DE4090351T1 - Rekombinantes Pockenvirus-Wirtsselektionssystem - Google Patents

Rekombinantes Pockenvirus-Wirtsselektionssystem

Info

Publication number
DE4090351T1
DE4090351T1 DE4090351T DE4090351T DE4090351T1 DE 4090351 T1 DE4090351 T1 DE 4090351T1 DE 4090351 T DE4090351 T DE 4090351T DE 4090351 T DE4090351 T DE 4090351T DE 4090351 T1 DE4090351 T1 DE 4090351T1
Authority
DE
Germany
Prior art keywords
selection system
smallpox virus
host selection
virus host
recombinant smallpox
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4090351T
Other languages
English (en)
Inventor
Enzo Paoletti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/320,471 external-priority patent/US5155020A/en
Application filed by Health Research Inc filed Critical Health Research Inc
Publication of DE4090351T1 publication Critical patent/DE4090351T1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE4090351T 1989-03-08 1990-03-02 Rekombinantes Pockenvirus-Wirtsselektionssystem Withdrawn DE4090351T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/320,471 US5155020A (en) 1989-03-08 1989-03-08 Recombinant poxvirus host range selection system
US47817990A 1990-02-14 1990-02-14
PCT/US1990/001268 WO1990010693A1 (en) 1989-03-08 1990-03-02 Recombinant poxvirus host selection system

Publications (1)

Publication Number Publication Date
DE4090351T1 true DE4090351T1 (de) 1997-07-24

Family

ID=26982509

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4090351T Withdrawn DE4090351T1 (de) 1989-03-08 1990-03-02 Rekombinantes Pockenvirus-Wirtsselektionssystem

Country Status (15)

Country Link
US (1) US5453364A (de)
JP (1) JP3044062B2 (de)
AT (1) AT400955B (de)
AU (1) AU625584B2 (de)
BE (1) BE1004212A5 (de)
CA (1) CA2011654C (de)
CH (1) CH682669A5 (de)
DE (1) DE4090351T1 (de)
DK (1) DK157091A (de)
GB (1) GB2245272B (de)
IE (1) IE62441B1 (de)
IT (1) IT1239987B (de)
LU (1) LU88000A1 (de)
NL (1) NL9020389A (de)
WO (1) WO1990010693A1 (de)

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US5665362A (en) * 1990-09-25 1997-09-09 Cantab Pharmaceuticals Research Limited Viral vaccines
AU699903B2 (en) * 1990-11-20 1998-12-17 Virogenetics Corporation Measles virus recombinant poxvirus vaccine
US5756102A (en) * 1990-11-20 1998-05-26 Virogenetics Corporation Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants
US6309647B1 (en) 1999-07-15 2001-10-30 Aventis Pasteur Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
EP0575491B1 (de) * 1991-03-07 2003-08-13 Virogenetics Corporation Gentechnologisch hergestellter stamm für impfstoffe
US5766598A (en) * 1991-03-07 1998-06-16 Virogenetics Corporation Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products
DK0592546T3 (da) * 1991-06-14 2003-09-15 Us Gov Health & Human Serv Immundeficiens-virus rekombinant poxvirus-vaccine
DE69229390T2 (de) * 1991-08-26 1999-11-11 Immuno Ag Direkt molekuläre Klonierung eines modifizierten Genoms eines Chordopocken-Virus
WO1995030018A2 (en) * 1994-04-29 1995-11-09 Immuno Aktiengesellschaft Recombinant poxviruses with foreign polynucleotides in essential regions
EP1683858A3 (de) 1995-02-21 2006-08-02 Cantab Pharmaceuticals Research Limited Virale Zubereitungen, Vektoren, Immunogene und Impfstoffe
WO1997011714A1 (en) * 1995-09-29 1997-04-03 Immunex Corporation Chemokine inhibitor
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
US20030138454A1 (en) * 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
GB9711957D0 (en) 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
MXPA00008352A (es) 1998-02-27 2002-10-17 Univ Pennsylvania Vacunas, composiciones inmunoterapeuticas y metodos para usar las mismas.
CN1196495C (zh) 1999-04-30 2005-04-13 宾夕法尼亚大学理事会 突变的人cd80及其制备和应用组合物和方法
CA2408328C (en) * 2000-05-10 2012-04-17 Aventis Pasteur Limited Immunogenic polypeptides encoded by mage minigenes and uses thereof
CN1312171C (zh) * 2000-07-14 2007-04-25 宾夕法尼亚州立大学托管会 可编码hiv辅助蛋白的dna疫苗
WO2002029088A2 (en) * 2000-10-04 2002-04-11 The Trustees Of The University Of Pennsylvania Highly expressible genes
US8216585B2 (en) 2001-05-25 2012-07-10 The Trustees Of The University Of Pennsylvania Targeted particles and methods of using the same
GB0118532D0 (en) * 2001-07-30 2001-09-19 Isis Innovation Materials and methods relating to improved vaccination strategies
CA2467486A1 (en) 2001-11-30 2003-06-12 Isis Innovation Limited Vaccine
WO2003072718A2 (en) * 2002-02-22 2003-09-04 Ivigene Corporation In situ induced antigen technology (isiat) for identification of polynucleotides expressed during infection or colonization
AU2003223527B2 (en) 2002-04-09 2009-01-15 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
PL372091A1 (en) * 2002-05-16 2005-07-11 Bavarian Nordic A/S Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter
NZ570709A (en) 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
US8008265B2 (en) 2003-06-13 2011-08-30 The Trustees Of The University Of Pennsylvania Vaccines, immunotherapeutics and methods for using the same
US20050175627A1 (en) * 2003-09-24 2005-08-11 Oxxon Therapeutics Ltd. HIV pharmaccines
KR101162970B1 (ko) * 2003-10-08 2012-07-12 테리온 바이오로직스, 인크. 변형된 ｃｅａ/ｂ7 벡터
US20080274140A1 (en) * 2004-11-19 2008-11-06 David B Weiner Vaccines and Methods for Using the Same
CA2636867C (en) * 2006-01-13 2015-12-01 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using codon optimized il-15 and methods for using the same
EP1981905B1 (de) 2006-01-16 2016-08-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Chlamydia-impfstoff
KR101710981B1 (ko) 2006-07-28 2017-02-28 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 개선된 백신 및 이의 사용 방법
WO2009065546A1 (en) * 2007-11-19 2009-05-28 Transgene Sa Poxviral oncolytic vectors
US9687515B2 (en) 2007-11-19 2017-06-27 Transgene S.A. Poxviral oncolytic vectors
AU2009231598B2 (en) 2008-04-04 2015-03-12 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same
WO2009124312A2 (en) * 2008-04-04 2009-10-08 The Trustees Of The University Of Pennsylvania Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
US8921536B2 (en) 2008-10-29 2014-12-30 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
US8829174B2 (en) 2008-10-29 2014-09-09 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
CA2653478A1 (en) 2009-01-23 2010-07-23 Gregg Martin Automated wash system for industrial vehicles
US9050287B2 (en) 2009-01-23 2015-06-09 The Trustees Of The University Of Pennsylvania Vaccines for human papilloma virus and methods for using the same
WO2011032179A1 (en) 2009-09-14 2011-03-17 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
KR101965337B1 (ko) 2009-11-02 2019-04-03 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 구제역 바이러스(ｆｍｄｖ) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
WO2011097640A1 (en) 2010-02-08 2011-08-11 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
CN101935676A (zh) * 2010-08-20 2011-01-05 中国海洋大学 一种诱导扇贝组织细胞体外转化的方法
SI3536703T1 (sl) 2010-11-12 2022-04-29 The Trustees Of The University Of Pennsylvania Konsenzni prostatični antigeni, molekule nukleinske kisline, ki jih kodirajo in uporabe le-teh
JP6099573B2 (ja) 2011-01-31 2017-03-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 新規なヘルペス抗原をコードする核酸分子、それを含むワクチン及びその使用方法
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
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CA2851336C (en) 2011-10-24 2021-01-12 The Trustees Of The University Of Pennsylvania Improved hcv vaccines and methods for using the same
KR20220132652A (ko) 2011-12-12 2022-09-30 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 개선된 il-12 유전적 컨스트럭트 및 백신을 포함하는 조성물, 면역치료제 및 이를 이용하는 방법
JP6407028B2 (ja) 2011-12-12 2018-10-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＭＲＳＡのＰＢＰ２ａ及びその断片を含むタンパク質、それをコードする核酸、並びにＭＲＳＡ感染を予防する及び治療するための組成物及びそれらの使用
KR20140146651A (ko) 2012-04-10 2014-12-26 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 인간 호흡기 합포체 바이러스 공통 항원, 핵산 컨스트럭트 및 이들로부터 제조된 백신, 및 이들을 사용하는 방법
SG10201702292YA (en) * 2012-09-21 2017-05-30 Agency Science Tech & Res Novel attenuated dengue virus strains for vaccine application
EP3586870A1 (de) 2013-03-12 2020-01-01 The Trustees Of The University Of Pennsylvania Verbesserte impfstoffe gegen humanes papillomavirus und verfahren zur verwendung davon
KR20150130284A (ko) 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 백신 및 이를 이용한 치료 방법
KR102276405B1 (ko) 2013-03-15 2021-07-12 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 구제역 바이러스 (fmdv) 공통 단백질, 그에 대한 코딩 서열 및 그로부터 제조된 백신
JP7441169B2 (ja) 2017-12-13 2024-02-29 イノビオ ファーマシューティカルズ，インコーポレイティド Ｍｕｃ１６を標的とするがんワクチンおよびその使用
JP7352547B2 (ja) 2017-12-13 2023-09-28 イノビオ ファーマシューティカルズ，インコーポレイティド メソセリンを標的とするがんワクチンおよびその使用
BR112020011443A2 (pt) 2017-12-13 2020-12-01 Inovio Pharmaceuticals, Inc. molécula de ácido nucleico e seu uso, vetor e seu uso, composição, proteína e vacina
CN112779293A (zh) * 2021-01-27 2021-05-11 重庆市畜牧科学院 一种筛选LacZ基因标记山羊痘病毒的宿主细胞的方法

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Also Published As

Publication number Publication date
IE900814L (en) 1990-09-08
LU88000A1 (fr) 1992-03-11
GB2245272B (en) 1993-03-17
ATA902490A (de) 1995-09-15
DK157091A (da) 1991-09-26
AU5332090A (en) 1990-10-09
AU625584B2 (en) 1992-07-16
AT400955B (de) 1996-05-28
NL9020389A (nl) 1991-12-02
CA2011654A1 (en) 1990-09-08
BE1004212A5 (fr) 1992-10-13
IT9019623A0 (it) 1990-03-08
JPH04503904A (ja) 1992-07-16
IE62441B1 (en) 1995-02-08
WO1990010693A1 (en) 1990-09-20
CA2011654C (en) 1995-12-19
IT1239987B (it) 1993-11-27
US5453364A (en) 1995-09-26
DK157091D0 (da) 1991-09-06
IT9019623A1 (it) 1991-09-08
GB2245272A (en) 1992-01-02
CH682669A5 (fr) 1993-10-29
GB9117996D0 (en) 1991-10-09
JP3044062B2 (ja) 2000-05-22

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