DE60012485D1 - Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker - Google Patents
Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarkerInfo
- Publication number
- DE60012485D1 DE60012485D1 DE60012485T DE60012485T DE60012485D1 DE 60012485 D1 DE60012485 D1 DE 60012485D1 DE 60012485 T DE60012485 T DE 60012485T DE 60012485 T DE60012485 T DE 60012485T DE 60012485 D1 DE60012485 D1 DE 60012485D1
- Authority
- DE
- Germany
- Prior art keywords
- salicylamide
- lanthanide complexes
- ligands
- luminescent markers
- salicylamidyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1003—Carbocyclic compounds
- C09K2211/1007—Non-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/18—Metal complexes
- C09K2211/182—Metal complexes of the rare earth metals, i.e. Sc, Y or lanthanide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/40—Rare earth chelates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US507599 | 1995-07-26 | ||
| US12060099P | 1999-02-18 | 1999-02-18 | |
| US120600P | 1999-02-18 | ||
| US09/507,599 US6406297B1 (en) | 1999-02-18 | 2000-02-18 | Salicylamide-lanthanide complexes for use as luminescent markers |
| PCT/US2000/004284 WO2000048991A1 (en) | 1999-02-18 | 2000-02-18 | Salicylamide-lanthanide complexes for use as luminescent markers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60012485D1 true DE60012485D1 (de) | 2004-09-02 |
| DE60012485T2 DE60012485T2 (de) | 2005-08-18 |
Family
ID=26818543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60012485T Expired - Lifetime DE60012485T2 (de) | 1999-02-18 | 2000-02-18 | Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6406297B1 (de) |
| EP (1) | EP1154991B1 (de) |
| JP (1) | JP4943585B2 (de) |
| AT (1) | ATE272049T1 (de) |
| AU (1) | AU762754B2 (de) |
| CA (1) | CA2371818C (de) |
| DE (1) | DE60012485T2 (de) |
| DK (1) | DK1154991T3 (de) |
| WO (1) | WO2000048991A1 (de) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6749811B2 (en) | 1998-04-28 | 2004-06-15 | The Johns Hopkins University | Molecularly imprinted polymer solution anion sensor |
| AU5142899A (en) * | 1999-02-17 | 2000-09-04 | Resolution Pharmaceuticals Inc. | Immobilized labeling compounds and methods |
| JP4943585B2 (ja) * | 1999-02-18 | 2012-05-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発光マーカーとして用いるためのサリチルアミド−ランタニド錯体 |
| CA2371816C (en) * | 1999-02-18 | 2010-04-27 | The Regents Of The University Of California | Phthalamide-lanthanide complexes for use as luminescent markers |
| DE19936997B4 (de) * | 1999-08-02 | 2007-06-14 | Biolitec Ag | Verfahren zur Applikation von Photosensibilisatoren (PS) mittels Multiplikatoren in der photodymamischen Therapie |
| US7166719B2 (en) | 2002-06-27 | 2007-01-23 | Health Research, Inc. | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy |
| US7897140B2 (en) * | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
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| US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
| EP1365745A2 (de) * | 2001-02-15 | 2003-12-03 | King Pharmaceuticals, Inc. | Stabilisierte pharmazeutische und schilddrüsenhormon-zusammensetzungen und herstellungsverfahren |
| AU2002365421A1 (en) | 2001-07-10 | 2003-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting the activation state of the multiple proteins in single cells |
| US7393656B2 (en) * | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
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| US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
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| US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
| US6846915B2 (en) * | 2001-08-13 | 2005-01-25 | The Regents Of The University Of California | Hydroxypyridonate and hydroxypyrimidinone chelating agents |
| US20030195253A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration |
| US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
| US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
| US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
| US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
| US20030181524A1 (en) * | 2001-10-29 | 2003-09-25 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
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| US7910376B2 (en) * | 2003-05-27 | 2011-03-22 | Alexander Menzel | Method for detecting trace explosives using photoluminescence |
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| JPWO2021111820A1 (de) | 2019-12-06 | 2021-06-10 | ||
| EP4073066A4 (de) * | 2019-12-13 | 2023-12-27 | University of Pittsburgh - of the Commonwealth System of Higher Education | Lanthanidverbindungen für die lumineszenz-einschalt-detektion |
| WO2021242725A1 (en) | 2020-05-28 | 2021-12-02 | Procisedx Inc. | Predetermined calibration curve |
| EP4343775A1 (de) | 2022-09-22 | 2024-03-27 | SurgeCare | Verfahren zur bestimmung eines medizinischen ergebnisses für eine person, zugehöriges elektronisches system und computerprogramm |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2588265B3 (fr) * | 1985-10-04 | 1988-01-15 | Inst Francais Du Petrole | Procede d'adoucissement d'une charge d'hydrocarbures contenant des produits soufres |
| SE8703682L (sv) * | 1987-09-24 | 1989-03-25 | Wallac Oy | Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner |
| AU9163491A (en) | 1990-12-17 | 1992-07-22 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Derivatized tris-catechol chelating agents |
| DE4222255A1 (de) | 1992-07-07 | 1994-01-13 | Bayer Ag | Fotochemische Markierung von Nukleinsäuren mit Europiumchelat-Reagenzien und ihre Verwendung in Gensondentestsystemen |
| DE19525924A1 (de) * | 1995-07-04 | 1997-01-09 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| DE19728021A1 (de) * | 1997-07-01 | 1999-01-07 | Clariant Gmbh | Metall-Komplexe als Bleichaktivatoren |
| CA2371816C (en) * | 1999-02-18 | 2010-04-27 | The Regents Of The University Of California | Phthalamide-lanthanide complexes for use as luminescent markers |
| JP4943585B2 (ja) * | 1999-02-18 | 2012-05-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発光マーカーとして用いるためのサリチルアミド−ランタニド錯体 |
-
2000
- 2000-02-18 JP JP2000599732A patent/JP4943585B2/ja not_active Expired - Lifetime
- 2000-02-18 US US09/507,599 patent/US6406297B1/en not_active Expired - Lifetime
- 2000-02-18 AU AU36006/00A patent/AU762754B2/en not_active Expired
- 2000-02-18 AT AT00914643T patent/ATE272049T1/de active
- 2000-02-18 CA CA002371818A patent/CA2371818C/en not_active Expired - Lifetime
- 2000-02-18 DE DE60012485T patent/DE60012485T2/de not_active Expired - Lifetime
- 2000-02-18 WO PCT/US2000/004284 patent/WO2000048991A1/en active IP Right Grant
- 2000-02-18 EP EP00914643A patent/EP1154991B1/de not_active Expired - Lifetime
- 2000-02-18 DK DK00914643T patent/DK1154991T3/da active
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2002
- 2002-06-07 US US10/165,818 patent/US7018850B2/en not_active Expired - Lifetime
-
2006
- 2006-02-06 US US11/347,881 patent/US7404912B2/en not_active Expired - Lifetime
-
2008
- 2008-06-11 US US12/137,433 patent/US20080293155A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2371818C (en) | 2009-01-06 |
| US20060286567A1 (en) | 2006-12-21 |
| US7404912B2 (en) | 2008-07-29 |
| DK1154991T3 (da) | 2004-11-22 |
| ATE272049T1 (de) | 2004-08-15 |
| US20080293155A1 (en) | 2008-11-27 |
| AU762754B2 (en) | 2003-07-03 |
| EP1154991A1 (de) | 2001-11-21 |
| DE60012485T2 (de) | 2005-08-18 |
| US7018850B2 (en) | 2006-03-28 |
| AU3600600A (en) | 2000-09-04 |
| JP2003535812A (ja) | 2003-12-02 |
| EP1154991B1 (de) | 2004-07-28 |
| WO2000048991A1 (en) | 2000-08-24 |
| US20030027189A1 (en) | 2003-02-06 |
| US6406297B1 (en) | 2002-06-18 |
| JP4943585B2 (ja) | 2012-05-30 |
| CA2371818A1 (en) | 2000-08-24 |
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