DE60026561D1 - Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen - Google Patents

Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen

Info

Publication number
DE60026561D1
DE60026561D1 DE60026561T DE60026561T DE60026561D1 DE 60026561 D1 DE60026561 D1 DE 60026561D1 DE 60026561 T DE60026561 T DE 60026561T DE 60026561 T DE60026561 T DE 60026561T DE 60026561 D1 DE60026561 D1 DE 60026561D1
Authority
DE
Germany
Prior art keywords
treatment
suppressor
transplantations
prevention
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026561T
Other languages
English (en)
Other versions
DE60026561T2 (de
Inventor
Kevin Mcintosh
Elena Klushnenkova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osiris Therapeutics Inc
Original Assignee
Osiris Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osiris Therapeutics Inc filed Critical Osiris Therapeutics Inc
Application granted granted Critical
Publication of DE60026561D1 publication Critical patent/DE60026561D1/de
Publication of DE60026561T2 publication Critical patent/DE60026561T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46434—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
DE60026561T 1999-10-12 2000-10-10 Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen Expired - Lifetime DE60026561T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US415627 1999-10-12
US09/415,627 US6685936B2 (en) 1999-10-12 1999-10-12 Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
PCT/US2000/028011 WO2001026470A1 (en) 1999-10-12 2000-10-10 Suppressor cells for prevention and treatment of immune responses in transplantation

Publications (2)

Publication Number Publication Date
DE60026561D1 true DE60026561D1 (de) 2006-05-04
DE60026561T2 DE60026561T2 (de) 2007-03-15

Family

ID=23646488

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026561T Expired - Lifetime DE60026561T2 (de) 1999-10-12 2000-10-10 Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen

Country Status (12)

Country Link
US (2) US6685936B2 (de)
EP (1) EP1220611B1 (de)
JP (1) JP2003511398A (de)
AT (1) ATE319312T1 (de)
AU (1) AU775647B2 (de)
CA (1) CA2382737A1 (de)
CY (1) CY1106437T1 (de)
DE (1) DE60026561T2 (de)
DK (1) DK1220611T3 (de)
ES (1) ES2261250T3 (de)
PT (1) PT1220611E (de)
WO (1) WO2001026470A1 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6368636B1 (en) * 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US8147824B2 (en) 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
WO2001077299A2 (en) * 2000-04-11 2001-10-18 University Of Southern California A METHOD TO PREVENT GRAFT REJECTION USING TGF-β TO INDUCE T SUPPRESSOR CELLS
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
IL156303A0 (en) 2000-12-06 2004-01-04 Robert J Hariri Method of collecting placental stem cells
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP1362095B1 (de) * 2001-02-14 2015-05-27 Anthrogenesis Corporation Post-partum säugetier-plazenta, deren verwendung und daraus gewonnene stammzellen
KR101132545B1 (ko) * 2001-02-14 2012-04-02 안트로제네시스 코포레이션 산후 포유류의 태반, 이의 용도 및 태반 줄기세포
EP1487463A2 (de) * 2002-03-02 2004-12-22 Board Of Regents The University Of Texas System Lokale produktion und/oder abgabe von anti-krebsmitteln durch vorläufer von stromazellen
WO2004047770A2 (en) * 2002-11-26 2004-06-10 Anthrogenesis Corporation Cytotherapeutics, cytotherapeutic units and methods for treatments using them
KR20050105467A (ko) * 2003-02-13 2005-11-04 안트로제네시스 코포레이션 질병, 장애 또는 증상을 보유하는 개체의 치료에 있어서제대혈의 용도
WO2004090112A2 (en) * 2003-04-01 2004-10-21 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
GB0321337D0 (en) * 2003-09-11 2003-10-15 Massone Mobile Advertising Sys Method and system for distributing advertisements
WO2005055929A2 (en) * 2003-12-02 2005-06-23 Celgene Corporation Methods and compositions for the treatment and management of hemoglobinopathy and anemia
EP2824174B1 (de) 2004-03-22 2018-11-28 Mesoblast International Sàrl Mesenchymale stammzellen und verwendungen dafür
EP1799236B1 (de) * 2004-09-10 2012-05-23 Cognate Therapeutics, Inc. Leberstromazellen zur prävention und behandlung von immunantworten bei der transplantation
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
CA2512667A1 (en) * 2005-01-07 2006-07-07 Takahiro Ochiya Human hepatocyte-like cells and uses thereof
EP1880002A4 (de) * 2005-05-10 2009-03-11 Us Health Therapie von nierenkrankheiten und mehrfachem organversagen mit mesenchymalen stammzellen und durch mesenchymale stammzellen konditionierte medien
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
AU2006255183B2 (en) * 2005-06-08 2012-02-02 Centocor, Inc. A cellular therapy for ocular degeneration
EP2530145A1 (de) 2005-10-13 2012-12-05 Anthrogenesis Corporation Immunmodulation unter Verwendung von Plazenta-Stammzellen
US11000546B2 (en) 2005-11-09 2021-05-11 Athersys, Inc. Immunomodulatory properties of MAPCs and uses thereof
US10117900B2 (en) 2005-11-09 2018-11-06 Athersys, Inc. MAPC treatment of brain injuries and diseases
US20070122448A1 (en) * 2005-11-28 2007-05-31 Alireza Rezania Compositions and methods to create a vascularized environment for cellular transplantation
EP1976978A2 (de) 2005-12-29 2008-10-08 Anthrogenesis Corporation Cokultur von plazentastammzellen und stammzellen anderen ursprungs
ES2549111T3 (es) 2005-12-29 2015-10-23 Anthrogenesis Corporation Poblaciones de células madre placentarias
NZ744465A (en) 2006-01-23 2023-04-28 Abt Holding Co Mapc therapeutics without adjunctive immunosuppressive treatment
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US20080044848A1 (en) * 2006-06-09 2008-02-21 Heidaran Mohammad A Placental niche and use thereof to culture stem cells
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
NZ606814A (en) 2006-10-23 2014-10-31 Anthrogenesis Corp Methods and compositions for treatment of bone defects with placental cell populations
NZ597779A (en) * 2007-02-12 2013-07-26 Anthrogenesis Corp Treatment of inflammatory diseases using placental stem cells
US20100172830A1 (en) * 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
EP2155860B1 (de) 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotente stammzellen und ihre verwendung
TWM322542U (en) * 2007-05-23 2007-11-21 Universal Scient Ind Co Ltd Testing machine
US9080145B2 (en) * 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2185693B1 (de) 2007-07-31 2019-07-03 Lifescan, Inc. Differenzierung menschlicher embryonaler stammzellen
CN101978045A (zh) * 2007-09-26 2011-02-16 细胞基因细胞疗法公司 来自人胎盘灌洗液的血管生成细胞
EP3524253A1 (de) 2007-09-28 2019-08-14 Celularity, Inc. Tumorsuppression mit menschlichem plazentaperfusat und menschlichen natürlichen killerzellen eines zwischenproduktes aus der plazenta
DK2205721T3 (en) 2007-10-17 2016-10-24 Txcell TR1 cells mesenchymal stem cells and uses thereof
KR20210056449A (ko) * 2007-11-07 2021-05-18 안트로제네시스 코포레이션 조산 합병증의 치료에 있어서의 제대혈의 용도
MX2010005805A (es) * 2007-11-27 2010-06-09 Lifescan Inc Diferenciacion de celulas madre embrionarias humanas.
CN105886459A (zh) 2008-02-21 2016-08-24 詹森生物科技公司 用于细胞粘附、培养和分离的方法、表面改性培养板和组合物
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
WO2009134429A2 (en) * 2008-05-02 2009-11-05 Massachusetts Institute Of Technology Methods and compositions for modulating immunological tolerance
ES2697798T3 (es) 2008-06-30 2019-01-28 Janssen Biotech Inc Diferenciación de células madre pluripotentes
CA2729734A1 (en) * 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
US20100028307A1 (en) * 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
KR20180108887A (ko) * 2008-08-20 2018-10-04 안트로제네시스 코포레이션 단리된 태반 세포를 사용한 뇌졸중 치료
EP3539380A3 (de) * 2008-08-20 2019-12-18 Celularity, Inc. Verbesserte zellzusammensetzung und verfahren zur herstellung davon
CA2734446C (en) * 2008-08-22 2017-06-20 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
EP2350265B1 (de) * 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differenzierung menschlicher embryonaler stammzellen in die pankreatisch-endokrine linie
CA2742268C (en) 2008-10-31 2020-02-18 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
RU2562154C2 (ru) * 2008-11-19 2015-09-10 Антродженезис Корпорейшн Амниотические адгезивные клетки
ES2584053T3 (es) * 2008-11-20 2016-09-23 Janssen Biotech, Inc. Métodos y composiciones para la unión de células y cultivo en sustratos planos
JP2012509085A (ja) 2008-11-20 2012-04-19 ヤンセン バイオテツク，インコーポレーテツド マイクロキャリア上での多能性幹細胞の培養
WO2010060031A1 (en) * 2008-11-21 2010-05-27 Anthrogenesis Corporation Treatment of diseases, disorders or conditions of the lung using placental cells
US9301975B2 (en) 2009-05-01 2016-04-05 Biocardia, Inc. Method of preparing autologous cells and method of use for therapy
CA2768644A1 (en) * 2009-07-20 2011-01-27 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
RU2540016C2 (ru) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека
MX348077B (es) 2009-07-20 2017-05-25 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas.
DK2456853T3 (da) * 2009-07-21 2021-02-01 Abt Holding Co Anvendelse af stamceller til reduktion af leukocyt-ekstravasation
MX350966B (es) * 2009-10-29 2017-09-26 Janssen Biotech Inc Celulas madre pluripotentes.
AU2010333840B2 (en) * 2009-12-23 2016-01-07 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
KR101867369B1 (ko) 2009-12-23 2018-06-14 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
ES2646750T3 (es) * 2010-01-26 2017-12-15 Anthrogenesis Corporation Tratamiento de cánceres relacionados con hueso utilizando células madre placentarias
KR20130025375A (ko) 2010-03-01 2013-03-11 얀센 바이오테크 인코포레이티드 만능 줄기 세포로부터 유래된 세포의 정제 방법
TWI578993B (zh) 2010-04-07 2017-04-21 安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
TW201138792A (en) 2010-04-08 2011-11-16 Anthrogenesis Corp Treatment of sarcoidosis using placental stem cells
CA3128483A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy
CA2800610C (en) 2010-05-12 2019-09-24 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
KR20130093091A (ko) 2010-07-13 2013-08-21 안트로제네시스 코포레이션 천연 킬러 세포의 생성 방법
CN103154237B (zh) 2010-08-31 2016-03-16 詹森生物科技公司 多能干细胞的分化
EP2853589B1 (de) 2010-08-31 2017-12-27 Janssen Biotech, Inc. Differenzierung menschlicher embryonaler Stammzellen
KR101851956B1 (ko) 2010-08-31 2018-04-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP2658557A1 (de) 2010-12-31 2013-11-06 Anthrogenesis Corporation Verbesserung der plazentastammzellenpotenz mit modulatorischen rna-molekülen
TWI602570B (zh) 2011-06-01 2017-10-21 安瑟吉納西斯公司 使用胎盤幹細胞之疼痛治療
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
BR112014015417A8 (pt) 2011-12-22 2017-07-04 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em células positivas de insulina hormonal únicas
KR20140131999A (ko) 2012-03-07 2014-11-14 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 증폭 및 유지를 위한 한정 배지
ES2897649T3 (es) 2012-06-08 2022-03-02 Janssen Biotech Inc Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas
SG10201709338RA (en) 2012-12-31 2017-12-28 Janssen Biotech Inc Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
CA2896658C (en) 2012-12-31 2021-06-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
MX2015008619A (es) 2012-12-31 2016-01-12 Janssen Biotech Inc Suspension y agrupamiento de celulas humanas pluripotentes para la diferenciacion a celulas endocrinas pancreaticas.
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
EP3622960A1 (de) 2013-02-05 2020-03-18 Celularity, Inc. Natürliche killerzellen aus plazenta
WO2014165581A1 (en) 2013-04-02 2014-10-09 New York University Gpr15-mediated homing and uses thereof
SG10201914136UA (en) 2013-04-12 2020-03-30 Saverio Lafrancesca Improving organs for transplantation
CN105992816B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
JP6783143B2 (ja) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド 培地の受動的補充
EP3954759A1 (de) 2014-05-16 2022-02-16 Janssen Biotech, Inc. Verwendung kleiner moleküle zur verstärkung der mafa-expression in endokrinen pankreaszellen
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US11795433B2 (en) * 2017-05-23 2023-10-24 Creative Medical Technologies, Inc Generation of autologous immune modulatory cells for treatment of neurological conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99864A (en) * 1990-10-31 2000-11-21 Autoimmune Inc Compositions for suppressing transplant rejection in mammals which contain tissue donor derived MHC antigens
US5733542A (en) * 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
DE69232427T2 (de) * 1991-11-05 2002-11-21 Univ Leland Stanford Junior Suppressorzellen
AU6816194A (en) * 1993-04-20 1994-11-08 Robinson, William S. Methods and materials for treatment of individuals infected with intracellular infectious agents
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
DK1066052T3 (da) * 1998-03-18 2006-06-12 Osiris Therapeutics Inc Mesenchymstamceller til forebyggelse og behandling af immunreaktioner ved transplantationer

Also Published As

Publication number Publication date
DK1220611T3 (da) 2006-07-10
ATE319312T1 (de) 2006-03-15
DE60026561T2 (de) 2007-03-15
US20020034504A1 (en) 2002-03-21
EP1220611A1 (de) 2002-07-10
AU775647B2 (en) 2004-08-12
JP2003511398A (ja) 2003-03-25
AU1077801A (en) 2001-04-23
US6685936B2 (en) 2004-02-03
PT1220611E (pt) 2006-07-31
US6281012B1 (en) 2001-08-28
EP1220611A4 (de) 2004-12-22
EP1220611B1 (de) 2006-03-08
WO2001026470A1 (en) 2001-04-19
CY1106437T1 (el) 2011-10-12
CA2382737A1 (en) 2001-04-19
ES2261250T3 (es) 2006-11-16

Similar Documents

Publication Publication Date Title
DE60026561D1 (de) Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen
DE69929681D1 (de) Mesenchymale stammzellen für die prävention und behandlung von immunantworten bei transplantationen
ATE482712T1 (de) Überstände von mesenchymstammzellen zur vorbeugung und behandlung von immunantworten in transplantationen
DK0987998T3 (da) Decellulering af væv
DE68918285D1 (de) Methode für behandlung von transplantaten vor transplantationen.
MXPA05008973A (es) Metodo de tratamiento de rechazo de trasplante de cornea.
WO2004011631A3 (en) Methods and compositions for treating tissue defects using pulsed electromagnetic field stimulus
NO20054912D0 (no) Behandling av aspergillus infeksjoner med tymosin alfa 1
DE69633393D1 (de) Mitteln zur behandlung von auto-immun krankheiten
ATE234614T1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
WO2004009029A3 (en) Compositions and methods for treating and preventing infection
TW200621986A (en) Liver stromal cells for prevention and treatment of immune responses in transplantation
ES2180345T3 (es) Nuevo procedimiento para la crio-conservacion de plantas.
ATE305785T1 (de) Cd45 hemmer
ATE165509T1 (de) Avermectine und milbemycine zur behandlung von parazitären infektionen beim hund
UA69988A (en) Method for treating complicated choledocholithiasis
UA6151U (en) Method for treating experimental burns
ATE419843T1 (de) Methode zur in vitro reduzierung von durch freie radikale induzierte schäden
RU2002117852A (ru) Способ лечения больных псориазом в сочетании с хроническим описторхозом
ATE253378T1 (de) Xenogene transplantation
UA37531A (uk) Спосіб хірургічного лікування глибоких опіків

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: DR. VOLKER VOSSIUS, CORINNA VOSSIUS, TILMAN VOSSIU