DE60109164D1 - Verfahren und zusammensetzungen zur schmerzbehandlung der schleimhaut - Google Patents

Verfahren und zusammensetzungen zur schmerzbehandlung der schleimhaut

Info

Publication number
DE60109164D1
DE60109164D1 DE60109164T DE60109164T DE60109164D1 DE 60109164 D1 DE60109164 D1 DE 60109164D1 DE 60109164 T DE60109164 T DE 60109164T DE 60109164 T DE60109164 T DE 60109164T DE 60109164 D1 DE60109164 D1 DE 60109164D1
Authority
DE
Germany
Prior art keywords
compositions
treatment
tip
mucosal
inflamation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60109164T
Other languages
English (en)
Other versions
DE60109164T2 (de
Inventor
Robert O Williams
Feng Zhang
J Koleng
Gavril W Pasternak
A Kolesnikov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Pharmaceuticals Inc
Original Assignee
Epicept Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epicept Corp filed Critical Epicept Corp
Publication of DE60109164D1 publication Critical patent/DE60109164D1/de
Application granted granted Critical
Publication of DE60109164T2 publication Critical patent/DE60109164T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE60109164T 2000-06-26 2001-06-26 Verfahren und zusammensetzungen zur schmerzbehandlung der schleimhaut Expired - Fee Related DE60109164T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22216400P 2000-06-26 2000-06-26
US222164P 2000-06-26
PCT/US2001/020322 WO2002000195A2 (en) 2000-06-26 2001-06-26 Methods and compositions for treating pain of the mucous membrane

Publications (2)

Publication Number Publication Date
DE60109164D1 true DE60109164D1 (de) 2005-04-07
DE60109164T2 DE60109164T2 (de) 2005-12-29

Family

ID=22831130

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60109164T Expired - Fee Related DE60109164T2 (de) 2000-06-26 2001-06-26 Verfahren und zusammensetzungen zur schmerzbehandlung der schleimhaut

Country Status (11)

Country Link
US (3) US20020013331A1 (de)
EP (1) EP1296650B1 (de)
JP (2) JP2004501181A (de)
AT (1) ATE289802T1 (de)
AU (1) AU2001270177A1 (de)
CA (1) CA2413545A1 (de)
DE (1) DE60109164T2 (de)
ES (1) ES2239144T3 (de)
IL (2) IL153656A0 (de)
PT (1) PT1296650E (de)
WO (1) WO2002000195A2 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US9616150B2 (en) * 1999-10-29 2017-04-11 Children's Hospital Los Angeles Bone hemostasis method and materials
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US8017627B2 (en) 2000-07-31 2011-09-13 Nycomed Danmark Aps Fentanyl composition for nasal administration
DK1343492T3 (da) * 2000-11-22 2006-03-06 Rxkinetix Inc Behandling af mucositis
US20030114394A1 (en) * 2001-10-29 2003-06-19 Levine Howard L. Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US20080182841A1 (en) * 2001-10-29 2008-07-31 Levine Howard L Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US8425892B2 (en) * 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US20030166732A1 (en) * 2002-02-27 2003-09-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity
US6602490B1 (en) * 2002-03-04 2003-08-05 Richard A. Cloonan Dental cleaning formulation and manufacturing process
US7666876B2 (en) 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
GB0213869D0 (en) * 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
AU2003252178A1 (en) * 2002-07-25 2004-02-16 Advances Life Sciences, Inc. Use of 2,3 alkylcarbonyloxybenzoic acids, derivatives and analogues therefrom in the treatment of tissue and cellular dysfunction damage and injury in mammals
US7273889B2 (en) * 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) * 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US20040213828A1 (en) * 2003-04-23 2004-10-28 Smith David J. Pain relief lollipop compositions and methods
US20050266090A1 (en) * 2003-04-29 2005-12-01 Ales Prokop Nanoparticular targeting and therapy
CN1784212A (zh) * 2003-05-07 2006-06-07 Dmi生物科学公司 口腔护理方法和产品
US7106483B2 (en) * 2003-06-12 2006-09-12 Ricoh Company, Limited Optical scanner and image forming apparatus
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
GB0315632D0 (en) 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
US20050136116A1 (en) * 2003-12-18 2005-06-23 Keith Whitehead Stabilized prednisolone sodium phosphate solutions
GB0330049D0 (en) * 2003-12-24 2004-02-04 Arakis Ltd The treatment of neuropathic pain conditions
JP2007517806A (ja) * 2004-01-15 2007-07-05 オーラル バイオサイエンス ピーティーワイ． リミテッド 口腔用麻酔ゲル
US7947508B2 (en) * 2004-11-30 2011-05-24 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US7766658B2 (en) * 2004-11-30 2010-08-03 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US20060115785A1 (en) * 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
US20060115782A1 (en) * 2004-11-30 2006-06-01 Chunhua Li Systems and methods for coating a dental appliance
US20060134227A1 (en) * 2004-12-22 2006-06-22 Bortz Jonathan D Compositions including iron
US20090035385A1 (en) * 2004-12-22 2009-02-05 Drugtech Corporation Compositions including iron
JP4966204B2 (ja) * 2004-12-23 2012-07-04 ロックスロ ファーマ， インコーポレイテッド ケトロラクの鼻腔内投与のための治療用組成物
US20060252010A1 (en) * 2005-05-09 2006-11-09 Sunnen Gerard V Sodium chloride pad for treatment of dental conditions
US20080248090A1 (en) * 2005-05-09 2008-10-09 Sunnen Gerard V Graduated concentration sodium chloride patches for the treatment of dental conditions
US20070020186A1 (en) * 2005-07-22 2007-01-25 Alpex Pharma S.A. Solid dosage formulations of narcotic drugs having improved buccal adsorption
EP1749528A1 (de) 2005-08-05 2007-02-07 Pharma C S.A. Pharmazeutische Kombinationen, welche mu-opioid Agonisten und Inhibitoren der Stickstoffmonoxidherstellung enthalten
US8263047B2 (en) * 2005-09-29 2012-09-11 Wickenhauser Alan J Topical anesthetic for dental procedures
US8623334B1 (en) 2005-09-29 2014-01-07 Alan J. Wickenhauser Topical anesthetic
JP5217136B2 (ja) * 2005-10-18 2013-06-19 大正製薬株式会社 直腸、尿道および膣適用用半固形状製剤。
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
CA2635603C (en) * 2005-11-30 2016-01-19 Endo Pharmaceuticals Inc. Treatment of xerostomia
EP1998742A2 (de) * 2006-03-08 2008-12-10 Nuviance, INC. Zusammensetzungen für transdermale wirkstofffreisetzung und topische zusammensetzungen zum auftragen auf die haut
US20070231396A1 (en) * 2006-03-29 2007-10-04 Ray Charles D Medication spray formulation
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
CA2659909A1 (en) * 2006-08-01 2008-02-07 Phrixus Pharmaceuticals, Inc. Treatment for chronic progressive heart failure
WO2008060764A2 (en) * 2006-10-05 2008-05-22 Drugtech Corporation Topical therapies for oral mucositis and other conditions
AR065577A1 (es) * 2007-03-02 2009-06-17 Combe Internat Ltd Composicion anestesica en aerosol
ATE440598T1 (de) * 2007-03-02 2009-09-15 Flamek Corp Ou Analgesische zusammensetzung von topisch angewendeten, nichtsteroiden und entzündungshemmenden arzneimitteln und opioiden
US20080305149A1 (en) * 2007-06-11 2008-12-11 Thomas Hirt Mucoadhesive vesicles for drug delivery
US20090004248A1 (en) * 2007-06-29 2009-01-01 Frank Bunick Dual portion dosage lozenge form
US10512597B2 (en) * 2007-09-06 2019-12-24 Colgate-Palmolive Company Controlled surface gelling of mucoadhesive polymers on oral mucosa
JP2010538988A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのミニガストリン
US20090093547A1 (en) * 2007-10-09 2009-04-09 Sciele Pharma, Inc. Compositions and Methods for Treating Premature Ejaculation
US20090123390A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Compositions for the treatment of gastrointestinal inflammation
US20090123551A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Gastrointestinal delivery systems
GB2458403B (en) 2007-11-13 2010-01-13 Meritage Pharma Inc Stabilised corticosteroid compositions
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
JP5560201B2 (ja) * 2007-12-17 2014-07-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 骨格筋欠損症を治療および予防するための組成物および方法
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
KR20190026056A (ko) 2008-04-21 2019-03-12 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
JP5421366B2 (ja) 2008-07-21 2014-02-19 オトノミ―，インク． 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
DE102008037682A1 (de) 2008-08-14 2010-04-08 Strackharn, Klaus, Dr.med. Verwendung äquipotenter Dosierungen von Lokalanästetika oder Derivaten davon zur Therapie chronischer Schmerzen
EP3834819A1 (de) 2008-08-20 2021-06-16 The Regents of the University of California Kortikosteroide zur behandlung von entzündlichen erkrankungen des magendarm-trakts
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
WO2010144865A2 (en) * 2009-06-12 2010-12-16 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
US20110091618A1 (en) * 2009-10-16 2011-04-21 Frito-Lay North America, Inc. Method for preventing oxidation and off flavors in high carotenoid foods
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US20110117175A1 (en) * 2009-11-18 2011-05-19 Rosenbaum Richard J Sweet analgesic for use in medical procedures or treatments
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
WO2011066201A2 (en) * 2009-11-25 2011-06-03 The Regents Of The University Of Michigan Methods and systems for treating and preventing cardiac injury in dystrophic subjects
GB2477545B (en) * 2010-02-05 2011-12-21 Special Products Ltd A liquid morphine composition for buccal administration
JP2014500258A (ja) 2010-11-15 2014-01-09 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 制御放出粘膜付着システム
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
PT3284459T (pt) * 2011-04-29 2021-03-30 Moberg Pharma Ab Composições farmacêuticas que compreendem um anestésico local como bupivacaína para a administração tópica na boca ou garganta
US10022083B2 (en) 2011-06-02 2018-07-17 Abdulmohsen E. A. H. Al-Terki Multiple oral and nasal surgical procedures method and kit
US8387798B1 (en) 2012-04-27 2013-03-05 Abdulmohsen E. A. H. Al-Terki Mutiple oral and nasal surgical procedures method and kit
WO2013130577A2 (en) * 2012-02-27 2013-09-06 Eye Therapies, Llc Compositions and methods for the treatment of migraine
FR2994844B1 (fr) * 2012-08-31 2015-01-02 Assist Publ Hopitaux De Paris Formulation gelifiante a base de ketamine
WO2014098868A1 (en) 2012-12-20 2014-06-26 Colgate-Palmolive Company Oral care composition containing ionic liquids
US9801916B2 (en) 2013-02-07 2017-10-31 Tomás Bernardo Galvan Gonzalez Oral antiseptic composition useful for treating oral mucositis
US20140371305A1 (en) * 2013-06-14 2014-12-18 Professional Compounding Centers Of America Mupirocin Antibiotic Composition
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
CN106659676A (zh) * 2014-11-05 2017-05-10 四川海思科制药有限公司 一种罗哌卡因缓释凝胶制剂及其制备与应用
BR102014028009B1 (pt) 2014-11-10 2023-04-18 Universidade Federal De Pelotas Composições filmogênicas para bioadesivos anestésicos tópicos (bats) para liberação controlada de princípios ativos e bioadesivos anestésicos tópicos
US9943074B2 (en) * 2015-02-27 2018-04-17 Stanley James Balgaard Hinging and rotating coupler mechanism for avian spinning wing decoy
AU2016298307A1 (en) 2015-07-28 2018-02-15 Otonomy, Inc. TrkB or TrkC agonist compositions and methods for the treatment of OTIC conditions
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
ES2956040T3 (es) 2017-04-19 2023-12-12 Otsuka Pharma Factory Inc Olanexidina como agente antiinflamatorio
WO2019154895A1 (en) 2018-02-08 2019-08-15 Strekin Ag Gel formulation for preventing or treating hearing loss
JP6886551B1 (ja) * 2020-11-06 2021-06-16 医療法人祥和会 歯科用の局所麻酔液

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051234A (en) 1975-06-06 1977-09-27 The Procter & Gamble Company Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies
GB2042888B (en) 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US5225196A (en) 1983-11-14 1993-07-06 Columbia Laboratories, Inc. Bioadhesive compositions and methods of treatment therewith
DE3522550A1 (de) 1985-06-24 1987-01-02 Klinge Co Chem Pharm Fab Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
US4806543A (en) * 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury
US4855142A (en) 1987-02-27 1989-08-08 Ciba-Geigy Corporation Pharmaceutical plaster
US5906810A (en) 1987-03-17 1999-05-25 Turner; Robert E. Formulations and uses thereof in the prevention and treatment of oral lesions
IL87710A (en) * 1987-09-18 1992-06-21 Ciba Geigy Ag Covered floating retard form for controlled release in gastric juice
US4900552A (en) 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US5219861A (en) 1988-12-21 1993-06-15 Chugai Seiyaku Kabushiki Kaisha 6 β-Thiomorphine derivatives
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5112620A (en) * 1990-09-20 1992-05-12 Mikkur, Inc. Polyethylene glycol ointment for apthous ulcers
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
US5662924A (en) 1991-03-21 1997-09-02 Smith & Nephew Plc Wound dressing
IT1248014B (it) * 1991-06-07 1995-01-05 Inverni Della Beffa Spa Preparazioni oftalmiche a rilascio protratto
US5206248A (en) * 1992-03-27 1993-04-27 Smith Richard A Method for reducing emotional lability
US5972906A (en) 1991-07-03 1999-10-26 Hyal Pharmaceutical Corporation Treatment of mucous membrane disease, trauma or condition and for the relief of pain thereof
US5589840A (en) 1991-11-05 1996-12-31 Seiko Epson Corporation Wrist-type wireless instrument and antenna apparatus
GB9202464D0 (en) 1992-02-05 1992-03-18 Danbiosyst Uk Composition for nasal administration
DE4223004A1 (de) 1992-07-13 1994-01-20 Liedtke Pharmed Gmbh Einzeldosierte halbfeste topische Arzneiform zur Transdermaltherapie
US5234929A (en) * 1992-07-20 1993-08-10 William Chelen Method of treating motion sickness with anticonvulsants and antitussive agents
SG49746A1 (en) 1992-08-28 1998-06-15 Pharmos Corp Submicron emulsions as ocular drug delivery vehicles
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5817625A (en) 1992-09-21 1998-10-06 Oncogene Science, Inc. Methods of prevention of oral mucositis with transforming growth factor beta
DE69434304T2 (de) 1993-03-26 2005-12-29 Merkus, Franciscus Wilhelmus H.M. Pharmazeutische Zusammensetzungen zur intranasalen Verabreichung von Dihydroergotamin
US5744155A (en) 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5578315A (en) * 1993-12-01 1996-11-26 Rutgers, The State University Of New Jersey Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
US5395318A (en) 1994-01-24 1995-03-07 Kaprelian; Edward K. Method and apparatus for wound treatment
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
TW438601B (en) 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof
US5460826A (en) 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
IT1273742B (it) 1994-08-01 1997-07-09 Lifegroup Spa Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose
WO1996010389A1 (de) 1994-09-30 1996-04-11 Mika Pharma Gesellschaft Für Die Entwicklung Und Vermarktung Pharmazeutischer Produkte Mbh Pharmazeutische zusammensetzung
US5635540A (en) 1994-12-09 1997-06-03 The University Of Virginia Patent Foundation Stabilized topical pharmaceutical preparations
US5626878A (en) * 1995-01-10 1997-05-06 Warner Lambert Company Reduction of electrostatic forces between magnesium trisilicate adsorbates
US5866143A (en) 1995-03-24 1999-02-02 El Khoury And Stein, Ltd. Topical application of opioid drugs such as morphine for relief of itching and skin disease
US5713852A (en) 1995-06-07 1998-02-03 Alza Corporation Oral dosage and method for treating painful conditions of the oral cavity
US5948389A (en) * 1995-06-07 1999-09-07 El Khoury & Stein, Ltd. Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
JP2002516617A (ja) * 1995-06-16 2002-06-04 メドロジック グローバル コーポレイション 反応性ポリマー網状構造体及びその使用法
EP0832151A2 (de) * 1995-06-16 1998-04-01 Gel Sciences, Inc. Auf umweltänderungen reagierende polymernetzwerke und verfahren zu deren herstellung
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5849322A (en) 1995-10-23 1998-12-15 Theratech, Inc. Compositions and methods for buccal delivery of pharmaceutical agents
FR2742989B1 (fr) 1995-12-29 1998-01-23 Adir Composition pharmaceutique bioadhesive pour la liberation controlee de principes actifs
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5667773A (en) 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
JP2000507546A (ja) * 1996-03-25 2000-06-20 イーライ・リリー・アンド・カンパニー 麻酔方法
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
US5846971A (en) 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
US5976573A (en) 1996-07-03 1999-11-02 Rorer Pharmaceutical Products Inc. Aqueous-based pharmaceutical composition
EP0829481A1 (de) 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate
US5955097A (en) 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US5942243A (en) 1996-11-12 1999-08-24 Polytherapeutics, Inc. Mucoadhesive compositions for administration of biologically active agents to animal tissue
EP0946157B1 (de) * 1996-12-16 2002-03-13 Alcon Laboratories, Inc. Topische verwendung von kappa-opioidrezeptoragonisten zur behandlung von augenschmerz
US5811078A (en) 1997-03-14 1998-09-22 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions therewith
US5798093A (en) 1997-03-14 1998-08-25 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
US5855907A (en) 1997-03-24 1999-01-05 Peyman; Gholam A. Method of treatment of migraine
US5849762A (en) 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US5989535A (en) 1997-08-15 1999-11-23 Soma Technologies Polymeric bioadhesive emulsions and suspensions and methods of treatment
RU2234337C2 (ru) * 1997-09-26 2004-08-20 Ноувен Фамэсьютикэлз, Инк. Биоадгезивная композиция (варианты), способ ее получения (варианты), устройство для доставки через слизистую оболочку активного агента, способ пролонгированного местного введения одного или более активных агентов субъекту (варианты) и способ сокращения времени, требуемого для приклеивания композиции к слизистой ткани
US5885597A (en) 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain
SI2266564T1 (sl) * 1997-12-22 2013-07-31 Euro-Celtique S.A. Farmacevtska oralna dozirna oblika, ki vsebuje kombinacijo opioidnega agonista in opioidnega antagonista
AU2981099A (en) * 1998-03-09 1999-09-27 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
DE69933874T2 (de) 1998-07-16 2007-10-04 Memorial Sloan-Kettering Institute For Cancer Research Topische zusammensetzung enthaltend ein opioid-analgetika und einen nmda-antagonist
FR2781156B1 (fr) * 1998-07-20 2001-06-29 Lafon Labor Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane

Also Published As

Publication number Publication date
IL153656A (en) 2010-05-31
EP1296650B1 (de) 2005-03-02
JP2009001574A (ja) 2009-01-08
US20020013331A1 (en) 2002-01-31
AU2001270177A1 (en) 2002-01-08
US20030124190A1 (en) 2003-07-03
ATE289802T1 (de) 2005-03-15
EP1296650A2 (de) 2003-04-02
IL153656A0 (en) 2003-07-06
ES2239144T3 (es) 2005-09-16
PT1296650E (pt) 2005-06-30
WO2002000195A2 (en) 2002-01-03
JP2004501181A (ja) 2004-01-15
CA2413545A1 (en) 2002-01-03
US6509028B2 (en) 2003-01-21
DE60109164T2 (de) 2005-12-29
US20020192288A1 (en) 2002-12-19
WO2002000195A3 (en) 2002-08-15

Similar Documents

Publication Publication Date Title
DE60109164D1 (de) Verfahren und zusammensetzungen zur schmerzbehandlung der schleimhaut
ATE525061T1 (de) Feste selbst-haftende zusammensetzungen zur topischen behandlung von störungen der mundschleimhaut
WO2004004650A3 (en) Antibacterial formulations
DE60128673D1 (de) Verfahren zur verbesserung der grösse und des aussehens einer wunde
ATE269113T1 (de) Sprühfähige wundversorgungszusammensetzung
DE60213449D1 (de) Zusammensetzungen enthaltend ein ethanolaminderivat sowie organische metallsalze
IL139826A0 (en) BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF IgE
DE60335560D1 (de) Zusammensetzungen enthaltend zitronensäure zur behandlung von nagelpilzerkrankungen
RS49756B (sr) Primena ksenona ili smeša ksenonskog gasa za proizvodnju farmaceutskog preparata za lečenje neurointoksikacija
ATE338806T1 (de) Verfahren zur oberflächenbehandlung mittels eines gels zur behandlung, und gel zur behandlung
NO20030411D0 (no) Farmasöytiske sammensetninger for behandlingen av smertefulle, inflammatoriske og ulceröse tilstander av fuktige epiteloverflater slik sommukositt, stomatitt og Behcets syndrom
ATE273690T1 (de) Zusammensetzung zur hautdesinfizierung
DE60213407D1 (de) Zusammensetzungen zur hemmung der angiogenese
WO2003072593A3 (en) Bone targeting peptides
CA2415354A1 (en) Phospholipid derivatives of valproic acid and mixtures thereof
WO2003003997A3 (de) Verwendung von hopfen- bzw. hopfen-malz-extrakten in kosmetischen oder dermatologischen zubereitungen
AU2003270498A1 (en) Topical veterinary compositions and methods for the treatment and prevention of infection
WO2008012107A3 (en) Use of polyethylene glycol in inflammatory skin conditions and wound healing
CY1106075T1 (el) Χρηση τουλαχιστον ενος παραγωγου του 10-υδροξυ-2-δεκενοϊκου οξεος σε ενα σκευασμα που προοριζεται για την προωθηση της απολεπισης του δερματος
CA2351947A1 (en) Hyperforin as cytostatic agent and hyperforin ointment or cream as application form
ATE437628T1 (de) Reizlinderndes hustenmittel enthaltend extrakte aus isländischem moos und malve sowie zinkverbindungen
DK0988033T3 (da) Anvendelse af dichlorbenzylalkohol til fremstilling af et præparat til topisk behandling af inflammation
WO2002083700A3 (en) Hypersulfated disaccharides and methods of using the same for the treatment of inflammations
CA2404210A1 (en) Pharmaceutical gel composition
WO2003002084A3 (en) Fragrance and flavour compositions

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee