DE528820T1 - Methoden und reagentien für die identifikation, charakterisierung und inhibition von farnesyl-protein-transferase. - Google Patents

Methoden und reagentien für die identifikation, charakterisierung und inhibition von farnesyl-protein-transferase.

Info

Publication number
DE528820T1
DE528820T1 DE0528820T DE91907853T DE528820T1 DE 528820 T1 DE528820 T1 DE 528820T1 DE 0528820 T DE0528820 T DE 0528820T DE 91907853 T DE91907853 T DE 91907853T DE 528820 T1 DE528820 T1 DE 528820T1
Authority
DE
Germany
Prior art keywords
enzyme
disclosed
inhibition
identification
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0528820T
Other languages
English (en)
Inventor
Michael S Brown
Joseph L Goldstein
Yuval Reiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27056998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE528820(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Texas System filed Critical University of Texas System
Publication of DE528820T1 publication Critical patent/DE528820T1/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1016Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1019Tetrapeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • Y10S435/815Enzyme separation or purification by sorption
DE0528820T 1990-04-18 1991-04-18 Methoden und reagentien für die identifikation, charakterisierung und inhibition von farnesyl-protein-transferase. Pending DE528820T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51070690A 1990-04-18 1990-04-18
US07/615,715 US5141851A (en) 1990-04-18 1990-11-20 Isolated farnesyl protein transferase enzyme
PCT/US1991/002650 WO1991016340A1 (en) 1990-04-18 1991-04-18 Methods and compositions for the identification, characterization and inhibition of farnesyl protein transferase

Publications (1)

Publication Number Publication Date
DE528820T1 true DE528820T1 (de) 1995-06-29

Family

ID=27056998

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0528820T Pending DE528820T1 (de) 1990-04-18 1991-04-18 Methoden und reagentien für die identifikation, charakterisierung und inhibition von farnesyl-protein-transferase.
DE69122611T Expired - Lifetime DE69122611T3 (de) 1990-04-18 1991-04-18 Methoden und reagentien für die identifikation, charakterisierung und inhibition von farnesyl-protein-transferase

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69122611T Expired - Lifetime DE69122611T3 (de) 1990-04-18 1991-04-18 Methoden und reagentien für die identifikation, charakterisierung und inhibition von farnesyl-protein-transferase

Country Status (8)

Country Link
US (1) US5141851A (de)
EP (1) EP0528820B2 (de)
JP (1) JPH05506779A (de)
AT (1) ATE143973T1 (de)
AU (1) AU637497B2 (de)
CA (1) CA2076652C (de)
DE (2) DE528820T1 (de)
WO (1) WO1991016340A1 (de)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
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US6790633B1 (en) * 1990-04-18 2004-09-14 Michael S. Brown Method of inhibiting a farnesyl transferase enzyme
US5420245A (en) * 1990-04-18 1995-05-30 Board Of Regents, The University Of Texas Tetrapeptide-based inhibitors of farnesyl transferase
US6083917A (en) * 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5962243A (en) * 1990-04-18 1999-10-05 Board Of Regents, The University Of Texas System Methods for the identification of farnesyltransferase inhibitors
US8003342B1 (en) 1990-04-18 2011-08-23 Board Of Regents, The University Of Texas System Method for identifying farnesyl transferase inhibitors
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US5141851A (en) 1992-08-25
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EP0528820A1 (de) 1993-03-03
WO1991016340A1 (en) 1991-10-31
JPH05506779A (ja) 1993-10-07
EP0528820B2 (de) 2001-12-19
DE69122611T3 (de) 2002-08-14
AU7694691A (en) 1991-11-11
CA2076652C (en) 2003-06-10
EP0528820B1 (de) 1996-10-09
ATE143973T1 (de) 1996-10-15
AU637497B2 (en) 1993-05-27
DE69122611D1 (de) 1996-11-14
DE69122611T2 (de) 1997-05-07

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