DE60035871D1 - Expression und export von interferon-alpha proteinen als fc fusionsproteine - Google Patents
Expression und export von interferon-alpha proteinen als fc fusionsproteineInfo
- Publication number
- DE60035871D1 DE60035871D1 DE60035871T DE60035871T DE60035871D1 DE 60035871 D1 DE60035871 D1 DE 60035871D1 DE 60035871 T DE60035871 T DE 60035871T DE 60035871 T DE60035871 T DE 60035871T DE 60035871 D1 DE60035871 D1 DE 60035871D1
- Authority
- DE
- Germany
- Prior art keywords
- interferon
- alpha
- proteins
- nucleic acid
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13489599P | 1999-05-19 | 1999-05-19 | |
US134895P | 1999-05-19 | ||
PCT/US2000/013827 WO2000069913A1 (en) | 1999-05-19 | 2000-05-19 | EXPRESSION AND EXPORT OF INTERFERON-ALPHA PROTEINS AS Fc FUSION PROTEINS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60035871D1 true DE60035871D1 (de) | 2007-09-20 |
DE60035871T2 DE60035871T2 (de) | 2008-06-05 |
Family
ID=22465500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60035871T Expired - Lifetime DE60035871T2 (de) | 1999-05-19 | 2000-05-19 | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
Country Status (22)
Country | Link |
---|---|
US (2) | US20020081664A1 (de) |
EP (1) | EP1187852B1 (de) |
JP (1) | JP2003530070A (de) |
KR (1) | KR20020018197A (de) |
CN (1) | CN1361793A (de) |
AT (1) | ATE369384T1 (de) |
AU (1) | AU777963B2 (de) |
BR (1) | BR0010725A (de) |
CA (1) | CA2372400C (de) |
CZ (1) | CZ20014123A3 (de) |
DE (1) | DE60035871T2 (de) |
DK (1) | DK1187852T3 (de) |
ES (1) | ES2291205T3 (de) |
HK (1) | HK1046694A1 (de) |
HU (1) | HUP0201474A3 (de) |
MX (1) | MXPA01011845A (de) |
NO (1) | NO20015587L (de) |
PL (1) | PL352332A1 (de) |
PT (1) | PT1187852E (de) |
RU (1) | RU2262510C9 (de) |
WO (1) | WO2000069913A1 (de) |
ZA (1) | ZA200109227B (de) |
Families Citing this family (88)
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PT1187852E (pt) * | 1999-05-19 | 2007-11-14 | Merck Patent Gmbh | Expressão e exportação de proteínas interferão-alfa na forma de proteínas de fusão com fc |
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US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
MXPA02001417A (es) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
AU4314801A (en) * | 2000-02-11 | 2001-08-20 | Lexigen Pharm Corp | Enhancing the circulating half-life of antibody-based fusion proteins |
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CN1270775C (zh) * | 2000-06-29 | 2006-08-23 | 默克专利有限公司 | 通过与免疫细胞因子摄入促进剂联合治疗来增强抗体-细胞因子融合蛋白介导的免疫反应 |
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KR100900176B1 (ko) * | 2001-03-07 | 2009-06-02 | 메르크 파텐트 게엠베하 | 하이브리드 이소타입 항체 부분구조를 포함하는 단백질을위한 발현 기술 |
US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
WO2002088161A1 (en) * | 2001-05-02 | 2002-11-07 | Pepgen Corporation | Method for expression of human interferon alpha 1 in pichia pa storis |
DK1383785T3 (da) * | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
AU2002357784B2 (en) | 2001-12-04 | 2008-07-31 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
EP1463751B1 (de) | 2001-12-21 | 2013-05-22 | Human Genome Sciences, Inc. | Albuminfusionsproteine |
US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
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WO2004074486A2 (en) * | 2003-02-18 | 2004-09-02 | Merck Patent Gmbh | Fusion proteins of interferon alpha muteins with improved properties |
US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
US20040180054A1 (en) * | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
DK2298347T3 (en) * | 2003-05-06 | 2016-01-11 | Biogen Hemophilia Inc | COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER |
US7348004B2 (en) * | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
AU2004238263A1 (en) * | 2003-05-06 | 2004-11-25 | Syntonix Pharmaceuticals, Inc. | Inhibition of drug binding to serum albumin |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
US8383132B2 (en) * | 2003-10-16 | 2013-02-26 | The Regents Of The University Of California | Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use |
EP2385069A3 (de) | 2003-11-12 | 2012-05-30 | Biogen Idec MA Inc. | Neonataler Fc-Rezeptor (FcRn)-bindende Polypeptidvarianten, dimere Fc-Bindungsproteine und damit in Zusammenhang stehende Verfahren |
EP2256134B1 (de) * | 2003-11-13 | 2014-01-08 | Hanmi Science Co., Ltd. | IgG-Fc-Fragment für einen Arzneimittelträger und Verfahren zu dessen Herstellung |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
BRPI0418286A (pt) | 2003-12-30 | 2007-05-02 | Merck Patent Gmbh | proteìnas de fusão de il-7 |
CA2551916C (en) * | 2003-12-31 | 2014-04-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Fc-erythropoietin fusion protein with improved pharmacokinetics |
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CA2553883C (en) | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
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BRPI0511196A (pt) | 2004-05-19 | 2007-12-04 | Maxygen Inc | polipeptìdeo isolado ou recombinante, conjugado, composição, célula hospedeira, vetor, métodos para preparar um polipeptìdeo, para preparar um conjugado, para reduzir o número de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna hcv, dna hbv e rna hiv no soro de um paciente infectado com hcv, hbv e hiv, e, uso do polipeptìdeo, do conjugado ou da composição |
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- 2000-05-19 EP EP00932622A patent/EP1187852B1/de not_active Expired - Lifetime
- 2000-05-19 DE DE60035871T patent/DE60035871T2/de not_active Expired - Lifetime
- 2000-05-19 WO PCT/US2000/013827 patent/WO2000069913A1/en active IP Right Grant
- 2000-05-19 CA CA2372400A patent/CA2372400C/en not_active Expired - Lifetime
- 2000-05-19 PL PL00352332A patent/PL352332A1/xx unknown
- 2000-05-19 AT AT00932622T patent/ATE369384T1/de active
- 2000-05-19 JP JP2000618329A patent/JP2003530070A/ja active Pending
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- 2000-05-19 DK DK00932622T patent/DK1187852T3/da active
- 2000-05-19 CN CN00810671A patent/CN1361793A/zh active Pending
- 2000-05-19 AU AU50318/00A patent/AU777963B2/en not_active Expired
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- 2000-05-19 HU HU0201474A patent/HUP0201474A3/hu unknown
- 2000-05-19 CZ CZ20014123A patent/CZ20014123A3/cs unknown
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Also Published As
Publication number | Publication date |
---|---|
HK1046694A1 (zh) | 2003-01-24 |
NO20015587D0 (no) | 2001-11-15 |
AU777963B2 (en) | 2004-11-04 |
PT1187852E (pt) | 2007-11-14 |
JP2003530070A (ja) | 2003-10-14 |
ATE369384T1 (de) | 2007-08-15 |
ZA200109227B (en) | 2003-02-03 |
HUP0201474A2 (en) | 2002-08-28 |
US20050042729A1 (en) | 2005-02-24 |
ES2291205T3 (es) | 2008-03-01 |
WO2000069913A1 (en) | 2000-11-23 |
DK1187852T3 (da) | 2007-11-26 |
HUP0201474A3 (en) | 2002-11-28 |
AU5031800A (en) | 2000-12-05 |
CZ20014123A3 (cs) | 2002-06-12 |
RU2262510C2 (ru) | 2005-10-20 |
MXPA01011845A (es) | 2002-06-21 |
US20020081664A1 (en) | 2002-06-27 |
EP1187852A1 (de) | 2002-03-20 |
BR0010725A (pt) | 2002-02-19 |
KR20020018197A (ko) | 2002-03-07 |
EP1187852B1 (de) | 2007-08-08 |
DE60035871T2 (de) | 2008-06-05 |
PL352332A1 (en) | 2003-08-11 |
NO20015587L (no) | 2002-01-16 |
CA2372400A1 (en) | 2000-11-23 |
RU2262510C9 (ru) | 2006-04-20 |
CA2372400C (en) | 2010-04-27 |
CN1361793A (zh) | 2002-07-31 |
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