DE59908522D1 - Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung - Google Patents

Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Info

Publication number
DE59908522D1
DE59908522D1 DE59908522T DE59908522T DE59908522D1 DE 59908522 D1 DE59908522 D1 DE 59908522D1 DE 59908522 T DE59908522 T DE 59908522T DE 59908522 T DE59908522 T DE 59908522T DE 59908522 D1 DE59908522 D1 DE 59908522D1
Authority
DE
Germany
Prior art keywords
benzothiepine
compounds
production
products containing
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59908522T
Other languages
English (en)
Inventor
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE59908522T priority Critical patent/DE59908522D1/de
Application granted granted Critical
Publication of DE59908522D1 publication Critical patent/DE59908522D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE59908522T 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung Expired - Lifetime DE59908522D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59908522T DE59908522D1 (de) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE59908522T DE59908522D1 (de) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
PCT/EP1999/003743 WO1999064409A2 (de) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (1)

Publication Number Publication Date
DE59908522D1 true DE59908522D1 (de) 2004-03-18

Family

ID=7870440

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19825804A Expired - Lifetime DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE59903411T Expired - Lifetime DE59903411D1 (de) 1998-06-10 1999-05-28 BENZO(b)THIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG
DE59908522T Expired - Lifetime DE59908522D1 (de) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE19825804A Expired - Lifetime DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE59903411T Expired - Lifetime DE59903411D1 (de) 1998-06-10 1999-05-28 BENZO(b)THIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG

Country Status (26)

Country Link
US (1) US6387944B1 (de)
EP (2) EP1086092B1 (de)
JP (2) JP4374426B2 (de)
KR (2) KR100681721B1 (de)
CN (2) CN1127497C (de)
AR (2) AR018633A1 (de)
AT (2) ATE227715T1 (de)
AU (2) AU753275B2 (de)
BR (2) BR9912188B1 (de)
CA (2) CA2334775C (de)
CZ (2) CZ297989B6 (de)
DE (3) DE19825804C2 (de)
DK (2) DK1086092T3 (de)
ES (2) ES2182535T3 (de)
HK (2) HK1039490A1 (de)
HU (2) HU229761B1 (de)
ID (2) ID28695A (de)
IL (1) IL140078A (de)
NO (1) NO327075B1 (de)
NZ (1) NZ508681A (de)
PL (2) PL196074B1 (de)
PT (2) PT1086092E (de)
RU (2) RU2215001C2 (de)
TR (2) TR200003634T2 (de)
WO (2) WO1999064410A1 (de)
ZA (2) ZA200007060B (de)

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IL156550A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
IL160474A0 (en) * 2001-08-22 2004-07-25 Aventis Pharma Gmbh Combination products of 1,4-benzothiepine 1,1-dioxide derivatives with other active ingredients and the use thereof
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GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
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DE102006053635B4 (de) * 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
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US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
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JP2023537285A (ja) 2020-08-03 2023-08-31 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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Also Published As

Publication number Publication date
DK1086092T3 (da) 2003-03-10
HU228570B1 (en) 2013-04-29
CZ20004592A3 (cs) 2001-04-11
CN1127497C (zh) 2003-11-12
ID26876A (id) 2001-02-15
RU2220141C2 (ru) 2003-12-27
CA2334775C (en) 2009-10-13
PT1086092E (pt) 2003-03-31
JP4374426B2 (ja) 2009-12-02
HUP0102554A1 (hu) 2001-10-28
PT1086113E (pt) 2004-06-30
NO20006251D0 (no) 2000-12-08
AU4503199A (en) 1999-12-30
DE19825804A1 (de) 1999-12-16
AU4501999A (en) 1999-12-30
BR9911123B1 (pt) 2010-12-14
JP2002517490A (ja) 2002-06-18
ZA200007061B (en) 2001-07-18
RU2215001C2 (ru) 2003-10-27
CZ297925B6 (cs) 2007-05-02
KR100681721B1 (ko) 2007-02-15
ES2182535T3 (es) 2003-03-01
CA2334775A1 (en) 1999-12-16
JP3374129B2 (ja) 2003-02-04
IL140078A (en) 2004-08-31
TR200003632T2 (tr) 2001-04-20
HUP0102256A1 (hu) 2001-12-28
DK1086113T3 (da) 2004-05-24
WO1999064409A2 (de) 1999-12-16
WO1999064409A3 (de) 2000-03-02
JP2002517491A (ja) 2002-06-18
NZ508681A (en) 2002-06-28
BR9912188B1 (pt) 2010-12-14
AR018633A1 (es) 2001-11-28
CN1152039C (zh) 2004-06-02
EP1086092B1 (de) 2002-11-13
AU752633B2 (en) 2002-09-26
NO327075B1 (no) 2009-04-20
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
PL196057B1 (pl) 2007-11-30
HUP0102554A3 (en) 2002-12-28
CA2334773C (en) 2009-05-26
BR9911123A (pt) 2006-01-03
HK1036799A1 (en) 2002-01-18
CA2334773A1 (en) 1999-12-16
AU753275B2 (en) 2002-10-10
ZA200007060B (en) 2001-07-18
WO1999064410A1 (de) 1999-12-16
HUP0102256A3 (en) 2002-04-29
CZ20004591A3 (cs) 2001-04-11
EP1086113B1 (de) 2004-02-11
TR200003634T2 (tr) 2001-06-21
HU229761B1 (hu) 2014-06-30
CZ297989B6 (cs) 2007-05-16
DE19825804C2 (de) 2000-08-24
ATE227715T1 (de) 2002-11-15
PL344827A1 (en) 2001-11-19
BR9912188A (pt) 2001-04-10
DE59903411D1 (de) 2002-12-19
ATE259372T1 (de) 2004-02-15
AR018634A1 (es) 2001-11-28
HK1039490A1 (en) 2002-04-26
ID28695A (id) 2001-06-28
CN1305487A (zh) 2001-07-25
IL140078A0 (en) 2002-02-10
EP1086092A1 (de) 2001-03-28
KR20010052682A (ko) 2001-06-25
EP1086113A2 (de) 2001-03-28
PL196074B1 (pl) 2007-12-31
KR20010052701A (ko) 2001-06-25
ES2215387T3 (es) 2004-10-01
US6387944B1 (en) 2002-05-14
NO20006251L (no) 2001-02-07
CN1305469A (zh) 2001-07-25

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