DE60033653D1 - Nachweisverfahren unter verwendung eines mikromechanischen antikörpersensors - Google Patents

Nachweisverfahren unter verwendung eines mikromechanischen antikörpersensors

Info

Publication number
DE60033653D1
DE60033653D1 DE60033653T DE60033653T DE60033653D1 DE 60033653 D1 DE60033653 D1 DE 60033653D1 DE 60033653 T DE60033653 T DE 60033653T DE 60033653 T DE60033653 T DE 60033653T DE 60033653 D1 DE60033653 D1 DE 60033653D1
Authority
DE
Germany
Prior art keywords
approximately
mum
micromechanical
detection method
deflections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60033653T
Other languages
English (en)
Other versions
DE60033653T2 (de
Inventor
Thomas G Thundat
K Bruce Jacobson
Mitchel J Doktycz
Stephen J Kennel
Robert J Warmack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UT Battelle LLC
Original Assignee
UT Battelle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UT Battelle LLC filed Critical UT Battelle LLC
Publication of DE60033653D1 publication Critical patent/DE60033653D1/de
Application granted granted Critical
Publication of DE60033653T2 publication Critical patent/DE60033653T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
DE60033653T 1999-03-30 2000-03-29 Nachweisverfahren unter verwendung eines mikromechanischen antikörpersensors Expired - Fee Related DE60033653T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US281032 1999-03-30
US09/281,032 US6289717B1 (en) 1999-03-30 1999-03-30 Micromechanical antibody sensor
PCT/US2000/008256 WO2000058729A2 (en) 1999-03-30 2000-03-29 Micromechanical antibody sensor

Publications (2)

Publication Number Publication Date
DE60033653D1 true DE60033653D1 (de) 2007-04-12
DE60033653T2 DE60033653T2 (de) 2007-11-15

Family

ID=23075680

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60033653T Expired - Fee Related DE60033653T2 (de) 1999-03-30 2000-03-29 Nachweisverfahren unter verwendung eines mikromechanischen antikörpersensors

Country Status (6)

Country Link
US (1) US6289717B1 (de)
EP (1) EP1185865B1 (de)
AT (1) ATE355523T1 (de)
AU (1) AU3928100A (de)
DE (1) DE60033653T2 (de)
WO (1) WO2000058729A2 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9819319D0 (en) * 1998-09-05 1998-10-28 Aea Technology Plc Assay of chemical binding
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
WO2001014823A1 (en) * 1999-08-19 2001-03-01 The Regents Of The University Of California Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
DE60012962T2 (de) * 1999-11-03 2005-08-11 International Business Machines Corp. Sensoren und wandler mit freitragendem ausleger
US6523392B2 (en) * 2000-01-25 2003-02-25 Arizona Board Of Regents Microcantilever sensor
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
CA2417939A1 (en) * 2000-08-09 2002-02-14 California Institute Of Technology Active nems arrays for biochemical analyses
US7375321B2 (en) 2000-08-09 2008-05-20 California Institute Of Technology Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
CN1261745C (zh) * 2000-08-15 2006-06-28 拜澳富斯毫微科学有限公司 纳米级分子阵列排布机
JP3357914B2 (ja) * 2000-08-30 2002-12-16 独立行政法人産業技術総合研究所 溶液中の低分子化合物の検出方法
US20020115198A1 (en) * 2000-09-20 2002-08-22 Nerenberg Michael I. Microfabricated ultrasound array for use as resonant sensors
EP1202046A1 (de) * 2000-10-25 2002-05-02 Abb Research Ltd. Verfahren und Sensor zur Bestimmung biologischer Spezies
AU2002329606A1 (en) * 2001-07-17 2003-03-03 Bioforce Nanosciences, Inc. Combined molecular blinding detection through force microscopy and mass spectrometry
US20030062193A1 (en) * 2001-09-07 2003-04-03 Jacob Thaysen Flexible structure with integrated sensor/actuator
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
AU2002350427A1 (en) * 2001-11-19 2003-06-10 Cantion A/S Sensor system with a reference surface mimicking the detection surface but with low ligand binding capacity
US6671631B2 (en) 2002-01-04 2003-12-30 General Electric Company Systems and methods for analyzing viscoelastic properties of combinatorial libraries of materials
EP1467948A1 (de) * 2002-01-24 2004-10-20 Cantion A/S Sensor
AU2003206679A1 (en) * 2002-02-08 2003-09-02 Cantion A/S Scion.Dtu A sensor comprising mechanical amplification of surface stress sensitive cantilever
DE10209245B4 (de) * 2002-03-04 2005-12-22 Concentris Gmbh Vorrichtung und Verfahren zur Detektion von Mikroorganismen
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US7395693B2 (en) * 2004-12-02 2008-07-08 The Arizona Board of Regents, a body corporate of the state of Arizona acting for Northern Arizona University Embedded piezoelectric microcantilever sensors
CN100565198C (zh) * 2002-06-03 2009-12-02 北亚利桑那大学董事会 混合微悬臂传感器
AU2003232165A1 (en) * 2002-06-07 2003-12-22 Cantion A/S A cantilever sensor with a current shield and a method for its production
US8524488B2 (en) * 2002-09-10 2013-09-03 The Regents Of The University Of California Methods and devices for determining a cell characteristic, and applications employing the same
WO2004029625A2 (en) 2002-09-24 2004-04-08 Intel Corporation Detecting molecular binding by monitoring feedback controlled cantilever deflections
US7270952B2 (en) 2002-09-24 2007-09-18 Intel Corporation Detecting molecular binding by monitoring feedback controlled cantilever deflections
AU2003287182A1 (en) * 2002-10-21 2004-05-13 Alegis Microsystems Nanomotion sensing system and method
US20040152211A1 (en) * 2002-11-15 2004-08-05 The Regents Of The University Of California System and method for multiplexed biomolecular analysis
US7344678B2 (en) * 2002-11-15 2008-03-18 The Regents Of The University Of California Composite sensor membrane
CN1745179A (zh) * 2003-01-02 2006-03-08 拜澳富斯毫微科学有限公司 在小样品体积中分子分析的方法和装置
WO2004067130A2 (de) * 2003-01-26 2004-08-12 Eberhard-Karls-Universität Tübingen Univer Sität Sklinikum Verfahren zum separieren und nachweisen von zumindest einem analyten in biologischen matrizes
US7521257B2 (en) * 2003-02-11 2009-04-21 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno Chemical sensor with oscillating cantilevered probe and mechanical stop
US7260980B2 (en) 2003-03-11 2007-08-28 Adams Jesse D Liquid cell and passivated probe for atomic force microscopy and chemical sensing
JP4758342B2 (ja) * 2003-06-03 2011-08-24 キャンティマー インコーポレイテッド 相変化センサー
US6763705B1 (en) 2003-06-16 2004-07-20 Ut-Battelle, Llc High throughput microcantilever detector
AU2004276725A1 (en) * 2003-06-27 2005-04-07 Purdue Research Foundation Device for detecting biological and chemical particles
BRPI0413294B1 (pt) 2003-08-06 2019-01-02 Bridger Tech Inc dispositivo, método e sistema
TWI256473B (en) * 2003-08-27 2006-06-11 Ind Tech Res Inst Biosensor and method for bone mineral density measurement
DE10342331A1 (de) * 2003-09-11 2005-05-04 Surface Imaging Systems S I S Verfahren sowie Messvorrichtung zum Messen der Positionsänderung eines beweglichen Messcantilevers
US20060257286A1 (en) * 2003-10-17 2006-11-16 Adams Jesse D Self-sensing array of microcantilevers for chemical detection
WO2005043126A2 (en) * 2003-10-27 2005-05-12 Drexel University Piezoelectric cantilever sensors
US6978656B2 (en) * 2003-10-31 2005-12-27 Hewlett-Packard Development Company, L.P. Transducer-based sensor system and method
US20090246889A1 (en) * 2003-11-22 2009-10-01 Samsung Electronics Co., Ltd. Substrate having oxide layer, method for detecting target material using the substrate, and optical sensor including the substrate
KR100580631B1 (ko) * 2003-11-22 2006-05-16 삼성전자주식회사 산화막을 갖는 기판, 그를 이용한 표적 물질 검출 방법 및광학적 센서
EP1728065A1 (de) * 2003-11-28 2006-12-06 Lumiscence A/S Untersuchungssystem zur untersuchung eines präparats; untereinheiten und einheiten dafür, sensor und mikroskop
US7531002B2 (en) * 2004-04-16 2009-05-12 Depuy Spine, Inc. Intervertebral disc with monitoring and adjusting capabilities
US20050255448A1 (en) * 2004-05-13 2005-11-17 Arun Majumdar System for amplifying optical detection of cantilever deflection
US7497133B2 (en) 2004-05-24 2009-03-03 Drexel University All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement
US20050262943A1 (en) * 2004-05-27 2005-12-01 Glenn Claydon Apparatus, methods, and systems to detect an analyte based on changes in a resonant frequency of a spring element
US7217428B2 (en) * 2004-05-28 2007-05-15 Technology Innovations Llc Drug delivery apparatus utilizing cantilever
JP2006039260A (ja) * 2004-07-28 2006-02-09 Sii Nanotechnology Inc 原子間力顕微鏡を用いたフォトマスクのパーティクル除去方法
US7673517B2 (en) 2005-11-10 2010-03-09 The United States Of America As Represented By The Secretary Of The Navy System and method for optical interrogation of micro-mechanical sensors using microcavity interferometry
KR100583233B1 (ko) * 2004-09-16 2006-05-26 한국과학기술연구원 생체물질 측정 시스템 및 방법
US20060059984A1 (en) * 2004-09-23 2006-03-23 Doktycz Mitchel J Coupled spring system for measuring molecular forces
DE102004046685B3 (de) * 2004-09-24 2006-06-29 Concentris Gmbh Messzelle und Verfahren für die Flüssigkeitsanalyse
WO2006039506A2 (en) 2004-10-01 2006-04-13 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Cantilevered probe detector with piezoelectric element
JP2006153831A (ja) * 2004-10-27 2006-06-15 Mitsubishi Chemicals Corp カンチレバーセンサ、センサシステム及び検体液中の検出対象物質の検出方法
DE102004053261A1 (de) * 2004-11-04 2006-05-11 Robert Bosch Gmbh Mikromechanischer Sensor zur chemischen Analyse
US7280078B2 (en) 2004-11-20 2007-10-09 Scenterra, Inc. Sensor for detecting high frequency signals
JP2008522492A (ja) * 2004-11-20 2008-06-26 センテラ インコーポレイテッド 高周波信号放出装置
EP1674865B1 (de) * 2004-12-22 2008-01-23 C.R.F. Società Consortile per Azioni Miniaturisierter Sensor zur Erfassung von Eigenschaften einer Flüssigkeit, insbesondere eines Schmieröls
EP1850803B1 (de) 2005-02-18 2014-03-26 Zimmer, Inc. Gelenkimplantat mit smart sensors
JP4514639B2 (ja) * 2005-03-31 2010-07-28 国立大学法人群馬大学 カンチレバー型センサ
EP1913393A4 (de) * 2005-06-16 2010-03-03 Univ California Paralleler allergietest auf immunbasis im grossmassstab und vorrichtung zur fluoreszenzanregung mit evaneszenzfeld
US7313945B2 (en) * 2005-10-31 2008-01-01 Hewlett-Packard Development Company, L.P. Cantilevers for sensing fluid properties
US7429125B2 (en) * 2005-11-09 2008-09-30 Hewlett-Packard Development Company, L.P. System and method for cantilever based calorimetric analysis
US20070127164A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Nanoscale Sensor
US8171795B1 (en) * 2006-01-23 2012-05-08 Drexel University Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air
EP1977224B1 (de) * 2006-01-23 2013-04-03 Drexel University Selbsterregender und selbstmessender piezoelektrischer Cantilever-Sensor
US7691130B2 (en) * 2006-01-27 2010-04-06 Warsaw Orthopedic, Inc. Spinal implants including a sensor and methods of use
US20080011058A1 (en) * 2006-03-20 2008-01-17 The Regents Of The University Of California Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels
US7709264B2 (en) * 2006-09-21 2010-05-04 Philip Morris Usa Inc. Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines
US8481335B2 (en) * 2006-11-27 2013-07-09 Drexel University Specificity and sensitivity enhancement in cantilever sensing
US7992431B2 (en) 2006-11-28 2011-08-09 Drexel University Piezoelectric microcantilevers and uses in atomic force microscopy
WO2008067386A2 (en) 2006-11-28 2008-06-05 Drexel University Piezoelectric microcantilever sensors for biosensing
US20080160638A1 (en) * 2006-12-27 2008-07-03 David Lederman Functionalized Microcantilever Sensor and Associated Method For Detection of Targeted Analytes
EP2104847A4 (de) * 2007-01-05 2013-01-09 Innovative American Technology Verbesserte kalorimetrische spektroskopie für nutzanwendungen
CA2677196A1 (en) * 2007-02-01 2008-09-12 Drexel University A hand-held phase-shift detector for sensor applications
US8168120B1 (en) 2007-03-06 2012-05-01 The Research Foundation Of State University Of New York Reliable switch that is triggered by the detection of a specific gas or substance
US8191403B2 (en) * 2007-03-27 2012-06-05 Richmond Chemical Corporation Petroleum viscosity measurement and communication system and method
US8241569B2 (en) * 2007-11-23 2012-08-14 Drexel University Lead-free piezoelectric ceramic films and a method for making thereof
US8551407B2 (en) * 2007-11-29 2013-10-08 Michigan Technological University Bacteriorhodopsin-based sensors
WO2009126378A2 (en) 2008-03-11 2009-10-15 Drexel University Enhanced detection sensitivity with piezoelectric microcantilever sensors
AU2009246115A1 (en) 2008-05-16 2009-11-19 Drexel University System and method for evaluating tissue
US8459123B2 (en) * 2008-06-19 2013-06-11 The United States Of America, As Represented By The Secretary Of The Navy Micromechanical chemical sensors with multiple chemoselective resonant elements and frequency division multiplexed readout
US20110212511A1 (en) * 2008-11-11 2011-09-01 Korea Institute Of Science And Technology System for detecting biomolecule with high sensitivity using micro-cantilever
CN102356315A (zh) * 2009-03-20 2012-02-15 安塔纳公司 含有在其表面固定的细胞的质量敏感性传感器及利用所述传感器检测配体结合的方法
US8722427B2 (en) * 2009-10-08 2014-05-13 Drexel University Determination of dissociation constants using piezoelectric microcantilevers
US20110086368A1 (en) * 2009-10-08 2011-04-14 Drexel University Method for immune response detection
US20120220486A1 (en) * 2009-11-01 2012-08-30 Caerus Molecular Diagnostics Incorporated Methods and apparatus for binding assays
KR101118474B1 (ko) * 2009-12-15 2012-03-13 한국전기연구원 광간섭을 이용한 생화학 물질 검출 장치
US9562888B2 (en) 2010-03-31 2017-02-07 Cornell University Stress-based sensor, method, and applications
US9222867B2 (en) 2011-01-05 2015-12-29 Brian L. Norling Resonant micromachined biochemical sensor
PL2766722T3 (pl) 2011-10-14 2019-07-31 École Polytechnique Fédérale De Lausanne (Epfl) Nanoskalowy detektor ruchu
US8740209B2 (en) * 2012-02-22 2014-06-03 Expresslo Llc Method and apparatus for ex-situ lift-out specimen preparation
WO2014003709A1 (en) * 2012-06-25 2014-01-03 Empire Technology Development Llc Ultrasound based antigen binding detection
KR101583470B1 (ko) 2014-03-05 2016-01-12 한국과학기술연구원 슬릿을 갖는 캔틸레버 센서 및 이를 포함하는 바이오 센서
EP2955507A1 (de) 2014-06-12 2015-12-16 Danmarks Tekniske Universitet Substrat, Vorrichtung und Verfahren zur Bestimmung der Anwesenheit eines Moleküls
CN105486243B (zh) * 2015-12-24 2018-05-11 成都上甲光电科技有限公司 基于可见光成像技术的桥梁挠度监测系统
US10191036B1 (en) 2018-03-22 2019-01-29 NUB4U, Inc. System for detecting and removing biological analytes in fluids
DE102020107918B4 (de) * 2020-03-23 2021-11-18 Digital Diagnostics AG Detektion von viren
CN114371124B (zh) * 2022-01-14 2024-01-12 安徽理工大学 一种基于微悬臂梁的液滴附着力检测系统

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242096A (en) 1977-11-14 1980-12-30 Minnesota Mining And Manufacturing Company Immunoassay for antigens
US4236893A (en) 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
US4637987A (en) 1984-05-07 1987-01-20 Gould Inc. Gas monitoring device and method
US4596697A (en) 1984-09-04 1986-06-24 The United States Of America As Represented By The Secretary Of The Army Chemical sensor matrix
US4735906A (en) 1984-11-28 1988-04-05 Texas A&M University Sensor having piezoelectric crystal for microgravimetric immunoassays
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
JPH063448B2 (ja) 1987-03-31 1994-01-12 日本光電工業株式会社 抗原抗体反応検出方法及びその装置
US4847193A (en) 1987-06-18 1989-07-11 Gene-Trak Systems Signal amplification in an assay employing a piezoelectric oscillator
US4906840A (en) 1988-01-27 1990-03-06 The Board Of Trustees Of Leland Stanford Jr., University Integrated scanning tunneling microscope
US4999284A (en) 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
US5501986A (en) 1988-04-06 1996-03-26 E. I. Du Pont De Nemours And Company Piezoelectric specific binding assay with mass amplified reagents
US4905701A (en) 1988-06-15 1990-03-06 National Research Development Corporation Apparatus and method for detecting small changes in attached mass of piezoelectric devices used as sensors
US5306644A (en) 1988-09-29 1994-04-26 Hewlett-Packard Company Mass sensor method for measuring analytes in a sample
US5130257A (en) 1988-09-29 1992-07-14 Hewlett-Packard Company Chemical sensor utilizing a surface transverse wave device
US5283037A (en) 1988-09-29 1994-02-01 Hewlett-Packard Company Chemical sensor utilizing a surface transverse wave device
US5221415A (en) 1989-01-17 1993-06-22 Board Of Trustees Of The Leland Stanford Junior University Method of forming microfabricated cantilever stylus with integrated pyramidal tip
US5135852A (en) 1989-07-25 1992-08-04 E. I. Du Pont De Nemours And Company Piezoelectric cell growth biosensing method using polymer-metabolic product complex interactions
CA2024548C (en) 1989-09-05 2002-05-28 David Issachar Analyte specific chemical sensor
CA2066643A1 (en) 1989-10-04 1991-04-05 Richard Calvin Ebersole Assay method for biological target complexes on the surface of a biosensor
US5179028A (en) 1990-04-20 1993-01-12 Hughes Aircraft Company Antibody coated crystal chemical sensor
US5445971A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
EP0587408A1 (de) 1992-09-07 1994-03-16 Terumo Kabushiki Kaisha Methode zur Bestimmung von DNS und Sensor hierfür
US5339675A (en) 1992-10-08 1994-08-23 Millipore Corporation Apparatus for monitoring impurities in a gas stream
USRE35544E (en) 1992-10-08 1997-07-01 Millipore Corporation Apparatus for monitoring moisture in a gas stream
DE4334834A1 (de) 1993-10-13 1995-04-20 Andrzej Dr Ing Grzegorzewski Biosensor zum Messen von Viskositäts- und/oder Dichteänderungen
WO1994028372A1 (en) 1993-05-25 1994-12-08 Rosemount Inc. Organic chemical sensor
US5323636A (en) 1993-06-11 1994-06-28 The United States Of America As Represented By The Secretary Of The Army Dual-channel flexural acoustic wave chemical sensor
EP0711410B1 (de) * 1993-07-06 1997-03-26 International Business Machines Corporation Kalorimetrischer sensor
US5445008A (en) 1994-03-24 1995-08-29 Martin Marietta Energy Systems, Inc. Microbar sensor
US5705399A (en) 1994-05-20 1998-01-06 The Cooper Union For Advancement Of Science And Art Sensor and method for detecting predetermined chemical species in solution
US5719324A (en) 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
GB9522101D0 (en) 1995-10-28 1996-07-17 Aigis Ltd Blast attenuation
AU7016896A (en) * 1995-10-30 1997-05-22 Trustees Of Boston University Piezoelectric force sensing apparatus and methods for biopolymer sequencing
WO1998050773A2 (en) 1997-05-08 1998-11-12 University Of Minnesota Microcantilever biosensor
US6096559A (en) * 1998-03-16 2000-08-01 Lockheed Martin Energy Research Corporation Micromechanical calorimetric sensor
US6016686A (en) * 1998-03-16 2000-01-25 Lockheed Martin Energy Research Corporation Micromechanical potentiometric sensors

Also Published As

Publication number Publication date
ATE355523T1 (de) 2006-03-15
EP1185865B1 (de) 2007-02-28
WO2000058729A2 (en) 2000-10-05
AU3928100A (en) 2000-10-16
DE60033653T2 (de) 2007-11-15
WO2000058729B1 (en) 2001-10-18
US6289717B1 (en) 2001-09-18
WO2000058729A3 (en) 2001-05-17
EP1185865A2 (de) 2002-03-13

Similar Documents

Publication Publication Date Title
DE60033653D1 (de) Nachweisverfahren unter verwendung eines mikromechanischen antikörpersensors
US6167748B1 (en) Capacitively readout multi-element sensor array with common-mode cancellation
US5413939A (en) Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
Lang et al. A chemical sensor based on amicromechanical cantilever array for the identification of gases and vapors
Actis et al. Ultrasensitive mycotoxin detection by STING sensors
Suri et al. Label-free ultra-sensitive detection of atrazine based on nanomechanics
US20020137084A1 (en) Method for detecting chemical interactions between naturally occurring biological analyte molecules
NO20001326L (no) Kapasitets-affinitetssensor
ATE346297T1 (de) Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen
Li et al. A micro-machined optical fiber cantilever as a miniaturized pH sensor
CN101341388A (zh) 包括悬臂的光学装置及其制造和使用方法
Okan et al. Functional polymeric nanoparticle decorated microcantilever sensor for specific detection of erythromycin
Kooser et al. Investigation of the antigen antibody reaction between anti-bovine serum albumin (a-BSA) and bovine serum albumin (BSA) using piezoresistive microcantilever based sensors
Wang et al. A new device for liver cancer biomarker detection with high accuracy
Otto Biophysical approaches to study the dynamic process of bacterial adhesion
Kang et al. Label-free protein assay with site-directly immobilized antibody using self-actuating PZT cantilever
Nuryadi et al. Resonance frequency change in microcantilever-based sensor due to humidity variation
Tseng et al. 3, 4-Methylenedioxymethylamphetamine detection using a microcantilever-based biosensor
Choi et al. Label-free attomolar protein detection using a MEMS optical interferometric surface-stress immunosensor with a freestanding PMMA/parylene-C nanosheet
Samorì et al. STM and AFM Studies on (bio) molecular Systems: Unravelling the Nanoworld
Li et al. Label-free ferrule-top optical fiber micro-cantilever biosensor
Bache et al. Investigations on antibody binding to a micro-cantilever coated with a BAM pesticide residue
Morozov et al. Mechanical detection of interaction of small specific ligands with proteins and DNA in cross-linked samples
WO2014168924A1 (en) A novel sensor system utilizing piezoelectric microcantilever coupled with resonating circuit
US6124103A (en) Arrangement and method of examining hydrophilic macromolecules in an aqueous solution

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee