DE3940260A1 - Position determining appts. for objects or body constituents - introduces ferromagnetic substances to enable location of objects due to their magnetic field using field sensors - Google Patents

Position determining appts. for objects or body constituents - introduces ferromagnetic substances to enable location of objects due to their magnetic field using field sensors

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Publication number
DE3940260A1
DE3940260A1 DE3940260A DE3940260A DE3940260A1 DE 3940260 A1 DE3940260 A1 DE 3940260A1 DE 3940260 A DE3940260 A DE 3940260A DE 3940260 A DE3940260 A DE 3940260A DE 3940260 A1 DE3940260 A1 DE 3940260A1
Authority
DE
Germany
Prior art keywords
magnetic field
objects
spatial
biological organisms
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE3940260A
Other languages
German (de)
Inventor
Werner Weitschies
Ruediger Prof Dr Groening
Lutz Dr Trahms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE3940260A priority Critical patent/DE3940260A1/en
Publication of DE3940260A1 publication Critical patent/DE3940260A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/062—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers

Abstract

The method determines the resting place, the location or the speed of particles introduced in biological organisms, which due to their ferro or ferrimagnetism have a static magnetic field, or objects introduced in bioligical organisms, which due to the contained electrical circuits generate a magnetic field. The determination of the variables is carried out by measuring the spatial-time magnetic field course using suitable sensors. The movement of the resting place of organs or other constituent parts of biological organisms marked with ferror or ferrimagnetic materials as a static magnetic factor or with electric circuits which generate a magnetic field are determined by the measurement of the spatial-time magnetic field course using suitable sensors. USE/ADVANTAGE - Determines position and movement of objects, substances, body constituents and organs. Carried out without radioactive radiation. Has weak magnetic field, preventing adverse effect on organism or environment.

Description

Die vorliegende Erfindung betrifft ein Verfahren zur Darstellung und Lokalisation von Objekten und Substanzen in Organismen, die aufgrund ihres magnetischen Momentes mit Hilfe von Geräten zur Messung von Magnetfeldern dargestellt und lokalisiert werden können.The present invention relates to a method for displaying and Localization of objects and substances in organisms due to their magnetic moment with the help of devices for measuring Magnetic fields can be represented and localized.

In eine ganzen Reihe von medizinischen oder pharmazeutischen Fragestellungen ist es erforderlich, physiologische oder unphysiologische Verbindungen, Stoffe oder Träger im Organismus darzustellen, zu lokalisieren, sowie ihren Abbau, Verbleib und ihre Verstoffwechslung zu verfolgen, bzw. zu bestimmen. Hierfür werden bislang hauptsächlich Verfahren eingesetzt, die mit ionisierenden Strahlen arbeiten. Sie sind damit sowohl für Patienten und Anwender, als auch für die Umwelt belastend.In a whole range of medical or pharmaceutical Questions are required, physiological or non-physiological To represent compounds, substances or carriers in the organism localize, as well as their degradation, whereabouts and their metabolism track or determine. So far, mainly Processes used that work with ionizing radiation. you are thus both for patients and users, as well as for the environment stressful.

Der Vorteil des erfindungsgemäßen Verfahrens liegt darin, daß die Messungen ohne jede radioaktive Belastung durchgeführt werden können. Das Magnetfeld der zur Messung eingesetzten Verbindung ist in der Regel sehr schwach, dadurch sind belastende Effekte durch die Messung auf den Organismus oder die Umwelt praktisch auszuschließen.The advantage of the method according to the invention is that the Measurements can be carried out without any radioactive contamination can. The magnetic field of the connection used for the measurement is usually very weak, this has negative effects due to the Practically exclude measurement of the organism or the environment.

Als nicht beschränkendes Beispiel zum Einsatz des patentmäßigen Verfahrens wird die Markierung von Pellets mit Magnetit (Fe3O4) und die Bestimmung ihres Magnetfeldes in vivo beschrieben. Auf Streukügelchen aus Saccharose (Durchmesser ca. 0,8-1,0 mm) wird in einem Pelletierteller eine pro Pellet ca. 10-4 g Magnetit Fe34) enthaltende Schicht aus gepulvertem Magnetit in einer Polymethyl­ methacrylat-Lösung aufgetragen (10% Magnetitpulver suspendiert in einer Lösung von 5% Polymethylmethacrylat und 0,5% Dibutylphtalat in Aceton). Anschließend wird auf die Pellets noch eine Schutzschicht aus der Sprühlösung ohne suspendiertes Magnetit aufgebracht. Die fertigen wasserunlöslichen Pellets werden einzeln mit Hilfe eines geeigneten Magneten bis zur Sättigung magnetisiert.The marking of pellets with magnetite (Fe 3 O 4 ) and the determination of their magnetic field in vivo is described as a non-limiting example of the use of the patented method. On globules of sucrose (diameter about 0.8-1.0 mm) in a pelletizing pan is about 10 -4 g magnetite Fe 34 applied a) containing layer of powdered magnetite in a polymethyl methacrylate solution per pellet (10% magnetite suspended in a solution of 5% polymethyl methacrylate and 0.5% dibutyl phthalate in acetone). A protective layer from the spray solution without suspended magnetite is then applied to the pellets. The finished water-insoluble pellets are individually magnetized to saturation using a suitable magnet.

Nach peroraler Einnahme kann das Magnetfeld des Pellets mit Hilfe supraleitender Sensoren (SQUIDS) in vivo bestimmt werden. Aus der Kenntnis des raum-zeitlichen Verlaufs des Magnetfeldes läßt sich mittels etablierter Prozeduren 1,2,3 der Ort des Pellets als Funktion der Zeit bestimmen. Ebenso kann seine Bewegung im Gastrointestinaltrakt dargestellt werden, und mit Hilfe der gewonnenen Daten kann auf die Motilität des Gastrointestinaltraktes zurückgeschlossen werden.After oral intake, the pellet's magnetic field can be determined in vivo using superconducting sensors (SQUIDS). From the knowledge of the spatial-temporal course of the magnetic field, the location of the pellet can be determined as a function of time using established procedures 1 , 2, 3 . Its movement can also be shown in the gastrointestinal tract, and the data obtained can be used to determine the motility of the gastrointestinal tract.

Claims (6)

1. Verfahren zur Bestimmung
  • 1.1 des Aufenthaltsortes oder
  • 1.2 der Orientierung oder
  • 1.3 der Geschwindigkeit von
  • 1.4 in biologische Organismen eingebrachten Partikeln, die aufgrund ihres Ferro- oder Ferrimagnetismus ein statisches magnetisches Moment haben, oder
  • 1.5 in biologische Organismen eingebrachten Objekten, die aufgrund enthaltener elektrischer Schaltungen ein Magnetfeld generieren,
1. Procedure for determination
  • 1.1 the place of residence or
  • 1.2 the orientation or
  • 1.3 the speed of
  • 1.4 particles introduced into biological organisms that have a static magnetic moment due to their ferro- or ferrimagnetism, or
  • 1.5 objects introduced into biological organisms that generate a magnetic field due to the electrical circuits contained therein,
dadurch gekennzeichnet, daß durch die Messung des raum-zeitlichen Magnetfeldverlaufs mit Hilfe geeigneter Sensoren die Bestimmungsgrößen (1.1 bis 1.3) ermittelt werden. characterized in that the parameters (1.1 to 1.3) are determined by measuring the spatial-temporal magnetic field with the aid of suitable sensors. 2. Verfahren zur Bestimmung
  • 2.1 der Bewegung oder
  • 2.2 des Aufenthaltsortes von
  • 2.3 mit ferro- oder ferrimagnetischen Materialien als statisches magnetisches Moment markierten oder
  • 2.4 mit elektrischen Schaltungen, die ein Magnetfeld generieren, markierten Organen, oder anderen Bestandteilen biologischer Organismen,
2. Procedure for determination
  • 2.1 the movement or
  • 2.2 the whereabouts of
  • 2.3 marked with ferromagnetic or ferrimagnetic materials as static magnetic moment or
  • 2.4 with electrical circuits that generate a magnetic field, marked organs, or other components of biological organisms,
dadurch gekennzeichnet, daß durch die Messung des raum-zeitlichen Magnetfeldverlaufs mit Hilfe geeigneter Sensoren die Bestimmungsgrößen (2.1 und 2.2) ermittelt werden.characterized in that by measuring the spatial-temporal magnetic field with the help suitable parameters, the determinants (2.1 and 2.2) are determined will. 3. Verfahren zur Bestimmung
  • 3.1 des Abbaus oder
  • 3.2 der Freisetzung oder
  • 3.3 der Zersetzung von Objekten oder Stoffen, deren Markierung als statisches magnetisches Moment in ihrem zeitlichen Ausmaß von den Untersuchungsbedingungen oder den zur Markierung verwendeten ferro- oder ferrimagnetischen Materialien oder verwendeter Hilfsstoffe abhängt,
3. Procedure for determination
  • 3.1 the dismantling or
  • 3.2 the release or
  • 3.3 the decomposition of objects or substances, the marking of which, as a static magnetic moment, depends on the examination conditions or the ferromagnetic or ferrimagnetic materials or auxiliaries used for the marking,
dadurch gekennzeichnet, daß durch die Messung des raum-zeitlichen Magnetfeldverlaufs mit Hilfe geeigneter Sensoren die Bestimmungsgrößen (3.1 bis 3.3) ermittelt werden.characterized in that by measuring the spatial-temporal magnetic field with the help suitable parameters determine the parameters (3.1 to 3.3) will.
DE3940260A 1989-03-04 1989-12-06 Position determining appts. for objects or body constituents - introduces ferromagnetic substances to enable location of objects due to their magnetic field using field sensors Ceased DE3940260A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3940260A DE3940260A1 (en) 1989-03-04 1989-12-06 Position determining appts. for objects or body constituents - introduces ferromagnetic substances to enable location of objects due to their magnetic field using field sensors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3907102 1989-03-04
DE3940260A DE3940260A1 (en) 1989-03-04 1989-12-06 Position determining appts. for objects or body constituents - introduces ferromagnetic substances to enable location of objects due to their magnetic field using field sensors

Publications (1)

Publication Number Publication Date
DE3940260A1 true DE3940260A1 (en) 1990-09-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE3940260A Ceased DE3940260A1 (en) 1989-03-04 1989-12-06 Position determining appts. for objects or body constituents - introduces ferromagnetic substances to enable location of objects due to their magnetic field using field sensors

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686499A1 (en) * 1992-01-28 1993-07-30 Technomed Int Sa APPARATUS FOR TREATING A TARGET, SUCH AS A DAMAGE WITHIN THE BODY OF A MAMMAL, PARTICULARLY A HUMAN BEING, USING A MARKING ELEMENT IMPLANTED IN OR IN THE VICINITY OF THE TARGET TO CONTROL THERAPY OF THE SAME TARGET.
WO1997009640A1 (en) * 1995-09-05 1997-03-13 Institut für Physikalische Hochtechnologie e.V. Method and arrangement for determining the position of a marker in an organic cavity
DE19707556C1 (en) * 1995-09-05 1998-07-09 Inst Physikalische Hochtech Ev Magnetic marker pill revealing local velocities in digestive tract
WO1998037826A1 (en) * 1997-02-26 1998-09-03 Aesculap Meditec Gmbh Marker for determining its position in a cavity inside the organism of a living being
US6081734A (en) * 1996-08-16 2000-06-27 Roche Diagnostics Gmbh Monitoring system for the regular intake of a medicament
CN100394888C (en) * 2005-12-01 2008-06-18 上海交通大学 Swallowing type electronic remote detection continuous tracking and positioning system in capsule based on magnetic marker
DE102007036570A1 (en) * 2007-08-03 2009-02-19 Siemens Ag Screening test for detection of prostate disease and device and diagnostic substance for performing the test
US7778681B2 (en) * 2001-10-19 2010-08-17 Koninklijke Philips Electronics N.V. Method of determining the spatial distribution of magnetic particles
US9050256B2 (en) 2009-09-03 2015-06-09 Evonik Röhm Gmbh Oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles
RU2598341C2 (en) * 2011-12-21 2016-09-20 Эвоник Рем ГмбХ Detection system for detecting magnetic objects in human body

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
DE3813479A1 (en) * 1987-04-21 1988-11-10 Mccormick Lab Inc DEVICE FOR THE ACCURATE LOCALIZATION OF FERROMAGNETIC MATERIAL IN BIOLOGICAL TISSUE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
DE3813479A1 (en) * 1987-04-21 1988-11-10 Mccormick Lab Inc DEVICE FOR THE ACCURATE LOCALIZATION OF FERROMAGNETIC MATERIAL IN BIOLOGICAL TISSUE

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
US-Z.: Electronics, 22. März 1963, S. 58-60 *
US-Z.: Methods in Enzymology, Vol. 149, 1987, S. 301-313 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686499A1 (en) * 1992-01-28 1993-07-30 Technomed Int Sa APPARATUS FOR TREATING A TARGET, SUCH AS A DAMAGE WITHIN THE BODY OF A MAMMAL, PARTICULARLY A HUMAN BEING, USING A MARKING ELEMENT IMPLANTED IN OR IN THE VICINITY OF THE TARGET TO CONTROL THERAPY OF THE SAME TARGET.
WO1993014712A1 (en) * 1992-01-28 1993-08-05 Technomed International Apparatus for treating a target such as a lesion with a tracer element
WO1997009640A1 (en) * 1995-09-05 1997-03-13 Institut für Physikalische Hochtechnologie e.V. Method and arrangement for determining the position of a marker in an organic cavity
DE19532676C1 (en) * 1995-09-05 1997-05-07 Inst Physikalische Hochtech Ev Arrangement for determining the position of a marker in a cavity within the organism of a living being
DE19707556C1 (en) * 1995-09-05 1998-07-09 Inst Physikalische Hochtech Ev Magnetic marker pill revealing local velocities in digestive tract
US6082366A (en) * 1995-09-05 2000-07-04 Aesculap Meditec Gmbh Method and arrangement for determining the position of a marker in an organic cavity
US6081734A (en) * 1996-08-16 2000-06-27 Roche Diagnostics Gmbh Monitoring system for the regular intake of a medicament
WO1998037826A1 (en) * 1997-02-26 1998-09-03 Aesculap Meditec Gmbh Marker for determining its position in a cavity inside the organism of a living being
US7778681B2 (en) * 2001-10-19 2010-08-17 Koninklijke Philips Electronics N.V. Method of determining the spatial distribution of magnetic particles
CN100394888C (en) * 2005-12-01 2008-06-18 上海交通大学 Swallowing type electronic remote detection continuous tracking and positioning system in capsule based on magnetic marker
DE102007036570A1 (en) * 2007-08-03 2009-02-19 Siemens Ag Screening test for detection of prostate disease and device and diagnostic substance for performing the test
US9050256B2 (en) 2009-09-03 2015-06-09 Evonik Röhm Gmbh Oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles
RU2598341C2 (en) * 2011-12-21 2016-09-20 Эвоник Рем ГмбХ Detection system for detecting magnetic objects in human body
US9696279B2 (en) 2011-12-21 2017-07-04 Evonik Roehm Gmbh Detection system for detecting magnetic objects in the human organism

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