DE60019147D1 - Fibrinolytisch wirksames polypeptid - Google Patents

Fibrinolytisch wirksames polypeptid

Info

Publication number
DE60019147D1
DE60019147D1 DE60019147T DE60019147T DE60019147D1 DE 60019147 D1 DE60019147 D1 DE 60019147D1 DE 60019147 T DE60019147 T DE 60019147T DE 60019147 T DE60019147 T DE 60019147T DE 60019147 D1 DE60019147 D1 DE 60019147D1
Authority
DE
Germany
Prior art keywords
fibrinolytisch
wirksames
polypeptid
vivo
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60019147T
Other languages
English (en)
Other versions
DE60019147T2 (de
Inventor
Charles Boone
Huimin Li
Benjamin Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DE60019147D1 publication Critical patent/DE60019147D1/de
Publication of DE60019147T2 publication Critical patent/DE60019147T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60019147T 1999-10-01 2000-09-29 Fibrinolytisch wirksames polypeptid Expired - Fee Related DE60019147T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US411329 1999-10-01
US09/411,329 US6261820B1 (en) 1999-10-01 1999-10-01 Fibronolytically active polypeptide
PCT/US2000/027029 WO2001025445A1 (en) 1999-10-01 2000-09-29 Fibrinolytically active polypeptide

Publications (2)

Publication Number Publication Date
DE60019147D1 true DE60019147D1 (en) 2005-05-04
DE60019147T2 DE60019147T2 (de) 2006-05-11

Family

ID=23628486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60019147T Expired - Fee Related DE60019147T2 (de) 1999-10-01 2000-09-29 Fibrinolytisch wirksames polypeptid

Country Status (29)

Country Link
US (4) US6261820B1 (de)
EP (2) EP1605049A3 (de)
JP (1) JP2003511034A (de)
KR (2) KR100711312B1 (de)
CN (2) CN100357430C (de)
AT (1) ATE292180T1 (de)
AU (1) AU767827B2 (de)
BG (1) BG106577A (de)
BR (1) BR0014414A (de)
CA (1) CA2386185A1 (de)
CZ (1) CZ298502B6 (de)
DE (1) DE60019147T2 (de)
DK (1) DK1224298T3 (de)
EA (2) EA005944B1 (de)
ES (1) ES2240167T3 (de)
HK (1) HK1049351B (de)
HU (1) HUP0202650A3 (de)
IL (1) IL148787A0 (de)
MX (1) MXPA02003126A (de)
NO (1) NO20021501L (de)
NZ (1) NZ517951A (de)
PL (1) PL355017A1 (de)
PT (1) PT1224298E (de)
RS (1) RS20060033A (de)
SG (1) SG127720A1 (de)
SK (1) SK4232002A3 (de)
WO (1) WO2001025445A1 (de)
YU (2) YU22502A (de)
ZA (1) ZA200202206B (de)

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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6455269B1 (en) 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US6523647B2 (en) * 2001-05-21 2003-02-25 Hydro Mobile Inc. Elevating platform assembly
ATE524146T1 (de) * 2002-02-11 2011-09-15 Gold T Tech Inc Implantierbares gerät zur prävention von thrombusbildung
US7016409B2 (en) * 2003-11-12 2006-03-21 Sony Corporation Apparatus and method for use in providing dynamic bit rate encoding
ES2239532B1 (es) * 2004-02-06 2006-11-01 Proyecto De Biomedicina Cima S.L. Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr.
US20070141625A1 (en) * 2005-02-03 2007-06-21 Santos Jose H Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies
WO2007092820A2 (en) 2006-02-03 2007-08-16 Lazarus Effect, Inc. Methods and devices for restoring blood flow within blocked vasculature
EP2403583B1 (de) 2009-03-06 2016-10-19 Lazarus Effect, Inc. Abfragesysteme
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
CA2997906A1 (en) 2014-09-09 2016-03-17 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
EP3256200A1 (de) 2015-02-11 2017-12-20 Covidien LP Medizinische vorrichtungen mit erweiterbarer spitze und verfahren
CN107614700A (zh) 2015-03-11 2018-01-19 布罗德研究所有限公司 基因型和表型偶联
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
WO2017075265A1 (en) 2015-10-28 2017-05-04 The Broad Institute, Inc. Multiplex analysis of single cell constituents
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers

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FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4447236A (en) * 1982-02-05 1984-05-08 Cordis Corporation Infusion catheter system
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
US4610879A (en) 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
CA1237482A (en) * 1984-03-09 1988-05-31 Frank B. Stiles Catheter for effecting removal of obstructions from a biological duct
US4755167A (en) * 1984-04-10 1988-07-05 Research Corporation In vivo method for distribution and stirring of therapeutic agents
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4885242A (en) * 1984-10-30 1989-12-05 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4818700A (en) * 1985-10-25 1989-04-04 Phillips Petroleum Company Pichia pastoris argininosuccinate lyase gene and uses thereof
US4812405A (en) * 1986-02-18 1989-03-14 Phillips Petroleum Company Double auxotrophic mutants of Pichia pastoris and methods for preparation
US5000185A (en) * 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
ZA889415B (en) 1987-12-18 1989-09-27 Chiron Corp Compositions and method for recombinant production of crotalidus venum fibrolase
WO1990007352A1 (en) 1989-01-04 1990-07-12 Boston Scientific Corporation Angioplasty catheter
US5222941A (en) * 1990-01-12 1993-06-29 Don Michael T Anthony Method of dissolving an obstruction in a vessel
DK0438200T3 (da) * 1990-01-16 2002-11-11 Ct Ingenieria Genetica Biotech Fremgangsmåde til ekspression af heterologe gener i gæren Pichia pastoris, ekspressionsvektorer og transformerede mikroorganismer
US5709676A (en) * 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
US5250034A (en) * 1990-09-17 1993-10-05 E-Z-Em, Inc. Pressure responsive valve catheter
US5167628A (en) * 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5380273A (en) * 1992-05-19 1995-01-10 Dubrul; Will R. Vibrating catheter
EP0624642B1 (de) 1993-05-12 1999-01-20 Indian Council For Medical Research Neues thrombolytisches Agens, Verfahren zu seiner Herstellung und seines Gebrauches für die Herstellung eines thrombenauflösenden Arzneimittels
US5370653A (en) * 1993-07-22 1994-12-06 Micro Therapeutics, Inc. Thrombectomy method and apparatus
EP0689843B1 (de) 1993-12-17 2003-09-10 Mochida Pharmaceutical Co., Ltd. Lösliches thrombomodulin enthaltende zubereitung
US5626564A (en) * 1995-03-31 1997-05-06 Creighton University Adjustable sideholes catheter
US6020181A (en) * 1995-05-17 2000-02-01 New York Blood, Inc. Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase
US5830468A (en) 1995-05-17 1998-11-03 The New York Blood Center, Inc. Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
ATE302599T1 (de) * 1996-05-24 2005-09-15 Angiotech Pharm Inc Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US5951981A (en) * 1996-12-02 1999-09-14 Diatide, Inc. Thrombolytic agents with antithrombotic activity
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CA2312476A1 (en) * 1997-12-09 1999-06-17 Bristol-Myers Squibb Company Fibrinogen-converting enzyme hybrids
US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US20020081685A1 (en) 2000-08-03 2002-06-27 Fox Brian A. Disintegrin homologs, ZSNK10, ZSNK11, and ZSNK12

Also Published As

Publication number Publication date
EP1605049A2 (de) 2005-12-14
KR100700753B1 (ko) 2007-03-28
US20080058256A1 (en) 2008-03-06
EA200400290A1 (ru) 2005-02-24
WO2001025445A1 (en) 2001-04-12
PL355017A1 (en) 2004-03-22
US20030186422A1 (en) 2003-10-02
CA2386185A1 (en) 2001-04-12
HK1049351B (zh) 2005-07-29
PT1224298E (pt) 2005-06-30
SK4232002A3 (en) 2003-09-11
HUP0202650A2 (hu) 2002-12-28
CN100357430C (zh) 2007-12-26
DE60019147T2 (de) 2006-05-11
NZ517951A (en) 2004-02-27
NO20021501L (no) 2002-05-31
DK1224298T3 (da) 2005-05-30
MXPA02003126A (es) 2002-09-30
US6261820B1 (en) 2001-07-17
BR0014414A (pt) 2002-06-11
US6617145B2 (en) 2003-09-09
EP1224298B1 (de) 2005-03-30
EA006487B1 (ru) 2005-12-29
AU767827B2 (en) 2003-11-27
ES2240167T3 (es) 2005-10-16
EP1605049A3 (de) 2006-12-13
CZ298502B6 (cs) 2007-10-24
AU7625400A (en) 2001-05-10
SG127720A1 (en) 2006-12-29
US7195903B2 (en) 2007-03-27
CN101230340A (zh) 2008-07-30
US20020058322A1 (en) 2002-05-16
CZ20021034A3 (cs) 2003-06-18
BG106577A (bg) 2003-04-30
HK1049351A1 (en) 2003-05-09
KR20020047208A (ko) 2002-06-21
YU59604A (sh) 2005-11-28
HUP0202650A3 (en) 2005-01-28
RS20060033A (sr) 2006-12-15
KR100711312B1 (ko) 2007-04-27
EA005944B1 (ru) 2005-08-25
YU22502A (sh) 2005-07-19
KR20060114034A (ko) 2006-11-03
ATE292180T1 (de) 2005-04-15
EP1224298A1 (de) 2002-07-24
EA200200410A1 (ru) 2002-10-31
ZA200202206B (en) 2002-12-24
IL148787A0 (en) 2002-09-12
CN1402788A (zh) 2003-03-12
NO20021501D0 (no) 2002-03-26
JP2003511034A (ja) 2003-03-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee