DE3874485T3 - Injizierbare, opazifizierende liposomzusammensetzung. - Google Patents

Injizierbare, opazifizierende liposomzusammensetzung.

Info

Publication number
DE3874485T3
DE3874485T3 DE3874485T DE3874485T DE3874485T3 DE 3874485 T3 DE3874485 T3 DE 3874485T3 DE 3874485 T DE3874485 T DE 3874485T DE 3874485 T DE3874485 T DE 3874485T DE 3874485 T3 DE3874485 T3 DE 3874485T3
Authority
DE
Germany
Prior art keywords
injectable
opacificating
liposome composition
weight
encapsulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3874485T
Other languages
English (en)
Other versions
DE3874485D1 (de
DE3874485T2 (de
Inventor
Michel Schneider
Herve Tournier
Bernard Lamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dibra SpA
Original Assignee
Dibra SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4223355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3874485(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dibra SpA filed Critical Dibra SpA
Publication of DE3874485D1 publication Critical patent/DE3874485D1/de
Application granted granted Critical
Publication of DE3874485T2 publication Critical patent/DE3874485T2/de
Publication of DE3874485T3 publication Critical patent/DE3874485T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
DE3874485T 1987-05-22 1988-05-16 Injizierbare, opazifizierende liposomzusammensetzung. Expired - Fee Related DE3874485T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1991/87A CH672733A5 (de) 1987-05-22 1987-05-22
PCT/EP1988/000447 WO1988009165A1 (en) 1987-05-22 1988-05-16 Injectable opacifying liposome composition

Publications (3)

Publication Number Publication Date
DE3874485D1 DE3874485D1 (de) 1992-10-15
DE3874485T2 DE3874485T2 (de) 1993-03-11
DE3874485T3 true DE3874485T3 (de) 2000-09-14

Family

ID=4223355

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3874485T Expired - Fee Related DE3874485T3 (de) 1987-05-22 1988-05-16 Injizierbare, opazifizierende liposomzusammensetzung.

Country Status (13)

Country Link
US (3) US5312615A (de)
EP (1) EP0314764B2 (de)
JP (1) JP2619037B2 (de)
AT (1) ATE80294T1 (de)
AU (1) AU612371B2 (de)
CA (1) CA1303978C (de)
CH (1) CH672733A5 (de)
DE (1) DE3874485T3 (de)
ES (1) ES2009917A6 (de)
IL (1) IL86409A (de)
MX (1) MX9203271A (de)
WO (1) WO1988009165A1 (de)
ZA (1) ZA883449B (de)

