DE60038124D1 - Direktes screeningverfahren - Google Patents

Direktes screeningverfahren

Info

Publication number
DE60038124D1
DE60038124D1 DE60038124T DE60038124T DE60038124D1 DE 60038124 D1 DE60038124 D1 DE 60038124D1 DE 60038124 T DE60038124 T DE 60038124T DE 60038124 T DE60038124 T DE 60038124T DE 60038124 D1 DE60038124 D1 DE 60038124D1
Authority
DE
Germany
Prior art keywords
polypeptides
target
support
molecules
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038124T
Other languages
English (en)
Other versions
DE60038124T2 (de
Inventor
Lucy Jessica Holt
Wildt Rudolf Maria De
Ian Tomlinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domantis Ltd
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd filed Critical Domantis Ltd
Application granted granted Critical
Publication of DE60038124D1 publication Critical patent/DE60038124D1/de
Publication of DE60038124T2 publication Critical patent/DE60038124T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
DE60038124T 1999-12-03 2000-12-04 Direktes screeningverfahren Expired - Lifetime DE60038124T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9928787.2A GB9928787D0 (en) 1999-12-03 1999-12-03 Direct screening method
GB9928787 1999-12-03
PCT/GB2000/004638 WO2001040803A1 (en) 1999-12-03 2000-12-04 Direct screening method

Publications (2)

Publication Number Publication Date
DE60038124D1 true DE60038124D1 (de) 2008-04-03
DE60038124T2 DE60038124T2 (de) 2009-02-12

Family

ID=10865784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038124T Expired - Lifetime DE60038124T2 (de) 1999-12-03 2000-12-04 Direktes screeningverfahren

Country Status (13)

Country Link
US (1) US20030039958A1 (de)
EP (2) EP1242821B8 (de)
JP (1) JP2003515745A (de)
AT (1) ATE386939T1 (de)
AU (1) AU1541701A (de)
CA (1) CA2392981A1 (de)
DE (1) DE60038124T2 (de)
DK (1) DK1242821T3 (de)
ES (1) ES2300279T3 (de)
GB (1) GB9928787D0 (de)
NO (1) NO20022312L (de)
PT (1) PT1242821E (de)
WO (1) WO2001040803A1 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
AU2001292959A1 (en) 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
WO2002059601A1 (en) 2001-01-23 2002-08-01 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US20050019942A1 (en) * 2001-03-16 2005-01-27 Proteome Systems Ltd. Array-based biomolecule analysis
WO2003000404A1 (en) * 2001-06-22 2003-01-03 Domantis Limited Matrix screening method
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US6797393B2 (en) 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
US6815078B2 (en) 2002-03-06 2004-11-09 Eastman Kodak Company Substrate for protein microarray containing functionalized polymer
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
AU2003304409A1 (en) * 2002-06-07 2005-03-07 President And Fellows Of Harvard College Evaluating protein signatures
ES2368733T3 (es) * 2002-07-18 2011-11-21 Merus B.V. Producción recombinante de mezclas de anticuerpos.
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
ES2362424T3 (es) 2003-01-07 2011-07-05 Dyax Corporation Biblioteca del dominio kunitz.
GB0304832D0 (en) * 2003-03-04 2003-04-09 Secr Defence Assay method
CA2527694C (en) 2003-05-30 2015-07-14 Hendricus Renerus Jacobus Mattheus Hoogenboom Fab library for the preparation of anti vegf and anti rabies virus fabs
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CA2534661A1 (en) 2003-08-08 2005-02-17 Genenews Inc. Osteoarthritis biomarkers and uses thereof
US7153896B2 (en) 2003-11-14 2006-12-26 Eastman Kodak Company Element for protein microarrays
EP1737971B1 (de) * 2004-01-20 2017-08-16 Merus N.V. Gemische bindender proteine
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
EP2520669A3 (de) 2005-02-07 2013-02-27 GeneNews Inc. Biomarker für milde Arthrose und Verwendungen davon
US20080145364A1 (en) * 2005-02-15 2008-06-19 Yale University Method for High Throughput Screening for Anitbodies and Proteins Inducing Apoptosis
WO2006111424A1 (en) * 2005-04-22 2006-10-26 Life & Brain Gmbh Methods for identifying modulators of cb1 and cb2 cannabinoid receptors and their use in wound healing
ATE518007T1 (de) 2005-10-21 2011-08-15 Genenews Inc Verfahren und vorrichtung zur korrelierung der ebenen von biomarker-produkten mit erkrankungen
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
TWI369402B (en) 2006-07-05 2012-08-01 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
EP2041570A4 (de) * 2006-07-12 2010-02-24 Trellis Bioscience Inc CellSpotTM-ANWENDUNGEN
US20100003189A1 (en) 2006-07-14 2010-01-07 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
MX2009010997A (es) 2007-04-13 2009-11-02 Catalyst Biosciences Inc Polipeptidos modificados con el factor vii y usos de los mismos.
CL2008001887A1 (es) 2007-06-29 2008-10-03 Amgen Inc Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende.
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
WO2009075773A2 (en) 2007-12-07 2009-06-18 Goldstein Steven A Identification of toxin ligands
ES2334084B1 (es) 2007-12-21 2011-01-24 Inst Cientifico Tecnol Navarra Marcadores geneticos para el pronostico de la esclerosis multiple.
US9873957B2 (en) 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
EP2281078B1 (de) 2008-04-24 2014-10-22 Dyax Corporation Bibliotheken von genetischen packungen, umfassend neue hc-cdr1, -cdr2, und -cdr3, und neue lc-cdr1-, -cdr2- und -cdr3-designs
CA2722082C (en) 2008-04-25 2021-11-09 Christopher Tenhoor Fc receptor binding proteins
US20100093563A1 (en) 2008-09-22 2010-04-15 Robert Anthony Williamson Methods and vectors for display of molecules and displayed molecules and collections
EP2169078A1 (de) 2008-09-26 2010-03-31 Fundacion Gaiker Verfahren und Kits zur Diagnose und Abstufung von Kolorektalkrebs
CA2740440A1 (en) 2008-10-14 2010-04-22 Dyax Corp. Use of igf-ii/igf-iie binding proteins for the treatment and prevention of systemic sclerosis-associated pulmonary fibrosis
WO2010107752A2 (en) 2009-03-20 2010-09-23 Amgen Inc. Alpha-4-beta-7 heterodimer specific antagonist antibody
EP2459213A1 (de) 2009-07-31 2012-06-06 Amgen Inc. Metalloproteinase-typ-3 (timp-3)-gewebehemmer bindende polypeptide, zusammensetzungen und verfahren
JP2013504602A (ja) 2009-09-14 2013-02-07 ダイアックス コーポレーション 新しく設計したhccdr3を含む遺伝子パッケージライブラリー
US20110189183A1 (en) 2009-09-18 2011-08-04 Robert Anthony Williamson Antibodies against candida, collections thereof and methods of use
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
SI2521568T1 (sl) 2010-01-06 2019-01-31 Dyax Corp. Proteini, ki vežejo plazemski kalikrein
AU2011239689A1 (en) 2010-04-15 2012-11-08 Amgen Inc. Human FGF receptor and beta-Klotho binding proteins
EP3508854A1 (de) 2010-04-27 2019-07-10 The Regents of The University of California Krebsbiomarker und verfahren zur verwendung davon
US20130210663A1 (en) 2010-08-04 2013-08-15 Cizzle Biotechnology Limited Methods and compounds for the diagnosis and treatment of cancer
AU2011292197B2 (en) 2010-08-16 2015-05-28 Amgen Inc. Antibodies that bind myostatin, compositions and methods
EP2428583A1 (de) 2010-09-10 2012-03-14 Bioftalmik, S.L. Verfahren zur Prognose des Erfolgs einer Filtrationsoperation und zur Bestimmung des Heilungsprozesses
WO2012092376A2 (en) 2010-12-31 2012-07-05 Short Jay M Comprehensive monoclonal antibody generation
JP2014510265A (ja) 2011-02-02 2014-04-24 アムジェン インコーポレイテッド Igf−1rの阻害に関する方法および組成物
KR20140044329A (ko) 2011-05-12 2014-04-14 트래스래셔널 캔서 드럭스 파마 에스.엘. Kiaa1456 발현의 결장암 환자 생존에 대한 예측
EP2714084B1 (de) 2011-06-02 2019-05-22 Dyax Corp. Fc-REZEPTOR-BINDENDE PROTEINE
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
WO2012170703A1 (en) * 2011-06-07 2012-12-13 Mbio Diagnostics, Inc. System and method for detection and analysis of a molecule in a sample
MX361039B (es) 2011-10-26 2018-11-26 Amgen Inc Métodos para reducir o eliminar modificación de proteína y degradación que surge de la exposición a luz ultravioleta.
AU2012344155A1 (en) 2011-11-28 2014-07-03 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Methods and kits for the prognosis of colorectal cancer
WO2013092960A1 (en) 2011-12-22 2013-06-27 Fundacion Gaiker Methods and kits for the diagnosis of colorectal cancer
MX360109B (es) 2012-04-20 2018-10-23 Merus Nv Metodos y medios para la produccion de moleculas de tipo ig.
US9441039B2 (en) 2012-05-07 2016-09-13 Amgen Inc. Anti-erythropoietin antibodies
AU2013267161A1 (en) 2012-05-31 2014-11-20 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-L1
US10377827B2 (en) 2012-06-21 2019-08-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind c-met
JP6438391B2 (ja) 2012-06-22 2018-12-12 ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. Ccr2に結合する抗原結合タンパク質
WO2013190081A1 (en) 2012-06-22 2013-12-27 Proyecto De Biomedicina Cima, S.L. Methods and reagents for the prognosis of cancer
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
WO2014022102A1 (en) 2012-08-01 2014-02-06 Amgen Inc. Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture
WO2014072517A1 (en) 2012-11-12 2014-05-15 Institució Catalana De Recerca I Estudis Avançats Methods and kits for the prognosis of colorectal cancer
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
MX2015009901A (es) 2013-02-01 2016-04-06 Santa Maria Biotherapeutics Inc Administración de un compuesto de antiactivina a a un sujeto.
EP3888671A3 (de) 2013-03-11 2022-01-05 Amgen Inc. Proteinformulierungen
US20140271629A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Chrdl-1 antigen binding proteins and methods of treatment
GB2584364A (en) 2013-03-15 2020-12-02 Abvitro Llc Single cell bar-coding for antibody discovery
AU2014342232B2 (en) 2013-10-31 2017-12-21 Amgen Inc. Use of monensin to regulate glycosylation of recombinant proteins
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
IL282517B (en) 2014-01-29 2022-07-01 Amgen Inc Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
MX2017002380A (es) 2014-08-22 2017-09-15 Sorrento Therapeutics Inc Proteinas de union de antigeno que se unen a cxcr3.
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
SG11201702060VA (en) 2014-09-15 2017-04-27 Abvitro Inc High-throughput nucleotide library sequencing
WO2016061551A1 (en) 2014-10-17 2016-04-21 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
CN111018987B (zh) 2014-12-05 2023-11-21 鸿运华宁(杭州)生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其应用
JP6917902B2 (ja) 2015-02-13 2021-08-11 ソレント・セラピューティクス・インコーポレイテッド Ctla4に結合する抗体医薬
US10100126B2 (en) 2015-03-10 2018-10-16 Sorrento Therapeutics, Inc. Antibody therapeutics that bind PSMA
US9951144B2 (en) 2015-04-08 2018-04-24 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD38
JP2018535655A (ja) 2015-09-29 2018-12-06 アムジエン・インコーポレーテツド Asgr阻害剤
JP6883590B2 (ja) 2016-01-29 2021-06-09 ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. Pd−l1に結合する抗原結合性タンパク質
SG11201810040WA (en) 2016-05-11 2018-12-28 Amgen Inc Direct selection of cells expressing high levels of heteromeric proteins using glutamine synthetase intragenic complementation vectors
EP3246415A1 (de) 2016-05-18 2017-11-22 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
TWI826351B (zh) 2016-05-31 2023-12-21 大陸商鴻運華寧(杭州)生物醫藥有限公司 R抗體,其藥物組合物及其應用
ES2688737A1 (es) 2017-05-04 2018-11-06 Universidad Del País Vasco / Euskal Herriko Unibertsitatea Método para diagnosticar placa ateroesclerótica inestable
CN111148849A (zh) 2017-05-26 2020-05-12 阿布维托有限责任公司 高通量多核苷酸文库测序和转录组分析
CN107563133B (zh) * 2017-08-30 2021-05-04 大连理工大学 采用定量结构-活性关系模型预测有机化学品的氯自由基反应速率常数的方法
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. METHODS OF IDENTIFYING CELLULAR CHARACTERISTICS RELATED TO RESPONSES ASSOCIATED WITH CELL THERAPY
CN117126279A (zh) 2018-03-20 2023-11-28 鸿运华宁(杭州)生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用
CN110357959B (zh) 2018-04-10 2023-02-28 鸿运华宁(杭州)生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用
CN110655577A (zh) 2018-06-13 2020-01-07 鸿运华宁(杭州)生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质,以及其药物组合物和应用
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
US20220026444A1 (en) 2018-11-26 2022-01-27 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for diagnosing and/or treating acute or chronic liver, kidney or lung disease
EP3674421A1 (de) 2018-12-28 2020-07-01 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
CA3130449A1 (en) 2019-04-30 2020-11-05 Gigagen, Inc. Recombinant polyclonal proteins and methods of use thereof
CN112239507A (zh) 2019-07-17 2021-01-19 鸿运华宁(杭州)生物医药有限公司 ETA抗体与TGF-β Trap的融合蛋白质,以及其药物组合物和应用
CN112521501A (zh) 2019-09-18 2021-03-19 鸿运华宁(杭州)生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用
JP2023505256A (ja) 2019-12-05 2023-02-08 ソレント・セラピューティクス・インコーポレイテッド 腫瘍ターゲティング抗体と組み合わせた抗cd47抗体を含む組成物および方法
CA3168986A1 (en) 2020-02-26 2021-09-02 Sorrento Therapeutics, Inc. Activatable antigen binding proteins with universal masking moieties
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
US20230167191A1 (en) 2020-04-24 2023-06-01 Sorrento Therapeutics, Inc. Memory Dimeric Antigen Receptors (mDARs)
CA3175960A1 (en) 2020-04-24 2021-10-28 Henry Hongjun Ji Lateral flow device for detection of coronavirus infection
CA3177152A1 (en) 2020-06-12 2021-12-16 David Scott Johnson Recombinant polyclonal proteins targeting covid-19 and methods of use thereof
CN116209677A (zh) 2020-06-26 2023-06-02 索伦托药业有限公司 抗pd1抗体及其用途
WO2022003146A1 (en) 2020-07-03 2022-01-06 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Methods for predicting the risk of local invasion and/or metastasis induced by an antiangiogenic treatment
WO2022031834A1 (en) 2020-08-05 2022-02-10 Gigagen, Inc. Recombinant polyclonal proteins targeting zika and methods of use thereof
TW202233660A (zh) 2020-10-30 2022-09-01 美商安進公司 過表現胰島素樣生長因子受體突變體以調節igf補充
EP4241085A1 (de) 2020-11-04 2023-09-13 Sorrento Therapeutics, Inc. Lateralflussvorrichtungen zur hochempfindlichen detektion einer coronavirusinfektion und verfahren zur herstellung und verwendung davon
WO2022192594A2 (en) 2021-03-11 2022-09-15 Sorrento Therapeutics, Inc. Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease
CN115141276A (zh) 2021-03-31 2022-10-04 鸿运华宁(杭州)生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其在糖尿病肾病和慢性肾病治疗中的应用
AU2022290563A1 (en) 2021-06-09 2024-01-25 Sorrento Therapeutics, Inc. Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device
TW202328442A (zh) 2021-09-10 2023-07-16 美商安進公司 平臺宿主對igf—培養基之適應

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US31006A (en) 1861-01-01 Feeding mechanism for spoke-machines
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0562025B1 (de) 1990-12-06 2001-02-07 Affymetrix, Inc. (a Delaware Corporation) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5326691A (en) 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
DE4237113B4 (de) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
US5516637A (en) * 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5736388A (en) * 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
AU740830B2 (en) * 1998-01-29 2001-11-15 Glaucus Proteomics B.V. High density arrays for proteome analysis and methods and compositions therefor
JP2002507393A (ja) * 1998-02-11 2002-03-12 マキシジェン, インコーポレイテッド 抗原ライブラリー免疫

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PT1242821E (pt) 2008-07-14
ATE386939T1 (de) 2008-03-15
AU1541701A (en) 2001-06-12
NO20022312L (no) 2002-06-03
EP2000804A2 (de) 2008-12-10
EP2000804A3 (de) 2009-06-03
GB9928787D0 (en) 2000-02-02
EP1242821B1 (de) 2008-02-20
JP2003515745A (ja) 2003-05-07
WO2001040803A1 (en) 2001-06-07
US20030039958A1 (en) 2003-02-27
DK1242821T3 (da) 2008-06-09
NO20022312D0 (no) 2002-05-15
EP1242821A1 (de) 2002-09-25

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