DE60037817D1 - Identifizierung genetischer marker des biologischen alters und des metabolismus - Google Patents

Identifizierung genetischer marker des biologischen alters und des metabolismus

Info

Publication number
DE60037817D1
DE60037817D1 DE60037817T DE60037817T DE60037817D1 DE 60037817 D1 DE60037817 D1 DE 60037817D1 DE 60037817 T DE60037817 T DE 60037817T DE 60037817 T DE60037817 T DE 60037817T DE 60037817 D1 DE60037817 D1 DE 60037817D1
Authority
DE
Germany
Prior art keywords
organ
tissue
cell
gene expression
subjects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037817T
Other languages
English (en)
Inventor
Richard H Weindruch
Tomas A Prolla
Cheol-Koo Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE60037817D1 publication Critical patent/DE60037817D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
DE60037817T 1999-08-12 2000-08-08 Identifizierung genetischer marker des biologischen alters und des metabolismus Expired - Lifetime DE60037817D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14854099P 1999-08-12 1999-08-12
US17823200P 2000-01-26 2000-01-26
US21192300P 2000-06-16 2000-06-16
PCT/US2000/021603 WO2001012851A2 (en) 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism

Publications (1)

Publication Number Publication Date
DE60037817D1 true DE60037817D1 (de) 2008-03-06

Family

ID=27386702

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60037817T Expired - Lifetime DE60037817D1 (de) 1999-08-12 2000-08-08 Identifizierung genetischer marker des biologischen alters und des metabolismus

Country Status (7)

Country Link
US (3) US6569624B1 (de)
EP (1) EP1200629B1 (de)
AT (1) ATE384137T1 (de)
AU (1) AU782102B2 (de)
CA (1) CA2381777C (de)
DE (1) DE60037817D1 (de)
WO (1) WO2001012851A2 (de)

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US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US7452664B2 (en) 1999-12-15 2008-11-18 Massachusetts Institute Of Technology Methods for identifying agents which alter histone protein acetylation
US8642284B1 (en) 1999-12-15 2014-02-04 Massachusetts Institute Of Technology Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
US6406853B1 (en) 1999-12-23 2002-06-18 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
WO2001045752A1 (en) * 1999-12-23 2001-06-28 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
WO2002059310A2 (en) 2000-12-12 2002-08-01 University Of Connecticut Polynucleotides encoding cellular transporters and methods of use thereof
US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
US7041449B2 (en) * 2001-03-19 2006-05-09 Wisconsin Alumni Research Foundation Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice
CA2451247A1 (en) 2001-06-22 2003-01-03 The Regents Of The University Of California Eukaryotic genes involved in adult lifespan regulation
US20030036079A1 (en) * 2001-06-26 2003-02-20 Weindruch Richard H. Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
AU2002313737A1 (en) * 2001-08-13 2003-04-01 University Of Kentucky Research Foundation Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment
WO2003016573A1 (en) * 2001-08-15 2003-02-27 Elixir Pharmaceuticals, Inc. Age-associated markers
KR20040064275A (ko) 2001-11-09 2004-07-16 소스 프리시전 메디슨, 인코포레이티드 유전자 발현 프로파일을 이용한 질병의 동정, 모니터링,치료 및 생물학적 상태의 확인
WO2003099781A2 (en) * 2002-05-24 2003-12-04 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR THE IDENTIFICATION OF IKKα FUNCTION AND OTHER GENES USEFUL FOR TREATMENT OF INFLAMMATORY DISEASES
CA2494066A1 (en) * 2002-08-09 2004-02-19 Cynthia Kenyon Eukaryotic genes involved in adult lifespan regulation
FR2847269B1 (fr) * 2002-11-19 2006-07-28 Coletica Procede d'identification d'une modification eventuelle d'au moins un parametre biologique mettant en oeuvre des cellules vivantes jeunes et agees
EP2308968A1 (de) * 2002-11-26 2011-04-13 Genentech, Inc. Zusammensetzung und Verfahren zur Behandlung von Immunerkrankungen
US20040191775A1 (en) * 2003-03-12 2004-09-30 Spindler Stephen R. Methods of analyzing genes affected by caloric restriction or caloric restriction mimetics
WO2005042795A2 (en) * 2003-10-31 2005-05-12 Queststar Medical, Inc. Plasma polymerization of atomically modified surfaces
US20070275108A1 (en) * 2003-12-19 2007-11-29 Geesamen Bard J Life Span Managment
WO2005089436A2 (en) * 2004-03-16 2005-09-29 The Regents Of The University Of California Genetic networks regulated by attenuated gh/igf1 signaling and caloric restriction
US20050228237A1 (en) * 2004-04-12 2005-10-13 Frank Shallenberger Method for analyzing the biological age of a subject
US7273453B2 (en) * 2004-04-12 2007-09-25 Frank Shallenberger Method for analyzing the biological age of a subject
WO2005123955A2 (en) * 2004-06-09 2005-12-29 Children's Medical Center Corporation Methods and compositions for modifying gene regulation and dna damage in ageing
EP1854510B1 (de) * 2005-02-15 2012-04-04 Yugenkaisha Japan Tsusyo Methode zur Altersbestimmung durch Messung der Körperkraft
US20070099830A1 (en) 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
US7960605B2 (en) * 2006-03-17 2011-06-14 BioMaker Pharmaceuticals, Inc. Methods for testing for caloric restriction (CR) mimetics
EP2813580A1 (de) * 2006-10-13 2014-12-17 Metabolon, Inc. Mit metabolischem Alter verbundene Biomarker und Verfahren zur Verwendung davon
WO2008102038A2 (es) * 2007-02-23 2008-08-28 Progenika Biopharma, S.A. Método y producto para genotipado “in vitro” con aplicación en medicina anti-envejecimiento
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
US7666137B2 (en) * 2008-04-10 2010-02-23 Frank Shallenberger Method for analyzing mitochondrial function
AU2009246180B2 (en) 2008-05-14 2015-11-05 Dermtech International Diagnosis of melanoma and solar lentigo by nucleic acid analysis
CA2734521A1 (en) * 2008-08-28 2010-03-04 Dermtech International Determining age ranges of skin samples
US20120040855A1 (en) * 2009-03-11 2012-02-16 Yuanlong Pan Tissue-specific aging biomarkers
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
US8824769B2 (en) * 2009-10-16 2014-09-02 General Electric Company Process and system for analyzing the expression of biomarkers in a cell
BR112012011133A2 (pt) * 2009-11-10 2016-07-05 Nestec Sa biomarcadores de envelhecimento cardíaco e métodos de uso
KR101993009B1 (ko) 2010-05-24 2019-06-25 엔에스이 프로덕츠, 인크. 노화의 효과에 대항하기 위한 경구 제제
WO2013027191A1 (en) 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
US8652518B2 (en) 2012-04-15 2014-02-18 Jahahreeh Finley Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation
FR2993282B1 (fr) * 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
US20190093163A1 (en) * 2015-06-12 2019-03-28 President And Fellows Of Harvard College Compositions and methods for maintaining splicing fidelity
US20190078162A1 (en) * 2017-09-14 2019-03-14 OneSkin Technologies, Inc. In vitro methods for skin therapeutic compound discovery using skin age biomarkers
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
US11227691B2 (en) 2019-09-03 2022-01-18 Kpn Innovations, Llc Systems and methods for selecting an intervention based on effective age
US11250337B2 (en) 2019-11-04 2022-02-15 Kpn Innovations Llc Systems and methods for classifying media according to user negative propensities

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Publication number Priority date Publication date Assignee Title
US5744300A (en) 1993-03-24 1998-04-28 Geron Corporation Methods and reagents for the identification and regulation of senescence-related genes
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6406853B1 (en) 1999-12-23 2002-06-18 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction

Also Published As

Publication number Publication date
WO2001012851A2 (en) 2001-02-22
AU6528900A (en) 2001-03-13
WO2001012851A3 (en) 2001-08-23
AU782102B2 (en) 2005-07-07
US6569624B1 (en) 2003-05-27
ATE384137T1 (de) 2008-02-15
US20030157526A1 (en) 2003-08-21
EP1200629B1 (de) 2008-01-16
CA2381777A1 (en) 2001-02-22
EP1200629A2 (de) 2002-05-02
CA2381777C (en) 2011-10-04
US20080254464A1 (en) 2008-10-16

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