DE60025400D1 - Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays - Google Patents
Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarraysInfo
- Publication number
- DE60025400D1 DE60025400D1 DE60025400T DE60025400T DE60025400D1 DE 60025400 D1 DE60025400 D1 DE 60025400D1 DE 60025400 T DE60025400 T DE 60025400T DE 60025400 T DE60025400 T DE 60025400T DE 60025400 D1 DE60025400 D1 DE 60025400D1
- Authority
- DE
- Germany
- Prior art keywords
- fluorophore
- dilution
- detection system
- brightness
- microarray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US437039 | 1999-11-09 | ||
US09/437,039 US6471916B1 (en) | 1999-11-09 | 1999-11-09 | Apparatus and method for calibration of a microarray scanning system |
PCT/US2000/041170 WO2001035074A1 (en) | 1999-11-09 | 2000-10-12 | Apparatus and method for calibration of a microarray scanning system |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60025400D1 true DE60025400D1 (de) | 2006-03-30 |
DE60025400T2 DE60025400T2 (de) | 2006-08-31 |
Family
ID=23734812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60025400T Expired - Lifetime DE60025400T2 (de) | 1999-11-09 | 2000-10-12 | Vorrichtung und verfahren zum kalibrieren eines abtastsystems für mikroarrays |
Country Status (6)
Country | Link |
---|---|
US (1) | US6471916B1 (de) |
EP (1) | EP1228354B1 (de) |
AT (1) | ATE315222T1 (de) |
CA (1) | CA2390651A1 (de) |
DE (1) | DE60025400T2 (de) |
WO (1) | WO2001035074A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3469504B2 (ja) * | 1999-06-01 | 2003-11-25 | 日立ソフトウエアエンジニアリング株式会社 | マイクロアレイチップ及びそのインデックス方法 |
US7062092B2 (en) | 2000-08-22 | 2006-06-13 | Affymetrix, Inc. | System, method, and computer software product for gain adjustment in biological microarray scanner |
JP3596868B2 (ja) * | 2000-11-24 | 2004-12-02 | キヤノン株式会社 | 末端標識プローブアレイのプローブの量の評価方法、及び、該標識プローブアレイを用いた標的物質量の評価方法 |
JP3663125B2 (ja) * | 2000-11-28 | 2005-06-22 | 日立ソフトウエアエンジニアリング株式会社 | 蛍光読み取り方法及び蛍光読み取り装置 |
GB0102357D0 (en) * | 2001-01-30 | 2001-03-14 | Randox Lab Ltd | Imaging method |
JP3695340B2 (ja) * | 2001-03-30 | 2005-09-14 | 株式会社日立製作所 | Dna検査方法及びその装置並びに蛍光検出方法 |
AU2002245988A1 (en) * | 2001-04-18 | 2002-10-28 | Ulrich J. Krull | Gradient resolved hybridisation platform |
US6490533B2 (en) * | 2001-04-26 | 2002-12-03 | Affymetrix, Inc. | System, method, and product for dynamic noise reduction in scanning of biological materials |
WO2004010099A2 (en) * | 2001-05-16 | 2004-01-29 | Burstein Technologies, Inc. | Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly |
US6583424B2 (en) * | 2001-06-25 | 2003-06-24 | Agilent Technologies Inc. | Scanning system with calibrated detection and method |
US6673315B2 (en) | 2001-06-29 | 2004-01-06 | Biomachines, Inc. | Method and apparatus for accessing a site on a biological substrate |
US7115232B2 (en) * | 2001-07-13 | 2006-10-03 | Hudson Gordon S | Fluorescence validation microplate and method of use |
US6767733B1 (en) | 2001-10-10 | 2004-07-27 | Pritest, Inc. | Portable biosensor apparatus with controlled flow |
US6929951B2 (en) * | 2002-02-28 | 2005-08-16 | Agilent Technologies, Inc. | Method and system for molecular array scanner calibration |
US6870166B2 (en) * | 2002-02-28 | 2005-03-22 | Agilent Technologies, Inc. | Maximum sensitivity optical scanning system |
AU2003224012A1 (en) * | 2002-03-28 | 2003-10-13 | Deutsches Krebsforschungszentrum | Method and system for determining absolute mrna quantities |
US20040060987A1 (en) * | 2002-05-07 | 2004-04-01 | Green Larry R. | Digital image analysis method for enhanced and optimized signals in fluorophore detection |
US7354389B2 (en) * | 2002-05-28 | 2008-04-08 | Autogenomics, Inc. | Microarray detector and methods |
JP4628095B2 (ja) * | 2002-05-29 | 2011-02-09 | オウトジエノミクス・インコーポレーテツド | 統合されたマイクロアレイシステムおよびその製造方法 |
US7089123B2 (en) * | 2002-09-30 | 2006-08-08 | Agilent Technologies, Inc | Array scanner control system |
US7013220B2 (en) * | 2002-09-30 | 2006-03-14 | Agilent Technologies, Inc. | Biopolymer array scanner with real-time saturation detection |
US20040201844A1 (en) * | 2003-02-03 | 2004-10-14 | Affymetrix, Inc., A Corporation Organized Under The Laws Of Delaware | System, method and product for providing a stable calibration standard for optical systems |
US6970240B2 (en) * | 2003-03-10 | 2005-11-29 | Applera Corporation | Combination reader |
US20050030601A1 (en) * | 2003-06-12 | 2005-02-10 | Affymetrix, Inc. | System and method for scanner instrument calibration using a calibration standard |
SE0301897D0 (sv) * | 2003-06-27 | 2003-06-27 | Foss Tecator Ab | Referece standard and method for calibration |
US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
US20060024690A1 (en) * | 2003-09-19 | 2006-02-02 | Kao H P | Normalization of data using controls |
EP3246093A1 (de) | 2003-10-24 | 2017-11-22 | Aushon Biosystems, Inc. | Vorrichtung und verfahren zur ausgabe von flüssigen, halbflüssigen und festen proben |
DE102004022263A1 (de) * | 2004-05-06 | 2005-12-15 | Clondiag Chip Technologies Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
US7499166B2 (en) * | 2004-05-20 | 2009-03-03 | The Regents Of The University Of California | Wide field imager for quantitative analysis of microarrays |
US20050287040A1 (en) * | 2004-06-29 | 2005-12-29 | Molecular Devices Corporation | Fluorescence validation plate |
CN1280623C (zh) | 2004-07-16 | 2006-10-18 | 北京博奥生物芯片有限责任公司 | 一种用于荧光仪器校准测量的校准基片及其制备方法 |
US20060063274A1 (en) * | 2004-09-23 | 2006-03-23 | Schremp Donald J | Methods for manufacturing and using chemical array calibration devices |
DE102004047593A1 (de) * | 2004-09-30 | 2006-04-13 | Carl Zeiss Jena Gmbh | Referenzkörper für Fluoreszenzmessungen und Verfahren zur Herstellung desselben |
JP4577645B2 (ja) * | 2004-09-30 | 2010-11-10 | 横河電機株式会社 | スクリーニング装置 |
US8173367B2 (en) * | 2004-10-18 | 2012-05-08 | Sherri Boucher | In situ dilution of external controls for use in microarrays |
US8084260B2 (en) * | 2004-11-24 | 2011-12-27 | Applied Biosystems, Llc | Spectral calibration method and system for multiple instruments |
US7324202B2 (en) * | 2004-12-07 | 2008-01-29 | Novx Systems Inc. | Optical system |
WO2006102352A2 (en) * | 2005-03-22 | 2006-09-28 | Applera Corporation | Normalization of data using controls |
US20060264783A1 (en) | 2005-05-09 | 2006-11-23 | Holmes Elizabeth A | Systems and methods for monitoring pharmacological parameters |
US7858382B2 (en) * | 2005-05-27 | 2010-12-28 | Vidar Systems Corporation | Sensing apparatus having rotating optical assembly |
WO2006128322A1 (en) * | 2005-06-02 | 2006-12-07 | Capitalbio Corporation | High speed scanning platform for microarray scanner |
WO2006128321A1 (en) * | 2005-06-02 | 2006-12-07 | Capitalbio Corporation | Laser confocal microarray scanner |
CN101203790A (zh) * | 2005-06-03 | 2008-06-18 | 博奥生物有限公司 | 一种微阵列芯片激光扫描仪光学系统 |
