DE60001944D1 - Verfahren zur herstellung von partikeln - Google Patents

Verfahren zur herstellung von partikeln

Info

Publication number
DE60001944D1
DE60001944D1 DE60001944T DE60001944T DE60001944D1 DE 60001944 D1 DE60001944 D1 DE 60001944D1 DE 60001944 T DE60001944 T DE 60001944T DE 60001944 T DE60001944 T DE 60001944T DE 60001944 D1 DE60001944 D1 DE 60001944D1
Authority
DE
Germany
Prior art keywords
vehicles
vehicle
solvent
target substance
dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60001944T
Other languages
English (en)
Other versions
DE60001944T2 (de
Inventor
Hermiz Hanna
Peter York
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Bradford Particle Design Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bradford Particle Design Ltd filed Critical Bradford Particle Design Ltd
Application granted granted Critical
Publication of DE60001944D1 publication Critical patent/DE60001944D1/de
Publication of DE60001944T2 publication Critical patent/DE60001944T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0488—Flow sheets
DE60001944T 1999-07-07 2000-07-07 Verfahren zur herstellung von partikeln Expired - Lifetime DE60001944T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9915975.8A GB9915975D0 (en) 1999-07-07 1999-07-07 Method for the formation of particles
PCT/GB2000/002606 WO2001003821A1 (en) 1999-07-07 2000-07-07 Method of particle formation

Publications (2)

Publication Number Publication Date
DE60001944D1 true DE60001944D1 (de) 2003-05-08
DE60001944T2 DE60001944T2 (de) 2003-12-24

Family

ID=10856857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60001944T Expired - Lifetime DE60001944T2 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von partikeln

Country Status (12)

Country Link
US (2) US6860907B1 (de)
EP (1) EP1191999B1 (de)
JP (1) JP4490016B2 (de)
AT (1) ATE235956T1 (de)
AU (1) AU773548B2 (de)
CA (1) CA2376593C (de)
DE (1) DE60001944T2 (de)
DK (1) DK1191999T3 (de)
ES (1) ES2195908T3 (de)
GB (2) GB9915975D0 (de)
MX (1) MXPA01013259A (de)
WO (1) WO2001003821A1 (de)

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GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
GB9927011D0 (en) 1999-11-16 2000-01-12 Advanced Phytonics Ltd Method for the production of particles
FR2815540B1 (fr) † 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
KR100923514B1 (ko) * 2000-12-28 2009-10-27 알투스 파마슈티컬스 인코포레이티드 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법
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GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
JP4374249B2 (ja) * 2001-10-22 2009-12-02 ドンペ ピーエイチエー．アール．エムエー エス．ピー．エー． 超臨界的流体による処理方法：タンパク質微粒子の調製およびそれらの安定化
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
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US7827822B2 (en) * 2007-07-25 2010-11-09 Schott Corporation Method and apparatus for spray-forming melts of glass and glass-ceramic compositions
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WO2016040243A1 (en) * 2014-09-08 2016-03-17 Uwe Weierstall Nozzle apparatus and methods for use thereof
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DE102015007604A1 (de) * 2015-06-12 2016-12-29 Messer France S.A.S Vorrichtung und Verfahren zum Kühlen und Zerstäuben flüssiger oder pastöser Stoffe
JP7304043B2 (ja) 2015-07-22 2023-07-06 アナベックス ライフ サイエンシズ コーポレイション テトラヒドロ－ｎ，ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミンヒドロクロリドの結晶形態、かかる形態の作製方法およびその薬学的組成物
CN108969555B (zh) * 2017-09-25 2021-08-10 安徽九鑫药业有限公司 一种补肾、益精血、增强免疫力的淫羊藿中药组合物的制备方法
US11724241B2 (en) 2018-02-15 2023-08-15 Cambridge Enterprise Limited Constant shear continuous reactor device
CN112657301A (zh) * 2020-12-01 2021-04-16 大连理工大学 一种超临界气固分离装置及方法
EP4190437A1 (de) * 2021-12-03 2023-06-07 SiTec PharmaBio SL Verfahren und vorrichtung zur herstellung von festen mikropartikeln

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GB9804379D0 (en) 1998-03-02 1998-04-22 Bradford Particle Design Ltd Method of particle formation
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GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles

Also Published As

Publication number Publication date
MXPA01013259A (es) 2002-12-13
ES2195908T3 (es) 2003-12-16
US7150766B2 (en) 2006-12-19
JP4490016B2 (ja) 2010-06-23
DK1191999T3 (da) 2003-07-21
WO2001003821A1 (en) 2001-01-18
US20050206023A1 (en) 2005-09-22
US6860907B1 (en) 2005-03-01
CA2376593A1 (en) 2001-01-18
CA2376593C (en) 2009-12-01
AU5699000A (en) 2001-01-30
GB0016618D0 (en) 2000-08-23
JP2003504178A (ja) 2003-02-04
ATE235956T1 (de) 2003-04-15
DE60001944T2 (de) 2003-12-24
EP1191999A1 (de) 2002-04-03
GB2354968A (en) 2001-04-11
GB9915975D0 (en) 1999-09-08
GB2354968B (en) 2001-09-12
EP1191999B1 (de) 2003-04-02
AU773548B2 (en) 2004-05-27

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