DE60118527D1 - Sensible und multiplexe diagnostische tests zur proteinanalyse - Google Patents
Sensible und multiplexe diagnostische tests zur proteinanalyseInfo
- Publication number
- DE60118527D1 DE60118527D1 DE60118527T DE60118527T DE60118527D1 DE 60118527 D1 DE60118527 D1 DE 60118527D1 DE 60118527 T DE60118527 T DE 60118527T DE 60118527 T DE60118527 T DE 60118527T DE 60118527 D1 DE60118527 D1 DE 60118527D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- protein
- binding reagents
- sample
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17787300P | 2000-01-24 | 2000-01-24 | |
| PCT/US2001/000291 WO2001053539A1 (en) | 2000-01-24 | 2001-01-04 | Sensitive, multiplexed diagnostic assays for protein analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60118527D1 true DE60118527D1 (de) | 2006-05-18 |
Family
ID=22650272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60118527T Expired - Lifetime DE60118527D1 (de) | 2000-01-24 | 2001-01-04 | Sensible und multiplexe diagnostische tests zur proteinanalyse |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6489116B2 (de) |
| EP (1) | EP1250463B1 (de) |
| JP (1) | JP2003520050A (de) |
| AT (1) | ATE322558T1 (de) |
| AU (1) | AU783689B2 (de) |
| CA (1) | CA2396810A1 (de) |
| DE (1) | DE60118527D1 (de) |
| WO (1) | WO2001053539A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004532981A (ja) * | 2001-04-10 | 2004-10-28 | チルドレンズ メディカル センター コーポレーション | タンパク質−タンパク質相互作用の解析および標識の方法 |
| WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| EP1419274A4 (de) * | 2001-07-31 | 2006-02-08 | Phylos Inc | Modulare konstruktion von nukleinsäure-protein-fusionsmultimeren |
| DE10145226A1 (de) * | 2001-09-13 | 2003-04-10 | Lifebits Ag | Herstellung von trägergebundenen Molekülen |
| US7045311B2 (en) * | 2001-10-25 | 2006-05-16 | Monogram Biosciences, Inc. | Whole cell assay systems for cell surface proteases |
| AU2002365404A1 (en) * | 2001-11-27 | 2003-06-10 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| WO2003061570A2 (en) * | 2002-01-16 | 2003-07-31 | Zyomyx, Inc. | Engineered binding proteins |
| US20030166010A1 (en) * | 2002-02-25 | 2003-09-04 | Affholter Joseph A. | Custom ligand design for biomolecular filtration and purification for bioseperation |
| DE60324778D1 (de) | 2002-03-15 | 2009-01-02 | Nuevolution As | Eine verbesserte methode zur synthese von matritzenabhängigen molekülen |
| US20030198973A1 (en) * | 2002-04-23 | 2003-10-23 | The Molecular Sciences Institute, Inc. | Chimeric fusion molecule for analyte detection and quantitation |
| US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| US10730906B2 (en) | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
| ATE513055T1 (de) | 2002-10-30 | 2011-07-15 | Nuevolution As | Enzymatisches codieren |
| US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
| JP5117719B2 (ja) * | 2003-04-18 | 2013-01-16 | ベクトン・ディキンソン・アンド・カンパニー | 免疫増幅 |
| EP1625232B1 (de) * | 2003-05-16 | 2013-09-04 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nukleinsäuremolekül als interne kontrolle für nukleinsäureamplifikationssysteme |
| EP2711025A3 (de) * | 2003-06-25 | 2014-09-10 | Massachusetts Institute of Technology | Selbstangeordnete Peptide mit Modifikationen und Verwendungsverfahren dafür |
| US7713923B2 (en) | 2003-06-25 | 2010-05-11 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| EP1670939B1 (de) * | 2003-09-18 | 2009-11-04 | Nuevolution A/S | Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen |
| EP1681983A4 (de) * | 2003-10-14 | 2008-12-10 | Monogram Biosciences Inc | Rezeptor-tyrosin-kinase-signalpfad-analyse für diagnose und therapie |
| US7785843B2 (en) * | 2004-06-23 | 2010-08-31 | Sequenom, Inc. | Target-specific compomers and methods of use |
| US20060110724A1 (en) | 2004-11-19 | 2006-05-25 | Burkhardt William Iii | Quantitative real-time assay for noroviruses and enteroviruses with built in quality control standard |
| US20060204999A1 (en) * | 2005-03-14 | 2006-09-14 | Stephen Macevicz | Detecting molecular complexes |
| ES2427565T3 (es) * | 2005-04-25 | 2013-10-31 | Massachusetts Institute Of Technology | Péptidos autoensambladores para promover la hemostasia |
| US20090018029A1 (en) | 2005-11-16 | 2009-01-15 | Ambrx, Inc. | Methods and Compositions Comprising Non-Natural Amino Acids |
| ES2901551T3 (es) | 2005-12-01 | 2022-03-22 | Nuevolution As | Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes |
| EP2012842B1 (de) | 2006-04-25 | 2018-04-04 | Massachusetts Institute of Technology | Zusammensetzungen und verfahren zur beeinflussung der bewegung von kontaminantien, körperflüssigkeiten und anderen entitäten und/oder anderer physiologischer merkmale |
| WO2008039483A2 (en) * | 2006-09-26 | 2008-04-03 | Massachusetts Institute Of Technology | Modified self-assembling peptides |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| WO2009073569A2 (en) | 2007-11-30 | 2009-06-11 | Abbott Laboratories | Protein formulations and methods of making same |
| EP3629022A1 (de) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Proteinscreeningverfahren |
| WO2011072482A1 (en) | 2009-12-14 | 2011-06-23 | The University Of Hong Kong | Nano cancer barrier device(ncbd) to immobilize and inhibit the division of metastic cancer stem cells |
| WO2011127933A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
| CA3078215A1 (en) | 2011-04-28 | 2012-11-01 | Department Of Veterans Affairs | Identification of polynucleotides associated with a sample |
| JP6483442B2 (ja) | 2011-12-05 | 2019-03-13 | エックス−ボディ インコーポレイテッド | Ｐｄｇｆ受容体ベータ結合ポリペプチド |
| GB2504240B (en) | 2012-02-27 | 2015-05-27 | Cellular Res Inc | Compositions and kits for molecular counting of nucleic acids |
| ES2920601T3 (es) | 2013-06-28 | 2022-08-05 | X Body Inc | Descubrimiento de antígenos objetivo, cribados fenotípicos y uso de los mismos para la identificación de epítopos objetivo específicos de células objetivo |
| KR102536833B1 (ko) | 2013-08-28 | 2023-05-26 | 벡톤 디킨슨 앤드 컴퍼니 | 대량의 동시 단일 세포 분석 |
| CA2924879C (en) | 2013-09-23 | 2023-01-10 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
| SG10202005892SA (en) * | 2014-06-06 | 2020-07-29 | Herlev Hospital | Determining antigen recognition through barcoding of mhc multimers |
| WO2015188839A2 (en) | 2014-06-13 | 2015-12-17 | Immudex Aps | General detection and isolation of specific cells by binding of labeled molecules |
| EP3262192B1 (de) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Räumlich adressierbare molekulare barcodierung |
| EP4180535A1 (de) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Verfahren und zusammensetzungen für kombinatorische barcodierung |
| EP3286326A1 (de) | 2015-04-23 | 2018-02-28 | Cellular Research, Inc. | Verfahren und zusammensetzungen zur gesamttranskriptomamplifikation |
| US10619186B2 (en) | 2015-09-11 | 2020-04-14 | Cellular Research, Inc. | Methods and compositions for library normalization |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| SG11201901733PA (en) | 2016-09-26 | 2019-04-29 | Cellular Res Inc | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
| AU2018281745B2 (en) | 2017-06-05 | 2022-05-19 | Becton, Dickinson And Company | Sample indexing for single cells |
| WO2019213237A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
| JP7407128B2 (ja) | 2018-05-03 | 2023-12-28 | ベクトン・ディキンソン・アンド・カンパニー | ハイスループットマルチオミクスサンプル解析 |