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CH672733A5 (de) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
MX9203504A (es) * 1988-04-20 1992-07-01 Liposome Co Inc Complejo agente: lipido activo de alta proporcion.
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) * 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
SE470086B (sv) * 1991-04-23 1993-11-08 Kabi Pharmacia Ab Organspecifik emulsion
SE9101709L (sv) * 1991-06-03 1992-12-04 Karlshamns Lipidteknik Ab Lipidderivat som diagnostikum eller kontrastmedel
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US6241967B1 (en) * 1992-10-16 2001-06-05 Andreas Sachse Process and device for the production of liquid, disperse systems
JPH08510748A (ja) * 1993-05-21 1996-11-12 ザ リポソーム カンパニー、インコーポレーテッド リポソームが誘発する生理的副作用の低減
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
CN1068229C (zh) * 1993-12-15 2001-07-11 勃勒柯研究有限公司 超声对比介质、含该介质的对比剂及方法
CN1148812A (zh) * 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
ES2165971T3 (es) * 1995-02-24 2002-04-01 Bracco Research Sa Suspensiones de liposomas como agentes de contraste para la imagineria de la sangre.
DE19518221A1 (de) * 1995-05-10 1996-11-14 Schering Ag Verwendung nichtsteroidaler Entzündungshemmer zur Verbesserung der physiologischen Verträglichkeit partikulärer pharmazeutischer Zubereitungen
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JP4109780B2 (ja) 1998-03-06 2008-07-02 株式会社東海理化電機製作所 ギヤ機構及びウエビング巻取装置
WO1999049849A1 (en) * 1998-03-31 1999-10-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal bupivacaine compositions and methods of preparation
US6706280B2 (en) * 1998-08-19 2004-03-16 Bracco Research S.A. Carboxylated phosphatidic acid esters
JP3980777B2 (ja) 1998-11-02 2007-09-26 株式会社東海理化電機製作所 ウエビング巻取装置
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
PT1502586E (pt) 1999-05-27 2007-01-31 Euro Celtique Sa Utilização de anti-sépticos no fabrico de uma preparação farmacêutica para a prevenção ou o tratamento de processos inflamatórios no interior do corpo humano
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
US7297344B1 (en) 1999-05-27 2007-11-20 Euro-Celtique, S.A. Preparations for the promotion of wound healing in the upper respiratory tract and/or ear
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
US8357351B2 (en) * 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7713517B2 (en) * 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
WO2006009022A1 (ja) * 2004-07-21 2006-01-26 Konica Minolta Medical & Graphic, Inc. リポソーム含有ｘ線造影剤およびその製造方法
EP1776948B1 (de) * 2004-08-11 2015-12-09 Konica Minolta Medical & Graphic, Inc. Verfahren zur herstellung einer liposomhaltigen zubereitung
WO2006047409A2 (en) * 2004-10-22 2006-05-04 Dynamis Therapeutics, Inc. Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds
WO2007129311A2 (en) * 2006-05-04 2007-11-15 Pan Sci Tech S.A. Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct
JP2011506325A (ja) * 2007-12-05 2011-03-03 マーバル バイオサイエンシーズ インコーポレイテッド ナノスケールのコントラスト剤及びその使用方法
US20090311191A1 (en) * 2008-06-13 2009-12-17 Ananth Annapragada Imaging of atherosclerotic plaques using liposomal imaging agents
WO2010107990A1 (en) * 2009-03-19 2010-09-23 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
IT1404011B1 (it) 2010-12-03 2013-11-08 Uni Degli Studi Magna Graecia Di Catanzaro Nanovettore coniugato con tsh per il trattamento del cancro della tiroide
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
WO2016109400A2 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
AU2017260532A1 (en) 2016-05-04 2018-11-22 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

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US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
CH641682A5 (en) * 1978-10-05 1984-03-15 Daeniker Felix X-ray contrast medium
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4519024A (en) * 1983-09-02 1985-05-21 At&T Bell Laboratories Two-terminal transistor rectifier circuit arrangement
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4567034A (en) * 1984-09-07 1986-01-28 E. R. Squibb & Sons, Inc. Esters of diatrizoic acid as X-ray contrast agents
CH672733A5 (de) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
CA1303978C (en) 1992-06-23
IL86409A0 (en) 1988-11-15
US5312615A (en) 1994-05-17
ES2009917A6 (es) 1989-10-16
EP0314764B2 (de) 2000-02-02
ATE80294T1 (de) 1992-09-15
US5445810A (en) 1995-08-29
AU612371B2 (en) 1991-07-11
WO1988009165A1 (en) 1988-12-01
EP0314764B1 (de) 1992-09-09
EP0314764A1 (de) 1989-05-10
CH672733A5 (de) 1989-12-29
US5626832A (en) 1997-05-06
IL86409A (en) 1991-12-12
AU1805488A (en) 1988-12-21
JPH02500192A (ja) 1990-01-25
ZA883449B (en) 1988-11-16
DE3874485D1 (de) 1992-10-15
MX9203271A (es) 1992-07-01
JP2619037B2 (ja) 1997-06-11
DE3874485T2 (de) 1993-03-11

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8339 Ceased/non-payment of the annual fee