DE3877492T2 - Pharmazeutisches praeparat mit verzoegerter abgabe eines dihydropyridins und eines beta-adrenorezeptor-antagonisten und herstellungsverfahren dessen. - Google Patents

Pharmazeutisches praeparat mit verzoegerter abgabe eines dihydropyridins und eines beta-adrenorezeptor-antagonisten und herstellungsverfahren dessen.

Info

Publication number
DE3877492T2
DE3877492T2 DE8888850319T DE3877492T DE3877492T2 DE 3877492 T2 DE3877492 T2 DE 3877492T2 DE 8888850319 T DE8888850319 T DE 8888850319T DE 3877492 T DE3877492 T DE 3877492T DE 3877492 T2 DE3877492 T2 DE 3877492T2
Authority
DE
Germany
Prior art keywords
dihydropyridine
beta
production method
receptor antagonist
pharmaceutical preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888850319T
Other languages
English (en)
Other versions
DE3877492D1 (de
Inventor
Gert Anders Ragnarsson
Kajsa Margareta Silfverstrand
John Albert Sjoegren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20369795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3877492(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hassle AB filed Critical Hassle AB
Publication of DE3877492D1 publication Critical patent/DE3877492D1/de
Application granted granted Critical
Publication of DE3877492T2 publication Critical patent/DE3877492T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
DE8888850319T 1987-10-08 1988-09-22 Pharmazeutisches praeparat mit verzoegerter abgabe eines dihydropyridins und eines beta-adrenorezeptor-antagonisten und herstellungsverfahren dessen. Expired - Lifetime DE3877492T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8703881A SE8703881D0 (sv) 1987-10-08 1987-10-08 New pharmaceutical preparation

Publications (2)

Publication Number Publication Date
DE3877492D1 DE3877492D1 (de) 1993-02-25
DE3877492T2 true DE3877492T2 (de) 1993-05-13

Family

ID=20369795

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888850319T Expired - Lifetime DE3877492T2 (de) 1987-10-08 1988-09-22 Pharmazeutisches praeparat mit verzoegerter abgabe eines dihydropyridins und eines beta-adrenorezeptor-antagonisten und herstellungsverfahren dessen.

Country Status (26)

Country Link
US (1) US4942040A (de)
EP (1) EP0311582B1 (de)
JP (1) JP2619936B2 (de)
KR (1) KR960009411B1 (de)
CN (1) CN1029935C (de)
AT (1) ATE84412T1 (de)
AU (1) AU615211B2 (de)
CA (1) CA1312286C (de)
CY (1) CY1896A (de)
DE (1) DE3877492T2 (de)
DK (1) DK175085B1 (de)
ES (1) ES2053815T3 (de)
FI (1) FI92903C (de)
GR (1) GR3006788T3 (de)
HK (1) HK6296A (de)
HU (1) HU210461A9 (de)
IE (1) IE63084B1 (de)
IL (1) IL87922A (de)
IS (1) IS1584B (de)
MX (1) MX169243B (de)
MY (1) MY104065A (de)
NO (1) NO177375C (de)
NZ (1) NZ226245A (de)
PH (1) PH25568A (de)
PT (1) PT88711B (de)
SE (1) SE8703881D0 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268182A (en) * 1988-06-24 1993-12-07 Abbott Laboratories Sustained-release drug dosage units of terazosin
GB9025251D0 (en) * 1990-11-20 1991-01-02 Solomon Montague C Nifedipine dosage forms
CA2106494A1 (en) * 1991-03-18 1992-09-19 James W. Young Composition and method containing optically pure (s) metoprolol
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
US5773025A (en) 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US6726930B1 (en) 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5662933A (en) * 1993-09-09 1997-09-02 Edward Mendell Co., Inc. Controlled release formulation (albuterol)
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US5399358A (en) * 1993-11-12 1995-03-21 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metroprolol
US5399359A (en) * 1994-03-04 1995-03-21 Edward Mendell Co., Inc. Controlled release oxybutynin formulations
US5399362A (en) * 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
ATE209906T1 (de) * 1994-04-25 2001-12-15 Mendell Co Inc Edward Trägerstoff zur verzögerten freisetzung
US5478572A (en) * 1994-09-06 1995-12-26 Bristol-Myers Squibb Co. Gepirone dosage form
US5945125A (en) * 1995-02-28 1999-08-31 Temple University Controlled release tablet
AU2068797A (en) * 1996-01-29 1997-08-20 Edward Mendell Co. Inc. Sustained release excipient
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
US6093420A (en) * 1996-07-08 2000-07-25 Edward Mendell Co., Inc. Sustained release matrix for high-dose insoluble drugs
US6056977A (en) * 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
CA2354057C (en) * 1998-12-11 2009-02-10 Nostrum Pharmaceuticals, Inc. Sustained release tablet containing hydrocolloid and cellulose ether
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
MXPA01005370A (es) * 1999-09-30 2004-05-14 Penwest Pharmaceuticals Co Sistema de matriz de liberacion sostenida para farmacos altamente solubles.
HU230828B1 (en) 1999-10-29 2018-08-28 Euro Celtique Sa Controlled release hydrocodone formulations
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
BR0109991A (pt) * 2000-04-11 2003-05-27 Sankyo Co Composição farmacêutica
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
WO2002036099A1 (en) 2000-10-30 2002-05-10 Euro-Celtique S.A. Controlled release hydrocodone formulations
CA2452871C (en) * 2001-07-06 2011-10-04 Endo Pharmaceuticals, Inc. Oxymorphone controlled release formulations
CA2459014C (en) * 2001-09-14 2010-08-10 Scolr, Inc. Amino acid modulated extended release dosage form
US20040009220A1 (en) * 2001-12-31 2004-01-15 Vinay Sharma Rate-controlled beta blockers and process for forming same
WO2003086353A1 (en) * 2002-04-05 2003-10-23 Penwest Pharmaceuticals Co. Sustained release metoprolol formulations
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20080051428A1 (en) * 2002-05-15 2008-02-28 Davis Paul J Pyrroloquinoline quinone drugs and methods of use thereof
US7276514B2 (en) * 2002-05-15 2007-10-02 Charitable Leadership Foundation - Medical Technology Acceleration Program Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
US20050267143A1 (en) * 2002-05-15 2005-12-01 Davis Paul J Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
KR20030095600A (ko) * 2002-06-12 2003-12-24 환인제약 주식회사 펠로디핀을 포함하는 제어방출형 조성물 및 그 제조방법
US7314640B2 (en) * 2003-07-11 2008-01-01 Mongkol Sriwongjanya Formulation and process for drug loaded cores
US20070092573A1 (en) * 2005-10-24 2007-04-26 Laxminarayan Joshi Stabilized extended release pharmaceutical compositions comprising a beta-adrenoreceptor antagonist
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
PL2255791T3 (pl) * 2009-04-03 2012-05-31 Zakl Farmaceutyczne Polpharma Sa Kompozycja farmaceutyczna o przedłużonym uwalnianiu zawierająca bursztynian metoprololu
US20130202705A1 (en) * 2010-05-11 2013-08-08 Cima Labs Inc. Alcohol-resistant formulations
CA2798702A1 (en) 2010-05-11 2011-11-17 Cima Labs Inc. Alcoholresistant metoprolol-containing extended-release oral dosage forms
EP2747757A1 (de) * 2011-08-26 2014-07-02 Wockhardt Limited Verfahren zur behandlung kardiovaskulärer erkrankungen
GB2512059B (en) * 2013-03-18 2016-08-31 Rolls Royce Plc An independently moveable machine tool
