DE3856354T2 - Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren - Google Patents

Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren

Info

Publication number
DE3856354T2
DE3856354T2 DE3856354T DE3856354T DE3856354T2 DE 3856354 T2 DE3856354 T2 DE 3856354T2 DE 3856354 T DE3856354 T DE 3856354T DE 3856354 T DE3856354 T DE 3856354T DE 3856354 T2 DE3856354 T2 DE 3856354T2
Authority
DE
Germany
Prior art keywords
receptor
retinoic acid
novel
glucocorticoid
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3856354T
Other languages
English (en)
Other versions
DE3856354D1 (de
Inventor
Ronald Mark Evans
Vincent Giguere
Estelita Sebastian Ong
Prudimar Serrano Segui
Kazuhiko Umesono
Catherine Caroline Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26826487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3856354(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of DE3856354D1 publication Critical patent/DE3856354D1/de
Application granted granted Critical
Publication of DE3856354T2 publication Critical patent/DE3856354T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
DE3856354T 1987-12-02 1988-12-02 Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren Expired - Fee Related DE3856354T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12833187A 1987-12-02 1987-12-02
US07/276,536 US4981784A (en) 1987-12-02 1988-11-30 Retinoic acid receptor method

Publications (2)

Publication Number Publication Date
DE3856354D1 DE3856354D1 (de) 1999-09-02
DE3856354T2 true DE3856354T2 (de) 1999-12-16

Family

ID=26826487

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3854120T Expired - Fee Related DE3854120T2 (de) 1987-12-02 1988-12-02 Retinoesäure-Rezeptor-Komposition und Verfahren zur Ligand-Identifizierung.
DE3856354T Expired - Fee Related DE3856354T2 (de) 1987-12-02 1988-12-02 Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3854120T Expired - Fee Related DE3854120T2 (de) 1987-12-02 1988-12-02 Retinoesäure-Rezeptor-Komposition und Verfahren zur Ligand-Identifizierung.

Country Status (11)

Country Link
US (2) US4981784A (de)
EP (2) EP0325849B1 (de)
JP (3) JP3006716B2 (de)
KR (1) KR970009951B1 (de)
AT (2) ATE182685T1 (de)
AU (1) AU628312B2 (de)
DE (2) DE3854120T2 (de)
DK (1) DK136890D0 (de)
ES (1) ES2073408T3 (de)
IE (1) IE68590B1 (de)
WO (1) WO1989005355A1 (de)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
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DK136890A (da) 1990-06-01
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