DE102005036149B4 (de) * | 2005-07-28 | 2007-07-12 | Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. | Anordung für eine schnelle, räumlich und spektral auflösende Fluoreszenzanalyse von Biochips |
US7397042B2 (en) | 2005-08-24 | 2008-07-08 | Dr. Chip Biotechnology Incorporation | Optical detection apparatus and method thereof |
US7528374B2 (en) * | 2006-03-03 | 2009-05-05 | Vidar Systems Corporation | Sensing apparatus having optical assembly that collimates emitted light for detection |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
US20090047673A1 (en) | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
JP5172162B2 (ja) * | 2006-08-25 | 2013-03-27 | 株式会社日立ハイテクノロジーズ | 欠陥検査装置 |
US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
US20080113391A1 (en) | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
US20080178653A1 (en) * | 2007-01-29 | 2008-07-31 | Applera Corporation | System and Method for Interpolative Calibration |
WO2008096318A2 (en) * | 2007-02-09 | 2008-08-14 | Koninklijke Philips Electronics N.V. | Identification system |
KR101530943B1 (ko) * | 2007-04-04 | 2015-06-23 | 네트바이오, 인코포레이티드 | 통합된 핵산 분석 |
US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
AU2008308686B2 (en) | 2007-10-02 | 2015-01-22 | Labrador Diagnostics Llc | Modular point-of-care devices and uses thereof |
JP4389991B2 (ja) * | 2007-10-26 | 2009-12-24 | ソニー株式会社 | 微小粒子の光学的測定方法及び光学的測定装置 |
DE102007055386B4 (de) * | 2007-11-20 | 2015-07-16 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren zur Kalibrierung eines Sensorelements |
WO2009137059A1 (en) | 2008-05-05 | 2009-11-12 | Los Alamos National Security, Llc | Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control |
WO2009137055A1 (en) * | 2008-05-05 | 2009-11-12 | Los Alamos National Security, Llc | Nanocrystal-based lateral flow microarrays and low-voltage signal detection systems |
DE102008040513B4 (de) * | 2008-07-17 | 2010-08-26 | BAM Bundesanstalt für Materialforschung und -prüfung | Verwendung einer langwellig emittierenden Cyaninverbindung als NIR-Fluoreszenzstandard und Kit zur Kalibrierung von Photolumineszenzmesssystemen |
JP2010101835A (ja) * | 2008-10-27 | 2010-05-06 | Toshiba Corp | 蛍光基準部材、及び蛍光基準部材を備える蛍光検知装置 |
PT3299800T (pt) * | 2009-03-16 | 2020-03-04 | Alere Tech Gmbh | Dispositivo microfluídico |
WO2010147654A2 (en) | 2009-06-15 | 2010-12-23 | Netbio Inc. | Improved methods for forensic dna quantitation |
BR112012009196B1 (pt) | 2009-10-19 | 2021-03-30 | Labrador Diagnostics Llc | Sistema para modelar a progressão de uma doença dentro de uma população |
EP2612131B1 (de) * | 2010-09-01 | 2019-08-21 | Analogic Corporation | Verifizierung der kalibrierung eines optischen systems |
AR085087A1 (es) | 2011-01-21 | 2013-09-11 | Theranos Inc | Sistemas y metodos para maximizar el uso de muestras |
DE102011002080B4 (de) * | 2011-04-15 | 2016-05-04 | Lre Medical Gmbh | Vorrichtung und Verfahren zur Bestimmung der Konzentration von Fluorophoren in einer Probe |
PT2699698T (pt) | 2011-04-20 | 2017-04-11 | Mesa Biotech Inc | Reação de amplificação oscilante para ácidos nucleicos |
CA2835620C (en) | 2011-05-12 | 2021-02-23 | Netbio, Inc. | Methods and compositions for rapid multiplex amplification of str loci |
AU2013202804A1 (en) | 2012-06-14 | 2014-01-16 | Gen-Probe Incorporated | Use of a fluorescent material to detect failure or deteriorated performance of a fluorometer |
WO2014100626A1 (en) * | 2012-12-21 | 2014-06-26 | Hutman Diagnostics AG | Microarrays |
GB201321609D0 (en) | 2013-12-06 | 2014-01-22 | Starna Scient Ltd | PCR Validation Tubes |
DE102013021097A1 (de) * | 2013-12-18 | 2015-06-18 | Euroimmun Medizinische Labordiagnostika Ag | Kalibriernormal für eine Vorrichtung zur bildlichen Darstellung biologischen Materials |
US9233568B1 (en) | 2014-06-25 | 2016-01-12 | Xerox Corporation | Cross-process direction uniformity for wide format printers |
US10191194B2 (en) * | 2014-11-05 | 2019-01-29 | Rochester Institute Of Technology | Spectral target for macroscopic and microscopic reflectance imaging |
US20170284942A1 (en) * | 2016-03-31 | 2017-10-05 | Plexbio Co., Ltd. | Method for calibrating fluorescent plate readers |
CN115876735A (zh) * | 2017-04-13 | 2023-03-31 | 豪夫迈·罗氏有限公司 | 荧光图像中靶分子密度的确定 |
US20220026361A1 (en) * | 2018-12-18 | 2022-01-27 | Hewlett-Packard Development Company, L.P. | Ordered arrays of microdots |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH568564A5 (de) * | 1974-06-10 | 1975-10-31 | Killer W Dr Ag | |
US3973129A (en) * | 1975-01-10 | 1976-08-03 | Bell Telephone Laboratories, Incorporated | Fluorimetric apparatus and method for analysis of body fluid |
US5091652A (en) * | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
WO1996007888A1 (en) | 1994-09-02 | 1996-03-14 | Biometric Imaging, Inc. | Calibration method and apparatus for optical scanner |
US5585639A (en) * | 1995-07-27 | 1996-12-17 | Hewlett-Packard Company | Optical scanning apparatus |
US5742380A (en) * | 1996-12-31 | 1998-04-21 | Ronn Avigdor M | Plasma assay spectrometer |
US5798206A (en) * | 1997-01-10 | 1998-08-25 | New York Blood Center | Methods for screening of test compounds for inhibiting binding of a CD4-HIV 1 complex to a chemokine receptor |
US5838435A (en) | 1997-10-20 | 1998-11-17 | Sandia Corporation | Calibration method for spectroscopic systems |
US6078390A (en) * | 1998-05-04 | 2000-06-20 | General Scanning, Inc. | Scanning system and method of operation for automatically setting detection sensitivity |
US6245517B1 (en) * | 1998-09-29 | 2001-06-12 | The United States Of America As Represented By The Department Of Health And Human Services | Ratio-based decisions and the quantitative analysis of cDNA micro-array images |
US6251601B1 (en) * | 1999-02-02 | 2001-06-26 | Vysis, Inc. | Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays |
US6215894B1 (en) * | 1999-02-26 | 2001-04-10 | General Scanning, Incorporated | Automatic imaging and analysis of microarray biochips |
US6075613A (en) * | 1999-02-26 | 2000-06-13 | General Scanning, Inc. | Optical scanner calibration device |
-
1999
- 1999-11-09 US US09/437,039 patent/US6471916B1/en not_active Expired - Fee Related
-
2000
- 2000-10-12 DE DE60025400T patent/DE60025400T2/de not_active Expired - Lifetime
- 2000-10-12 WO PCT/US2000/041170 patent/WO2001035074A1/en active IP Right Grant
- 2000-10-12 EP EP00989657A patent/EP1228354B1/de not_active Expired - Lifetime
- 2000-10-12 AT AT00989657T patent/ATE315222T1/de not_active IP Right Cessation
- 2000-10-12 CA CA002390651A patent/CA2390651A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60025400T2 (de) | 2006-08-31 |
CA2390651A1 (en) | 2001-05-17 |
ATE315222T1 (de) | 2006-02-15 |
US6471916B1 (en) | 2002-10-29 |
EP1228354A1 (de) | 2002-08-07 |
WO2001035074A1 (en) | 2001-05-17 |
WO2001035074A9 (en) | 2002-08-01 |
EP1228354B1 (de) | 2006-01-04 |
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