DE60113287D1 - Systeme und verfahren zur zellteilbevölkerungsanalyse - Google Patents

Systeme und verfahren zur zellteilbevölkerungsanalyse

Info

Publication number
DE60113287D1
DE60113287D1 DE60113287T DE60113287T DE60113287D1 DE 60113287 D1 DE60113287 D1 DE 60113287D1 DE 60113287 T DE60113287 T DE 60113287T DE 60113287 T DE60113287 T DE 60113287T DE 60113287 D1 DE60113287 D1 DE 60113287D1
Authority
DE
Germany
Prior art keywords
cells
separator
dielectrophoretic
systems
force
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113287T
Other languages
English (en)
Inventor
R Gascoyne
F Becker
Jody Vykoukal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE60113287D1 publication Critical patent/DE60113287D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/028—Non-uniform field separators using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44786—Apparatus specially adapted therefor of the magneto-electrophoresis type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005—Field flow fractionation
    • G01N15/1023—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G01N2015/1028—
DE60113287T 2000-06-14 2001-06-14 Systeme und verfahren zur zellteilbevölkerungsanalyse Expired - Lifetime DE60113287D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21151400P 2000-06-14 2000-06-14
PCT/US2001/019479 WO2001096025A2 (en) 2000-06-14 2001-06-14 Systems and methods for cell subpopulation analysis

Publications (1)

Publication Number Publication Date
DE60113287D1 true DE60113287D1 (de) 2005-10-13

Family

ID=22787235

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60113287T Expired - Lifetime DE60113287D1 (de) 2000-06-14 2001-06-14 Systeme und verfahren zur zellteilbevölkerungsanalyse

Country Status (8)

Country Link
US (1) US6790330B2 (de)
EP (1) EP1328803B1 (de)
JP (1) JP2004532968A (de)
AT (1) ATE304174T1 (de)
AU (1) AU2001269896A1 (de)
CA (1) CA2413194A1 (de)
DE (1) DE60113287D1 (de)
WO (1) WO2001096025A2 (de)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
CA2413634A1 (en) * 2000-06-14 2001-12-20 Peter R. C. Gascoyne Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) * 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) * 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
EP1463796B1 (de) * 2001-11-30 2013-01-09 Fluidigm Corporation Mikrofluidische vorrichtung und verfahren zu ihrer verwendung
US20030209438A1 (en) * 2002-05-09 2003-11-13 Vincent Bressler Particle characterization using gravity in opposition to an induced force
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
EP1583956A4 (de) * 2002-12-20 2009-07-15 Univ Texas Verfahren und vorrichtung für elektroabstrichanalyse
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
DE10320870A1 (de) * 2003-05-09 2004-12-09 Evotec Technologies Gmbh Partikelinjektor für einen Zellsortierer
US7169282B2 (en) * 2003-05-13 2007-01-30 Aura Biosystems Inc. Dielectrophoresis apparatus
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
ES2239886B1 (es) * 2003-11-05 2006-12-16 Universidad De Barcelona Metodo y aparato para la determinacion de la viabilidad celular.
AU2005241080B2 (en) 2004-05-03 2011-08-11 Handylab, Inc. Processing polynucleotide-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8974652B2 (en) * 2004-05-28 2015-03-10 Board Of Regents, The University Of Texas System Programmable fluidic processors
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
US20060091015A1 (en) * 2004-11-01 2006-05-04 Applera Corporation Surface modification for non-specific adsorption of biological material
US20060177815A1 (en) * 2004-11-29 2006-08-10 The Regents Of The University Of California Dielectrophoretic particle sorter
WO2006063625A1 (en) * 2004-12-17 2006-06-22 Agilent Technologies, Inc. Fractionation using electro elution
EP1859330B1 (de) 2005-01-28 2012-07-04 Duke University Vorrichtungen und verfahren zur manipulation von tropfen auf einer leiterplatte
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1764418B1 (de) * 2005-09-14 2012-08-22 STMicroelectronics Srl Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese
US8721161B2 (en) 2005-09-15 2014-05-13 Alcatel Lucent Fluid oscillations on structured surfaces
US20070059213A1 (en) * 2005-09-15 2007-03-15 Lucent Technologies Inc. Heat-induced transitions on a structured surface
US8734003B2 (en) * 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US20070095666A1 (en) * 2005-10-27 2007-05-03 Applera Corporation Surface Modification in a Manipulation Chamber
US20070095667A1 (en) * 2005-10-27 2007-05-03 Applera Corporation Optoelectronic Separation of Biomolecules
KR101157175B1 (ko) * 2005-12-14 2012-07-03 삼성전자주식회사 세포 또는 바이러스의 농축 및 용해용 미세유동장치 및방법
WO2007091450A1 (ja) * 2006-02-10 2007-08-16 Kochi University Of Technology 粒子状物質の角度変調波による誘電泳動を利用した特性分析装置並びに方法
JP5415253B2 (ja) 2006-03-24 2014-02-12 ハンディラブ・インコーポレーテッド 微小流体サンプルを処理するための一体化システム及びその使用方法
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
WO2007115815A1 (en) * 2006-04-07 2007-10-18 Pauwels, Rudi Method and apparatus for labelling, reading and sorting of microcarriers
JPWO2007129383A1 (ja) * 2006-05-01 2009-09-17 株式会社島津製作所 全有機体炭素測定装置
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8656949B2 (en) 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
ATE472372T1 (de) * 2006-10-26 2010-07-15 Imec Handhabung von magnetischen oder magnetisierbaren objekten unter verwendung von kombinierter magnetophorese und dielektrophorese
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US8702945B2 (en) * 2007-05-18 2014-04-22 University Of Washington Time-varying flows for microfluidic particle separation
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
EP2042239A1 (de) * 2007-09-10 2009-04-01 Koninklijke Philips Electronics N.V. Dielektrophoretische Vorrichtung und entsprechendes Verfahren für Zellmembran-Studien
AU2008318813A1 (en) * 2007-10-29 2009-05-07 Purdue Research Foundation Hybrid microfluidic SPR and molecular imaging device
US20090137925A1 (en) * 2007-11-23 2009-05-28 Divya Cantor Impedance Spectroscopy Cervix Scanning Apparatus and Method
CN102037351A (zh) * 2008-04-03 2011-04-27 加利福尼亚大学董事会 分离并离析细胞、囊泡、纳米颗粒和生物标记的离体多维系统
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
CN102197308A (zh) * 2008-10-31 2011-09-21 皇家飞利浦电子股份有限公司 具有多腔室筒体的生物传感器
US8162149B1 (en) 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
KR101273453B1 (ko) * 2010-05-20 2013-06-11 고려대학교 산학협력단 효소가 집적된 미세튜브를 이용한 정량분석법
US8163182B2 (en) 2010-05-28 2012-04-24 Wyatt Technology Corporation Compartmentalized field flow fractionation
WO2012075009A1 (en) * 2010-11-29 2012-06-07 President And Fellows Of Harvard College Quality control of diamagnetic materials using magnetic levitation
US8459464B2 (en) * 2011-03-18 2013-06-11 Fred C. Senftleber Apparatus and method for sedimentation field-flow fractionation
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
DE102011050254A1 (de) * 2011-05-10 2012-11-15 Technische Universität Dortmund Verfahren zur Separation polarisierbarer Biopartikel
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
EP2739587B1 (de) 2011-08-01 2020-05-27 Denovo Sciences Zellerfassungssystem
KR102121853B1 (ko) 2011-09-30 2020-06-12 벡톤 디킨슨 앤드 컴퍼니 일체화된 시약 스트립
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US11198126B2 (en) 2011-10-31 2021-12-14 Fluid-Screen, Inc. Apparatus for pathogen detection
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
US8932815B2 (en) 2012-04-16 2015-01-13 Biological Dynamics, Inc. Nucleic acid sample preparation
WO2013158686A1 (en) 2012-04-16 2013-10-24 Biological Dynamics, Inc. Nucleic acid sample preparation
IN2014DN11074A (de) 2012-06-25 2015-09-25 Gen Hospital Corp
EP2906953B1 (de) * 2012-10-12 2017-12-06 HI-STEM gGmbH Im Deutschen Krebsforschungszentrum DKFZ Neuartige biomarker zur subtypisierung von duktalem pankreasadenokarzinom
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
WO2014123949A1 (en) 2013-02-05 2014-08-14 Ohio State Innovation Foundation A non-contact method for accelerating wound healing
US9885031B2 (en) 2013-02-05 2018-02-06 Ohio State Innovation Foundation Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
WO2014123947A1 (en) * 2013-02-05 2014-08-14 Ohio State Innovation Foundation A galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
EP2781906B1 (de) 2013-03-19 2021-08-18 IMEC vzw Verfahren zur Identifizierung Zellen
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US9511368B2 (en) * 2013-08-29 2016-12-06 The Industry & Academic Cooperation In Chungnam National University (Iac) Transporting, trapping and escaping manipulation device for magnetic bead biomaterial comprising micro-magnetophoretic circuit
JP2017512483A (ja) 2014-04-08 2017-05-25 バイオロジカル ダイナミクス，インク． 生体物質の単離のための改良された装置
US9744533B2 (en) * 2014-12-10 2017-08-29 Berkeley Lights, Inc. Movement and selection of micro-objects in a microfluidic apparatus
DE102015202667A1 (de) * 2015-02-13 2016-08-18 Postnova Analytics Gmbh Vorrichtung für die Feldflussfraktionierung
EP3402814B1 (de) * 2016-01-15 2021-04-21 Berkeley Lights, Inc. Verfahren zur herstellung patientenspezifischer antikrebstherapeutika und behandlungsverfahren dafür
JP6441838B2 (ja) * 2016-01-29 2018-12-19 株式会社Ａｆｉテクノロジー 解析装置及び分離装置
JP6273467B2 (ja) * 2016-02-08 2018-02-07 パナソニックＩｐマネジメント株式会社 誘電泳動による被検物質の検出
AU2017237187B2 (en) 2016-03-24 2022-12-08 Biological Dynamics, Inc. Disposable fluidic cartridge and components
US11040345B2 (en) 2016-03-30 2021-06-22 Sharp Life Science (Eu) Limited Microfluidic device
CA3020841A1 (en) * 2016-04-15 2017-10-19 Fluid-Screen, Inc. Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
US11874268B2 (en) * 2016-06-12 2024-01-16 Nanohesgarsazan Salamat Arya Ncubation Center For Equipment And Devices Method and system for metastasis diagnosis and prognosis
WO2018187610A1 (en) 2017-04-05 2018-10-11 The Regents Of The University Of California A device for continuous focusing and rotation of biological cells and its use for high throughput electrorotation flow cytometry
US10818379B2 (en) 2017-05-08 2020-10-27 Biological Dynamics, Inc. Methods and systems for analyte information processing
AU2018323449B2 (en) 2017-08-29 2020-09-03 Bio-Rad Laboratories, Inc. System and method for isolating and analyzing cells
EP3727693A4 (de) 2017-12-19 2021-08-25 Biological Dynamics, Inc. Verfahren und vorrichtungen zum nachweis mehrerer analyten aus einer biologischen probe
MX2020009199A (es) 2018-03-30 2021-01-20 Idexx Lab Inc Control de calidad para sistemas de diagnostico de punto de atencion.
WO2019195196A1 (en) 2018-04-02 2019-10-10 Biological Dynamics, Inc. Dielectric materials
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
JP7413408B2 (ja) 2019-05-07 2024-01-15 バイオ－ラッド ラボラトリーズ インコーポレイテッド 自動化された単一細胞処理のためのシステムおよび方法
AU2020290981B2 (en) 2019-06-14 2024-03-07 Bio-Rad Laboratories, Inc. System and method for automated single cell processing and analyses
US20200408726A1 (en) * 2019-06-25 2020-12-31 Wyatt Technology Corporation Sealing a field flow fractionator
JP7215366B2 (ja) * 2019-07-17 2023-01-31 株式会社島津製作所 非対称流流動場分画装置
WO2021067650A1 (en) * 2019-10-02 2021-04-08 The Regents Of The University Of California Timed release analysis of cells incubated in microenvironment nodes
WO2021097035A1 (en) 2019-11-13 2021-05-20 Fluid-Screen, Inc. An apparatus and methods to rapidly detect, separate, purify, and quantify various viruses from cells, cultured medium and other fluids
CA3161454A1 (en) 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
DE102020202274A1 (de) 2020-02-21 2021-08-26 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidikkanalelement zur verbesserten Separation von Zielpartikeln aus Nicht-Zielpartikeln innerhalb eines Mediums auf der Basis von Dielektrophorese
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
EP4089394A1 (de) * 2021-05-11 2022-11-16 Ceidos SA Zellkulturüberwachungssystem

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001102A (en) * 1973-04-06 1977-01-04 The Carborundum Company Process for generating periodic non-uniform electric field, and for removing polarizable particulate material from fluid, using ferroelectric apparatus
SU474723A1 (ru) 1973-06-04 1975-06-25 Институт биологической физики АН СССР Устройство разделени дисперсных частиц
US4214981A (en) * 1978-10-23 1980-07-29 University Of Utah Steric field-flow fractionation
US4326934A (en) * 1979-12-31 1982-04-27 Pohl Herbert A Continuous dielectrophoretic cell classification method
US4440638A (en) * 1982-02-16 1984-04-03 U.T. Board Of Regents Surface field-effect device for manipulation of charged species
JP2720161B2 (ja) 1988-02-01 1998-02-25 株式会社アドバンス 細胞変形能測定装置
US4966918A (en) 1989-01-27 1990-10-30 Sloan-Kettering Institute For Cancer Research Derivatives of chryosphanol
US5344535A (en) * 1989-11-27 1994-09-06 British Technology Group Limited Dielectrophoretic characterization of micro-organisms and other particles
GB9002092D0 (en) 1990-01-30 1990-03-28 P & B Sciences Ltd Manipulation of solid,semi-solid or liquid materials
DE4127405C2 (de) * 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
JP3097932B2 (ja) 1991-11-05 2000-10-10 株式会社アドバンス 静電クロマトグラフィー装置
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
CA2129729C (en) 1992-02-08 2008-10-07 Adrian Parton Electrorotation
GB9208357D0 (en) 1992-04-16 1992-06-03 British Tech Group Apparatus for separating a mixture
JP3282679B2 (ja) 1992-07-01 2002-05-20 株式会社アドバンス Ｄｎａ塩基配列決定の方法
US5489506A (en) * 1992-10-26 1996-02-06 Biolife Systems, Inc. Dielectrophoretic cell stream sorter
GB9301122D0 (en) 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
GB9306729D0 (en) 1993-03-31 1993-05-26 British Tech Group Improvements in separators
US6129828A (en) * 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6099803A (en) * 1994-07-07 2000-08-08 Nanogen, Inc. Advanced active electronic devices for molecular biological analysis and diagnostics
US6225059B1 (en) * 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US5436243A (en) 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
DE4400955C2 (de) * 1993-12-23 1999-04-01 Fraunhofer Ges Forschung Adhäsionssteuerbare Oberflächenstruktur
US5788833A (en) * 1995-03-27 1998-08-04 California Institute Of Technology Sensors for detecting analytes in fluids
US5571401A (en) * 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
GB9507125D0 (en) 1995-04-06 1995-05-31 Scient Generics Ltd Travelling wave electrodes
DE19515524C2 (de) * 1995-04-27 1999-09-09 Private Uni Witten Herdecke Gm Verfahren und Vorrichtung zum fortlaufenden Nachweis wenigstens einer Substanz in einem gasförmigen oder flüssigen Gemisch mittels einer Sensorelektrode
US5993630A (en) * 1996-01-31 1999-11-30 Board Of Regents The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
US5888370A (en) * 1996-02-23 1999-03-30 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation
US5683569A (en) * 1996-02-28 1997-11-04 Motorola, Inc. Method of sensing a chemical and sensor therefor
NZ331865A (en) 1996-03-18 1999-04-29 Univ Wales Bangor Change Of Na Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions
US5858192A (en) * 1996-10-18 1999-01-12 Board Of Regents, The University Of Texas System Method and apparatus for manipulation using spiral electrodes
JP2002516742A (ja) * 1998-05-29 2002-06-11 インダストリアル リサーチ リミテッド 粒子または細胞の集中および／または定位置への移動のための方法および装置
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
IT1309430B1 (it) 1999-05-18 2002-01-23 Guerrieri Roberto Metodo ed apparato per la manipolazione di particelle per mezzo delladielettroforesi

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EP1328803A2 (de) 2003-07-23
ATE304174T1 (de) 2005-09-15
WO2001096025A3 (en) 2003-05-15
WO2001096025A2 (en) 2001-12-20
AU2001269896A1 (en) 2001-12-24
CA2413194A1 (en) 2001-12-20
US6790330B2 (en) 2004-09-14
JP2004532968A (ja) 2004-10-28
EP1328803B1 (de) 2005-09-07
US20020036142A1 (en) 2002-03-28

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