CN113143877A (zh) * 2021-05-07 2021-07-23 苏州康恒研新药物技术有限公司 一种琥珀酸美托洛尔微丸缓释片的制备方法
CN114712319B (zh) * 2022-03-25 2024-01-09 北京诺康达医药科技股份有限公司 一种非洛地平盐酸普萘洛尔复方制剂及其制备方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870790A (en) * 1970-01-22 1975-03-11 Forest Laboratories Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose
CH532038A (de) * 1970-05-25 1972-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Cycloheptenderivaten
US3951821A (en) * 1972-07-14 1976-04-20 The Dow Chemical Company Disintegrating agent for tablets
US4123382A (en) * 1973-05-25 1978-10-31 Merck & Co., Inc. Method of microencapsulation
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
US4016880A (en) * 1976-03-04 1977-04-12 Alza Corporation Osmotically driven active agent dispenser
US4291016A (en) * 1976-07-27 1981-09-22 Sandoz Ltd. Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate
GB1542414A (en) * 1976-08-19 1979-03-21 Standard Telephones Cables Ltd Arrangements for the controlled release of biologically active materials
DE2642032A1 (de) * 1976-09-18 1978-03-30 Merck Patent Gmbh Siliciumdioxidhaltige zubereitungen und verfahren zu ihrer herstellung
GB1576376A (en) * 1977-03-30 1980-10-08 Benzon As Alfred Multiple-unit drug dose
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
SE426548B (sv) * 1978-12-05 1983-01-31 Haessle Ab Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer
US4226849A (en) * 1979-06-14 1980-10-07 Forest Laboratories Inc. Sustained release therapeutic compositions
US4357469A (en) * 1979-06-14 1982-11-02 Forest Laboratories, Inc. Carrier base material for prolonged release therapeutic compositions
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4309406A (en) * 1979-07-10 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4309404A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung
CH655658B (de) * 1980-09-18 1986-05-15
US4326525A (en) * 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4439195A (en) * 1980-10-14 1984-03-27 Alza Corporation Theophylline therapy
US4428883A (en) * 1981-03-06 1984-01-31 The University Of Kentucky Research Foundation Novel method of administering β-blockers and novel dosage forms containing same
IT1144911B (it) * 1981-03-19 1986-10-29 Pharmatec Spa Composizione farmaceutica a rilascio controllato contenente ibuprofen
GB2098867B (en) * 1981-05-21 1984-10-24 Wyeth John & Brother Ltd Sustained release pharmaceutical composition
JPS57209223A (en) * 1981-06-19 1982-12-22 Tanabe Seiyaku Co Ltd Microcapsule for intracranial anti hypotension and its production
US4369272A (en) * 1981-07-07 1983-01-18 E. I. Du Pont De Nemours And Company Process for preparing polyolefin resin extended pigments comprising salt milling crude pigment with the resin
US4484921A (en) * 1982-02-01 1984-11-27 Alza Corporation Theophylline therapy utilizing osmotic delivery
US4642233A (en) * 1982-03-22 1987-02-10 Alza Corporation Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills
US4449983A (en) * 1982-03-22 1984-05-22 Alza Corporation Simultaneous delivery of two drugs from unit delivery device
US4649043A (en) * 1982-03-22 1987-03-10 Alza Corporation Drug delivery system for delivering a plurality of tiny pills in the gastrointestinal tract
US4434153A (en) * 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
JPS58170712A (ja) * 1982-03-31 1983-10-07 Chiyoda Yakuhin Kk インドメタシン徐放錠
US4415547A (en) * 1982-06-14 1983-11-15 Sterling Drug Inc. Sustained-release pharmaceutical tablet and process for preparation thereof
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4681583A (en) * 1982-12-20 1987-07-21 Alza Corporation System for dispersing drug in biological environment
US4578075A (en) * 1982-12-20 1986-03-25 Alza Corporation Delivery system housing a plurality of delivery devices
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
PH18946A (en) * 1983-04-21 1985-11-14 Elan Corp Plc Controlled absorption pharmaceutical composition
GB2146531B (en) * 1983-09-15 1987-04-29 Stc Plc Controlled release system
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
US4716041A (en) * 1984-02-10 1987-12-29 A/S Alfred Benzon Diffusion coated multiple-units dosage form
GB2154874B (en) * 1984-02-29 1987-11-04 Sandoz Ltd Bromoscriptine compositions
IT1206166B (it) * 1984-07-26 1989-04-14 Sigma Tau Ind Farmaceuti Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
DE3419131A1 (de) * 1984-05-23 1985-11-28 Bayer Ag, 5090 Leverkusen Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung
GB2159715B (en) * 1984-06-04 1988-05-05 Sterwin Ag Pharmaceutical composition in sustained release unit dose form and process for its preparation
SE455836B (sv) * 1985-10-11 1988-08-15 Haessle Ab Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning
US4808413A (en) * 1987-04-28 1989-02-28 E. R. Squibb & Sons, Inc. Pharmaceutical compositions in the form of beadlets and method

Also Published As

Publication number Publication date
KR960009411B1 (en) 1996-07-19
CA1312286C (en) 1993-01-05
IS1584B (is) 1996-03-01
PT88711B (pt) 1992-12-31
CN1032490A (zh) 1989-04-26
CY1896A (en) 1996-09-27
NZ226245A (en) 1990-08-28
JPH01128917A (ja) 1989-05-22
IE882921L (en) 1989-04-08
HK6296A (en) 1996-01-19
FI884636A (fi) 1989-04-09
EP0311582A1 (de) 1989-04-12
IE63084B1 (en) 1995-03-22
PH25568A (en) 1991-08-08
NO884269D0 (no) 1988-09-27
DE3877492D1 (de) 1993-02-25
DK558688A (da) 1989-04-09
KR890006226A (ko) 1989-06-12
NO177375B (no) 1995-05-29
ES2053815T3 (es) 1994-08-01
IL87922A0 (en) 1989-03-31
DK175085B1 (da) 2004-05-24
HU210461A9 (en) 1995-04-28
AU2237488A (en) 1989-04-13
NO884269L (no) 1989-04-10
FI884636A0 (fi) 1988-10-07
IS3398A7 (is) 1989-04-09
ATE84412T1 (de) 1993-01-15
CN1029935C (zh) 1995-10-11
AU615211B2 (en) 1991-09-26
EP0311582B1 (de) 1993-01-13
SE8703881D0 (sv) 1987-10-08
DK558688D0 (da) 1988-10-06
GR3006788T3 (de) 1993-06-30
JP2619936B2 (ja) 1997-06-11
FI92903C (fi) 1995-01-25
MY104065A (en) 1993-11-30
MX169243B (es) 1993-06-25
IL87922A (en) 1993-07-08
US4942040A (en) 1990-07-17
NO177375C (no) 1995-09-06
FI92903B (fi) 1994-10-14

Similar Documents

Publication Publication Date Title
DE3877492D1 (de) Pharmazeutisches praeparat mit verzoegerter abgabe eines dihydropyridins und eines beta-adrenorezeptor-antagonisten und herstellungsverfahren dessen.
NO903264L (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat i form av mikropartikler.
IT8820145A0 (it) Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione.
FR2628109B1 (fr) Amphireguline, glycoproteine bifonctionnelle regulatrice de la croissance et son procede de preparation
NO885641L (no) Fremgangsmaate for fremstilling av farmasoeytisk preparat.
NO175287C (no) Fremgangsmåte for fremstilling av et intravenöst, farmasöytisk preparat
ATA195588A (de) Epipodophyllotoxinglucosid-4'-phosphat-derivate deren herstellung, sowie pharmazeutische zusammensetzungen hierzu
NO863997L (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat
NO923746L (no) Blanding inneholdende vekstfaktorer og polyelektrolytter,fremgangsmaate for fremstilling derav, samt farmasoeytisk preparat som inneholder blandingen
NO870368L (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat med langvarig virkning.
NO901391D0 (no) Fremgangsmaate for fremstilling av et 1,8-naftyridin-derivat.
DE3764235D1 (de) Ifosfamid-lyophilisat und verfahren zu dessen herstellung.
MA22097A1 (fr) Procede de preparation de polypeptide et procede de fabrication d'un vaccin contre le paludisme .
EG19645A (en) A method for preparing pharmaceutical by use bambuterol
FI870732A (fi) Glycero-3(2)-fosfo-l-serinderivat och deras salter, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat.
NO903442D0 (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat med regulert biologisk tilgjengelighet.
IT8720271A0 (it) Nuovi derivati dell'ergolene, composizioni farmaceutiche che licontengono e procedimento per lapreparazione dei medesimi.
HU9400417D0 (en) New leukotriene-b4 antagonists, methods for producing them and their use as drugs
FR2671105B1 (fr) Procede d'elaboration d'un materiau composite a matrice a base de titane, et materiau composite obtenu par ce procede.
IT8819182A0 (it) Derivati dell'ambroxol,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT8620713A0 (it) Nuovi derivati ad attivita'terapeutica, procedimento per la loro prepazione e relative compisizioni farmaceutiche.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings