DE59309257D1 - Verfahren zur herstellung von mikrokapseln - Google Patents

Verfahren zur herstellung von mikrokapseln

Info

Publication number
DE59309257D1
DE59309257D1 DE59309257T DE59309257T DE59309257D1 DE 59309257 D1 DE59309257 D1 DE 59309257D1 DE 59309257 T DE59309257 T DE 59309257T DE 59309257 T DE59309257 T DE 59309257T DE 59309257 D1 DE59309257 D1 DE 59309257D1
Authority
DE
Germany
Prior art keywords
microcapsules
producing microcapsules
solvents
biodegradable
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59309257T
Other languages
English (en)
Inventor
Bruno Gander
Hans Merkle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanol Schwarz GmbH
UCB Pharma GmbH
Original Assignee
Sanol Schwarz GmbH
UCB Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Schwarz GmbH, UCB Pharma GmbH filed Critical Sanol Schwarz GmbH
Application granted granted Critical
Publication of DE59309257D1 publication Critical patent/DE59309257D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
DE59309257T 1992-10-26 1993-10-18 Verfahren zur herstellung von mikrokapseln Expired - Fee Related DE59309257D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH331992 1992-10-26
PCT/CH1993/000246 WO1994009898A1 (de) 1992-10-26 1993-10-18 Verfahren zur herstellung von mikrokapseln

Publications (1)

Publication Number Publication Date
DE59309257D1 true DE59309257D1 (de) 1999-02-11

Family

ID=4253421

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59309257T Expired - Fee Related DE59309257D1 (de) 1992-10-26 1993-10-18 Verfahren zur herstellung von mikrokapseln

Country Status (14)

Country Link
US (1) US5648096A (de)
EP (1) EP0625069B1 (de)
JP (1) JP3523254B2 (de)
KR (1) KR100225983B1 (de)
CN (1) CN1058864C (de)
AT (1) ATE175132T1 (de)
CA (1) CA2126685C (de)
DE (1) DE59309257D1 (de)
DK (1) DK0625069T3 (de)
ES (1) ES2127835T3 (de)
FI (1) FI943067A (de)
GR (1) GR3029504T3 (de)
HU (1) HU221308B1 (de)
WO (1) WO1994009898A1 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
AU8303691A (en) 1991-04-24 1992-12-21 United States Of America, As Represented By The Secretary Of The Army, The Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
WO1994015636A1 (en) * 1993-01-08 1994-07-21 Csl Limited Vaccine preparations
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
GB9420355D0 (en) * 1994-10-10 1994-11-23 Univ Nottingham Preparation of protein microspheres, films and coatings
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6902743B1 (en) * 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
EP0862420A4 (de) * 1995-10-13 1999-11-03 Penn State Res Found Synthese von arzneistoffnanopartikeln durch sprühtrocknung
JP2000500744A (ja) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
FR2757510B1 (fr) * 1996-12-23 2000-01-07 Sanofi Sa Forme microparticulaire d'un derive de tetrahydropyridine
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
EP0971698A4 (de) 1996-12-31 2006-07-26 Nektar Therapeutics Aerolisiertes hydrophobisches medikament
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US20050171408A1 (en) * 1997-07-02 2005-08-04 Parker Jeffery R. Light delivery systems and applications thereof
DE69722610T2 (de) * 1997-08-08 2004-04-29 Rotta Research Laboratorium S.P.A., Monza Neue Inhalationspräparate enthaltend CR 2039 (Andolast)
US20030045492A1 (en) * 1997-08-13 2003-03-06 Tang De-Chu C. Vaccination by topical application of recombinant vectors
US6716823B1 (en) 1997-08-13 2004-04-06 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom, and uses thereof
US20030125278A1 (en) * 1997-08-13 2003-07-03 Tang De-Chu C. Immunization of animals by topical applications of a salmonella-based vector
US6348450B1 (en) 1997-08-13 2002-02-19 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom and uses thereof
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
AU744354B2 (en) 1998-03-20 2002-02-21 Takeda Chemical Industries Ltd. Sustained-release preparation of physiologically active polypeptide and production thereof
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
CA2335460A1 (en) 1998-06-18 1999-12-23 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
US20040009936A1 (en) * 1999-05-03 2004-01-15 Tang De-Chu C. Vaccine and drug delivery by topical application of vectors and vector extracts
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1292285A4 (de) * 2000-06-02 2009-07-22 Eisai Corp North America Darreichungssystem für bioaktive stoffe
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002009669A2 (en) * 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution and particles made thereby
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
DE10055857A1 (de) * 2000-11-10 2002-08-22 Creative Peptides Sweden Ab Dj Neue pharmazeutische Depotformulierung
US7749539B2 (en) * 2000-11-30 2010-07-06 Efrat Biopolymers Ltd. Polymeric formulations for drug delivery
ATE361057T1 (de) 2000-12-21 2007-05-15 Alrise Biosystems Gmbh Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
EP1365745A2 (de) * 2001-02-15 2003-12-03 King Pharmaceuticals, Inc. Stabilisierte pharmazeutische und schilddrüsenhormon-zusammensetzungen und herstellungsverfahren
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030198671A1 (en) * 2001-08-10 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique plasma AUC properties
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US7098305B2 (en) * 2001-09-06 2006-08-29 Ardana Bioscience Limited Sustained release of microcrystalline peptide suspensions
US20030181524A1 (en) * 2001-10-29 2003-09-25 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
AU2002342241B2 (en) * 2001-11-01 2007-07-19 Novartis Ag Spray drying methods and compositions thereof
US20040142902A1 (en) * 2001-11-08 2004-07-22 Struijker- Boudier Harry A.J. Implant dosage form and use thereof for the delivery of a cholosterol lowering agent
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
WO2004035028A1 (fr) * 2002-10-17 2004-04-29 Gosudarstvenny Nauchny Tsentr Virusologii I Biotekhnologii 'vektor' Procede de production d'une forme microencapsulee d'un vaccin viral vivant
MXPA05007154A (es) * 2002-12-30 2005-09-21 Nektar Therapeutics Atomizador prepeliculizacion.
KR101511196B1 (ko) * 2003-05-28 2015-04-10 노바르티스 아게 아미노산 및/또는 인지질로 부분 또는 완전 코팅된 수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의 분무 건조법
ATE454138T1 (de) * 2003-08-08 2010-01-15 Biovail Lab Int Srl Tablette mit modifizierter freisetzung von bupropion hydrochlorid
US20050037047A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US8221778B2 (en) * 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
SG173326A1 (en) * 2004-06-04 2011-08-29 Camurus Ab Liquid depot formulations
EP1863511A2 (de) * 2005-02-23 2007-12-12 UAB Research Foundation Alkyl-glykosid-verstärkte impfung
US7884136B2 (en) * 2005-06-27 2011-02-08 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt
EP1909771A1 (de) * 2005-08-02 2008-04-16 Miv Therapeutics Inc. Mikrovorrichtungen mit nanokapseln für die kontrollierte abgabe von arzneimitteln und herstellungsverfahren dafür
US20070286814A1 (en) * 2006-06-12 2007-12-13 Medispray Laboratories Pvt. Ltd. Stable aerosol pharmaceutical formulations
CN101239296B (zh) * 2008-03-07 2010-04-21 清华大学 一种制备溶剂微胶囊的方法
CN101543757B (zh) * 2009-04-30 2011-05-04 上海交通大学 利用声表面波雾化器实现芯材微胶囊化的制备方法
WO2012009973A1 (zh) * 2010-07-20 2012-01-26 上海交通大学医学院附属新华医院 一种含有抗帕金森病药物的微球组合药物及其应用
US10087401B2 (en) 2012-03-16 2018-10-02 Monosol, Llc Water soluble compositions incorporating enzymes, and method of making same
US9394092B2 (en) 2012-04-16 2016-07-19 Monosol, Llc Powdered pouch and method of making same
CN102698664B (zh) * 2012-05-26 2014-03-12 云南恩典科技产业发展有限公司 一种包水微胶囊的制备方法
EP2877155B1 (de) 2012-07-26 2020-10-28 Camurus AB Opioid-formulierungen
CN103506058B (zh) * 2013-10-09 2015-05-13 上海理工大学 微胶囊喷雾干燥装置
KR102544927B1 (ko) 2014-10-03 2023-06-16 모노졸, 엘엘씨 분해성 재료 및 이로부터 제조된 팩키징
WO2016097848A1 (en) 2014-12-18 2016-06-23 Dexcel Pharma Technologies Ltd. Alternating and semi-alternating poly(ester-anhydride) copolymers
AU2017406466A1 (en) 2017-03-29 2019-10-17 Dexcel Pharma Technologies Ltd. Compositions comprising biodegradable copolymers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS6067417A (ja) * 1983-09-24 1985-04-17 Tetsuo Kato 生体内代謝性マイクロカプセルの製法
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
ES2051968T3 (es) * 1988-12-22 1994-07-01 American Cyanamid Co Metodo para el tratamiento de enfermedad periodontal mediante la liberacion continua de un agente terapeutico a la bolsa periodontal; composicion de materia del mismo y aparato para su administracion.
IL92344A0 (en) * 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
JPH04247987A (ja) * 1991-01-18 1992-09-03 Fuji Photo Film Co Ltd 感熱記録材料
YU48420B (sh) * 1991-03-25 1998-07-10 Hoechst Aktiengesellschaft Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem

Also Published As

Publication number Publication date
DK0625069T3 (da) 1999-08-30
CA2126685C (en) 2002-07-23
KR100225983B1 (ko) 1999-10-15
CA2126685A1 (en) 1994-05-11
JP3523254B2 (ja) 2004-04-26
FI943067A0 (fi) 1994-06-23
GR3029504T3 (en) 1999-05-28
CN1058864C (zh) 2000-11-29
HUT70418A (en) 1995-10-30
ATE175132T1 (de) 1999-01-15
JPH07502686A (ja) 1995-03-23
HU9401329D0 (en) 1994-08-29
HU221308B1 (en) 2002-09-28
EP0625069B1 (de) 1998-12-30
EP0625069A1 (de) 1994-11-23
ES2127835T3 (es) 1999-05-01
US5648096A (en) 1997-07-15
FI943067A (fi) 1994-06-23
WO1994009898A1 (de) 1994-05-11
CN1090172A (zh) 1994-08-03
KR940703713A (ko) 1994-12-12

Similar Documents

Publication Publication Date Title
DE59309257D1 (de) Verfahren zur herstellung von mikrokapseln
DE69420632D1 (de) Verfahren zur Herstellung von Arzneizubereitungen mit verzögerter Wirkstoffabgabe
DE68919246T2 (de) Verfahren zur Herstellung von Aminosäuren.
DE69606495D1 (de) Verfahren zur Herstellung von depolymerisiertem Naturkautschuk
HUP0100535A2 (hu) Módosított hidrofóbitású proteinkészítmények és eljárások előállításukra
DE69423179T2 (de) Prozess zur Herstellung von optisch aktiven 2-Amino-1-phenylethanol Derivaten
DE69316344T2 (de) Prozess zur herstellung von oximen
DE3789309D1 (de) Enzymatische membran, verfahren zur herstellung und trennung von peptiden.
DE69021711D1 (de) Verfahren zur Herstellung von optisch aktiven Hydroxylactonen.
DE69311734D1 (de) Depolymerisation von nylon 66 (und gegebenenfalls nylon 6) zur herstellung von hexamethylendiamin (und caprolactam)
DE58907409D1 (de) Verfahren zur Herstellung von Caprolactam.
DE69619902D1 (de) Katalysatorsystem zur Herstellung von Kautschukpolymeren
DE58905768D1 (de) Verfahren zur herstellung von zur rektalen und vaginalen anwendung geeigneten praeparaten biologisch aktiver peptide.
DE60038281D1 (de) Verfahren zur herstellung von optisch aktiven pyridinethanol-derivaten
DE69002017T2 (de) Katalytisches Verfahren zur Herstellung von Oximen.
DE69603419T2 (de) Verfahren zur Herstellung von optisch aktiven Amiden
DE69315730D1 (de) Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
ATE132160T1 (de) Verfahren zur reinigung von aussenmembran-protein von haemophilus influenza
ATE163541T1 (de) Herstellungsverfahren von mit biologischen strukturen, biopolymeren und/oder oligomeren beladenen vesikeln
DE69410856T2 (de) Verfahren zur Herstellung von optisch aktiven Beta-hydroxy-ketonen
ATE235259T1 (de) Verfahren zur herstellung von kontrastmitteln
DE69403497T2 (de) Verfahren zur Herstellung von optisch aktivem 2-Aminopropanal
DE58907892D1 (de) Verfahren zur Herstellung von optisch aktiven alpha-Aminoacetalen.
DE68910033T2 (de) Katalytisches Verfahren zur Herstellung von optisch-aktiven Alpha-Hydroxycarboxylaten.
DE69330678D1 (de) Verfahren zur herstellung von aktivkohle ausgehend von gebrauchten reifen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee