DE60023943D1 - Antisense oligonucleotides zur inhibition der expression von type i procollagen - Google Patents
Antisense oligonucleotides zur inhibition der expression von type i procollagenInfo
- Publication number
- DE60023943D1 DE60023943D1 DE60023943T DE60023943T DE60023943D1 DE 60023943 D1 DE60023943 D1 DE 60023943D1 DE 60023943 T DE60023943 T DE 60023943T DE 60023943 T DE60023943 T DE 60023943T DE 60023943 D1 DE60023943 D1 DE 60023943D1
- Authority
- DE
- Germany
- Prior art keywords
- expression
- procollagen
- inhibition
- type
- antisense oligonucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9929487.8A GB9929487D0 (en) | 1999-12-15 | 1999-12-15 | Antisense oligonucleotides |
GB9929487 | 1999-12-15 | ||
PCT/GB2000/004741 WO2001044455A2 (en) | 1999-12-15 | 2000-12-12 | Antisense oligonucleotides for the inhibition of expression of type i procollagen |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60023943D1 true DE60023943D1 (de) | 2005-12-15 |
DE60023943T2 DE60023943T2 (de) | 2006-08-03 |
Family
ID=10866254
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60040495T Expired - Lifetime DE60040495D1 (de) | 1999-12-15 | 2000-12-12 | Antisense Oligonukleotide zur Expressionshemmung des Typ I-Prokollagens |
DE60023943T Expired - Lifetime DE60023943T2 (de) | 1999-12-15 | 2000-12-12 | Antisense oligonukleotide zur inhibition der expression von typ i prokollagen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60040495T Expired - Lifetime DE60040495D1 (de) | 1999-12-15 | 2000-12-12 | Antisense Oligonukleotide zur Expressionshemmung des Typ I-Prokollagens |
Country Status (17)
Country | Link |
---|---|
US (1) | US7173122B2 (de) |
EP (3) | EP2025752A3 (de) |
JP (1) | JP2003516752A (de) |
KR (1) | KR20020064936A (de) |
CN (1) | CN1423695A (de) |
AT (2) | ATE309338T1 (de) |
AU (1) | AU2529701A (de) |
BR (1) | BR0016347A (de) |
CA (1) | CA2390674A1 (de) |
DE (2) | DE60040495D1 (de) |
GB (1) | GB9929487D0 (de) |
IL (1) | IL149640A0 (de) |
MX (1) | MXPA02005871A (de) |
NO (1) | NO20022799L (de) |
NZ (1) | NZ519008A (de) |
WO (1) | WO2001044455A2 (de) |
ZA (1) | ZA200203878B (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7396823B2 (en) * | 1999-12-15 | 2008-07-08 | Nath Rahul K | Therapy inhalation involving antisense oligonucleotides for treating idiopathic pulmonary fibrosis |
CN111378657B (zh) * | 2018-12-28 | 2024-03-15 | 苏州瑞博生物技术股份有限公司 | 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6265157B1 (en) * | 1991-12-03 | 2001-07-24 | Allegheny University Of The Health Sciences | Compositions and methods for detecting altered COL1A1 gene sequences |
WO1993011149A1 (en) * | 1991-12-03 | 1993-06-10 | Thomas Jefferson University | Methods of detecting a genetic predisposition for osteoporosis |
JPH08503366A (ja) * | 1992-11-09 | 1996-04-16 | トーマス・ジェファーソン・ユニバーシティ | コラーゲンの突然変異および野生型遺伝子の発現を阻害するアンチセンスオリゴヌクレオチド |
CA2159195A1 (en) | 1993-03-26 | 1994-10-13 | Darwin J. Prockop | Use of a col 1a1 mini-gene construct to inhibit collagen synthesis |
EP0739898B1 (de) * | 1995-03-13 | 2001-09-26 | Aventis Pharma Deutschland GmbH | Phosphonomonoesternnukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE19508923A1 (de) * | 1995-03-13 | 1996-09-19 | Hoechst Ag | Phosphonomonoesternukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
EP0736608A1 (de) * | 1995-04-08 | 1996-10-09 | Roche Diagnostics GmbH | Verfahren zur spezifischen Vervielfältigung und zum Nachweis von DNA bzw. RNA |
EP0856579A1 (de) | 1997-01-31 | 1998-08-05 | BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH | Ein Verfahren zur Zubereitung von Antisense Oligonukleotiden |
US6238921B1 (en) * | 1998-03-26 | 2001-05-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of human mdm2 expression |
US6007995A (en) * | 1998-06-26 | 1999-12-28 | Isis Pharmaceuticals Inc. | Antisense inhibition of TNFR1 expression |
CA2399371A1 (en) * | 1999-11-12 | 2001-05-17 | Fibrogen, Inc. | Animal collagens and gelatins |
-
1999
- 1999-12-15 GB GBGB9929487.8A patent/GB9929487D0/en not_active Ceased
-
2000
- 2000-12-12 DE DE60040495T patent/DE60040495D1/de not_active Expired - Lifetime
- 2000-12-12 EP EP08017586A patent/EP2025752A3/de not_active Withdrawn
- 2000-12-12 EP EP05024183A patent/EP1698695B1/de not_active Expired - Lifetime
- 2000-12-12 NZ NZ519008A patent/NZ519008A/en unknown
- 2000-12-12 JP JP2001545532A patent/JP2003516752A/ja active Pending
- 2000-12-12 BR BR0016347-3A patent/BR0016347A/pt not_active Application Discontinuation
- 2000-12-12 CN CN00817282A patent/CN1423695A/zh active Pending
- 2000-12-12 AU AU25297/01A patent/AU2529701A/en not_active Abandoned
- 2000-12-12 US US10/149,352 patent/US7173122B2/en not_active Expired - Fee Related
- 2000-12-12 DE DE60023943T patent/DE60023943T2/de not_active Expired - Lifetime
- 2000-12-12 WO PCT/GB2000/004741 patent/WO2001044455A2/en active IP Right Grant
- 2000-12-12 AT AT00988966T patent/ATE309338T1/de not_active IP Right Cessation
- 2000-12-12 CA CA002390674A patent/CA2390674A1/en not_active Abandoned
- 2000-12-12 IL IL14964000A patent/IL149640A0/xx unknown
- 2000-12-12 MX MXPA02005871A patent/MXPA02005871A/es unknown
- 2000-12-12 AT AT05024183T patent/ATE410510T1/de not_active IP Right Cessation
- 2000-12-12 KR KR1020027007591A patent/KR20020064936A/ko not_active Application Discontinuation
- 2000-12-12 EP EP00988966A patent/EP1244781B1/de not_active Expired - Lifetime
-
2002
- 2002-05-15 ZA ZA200203878A patent/ZA200203878B/xx unknown
- 2002-06-12 NO NO20022799A patent/NO20022799L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE309338T1 (de) | 2005-11-15 |
AU2529701A (en) | 2001-06-25 |
EP1698695A3 (de) | 2007-02-14 |
NO20022799D0 (no) | 2002-06-12 |
IL149640A0 (en) | 2002-11-10 |
EP1698695A2 (de) | 2006-09-06 |
KR20020064936A (ko) | 2002-08-10 |
BR0016347A (pt) | 2002-09-10 |
NO20022799L (no) | 2002-06-12 |
CA2390674A1 (en) | 2001-06-21 |
WO2001044455A3 (en) | 2002-01-10 |
WO2001044455A2 (en) | 2001-06-21 |
CN1423695A (zh) | 2003-06-11 |
ATE410510T1 (de) | 2008-10-15 |
DE60023943T2 (de) | 2006-08-03 |
US7173122B2 (en) | 2007-02-06 |
NZ519008A (en) | 2004-04-30 |
EP2025752A3 (de) | 2009-08-12 |
US20030105050A1 (en) | 2003-06-05 |
EP2025752A2 (de) | 2009-02-18 |
ZA200203878B (en) | 2003-08-15 |
EP1244781A2 (de) | 2002-10-02 |
DE60040495D1 (de) | 2008-11-20 |
EP1698695B1 (de) | 2008-10-08 |
MXPA02005871A (es) | 2002-10-23 |
GB9929487D0 (en) | 2000-02-09 |
EP1244781B1 (de) | 2005-11-09 |
JP2003516752A (ja) | 2003-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |