DE60008565D1 - Extrakorporales verfahren zur entfernung von endotoxin - Google Patents
Extrakorporales verfahren zur entfernung von endotoxinInfo
- Publication number
- DE60008565D1 DE60008565D1 DE60008565T DE60008565T DE60008565D1 DE 60008565 D1 DE60008565 D1 DE 60008565D1 DE 60008565 T DE60008565 T DE 60008565T DE 60008565 T DE60008565 T DE 60008565T DE 60008565 D1 DE60008565 D1 DE 60008565D1
- Authority
- DE
- Germany
- Prior art keywords
- endotoxin
- blood
- oligopeptides
- adsorption
- extracorporal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002158 endotoxin Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 3
- 108010038807 Oligopeptides Proteins 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 238000001179 sorption measurement Methods 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000002635 electroconvulsive therapy Methods 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000006068 polycondensation reaction Methods 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0017—Filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US677375 | 1984-12-03 | ||
US15664999P | 1999-09-29 | 1999-09-29 | |
US156649P | 1999-09-29 | ||
US09/677,375 US6774102B1 (en) | 1999-09-29 | 2000-09-15 | Extracorporeal endotoxin removal method |
PCT/IB2000/001364 WO2001023413A1 (en) | 1999-09-29 | 2000-09-26 | Extracorporeal endotoxin removal method |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60008565D1 true DE60008565D1 (de) | 2004-04-01 |
DE60008565T2 DE60008565T2 (de) | 2004-12-16 |
Family
ID=26853386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60008565T Expired - Lifetime DE60008565T2 (de) | 1999-09-29 | 2000-09-26 | Extrakorporales verfahren zur entfernung von endotoxin |
Country Status (8)
Country | Link |
---|---|
US (1) | US6774102B1 (de) |
EP (1) | EP1220868B1 (de) |
JP (1) | JP4709452B2 (de) |
AT (1) | ATE260294T1 (de) |
CA (1) | CA2383955C (de) |
DE (1) | DE60008565T2 (de) |
ES (1) | ES2213604T3 (de) |
WO (1) | WO2001023413A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
US8197430B1 (en) * | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
US20020164644A1 (en) * | 2000-04-05 | 2002-11-07 | Ikuro Maruyama | Adsorbents for high mobility group proteins and column for purifying body fluid |
WO2004024099A2 (en) * | 2002-04-02 | 2004-03-25 | Scantibodies Laboratory, Inc. | Methods and devices for treating severe peripheral bacterial infections |
AU2008201015B2 (en) * | 2002-04-25 | 2008-11-13 | Alteco Medical Ab | Improved separation |
SE0201257D0 (sv) | 2002-04-25 | 2002-04-25 | Medical Invest In Sweden Ab | Improved Separation |
SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
US6803183B2 (en) | 2002-07-18 | 2004-10-12 | Clarigen, Inc. | Method for removing pyrogens from plasma and blood for treatment of septic shock |
FR2848223B1 (fr) * | 2002-12-09 | 2005-02-25 | Centre Nat Rech Scient | Nouveau procede d'isolement des endotoxines. |
EP1518870B1 (de) * | 2003-09-17 | 2018-11-28 | Gambro Lundia AB | Trennungsmaterial |
US8142844B2 (en) | 2003-09-17 | 2012-03-27 | Gambro Lundia Ab | Separating material |
US20050103712A1 (en) * | 2003-11-13 | 2005-05-19 | Voyce Brian D. | Methods and devices for treating severe peripheral bacterial infections |
SI1949915T1 (sl) * | 2004-04-30 | 2012-12-31 | Biopheresis Technologies, Inc. | Postopek in sistem za odstranitev topnih TNFR1, TNFR2 in IL2R pri pacientih |
US20050287515A1 (en) * | 2004-06-24 | 2005-12-29 | Reinhold Deppisch | Removal of bacterial DNA from therapeutic fluid formulations |
EP2059258B1 (de) * | 2006-09-08 | 2019-11-13 | Wyeth LLC | Argininwaschung bei der proteinreinigung mittels affinitätschromatografie |
GB0621454D0 (en) | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Goal directed therapy for liver failure |
GB0621452D0 (en) * | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Therapy for liver disease |
PT2115010E (pt) | 2007-02-28 | 2012-03-09 | Lipoxen Technologies Ltd | Redução de endotoxinas em ácidos polisiálicos |
GB0800228D0 (en) * | 2008-01-07 | 2008-02-13 | Novartis Ag | Lipopolysaccharide decontamination |
WO2012154218A2 (en) * | 2011-05-09 | 2012-11-15 | The University Of Miami | Reducing soluble urokinase receptor in the circulation |
US11724015B2 (en) | 2017-09-18 | 2023-08-15 | Santersus Ag | Method and device for purification of blood from circulating cell free DNA |
GB202004775D0 (en) | 2020-03-31 | 2020-05-13 | Ucl Business Ltd | Apparatus |
WO2022071849A1 (en) | 2020-10-01 | 2022-04-07 | Alteco Medical Ab | Matrices for selective binding of at least one component from a body fluid |
AU2021386427A1 (en) | 2020-11-30 | 2023-07-20 | Alteco Medical Ab | Device for binding and separation of at least one component from a body fluid |
CA3227866A1 (en) | 2021-07-29 | 2023-02-02 | Japan Hemotech Co., Ltd. | Nonwoven substrate, fibrous material for liquid clarification, production method for said material, and cleaner equipped with said material |
GB202307837D0 (en) | 2023-05-25 | 2023-07-12 | Yaqrit Ltd | Dialysis method |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5670028A (en) | 1979-11-12 | 1981-06-11 | Teijin Ltd | Polymer bonding with albumin |
CA1204667A (en) | 1982-10-04 | 1986-05-20 | Masashi Kodama | Blood treating material |
JPH0738880B2 (ja) | 1983-06-24 | 1995-05-01 | 東レ株式会社 | エンドトキシン血症治療剤 |
JPH01502584A (ja) * | 1986-03-24 | 1989-09-07 | ザ ユニバーシティー オブ シドニー | 抗原性物質 |
SE468881B (sv) | 1991-01-09 | 1993-04-05 | Kabi Pharmacia Ab | Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar |
DE4110730A1 (de) | 1991-04-03 | 1992-10-15 | Fresenius Ag | Vorrichtung zur auftrennung von zumindest zwei biologischen stoffen in loesung durch adsorption |
GB9215780D0 (en) * | 1992-07-24 | 1992-09-09 | Univ London Pharmacy | Peptide compounds |
JPH07509400A (ja) * | 1992-07-27 | 1995-10-19 | テラピン テクノロジーズ,インク. | 吸着剤群 |
US5780594A (en) * | 1993-03-01 | 1998-07-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Biologically active protein fragments containing specific binding regions of serum albumin or related proteins |
WO1995000540A1 (en) * | 1993-06-18 | 1995-01-05 | Robert Webber | Synthetic carrier and immunogen |
CA2146667A1 (en) | 1993-08-18 | 1995-02-23 | Adolf Hoess | Lipopolysaccharide-binding and neutralizing peptides |
WO1996020042A1 (en) | 1994-12-26 | 1996-07-04 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | ADSORBENT FOR ENDOTOXIN, TUMOR NECROSIS FACTOR-α OR INTERLEUKINS, METHOD FOR REMOVAL VIA ADSORPTION, AND ADSORBER |
DE69623769T2 (de) | 1995-06-02 | 2003-02-20 | Optilink Ab Malmoe | Physisch funktionelle materalien |
WO1996041185A1 (en) | 1995-06-07 | 1996-12-19 | Perseptive Biosystems, Inc. | Methods and compositions for binding endotoxins |
ES2141462T3 (es) | 1996-02-06 | 2000-03-16 | Bellco Spa | Dispositivo de separacion de toxinas en particular de citoquinas. |
DE19609479A1 (de) * | 1996-03-11 | 1997-09-18 | Biotechnolog Forschung Gmbh | Endotoxin-spezifische Membranen |
EP0884327B1 (de) * | 1997-06-11 | 2001-03-14 | The School Of Pharmacy, University Of London | Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung |
DE19740770A1 (de) * | 1997-09-17 | 1999-03-18 | Biotechnolog Forschung Gmbh | Mikrofiltrationsfilterschicht sowie deren Verwendung |
TWI227323B (en) * | 1998-03-11 | 2005-02-01 | Sensors For Med & Science Inc | Detection of analytes by fluorescent lanthanide metal chelate complexes containing substituted ligands |
-
2000
- 2000-09-15 US US09/677,375 patent/US6774102B1/en not_active Expired - Lifetime
- 2000-09-26 JP JP2001526563A patent/JP4709452B2/ja not_active Expired - Lifetime
- 2000-09-26 AT AT00960909T patent/ATE260294T1/de not_active IP Right Cessation
- 2000-09-26 WO PCT/IB2000/001364 patent/WO2001023413A1/en active IP Right Grant
- 2000-09-26 EP EP00960909A patent/EP1220868B1/de not_active Expired - Lifetime
- 2000-09-26 DE DE60008565T patent/DE60008565T2/de not_active Expired - Lifetime
- 2000-09-26 CA CA2383955A patent/CA2383955C/en not_active Expired - Fee Related
- 2000-09-26 ES ES00960909T patent/ES2213604T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1220868B1 (de) | 2004-02-25 |
DE60008565T2 (de) | 2004-12-16 |
JP4709452B2 (ja) | 2011-06-22 |
EP1220868A1 (de) | 2002-07-10 |
ES2213604T3 (es) | 2004-09-01 |
CA2383955A1 (en) | 2001-04-05 |
ATE260294T1 (de) | 2004-03-15 |
JP2003511354A (ja) | 2003-03-25 |
WO2001023413A1 (en) | 2001-04-05 |
CA2383955C (en) | 2010-10-12 |
US6774102B1 (en) | 2004-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: GAMBRO DIALYSATOREN GMBH, 72379 HECHINGEN, DE |
|
8364 | No opposition during term of opposition |