| CN112805389A (zh) | 2018-10-01 | 2021-05-14 | 贝克顿迪金森公司 | 确定5’转录物序列 |
| JP2022506546A (ja) | 2018-11-08 | 2022-01-17 | ベクトン・ディキンソン・アンド・カンパニー | ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析 |
| EP3894552A1 (de) | 2018-12-13 | 2021-10-20 | Becton, Dickinson and Company | Selektive verlängerung in der vollständigen transkriptomanalyse von einzelzellen |
| ES2945227T3 (es) | 2019-01-23 | 2023-06-29 | Becton Dickinson Co | Oligonucleótidos asociados con anticuerpos |
| US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| US11773436B2 (en) | 2019-11-08 | 2023-10-03 | Becton, Dickinson And Company | Using random priming to obtain full-length V(D)J information for immune repertoire sequencing |
| CN115244184A (zh) | 2020-01-13 | 2022-10-25 | 贝克顿迪金森公司 | 用于定量蛋白和rna的方法和组合物 |
| WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| EP4247967A1 (de) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profilierung von stark exprimierten und schwach exprimierten proteinen |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587044A (en) | 1983-09-01 | 1986-05-06 | The Johns Hopkins University | Linkage of proteins to nucleic acids |
| DE3546807C2 (de) | 1985-03-30 | 1991-03-28 | Marc Genf/Geneve Ch Ballivet | |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| ATE168416T1 (de) | 1989-10-05 | 1998-08-15 | Optein Inc | Zellfreie synthese und isolierung von genen und polypeptiden |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| WO1992002536A1 (en) | 1990-08-02 | 1992-02-20 | The Regents Of The University Of Colorado | Systematic polypeptide evolution by reverse translation |
| US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
| DE4112440C1 (de) | 1991-04-16 | 1992-10-22 | Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De | |
| US5795747A (en) | 1991-04-16 | 1998-08-18 | Evotec Biosystems Gmbh | Process for manufacturing new biopolymers |
| AU2313392A (en) | 1991-08-01 | 1993-03-02 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US6087186A (en) | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
| WO1995011922A1 (en) | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| PT1231268E (pt) | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
| US5561043A (en) | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| JPH10500951A (ja) | 1994-05-23 | 1998-01-27 | スミスクライン・ビーチャム・コーポレイション | コードされた組合せライブラリー |
| US5627024A (en) | 1994-08-05 | 1997-05-06 | The Scripps Research Institute | Lambdoid bacteriophage vectors for expression and display of foreign proteins |
| US5559000A (en) | 1995-01-18 | 1996-09-24 | The Scripps Research Institute | Encoded reaction cassette |
| US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
| DE19646372C1 (de) | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
| WO1998016636A1 (fr) | 1996-10-17 | 1998-04-23 | Mitsubishi Chemical Corporation | Molecule permettant d'homologuer un genotype et un phenotype, et utilisation de celle-ci |
| AU738328B2 (en) | 1997-01-21 | 2001-09-13 | General Hospital Corporation, The | Selection of proteins using RNA-protein fusions |
| US6261804B1 (en) * | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| GB9703369D0 (en) * | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| GB9712512D0 (en) | 1997-06-16 | 1997-08-20 | Bioinvent Int Ab | A method for in vitro molecular evolution of protein function |
| US6537749B2 (en) * | 1998-04-03 | 2003-03-25 | Phylos, Inc. | Addressable protein arrays |
| US5985575A (en) | 1998-05-20 | 1999-11-16 | Wisconsin Alumni Research Foundation | Tethered function assay for protein function |
| DE69941193D1 (de) | 1998-08-17 | 2009-09-10 | Bristol Myers Squibb Co | Identifizierung von verbindung-protein wechselwirkungen mit bibliotheken von gekoppelten protein-nukleinsäure-molekülen |
| JP4808315B2 (ja) * | 1998-12-02 | 2011-11-02 | ブリストル−マイヤーズ スクウィブ カンパニー | Ｄｎａ・蛋白質融合体とその利用 |
| DE69941267D1 (de) | 1998-12-10 | 2009-09-24 | Bristol Myers Squibb Co | Proteingerüste für antikörper-nachahmer und andere bindende proteine |
-
2001
- 2001-01-04 DE DE60118527T patent/DE60118527D1/de not_active Expired - Lifetime
- 2001-01-04 JP JP2001553398A patent/JP2003520050A/ja active Pending
- 2001-01-04 CA CA002396810A patent/CA2396810A1/en not_active Abandoned
- 2001-01-04 WO PCT/US2001/000291 patent/WO2001053539A1/en active IP Right Grant
- 2001-01-04 EP EP01942678A patent/EP1250463B1/de not_active Expired - Lifetime
- 2001-01-04 AT AT01942678T patent/ATE322558T1/de not_active IP Right Cessation
- 2001-01-04 US US09/755,663 patent/US6489116B2/en not_active Expired - Lifetime
- 2001-01-04 AU AU29279/01A patent/AU783689B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001053539A1 (en) | 2001-07-26 |
| CA2396810A1 (en) | 2001-07-26 |
| EP1250463A1 (de) | 2002-10-23 |
| US20010024784A1 (en) | 2001-09-27 |
| ATE322558T1 (de) | 2006-04-15 |
| JP2003520050A (ja) | 2003-07-02 |
| AU783689B2 (en) | 2005-11-24 |
| US6489116B2 (en) | 2002-12-03 |
| AU2927901A (en) | 2001-07-31 |
| EP1250463B1 (de) | 2006-04-05 |
| EP1250463A4 (de) | 2004-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60118527D1 (de) | Sensible und multiplexe diagnostische tests zur proteinanalyse | |
| DE69941085D1 (de) | Manipulierte proteine zum analyten nachweis | |
| CY1109246T1 (el) | Μεθοδος ανιχνευσης συνδετη | |
| SE0000538D0 (sv) | Methods and kits for proximity probing | |
| DE60041355D1 (de) | Verfahren zur detektion von erkrankungen | |
| EE200100340A (et) | Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks | |
| DE69700902D1 (de) | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit | |
| DE69941193D1 (de) | Identifizierung von verbindung-protein wechselwirkungen mit bibliotheken von gekoppelten protein-nukleinsäure-molekülen | |
| ATE317122T1 (de) | Fluoreszierende polarisation | |
| BRPI0610092B8 (pt) | métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado | |
| DE69732662D1 (de) | Verwendung von antikörpern gegen embryonales hämoglobin zur identifizierung von fötalen zellen | |
| DK0943097T3 (da) | Fremgangsmåde til at påvise IgE | |
| CY1106724T1 (el) | Εμβαπτιζομενος χαρτης αποξηραμενων αντιδραστηριων και μεθοδος για την ανιχνευση ή και προσδιορισμο ειδικων αλληλουχιων νουκλεϊκων οξεων | |
| TR199901569T2 (xx) | T�berk�lozun te�hisi i�in bile�ikler ve y�ntemler. | |
| DE69939121D1 (de) | Verfahren und materialien zum nachweis und zur messung von durch freie radikale verursachten schäden | |
| DK1639130T3 (da) | Prober, biblioteker og kits til analyse af blandinger af nukleinsyrer og metoder til opbygning af disse | |
| DE50109723D1 (de) | Nachweis und identifikation von bakteriengruppen | |
| SE0001670D0 (sv) | Mass-spectrometry-based biosensor | |
| DE69924147D1 (de) | Floureszenzintensitäts-test für eine protein- oder peptidbindung an nukleinsäuren | |
| ATE290692T1 (de) | Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen | |
| CA2499355A1 (en) | Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture | |
| DE60121547D1 (de) | Electrochemisches verfahren zum nachweis von nukleinsäuren | |
| CN112080550A (zh) | 一种检测基质金属蛋白酶的生物传感器及应用 | |
| ATE386270T1 (de) | Verfahren um molekül-molekül interaktionen in proteomanalyse festzustellen | |
| DE50113417D1 (de) | Zellbindende nukleinsäuremoleküle (aptamere) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |