115315273A
(zh)
|
2020-01-14 |
2022-11-08 |
辛德凯因股份有限公司 |
Il-2直向同源物及其使用方法
|
US20210222128A1
(en)
|
2020-01-22 |
2021-07-22 |
Massachusetts Institute Of Technology |
Inducible tissue constructs and uses thereof
|
WO2021173965A1
(en)
|
2020-02-28 |
2021-09-02 |
Massachusetts Institute Of Technology |
Identification of variable influenza residues and uses thereof
|
CN116096889A
(zh)
|
2020-03-18 |
2023-05-09 |
迪克纳制药公司 |
用于抑制angptl3表达的组合物和方法
|
WO2021188390A1
(en)
|
2020-03-19 |
2021-09-23 |
Avidity Biosciences, Inc. |
Compositions and methods of treating facioscapulohumeral muscular dystrophy
|
AU2021241682A1
(en)
|
2020-03-27 |
2022-10-13 |
Avidity Biosciences, Inc. |
Compositions and methods of treating muscle dystrophy
|
IL297442A
(en)
|
2020-04-22 |
2022-12-01 |
Iovance Biotherapeutics Inc |
Systems and methods for coordinating production of cells for patient-specific immunotherapy
|
CA3183351A1
(en)
|
2020-06-19 |
2021-12-23 |
Yale University |
Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery
|
WO2021255262A1
(en)
|
2020-06-19 |
2021-12-23 |
Sylentis Sau |
siRNA AND COMPOSITIONS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VIRUS DISEASES
|
US20220031633A1
(en)
|
2020-07-28 |
2022-02-03 |
Yale University |
Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
|
IL300283A
(en)
|
2020-08-04 |
2023-04-01 |
Dicerna Pharmaceuticals Inc |
Systemic administration of oligonucleotides
|
TW202221120A
(zh)
|
2020-08-04 |
2022-06-01 |
美商黛瑟納製藥公司 |
用於治療代謝症候群之組成物及方法
|
TW202221121A
(zh)
|
2020-08-04 |
2022-06-01 |
美商黛瑟納製藥公司 |
抑制plp1表現之組成物及方法
|
MX2023001443A
(es)
|
2020-08-05 |
2023-04-14 |
Hoffmann La Roche |
Tratamiento con oligonucleotidos de pacientes con hepatitis b.
|
KR20230043912A
(ko)
|
2020-08-05 |
2023-03-31 |
다이서나 파마수이티컬, 인크. |
Lpa 발현을 저해하기 위한 조성물 및 방법
|
MX2023002480A
(es)
|
2020-08-31 |
2023-05-18 |
Univ Yale |
"composiciones y métodos para el suministro de ácidos nucleicos a las células.
|
EP3964204A1
(de)
|
2020-09-08 |
2022-03-09 |
Université d'Aix-Marseille |
Verbindungen zur verwendung bei der behandlung und vorbeugung von gewebefibrose
|
EP4214515A1
(de)
|
2020-09-16 |
2023-07-26 |
Complement Therapeutics Limited |
Komplementom-assay
|
EP4251170A1
(de)
|
2020-11-25 |
2023-10-04 |
Akagera Medicines, Inc. |
Lipidnanopartikel zur abgabe von nukleinsäuren und zugehörige verfahren zur verwendung
|
CN117295753A
(zh)
|
2020-12-04 |
2023-12-26 |
基那奥生物公司 |
用于将核酸递送到细胞的组合物和方法
|
EP4015634A1
(de)
|
2020-12-15 |
2022-06-22 |
Sylentis, S.A.U. |
Sirna und zusammensetzungen zur prophylaktischen und therapeutischen behandlung von viruskrankheiten
|
WO2022187435A1
(en)
|
2021-03-04 |
2022-09-09 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
CN117202894A
(zh)
|
2021-03-31 |
2023-12-08 |
胭脂红治疗私人有限公司 |
负载至少两个不同核酸的细胞外囊泡
|
AU2022256742A1
(en)
|
2021-04-12 |
2023-09-07 |
Boehringer Ingelheim International Gmbh |
Compositions and methods for inhibiting ketohexokinase (khk)
|
AU2022258459A1
(en)
|
2021-04-14 |
2023-09-14 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for modulating pnpla3 expression
|
JP2023554579A
(ja)
|
2021-04-19 |
2023-12-28 |
ノヴォ ノルディスク アー/エス |
核内受容体サブファミリー1グループhメンバー3(nr1h3)発現を阻害するための組成物および方法
|
AU2022282579A1
(en)
|
2021-05-28 |
2023-11-02 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (marc1) expression
|
CA3221935A1
(en)
|
2021-05-29 |
2022-12-08 |
1Globe Health Institute Llc |
Asymmetric short duplex dna as a novel gene silencing technology and use thereof
|
KR20240014533A
(ko)
|
2021-05-29 |
2024-02-01 |
1글로브 헬스 인스티튜트 엘엘씨 |
신규한 유전자 침묵 기술로서의 짧은 듀플렉스 dna 및 이의 용도
|
AU2022299169A1
(en)
|
2021-06-23 |
2024-02-08 |
Beth Israel Deaconess Medical Center, Inc. |
Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
|
WO2023021046A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
AR124636A1
(es)
|
2021-08-25 |
2023-04-19 |
Dicerna Pharmaceuticals Inc |
COMPOSICIONES Y MÉTODOS PARA INHIBIR LA EXPRESIÓN DE a-1 ANTITRIPSINA
|
CA3232054A1
(en)
|
2021-09-21 |
2023-03-30 |
Kannan Rangaramanujam |
Dendrimer conjugates of small molecule biologics for intracellular delivery
|
WO2023083906A2
(en)
|
2021-11-11 |
2023-05-19 |
F. Hoffmann-La Roche Ag |
Pharmaceutical combinations for treatment of hbv
|
WO2023092089A1
(en)
|
2021-11-19 |
2023-05-25 |
Kist (Korea Institute Of Science And Technology) |
Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell
|
TW202330920A
(zh)
|
2021-12-01 |
2023-08-01 |
美商戴瑟納製藥股份有限公司 |
用於調節apoc3表現之組合物及方法
|
WO2023118546A2
(en)
|
2021-12-23 |
2023-06-29 |
Boehringer Ingelheim International Gmbh |
METHODS AND MOLECULES FOR RNA INTERFERENCE (RNAi)
|
WO2023159189A1
(en)
|
2022-02-18 |
2023-08-24 |
Yale University |
Branched poly(amine-co-ester) polymers for more efficient nucleic expression
|
GB202203627D0
(en)
|
2022-03-16 |
2022-04-27 |
Univ Manchester |
Agents for treating complement-related disorders
|
US20230302423A1
(en)
|
2022-03-28 |
2023-09-28 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
GB202204884D0
(en)
|
2022-04-04 |
2022-05-18 |
Fondo Ricerca Medica S R I |
Sirna targeting kcna1
|
TW202345873A
(zh)
|
2022-04-15 |
2023-12-01 |
美商戴瑟納製藥股份有限公司 |
調節scap活性之組合物及方法
|
US20230416742A1
(en)
|
2022-05-12 |
2023-12-28 |
Dicerna Phrmaceuticals, Inc. |
Compositions and methods for inhibiting mapt expression
|
US20230416743A1
(en)
|
2022-05-13 |
2023-12-28 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting snca expression
|
TW202400193A
(zh)
|
2022-06-24 |
2024-01-01 |
丹麥商諾佛 儂迪克股份有限公司 |
抑制跨膜絲胺酸蛋白酶6(tmprss6)表現的組成物及方法
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|