DE60008565D1 - Extrakorporales verfahren zur entfernung von endotoxin - Google Patents

Extrakorporales verfahren zur entfernung von endotoxin

Info

Publication number
DE60008565D1
DE60008565D1 DE60008565T DE60008565T DE60008565D1 DE 60008565 D1 DE60008565 D1 DE 60008565D1 DE 60008565 T DE60008565 T DE 60008565T DE 60008565 T DE60008565 T DE 60008565T DE 60008565 D1 DE60008565 D1 DE 60008565D1
Authority
DE
Germany
Prior art keywords
endotoxin
blood
oligopeptides
adsorption
extracorporal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60008565T
Other languages
English (en)
Other versions
DE60008565T2 (de
Inventor
Carl-Martin Bell
Markus Storr
Werner Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gambro Dialysatoren GmbH and Co KG
Original Assignee
Gambro Dialysatoren GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Dialysatoren GmbH and Co KG filed Critical Gambro Dialysatoren GmbH and Co KG
Application granted granted Critical
Publication of DE60008565D1 publication Critical patent/DE60008565D1/de
Publication of DE60008565T2 publication Critical patent/DE60008565T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
DE60008565T 1999-09-29 2000-09-26 Extrakorporales verfahren zur entfernung von endotoxin Expired - Lifetime DE60008565T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15664999P 1999-09-29 1999-09-29
US156649P 1999-09-29
US09/677,375 US6774102B1 (en) 1999-09-29 2000-09-15 Extracorporeal endotoxin removal method
US677375 2000-09-15
PCT/IB2000/001364 WO2001023413A1 (en) 1999-09-29 2000-09-26 Extracorporeal endotoxin removal method

Publications (2)

Publication Number Publication Date
DE60008565D1 true DE60008565D1 (de) 2004-04-01
DE60008565T2 DE60008565T2 (de) 2004-12-16

Family

ID=26853386

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60008565T Expired - Lifetime DE60008565T2 (de) 1999-09-29 2000-09-26 Extrakorporales verfahren zur entfernung von endotoxin

Country Status (8)

Country Link
US (1) US6774102B1 (de)
EP (1) EP1220868B1 (de)
JP (1) JP4709452B2 (de)
AT (1) ATE260294T1 (de)
CA (1) CA2383955C (de)
DE (1) DE60008565T2 (de)
ES (1) ES2213604T3 (de)
WO (1) WO2001023413A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8197430B1 (en) * 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6620382B1 (en) 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
AU783457B2 (en) * 2000-04-05 2005-10-27 Toray Industries, Inc. Adsorbents for high mobility group proteins and column for purifying body fluid
EP1575507A2 (de) * 2002-04-02 2005-09-21 Scantibodies Laboratory, Inc. Verfahren und vorrichtungen zur behandlung von schweren peripheren bakteriellen infektionen
SE0201257D0 (sv) * 2002-04-25 2002-04-25 Medical Invest In Sweden Ab Improved Separation
AU2008201015B2 (en) * 2002-04-25 2008-11-13 Alteco Medical Ab Improved separation
SE526038C2 (sv) * 2002-07-08 2005-06-21 Gambro Lundia Ab Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav
US6803183B2 (en) 2002-07-18 2004-10-12 Clarigen, Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
WO2005026224A1 (en) * 2003-09-17 2005-03-24 Gambro Lundia Ab Separating material
EP2261271B1 (de) 2003-09-17 2014-04-30 Gambro Lundia AB Trennungsmaterial
US20050103712A1 (en) * 2003-11-13 2005-05-19 Voyce Brian D. Methods and devices for treating severe peripheral bacterial infections
AU2005240082B2 (en) * 2004-04-30 2009-07-23 Innatus Corporation Method and system to remove soluble TNFR1,TNFR2, and IL2 in patients
US20050287515A1 (en) * 2004-06-24 2005-12-29 Reinhold Deppisch Removal of bacterial DNA from therapeutic fluid formulations
US7714111B2 (en) * 2006-09-08 2010-05-11 Wyeth Llc Arginine derivative wash in protein purification using affinity chromatography
GB0621452D0 (en) * 2006-10-27 2006-12-06 Ucl Business Plc Therapy for liver disease
GB0621454D0 (en) 2006-10-27 2006-12-06 Ucl Business Plc Goal directed therapy for liver failure
PT2115010E (pt) 2007-02-28 2012-03-09 Lipoxen Technologies Ltd Redução de endotoxinas em ácidos polisiálicos
GB0800228D0 (en) * 2008-01-07 2008-02-13 Novartis Ag Lipopolysaccharide decontamination
EP2707055B1 (de) * 2011-05-09 2019-10-23 The University of Miami Verminderung des löslichen urokinase-rezeptors im blutkreislauf
CN111433605B (zh) 2017-09-18 2023-09-08 圣特萨斯股份公司 用于针对循环无细胞dna纯化血液的方法和装置
GB202004775D0 (en) 2020-03-31 2020-05-13 Ucl Business Ltd Apparatus
WO2022071849A1 (en) 2020-10-01 2022-04-07 Alteco Medical Ab Matrices for selective binding of at least one component from a body fluid
JP2023550942A (ja) 2020-11-30 2023-12-06 アルテコ メディカル アクティエボラーグ 体液から少なくとも１つの成分を結合及び分離するための装置
WO2023008489A1 (ja) 2021-07-29 2023-02-02 ジャパン・ヘモテック株式会社 不織布基材、液体浄化用繊維材料、当該材料の製造方法および当該材料を備える洗浄器
GB202307837D0 (en) 2023-05-25 2023-07-12 Yaqrit Ltd Dialysis method

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5670028A (en) 1979-11-12 1981-06-11 Teijin Ltd Polymer bonding with albumin
CA1204667A (en) 1982-10-04 1986-05-20 Masashi Kodama Blood treating material
JPH0738880B2 (ja) 1983-06-24 1995-05-01 東レ株式会社 エンドトキシン血症治療剤
US5061626A (en) * 1986-03-24 1991-10-29 University Of Sydney Antigenic anarogues of platelet activating factor
SE468881B (sv) 1991-01-09 1993-04-05 Kabi Pharmacia Ab Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
DE4110730A1 (de) 1991-04-03 1992-10-15 Fresenius Ag Vorrichtung zur auftrennung von zumindest zwei biologischen stoffen in loesung durch adsorption
GB9215780D0 (en) * 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
CA2140257A1 (en) * 1992-07-27 1994-02-03 Lawrence M. Kauvar Sorbent families
US5780594A (en) * 1993-03-01 1998-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Biologically active protein fragments containing specific binding regions of serum albumin or related proteins
WO1995000540A1 (en) * 1993-06-18 1995-01-05 Robert Webber Synthetic carrier and immunogen
CA2146667A1 (en) 1993-08-18 1995-02-23 Adolf Hoess Lipopolysaccharide-binding and neutralizing peptides
DE69525655T2 (de) 1994-12-26 2002-09-12 Kanegafuchi Chemical Ind Adsorbent für endotoxine, tumor nekrose faktor-alpha oder interleukine, methode zur entfernung mittels adsorption sowie adsorber
AU5893596A (en) 1995-06-02 1996-12-18 Forskningscenter Riso Novel physically functional materials
WO1996041185A1 (en) 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Methods and compositions for binding endotoxins
EP0958839B1 (de) 1996-02-06 2004-12-29 BELLCO S.p.A. Adsorptive extrakoporale Entfernung von Zytokinen bei akutem Organversagen
DE19609479A1 (de) * 1996-03-11 1997-09-18 Biotechnolog Forschung Gmbh Endotoxin-spezifische Membranen
EP0884327B1 (de) * 1997-06-11 2001-03-14 The School Of Pharmacy, University Of London Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung
DE19740770A1 (de) * 1997-09-17 1999-03-18 Biotechnolog Forschung Gmbh Mikrofiltrationsfilterschicht sowie deren Verwendung
CA2322858C (en) * 1998-03-11 2009-06-02 Sensors For Medicine And Science, Inc. Detection of analytes by fluorescent lanthanide chelates

Also Published As

Publication number Publication date
US6774102B1 (en) 2004-08-10
ES2213604T3 (es) 2004-09-01
ATE260294T1 (de) 2004-03-15
JP4709452B2 (ja) 2011-06-22
CA2383955C (en) 2010-10-12
EP1220868B1 (de) 2004-02-25
CA2383955A1 (en) 2001-04-05
WO2001023413A1 (en) 2001-04-05
DE60008565T2 (de) 2004-12-16
EP1220868A1 (de) 2002-07-10
JP2003511354A (ja) 2003-03-25

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GAMBRO DIALYSATOREN GMBH, 72379 HECHINGEN, DE

8364 No opposition during term of opposition